Durham, NC - A team led by researchers at Newcastle University, UK has successfully created a model of the cells found in the lungs that can be used to replicate how COVID-19 infects the airways. This information, reported today in the STEM CELLS journal, paves the way for broader studies of viral lung infections using a cost-effective system that can easily be manufactured on a large scale. COVID-19, which to date has resulted in more than 3.5 million deaths worldwide, has brought on an urgent need for airway models that can be used to develop effective therapies. While the use of in vitro (outside the body) models generated from primary pulmonary epithelial cells that mimic the human ...

In a retrospective study believed to be one of the largest of its kind, researchers say they have successfully charted the health risks, growth patterns, and medical and surgical outcomes of 1,374 people with the most common form of dwarfism, called achondroplasia, seen over a 60-year period at four academic medical centers, including Johns Hopkins Medicine. The findings, according to the researchers, not only affirm some long-standing views and trends in the care of those with the condition, but also offer a standardized baseline, a blueprint investigators hope will serve to speed diagnosis and improve patients' quality of life and health. Achondroplasia is caused by a rare genetic mutation that alters the activity of the fibroblast growth factor receptor 3 (FGFR3) gene involved in bone ...

The most severe mass extinction event in the past 540 million years eliminated more than 90 percent of Earth's marine species and 75 percent of terrestrial species. Although scientists had previously hypothesized that the end-Permian mass extinction, which took place 251 million years ago, was triggered by voluminous volcanic eruptions in a region of what is now Siberia, they were not able to explain the mechanism by which the eruptions resulted in the extinction of so many different species, both in the oceans and on land. Associate professor Laura Wasylenki of Northern Arizona ...

Alexandria, VA, and New Rochelle, NY, June 17, 2021--Catherine F. Sinclair, MD, has been appointed the next Editor-in-Chief of VideoEndocrinology™, published by Mary Ann Liebert, Inc. "I am honored and delighted to have been selected as the next EIC of VideoEndocrinology. I look forward to helping promote novel concepts and techniques in thyroidology and to assisting the wider community in navigating the rapidly evolving landscape of surgical and non-surgical management options for thyroid disease. I eagerly anticipate the opportunity to work with colleagues from multiple disciplines to showcase ...

A method for making ultrathin sensors for monitoring the health of crops could help farmers grow more food without putting extra demands on the land. Intensive agriculture is already contributing to widespread biodiversity loss and climate change, yet growing populations continue to put pressure on farmers to produce more food. The challenge now lies in increasing agricultural output without clearing more land or applying excessive fertilizers. Precision farming is a promising solution that involves real-time monitoring of plant needs and responding to them with just the right amount of water, light or nutrients. "Precision farming typically relies on soil-based sensors or drones fitted with special cameras," says Ph.D. student Abdullah ...

A SARS-CoV-2 lateral flow test that combines two bacterial enzymes with genetic sequences and a couple of probes is cheaper and easier to use than PCR tests while producing comparably reliable results. Called Vigilant and designed at KAUST, the test can detect very small amounts of viral RNA in a sample. "Several types of lateral flow tests are currently available or under research for detecting SARS-CoV-2," says KAUST Ph.D. student Tin Marsic. "Depending on how they work, they all have disadvantages, including detecting the virus only several days after infection or producing false positive and false negative results." PCR tests, which are conducted in laboratories, produce more reliable results but are expensive and require sophisticated ...

In recent years, the use of medical cannabis to treat sick kids is on the rise, although questions remain about the benefits and safety of such treatments. Now, a team of researchers from the Hebrew University of Jerusalem (HU) has completed a first-ever meta-analysis of pediatric patients treated with medical cannabis to better understand the risks and benefits of cannabis use among young patients. The meta-review was led by Professor Ilan Matok at HU's School of Pharmacy and the David R. Bloom Center for Pharmacy, along with and PhD candidate Nir Treves. They will present their findings at the 31st Annual International Cannabinoid Research Society Symposium (ICRS) being held in ...

COLUMBUS, Ohio - Instagram users who detect self-promotion or corporate marketing in a post embracing the body positivity movement may be turned off by that dual messaging, new research suggests. In the study, women viewed experimental Instagram posts that borrowed body positive messages from actual users and contained body positive hashtags, such as #bopo. The posts all featured the same initial body positive sentiment, but some posts also asked viewers to either like and follow their profiles and others advertised products or services. Researchers found that participants who spotted self-promotion or advertising considered the posts less morally appropriate and not altogether sincere in their support of the body positivity movement ...

