PROVIDENCE, R.I. [Brown University]—When patients receive a low-dose computed tomography screen for lung cancer, doctors can see more than just the lungs. The screening test often picks up abnormalities or potentially “significant incidental findings” (SIFS) not associated with lung cancer. A new study led by Ilana Gareen, an associate professor of epidemiology at the Brown University School of Public Health, and published in JAMA Internal Medicine, highlights the need for proper reporting and management of these findings to reduce mortality, health care costs and unnecessary ...

“In summary, single-cell transcriptomic analysis has allowed us to identify the specific populations and the dynamic transition states during senescence initiation and progression.” BUFFALO, NY- May 9, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, “Single-cell transcriptomic analysis uncovers diverse and dynamic senescent cell populations.” Senescence is a state of enduring growth arrest triggered by sublethal cell damage. Given that senescent cells actively ...

Researchers at Baylor College of Medicine have linked specific variants or mutations of the gene myocardin-related transcription factor B (MRTFB) with a novel neurodevelopmental disorder. The team reports in the journal Genetics in Medicine that they were able to find variants in this gene in patients whose neurodevelopment disorders had previously gone undiagnosed. The research also revealed that the mutations disrupt the way the MRTFB protein controls other genes in the cell and this cascades to affect hundreds of other genes. “We identified ...

Many middle-aged and older women get mammograms every one to two years to screen for breast cancer, as recommended by their doctors. A study by researchers at Washington University School of Medicine in St. Louis indicates that previous mammograms hold underutilized data that could help identify women at high risk of breast cancer and even reveal which breast is likely to be affected. When doctors read mammograms, they assess breast density along with signs of cancer, comparing a woman’s previous mammograms to her most recent one to look for worrisome changes. But some changes are difficult to ...

(Boston)—COVID-19, the disease resulting from SARS-CoV-2 infection, is associated with highly variable clinical outcomes that range from asymptomatic disease to death. For those with milder infections, COVID-19 can produce respiratory infection symptoms (cough, congestion, fever) and sensory phenotypes such as headache and loss of sense of smell. In more severe cases, SARS-CoV-2 infection can affect nearly every organ and result in strokes from vascular occlusion, cardiovascular damage and acute renal failure. ...

New Method Uses Engineered Bacteria and AI to Sense and Record Environmental Signals Columbia synthetic biologists first to engineer bacterial swarm patterns to visibly record environment, use deep learning to decode patterns; applications could range from monitoring environmental pollution to building living materials  New York, NY—May 9, 2023—Researchers in Biomedical Engineering Professor Tal Danino’s lab were brainstorming several years ago about how they could engineer and apply naturally-pattern-forming bacteria. There are many bacteria species, such as Proteus mirabilis (P. mirabilis), that self-organize into defined patterns on solid surfaces that are visible ...

Philadelphia, May 9, 2023 – The increase in obesity in lower-middle-income countries (LMIC) is largely thought to be affected by lifestyle transition away from traditional diets toward unhealthy Western dietary patterns that follow economic development. This study in the Journal of Nutrition Education and Behavior, published by Elsevier, collected data on eating and physical activity behaviors from families in two socioeconomically-different communities in Nairobi, Kenya. Researchers found that increasing prosperity is linked to unhealthy eating patterns in Kenyan preadolescents. "Dietary ...

The University of Ottawa’s Interdisciplinary Centre for Black Health survey reveals scope of coronavirus vaccine hesitancy in Black communities in relation to healthcare. The health care system must play a significant role in combatting COVID-19 mistrust among Black individuals in Canada according to a new University of Ottawa study that found distrust in the healthcare network was so profound that educated individuals were hesitant to receive the vaccine. Professor Jude Mary Cénat, Associate Professor in the School of Psychology at the Faculty of Social Sciences, is the Chair of the Interdisciplinary Centre ...