DALLAS, June 21, 2021 — Health care experts urge increased awareness of obstructive sleep apnea among people with cardiovascular disease or risk factors such as high blood pressure, according to a new scientific statement from the American Heart Association, published today in Circulation, the Association’s flagship journal. Obstructive sleep apnea (OSA) occurs in 40% to 80% of people with cardiovascular disease, yet it is under-recognized and undertreated, according to the statement. OSA occurs when an upper airway obstruction causes repeated episodes of disrupted breathing during sleep. Symptoms include snoring, lapses in breathing, fragmented sleep and daytime sleepiness. In general, about 34% of middle-aged men and 17% of middle-aged women meet ...

DALLAS, June 21, 2021 — Older adults taking blood pressure-lowering medications known to cross the blood-brain barrier had better memory recall over time compared to those taking other types of medicines to treat high blood pressure, according to new research published today in the American Heart Association journal Hypertension. High blood pressure, or hypertension, is a risk factor for cognitive decline and dementia in older adults. Nearly half of American adults have elevated blood pressure. Treating high blood pressure with blood pressure-lowering medicines reduced the cases ...

New technology could help cities around the world improve people's lives while saving billions of dollars. The free, open-source software developed by the Stanford Natural Capital Project creates maps to visualize the links between nature and human wellbeing. City planners and developers can use the software to visualize where investments in nature, such as parks and marshlands, can maximize benefits to people, like protection from flooding and improved health. "This software helps design cities that are better for both people and nature," said Anne Guerry, Chief Strategy Officer and Lead Scientist at the Natural Capital Project. "Urban nature is a multitasking benefactor - the trees ...

São Paulo, Brazil - A multidisciplinary analysis by a group of Brazilian scientists, published online in the journal Scientific Reports on June 21, 2021, revealed that three major factors accounted for the geographic spread of SARS-COV-2 across Brazil, as well as the massive flow of people in search of hospital care throughout the country, during the first wave of the pandemic in 2020. SARS-CoV-2 entered Brazil at the end of February 2020 through the country's international airports. Mathematical modeling revealed that during the first weeks of March 2020, the "super-spreader city" of São Paulo, located next to both the largest Brazilian international ...

First and only report to interview large sample of workers in garment supply chain (1200 workers across 302 factories and four countries) found an increase in risk of forced labour during pandemic This risk has been exacerbated by the response of retail companies, and there is little evidence most have acted in line with their social responsibilities to support their supply chain workers, despite many accessing pandemic recovery funds A new comprehensive system was used during the study to look for the indicators that someone is vulnerable to forced labour The recovery from the pandemic should include support for supply chain workers to mitigate the deterioration ...

Indigenous people living in rural Canada are 16 times more likely to have to travel 200 km or more to give birth than non-Indigenous people, underscoring the need for more access to birthing facilities and providers for Indigenous families in rural regions, found new research published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.201903. Using data from the Canadian Maternity Experiences Survey (MES), this study included 3100 mothers living in rural and small towns in Canada and weighted the sample to represent 31,100 mothers, totaling 1800 Indigenous and 29,300 non-Indigenous mothers. First Nations women living on-reserve were excluded from the MES. Indigenous ...

In rare cases, adults who have recovered from COVID-19 may develop multisystem inflammatory syndrome, and clinicians should consider this possibility in adults with specific symptoms, as physicians describe in a case published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.210232. A 60-year-old man, who had tested positive for SARS-CoV-2 four weeks before, visited hospital for a range of symptoms, including prolonged shortness of breath, high fever, swelling and severe fatigue. Testing found an enlarged heart and lung swelling as well as other issues. "Given the patient's recent history of SARS-CoV-2 infection, fevers without localizing ...

New research uncovers substantial differences in rates of childhood cancers when considering single year of age rather than grouping several years together. The study published by Wiley early online in CANCER, a peer-reviewed journal of the American Cancer Society, also found that minority children have different risks than white children for many types of cancer. Cancer rates among children in the United States are typically reported in 5-year age groups, which may obscure important details. Also, racial and ethnic variations in pediatric cancer rates are typically presented in ...

When a University of Michigan-led research team reported last year that North American migratory birds have been getting smaller over the past four decades and that their wings have gotten a bit longer, the scientists wondered if they were seeing the fingerprint of earlier spring migrations. Multiple studies have demonstrated that birds are migrating earlier in the spring as the world warms. Perhaps the evolutionary pressure to migrate faster and arrive at breeding grounds earlier led to the physical changes the U-M-led team observed. "We know that bird morphology has a major effect on the efficiency and speed of flight, so we became curious whether the environmental ...

University of Maryland School of Medicine (UMSOM) researchers identified a new gene that may be linked to certain neurodevelopmental disorders and intellectual disabilities. The researchers believe that finding genes involved in certain types of developmental disorders, provide an important first step in determining the cause of these disorders and ultimately in developing potential therapies for treating them. The paper was recently published in the American Journal of Human Genetics. About 3 percent of the world's population has intellectual disability. Up to half the cases are due to genetics, however, because many thousands of genes contribute to brain development, it has been difficult to identify the specific cause for each patient. Once the researchers ...

People who struggle with social anxiety might experience increased distress related to mask-wearing during and even after the COVID-19 pandemic. A paper authored by researchers from the University of Waterloo's Department of Psychology and Centre for Mental Health Research and Treatment also has implications for those who haven't necessarily suffered from social anxiety in the past. "The adverse effects of the COVID-19 pandemic on mental health outcomes, including anxiety and depression, have been well-documented," said David Moscovitch, professor of clinical psychology and co-author of the paper. "However, little is known about effects of increased mask-wearing on social interactions, social anxiety, or overall mental health. "It is also possible ...

Pseudomonas aeruginosa is an opportunistic pathogenic bacterium present in many ecological niches, such as plant roots, stagnant water or even the pipes of our homes. Naturally very versatile, it can cause acute and chronic infections that are potentially fatal for people with weakened immune systems. The presence of P. aeruginosa in clinical settings, where it can colonise respirators and catheters, is a serious threat. In addition, its adaptability and resistance to many antibiotics make infections by P. aeruginosa increasingly difficult to treat. There is therefore an urgent need to develop new antibacterials. Scientists from the University of Geneva (UNIGE), Switzerland, ...

(Vienna, Monday, 21 June, 2021) COVID-19 patients suffer from cognitive and behavioural problems two months after being discharged from hospital, a new study presented at the 7th Congress of the European Academy of Neurology (EAN) has found. Issues with memory, spatial awareness and information processing problems were identified as possible overhangs from the virus in post-COVID-19 patients who were followed up within eight weeks. The research also found that one in 5 patients reported post-traumatic stress disorder (PTSD), with 16% presenting depressive symptoms. ...

The first global standards to embed health and wellbeing into the education system have been created amid a rise in mental health problems during the COVID-19 pandemic. Researchers at the Centre for Adolescent Health at the Murdoch Children's Research Institute (MCRI) led the two-year project at the invitation of the World Health Organization (WHO) and the United Nations Educational, Scientific and Cultural Organization (UNESCO). The two reports, to be launched this week in Geneva, provide a benchmarking framework to support the implementation of 'health promoting schools,' which aim to equally foster health ...

Washington, DC - June 20, 2021 - Researchers from Yonsei University in South Korea have found that certain commensal bacteria that reside in the human intestine produce compounds that inhibit SARS-CoV-2. The research will be presented on June 20 at World Microbe Forum, an online meeting of the American Society for Microbiology (ASM), the Federation of European Microbiological Societies (FEMS), and several other societies that will take place online June 20-24. Previous clinical findings have shown that some patients with moderate to severe COVID-19 have gastro-intestinal symptoms, while others showed signs of infection solely in the lungs. "We wondered whether gut ...

Washington, D.C. - June 20, 2021 - Increased screen time among young adults during the COVID-19 pandemic correlated with a rise in pandemic-related distress, according to research led by investigators at the Saint James School of Medicine on the Caribbean island nation, Saint Vincent. The increase in time spent viewing entertainment on a screen both prior to and during the pandemic was associated with a boost in anxiety scores. Students scored higher than non-students in pandemic-related distress. Surprisingly, the results showed no association of depression with screen ...

Washington, DC - June 20, 2021 - Researchers from the Miami University in Ohio have optimized a new technique that will allow scientists to evaluate how potential inhibitors work on antibiotic-resistant bacteria. This technique, called native state mass spectrometry, provides a quick way for scientists to identify the best candidates for effective clinical drugs, particularly in cases where bacteria can no longer be treated with antibiotics alone. This research will be presented at the American Society for Microbiology World Microbe Forum online conference on June 21, 2021. Overuse of antibiotics in the last century has led to a rise in bacterial resistance, leading to many bacterial infections that are no longer treatable with current antibiotics. In the United States each year, 2.8 million ...