CHICAGO, May 9, 2023 – Millions of people now regularly communicate with AI-based devices, such as smartphones, speakers, and cars. Studying these interactions can improve AI’s ability to understand human speech and determine how talking with technology impacts language. In their talk, “Clear speech in the new digital era: Speaking and listening clearly to voice-AI systems,” Georgia Zellou and Michelle Cohn of the University of California, Davis will describe experiments to investigate how speech and comprehension change when humans communicate ...

According to a new Johns Hopkins Medicine study, low pain self-efficacy can predict daily pre-surgery prescribed opioid use among patients seeking elective spine surgery. The study defined pain self-efficacy as the “beliefs held by people with chronic pain that they can carry out certain activities, even when experiencing pain.” Previous studies showed that lower pain self-efficacy is associated with higher pain intensity and greater pain interference in day-to-day life. However, the Johns Hopkins research team believes its study is among the first to investigate ...

Vitamin D intake could reduce cancer mortality in the population by twelve percent - provided the vitamin is taken daily. This was the result of an evaluation of 14 studies of the highest quality conducted at the German Cancer Research Center with a total of almost 105,000 participants. Vitamin D deficiency is widespread worldwide and is particularly common among cancer patients. Averaged over the year, the vitamin D blood levels of about 15 percent of German adults are below the threshold for a pronounced vitamin D deficiency*. In contrast, in a study of colorectal ...

Scientists from UNSW Sydney with collaborators at Boston University have developed a tool that shows early promise in detecting Parkinson’s disease years before the first symptoms start appearing. In research published today in the journal ACS Central Science, the researchers described how they used neural networks to analyse biomarkers in patients’ bodily fluids. The researchers from UNSW School of Chemistry examined blood samples taken from healthy individuals gathered by the Spanish European ...

SAN ANTONIO — May 9, 2023 —NASA has selected Southwest Research Institute for a Phase A study to develop SwRI’s Space Weather Solar Coronagraph (SwSCOR) on behalf of the National Oceanic and Atmospheric Administration (NOAA). NOAA’s Space Weather Next Program is charged with providing critical data for its space weather prediction center. SwRI is one of five organizations developing a definition-phase study to produce the next-generation NOAA L1 Series COR instrument to detect and characterize Earth-directed coronal mass ejections (CMEs). CMEs are huge bursts of coronal plasma threaded with intense magnetic fields ...

AUGUSTA, Ga. (May 9, 2023) –  A long molecule of RNA found in abundance in the healthy smooth muscle cells that give our blood vessels strength and flexibility is also essential to the continuous contraction that moves food through our gastrointestinal tract. Without CARMN, a long, noncoding RNA, which means it doesn’t produce proteins but does help regulate cell activity, the 30-foot-long GI tract doesn’t contract as it should. That can result in a painful even lethal situation where partially undigested food gets ...

A gene-edited calf shows resistance to a common bovine virus. Bovine viral diarrhea virus (BVDV) causes gastrointestinal and respiratory symptoms as well as reproductive failure in cattle around the world. Vaccines against the virus exist but the virus evolves quickly and vaccines are not always fully protective. Aspen Workman and colleagues used the CRISPR/Cas9 system to swap out just six amino acids in the bovine CD46 receptor in one calf. The calf showed a dramatic reduction in susceptibility to the virus and ...

Led by researchers from NYU Grossman School of Medicine and University of Szeged in Hungary, a new study in mice and rats found that restoring certain signals in a brain region that processes smells countered depression. Publishing in the journal Neuron online May 9, the study results revolve around nerve cells (neurons), which “fire” – or emit electrical signals – to transmit information. Researchers in recent years discovered that effective communication between brain regions ...

Scientists have used mitochondrial DNA to trace a female lineage from northern coastal China to the Americas. By integrating contemporary and ancient mitochondrial DNA, the team found evidence of at least two migrations: one during the last ice age, and one during the subsequent melting period. Around the same time as the second migration, another branch of the same lineage migrated to Japan, which could explain Paleolithic archeological similarities between the Americas, China, and Japan. The study appears May 9 in the journal Cell Reports. “The Asian ...

About The Study: Between 1999 and 2020, deaths coded as being caused by falls among adults age 65 or older in the U.S. increased in number and rates for the overall population and for every population subgroup, although the magnitude of the increase varied. However, the relative ranking of the different groups has not changed over time.  Authors: Alexis R. Santos-Lozada, Ph.D., of Pennsylvania State University in University Park, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2023.3054) Editor’s ...

WASHINGTON, May 9, 2023 – Espresso coffee is brewed by first grinding roasted coffee beans into grains. Hot water then forces its way through a bed of coffee grains at high pressure, and the soluble content of the coffee grains dissolves into the water (extraction) to produce espresso. In 2020, researchers found that more finely ground coffee beans brew a weaker espresso. This counterintuitive experimental result makes sense if, for some reason, regions exist within the coffee bed where less or even no coffee is extracted. This uneven extraction becomes more pronounced when coffee is ground more finely. In Physics of Fluids, from AIP Publishing, ...

WASHINGTON, May 9, 2023 – The mountain pine beetle is one of the main causes of tree mortality in the pine forests of North America. For example, the insect has killed thousands of acres of pine forest in British Columbia and Alberta, and as a result, the areas are more vulnerable to wildfire. Increased tree mortality has turned Canada’s forests into a large net source of atmospheric carbon dioxide – emitted from the burned or decaying wood of dead trees – rather than a sink. In Physics of Fluids, by AIP Publishing, researchers from the University of Alberta studied the flight performance of the mountain pine beetle from a fluid mechanics and an entomological perspective. ...

Study following Chicagoans over a 25-year period suggests over half of the city’s Black and Hispanic population, and a quarter of its White population, have seen a shooting by age 40. Researchers followed over two thousand people, with 50% of all the study’s participants witnessing a shooting. Average age when first witnessing a shooting was just 14 years old. Women only slightly less likely than men to witness shootings, despite men being far more likely to get shot. Such levels of violence exposure may cause chronic stress and knock-on health implications for populations in Chicago and elsewhere. A ...

About The Study: In this study, patients using medical cannabis reported improvements in health-related quality of life, which were mostly sustained over time. Adverse events were rarely serious but common, highlighting the need for caution with prescribing medical cannabis. Authors: Thomas R. Arkell, Ph.D., of the Swinburne University of Technology in Melbourne, Victoria, Australia, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi: ...

The SARS-Cov-2 pandemic illustrates how variable vaccines can be in their length of efficacy, with regular boosters needed to keep people protected. In comparison, the immunity generated by a single vaccination against the measles virus can last decades. It has always remained a scientific mystery as to why only some vaccines lead to life-long protection. Now a paper published in the journal, Immunity, led by Prof. David Tarlinton and Dr Marcus Robinson, both from Monash University’s Central Clinical School in Melbourne, Australia, has found that the clue likely lies in the body producing a unique subtype of an immune cell in response to some ...

Exposure to gun violence is one of the great traumas of American life, but its harms are not equally distributed. In a first-of-its-kind study published Tuesday in JAMA Network Open, a Harvard sociology professor and his colleagues set out to examine exposure to shootings by race, sex, and birth year in a long-term study that followed respondents from childhood up to age 40.   “The idea here is to take a life-course perspective,” said Robert J. Sampson, the Woodford L. and Ann A. Flowers University Professor. ...

We’ve all recently gotten a crash-course in drug repurposing, thanks to near-daily news reports about efforts to identify existing medicines that could help treat COVID-19 in the early phase of the pandemic. A team of scientists at the Wyss Institute at Harvard University jumped into the fray in the spring of 2020, applying novel computational drug repurposing approaches to confront the COVID-19 challenge. This early work led to the surprising prediction that a some, but not all, types of statins (drugs that are widely prescribed to lower cholesterol) might protect patients against SARS-CoV-2 infection. In the flurry of clinical studies being published by other scientists studying ...