Only four weeks of shift work-like patterns in female mice are enough to disrupt their biological clock and reduce fertility, according to research presented at the 25th European Congress of Endocrinology. The findings help scientists better understand how circadian disturbances impact female fertility, which could eventually lead to future prevention strategies for women working in non-standard work schedules. The circadian rhythm is generated by the body’s internal clocks which are synchronised to a 24-hour period, mostly by changes in light across days. These clocks regulate various biological functions and processes, including the sleep-wake cycle, ...

The board of governors of the SWOG Cancer Research Network has elected Primo N. Lara, Jr., MD, and Dawn L. Hershman, MD, MS, as group co-chairs-elect. The two will serve in that capacity until the term of the current group chair, Charles D. Blanke, MD, ends in spring 2025. They will then begin a six-year term as SWOG’s first group co-chairs. In a joint statement, Hershman and Lara said, “We both understand that the success of SWOG has been fundamentally anchored in collaborative interdisciplinary team science. We are convinced ...

Boulder, Colo., USA: The Geological Society of America (GSA) is pleased to announce the upcoming 2023 GSA Rocky Mountain Section Meeting to be held from 23–25 May in Fort Collins, Colorado, USA. This highly anticipated event will provide a dynamic platform for scientists, researchers, industry professionals, and students to exchange ideas, present research findings, and foster collaborations. The meeting will feature a wide range of engaging sessions, a plenary lecture on climate intervention, scientific field trips, informative short courses, and impactful mentoring programs ...

COMBINEDBrain’s Founder and Director, Dr. Terry Jo Bichell, understands the power of collaboration. In her years as a neuroscientist, advocate, and rare patient parent, she has witnessed the field of neurodevelopment transform from a broad focus on autism  or intellectual disability,  to an era based on rare genetic  disorders.  When new disorders are identified, Patient Advocacy Organizations spring up, led by passionate parents with the drive and determination to cure their children. Some of these organizations represent as many as 10,000 patients, some as few as 10.  No matter their size, each organization must follow a similar path to ...

Liquid biopsy is increasingly stepping up as a non-invasive approach in detecting and tracking circulating tumor DNA (ctDNA) in blood and providing crucial insights into the dynamics of cancer evolution and intra-tumor heterogeneity as drivers of cancer drug resistance.   One main limitation of liquid biopsy to-date is the low sensitivity of current approaches in tumor types that do not shed enough DNA into the bloodstream, including pancreatic cancer.   Co-led by VHIO’s Rodrigo A. Toledo, a study published in Genome Medicine (1) reports on the development of a novel ctDNA-based approach, Aneuploidy in Circulating Tumor DNA ...

Researchers at Rutgers University have found a major flaw in the way that algorithms designed to detect "fake news" evaluate the credibility of online news stories. Most of these algorithms rely on a credibility score for the "source" of the article, rather than assessing the credibility of each individual article, the researchers said. "It is not the case that all news articles published by sources labeled 'credible' (e.g., The New York Times) are accurate, nor is it the case that every article published by sources labeled 'noncredible' publications are 'fake news,'" ...

Spooked by volatile reports from the Silicon Valley Bank in early March, many customers panicked and withdrew their money, creating the largest bank failure since the 2007-2008 financial crisis. The problem — investors and customers lost confidence in the bank, proving the perception of a banks’ reliability can significantly impact its success. Investors tend to respond negatively to volatility in firms’ performance. To mitigate investors’ concerns, when some banks receive extremely high income, they occasionally delay reporting that amount until a later date when the income ...

“[...] we have developed a fully automated calling algorithm for determining B and T cell clonality from NGS [next-generation sequencing] data, with greater sensitivity than previously developed models.” BUFFALO, NY- May 16, 2023 – A new research paper was published in Oncotarget's Volume 14 on May 12, 2023, entitled, “Development and implementation of an automated and highly accurate reporting process for NGS-based clonality testing.” B and T cells undergo random recombination of the VH/DH/JH portions of the immunoglobulin loci (B cell) and T-cell receptors before becoming ...

“This study now links Msi 1 to PD-L1.” BUFFALO, NY- May 16, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, “Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow.” Breast cancer (BC) stem cells (CSCs) resist treatment and can exist as dormant cells in tissues such as the bone marrow (BM). Years before clinical diagnosis, BC cells (BCCs) could migrate from the primary site where the BM niche ...

Irvine, Calif., May 16, 2023 — The MGAT5 glycosylation enzyme plays a crucial role in brain development, according to a study by University of California, Irvine researchers, a discovery that may contribute to new therapeutic purposes for neural stem cells. Neurons, astrocytes and oligodendrocytes are the final mature cells of the brain and spinal cord formed by neural stem cells. Each has distinct and key functions. Neurons transmit signals, astrocytes help modify those signals, and oligodendrocytes ...

Like the lymphatic system in the body, the glymphatic system in the brain clears metabolic waste and distributes nutrients and other important compounds. Impairments in this system may contribute to brain diseases, such as neurodegenerative diseases and stroke. A team of researchers in the McKelvey School of Engineering at Washington University in St. Louis has found a noninvasive and nonpharmaceutical method to influence glymphatic transport using focused ultrasound, opening the opportunity to use the method to further study brain diseases and brain function. Results of the work are published in the Proceedings ...

The prize, now in its 10th year, is given annually to at least six early-career scientists based in the New York City area by The Pershing Square Sohn Cancer Research Alliance. Prizes are awarded to scientists who are pursuing innovative cancer research and taking risks that might preclude them from traditional funding. Winners receive $250,000 a year for up to three years and access to networking opportunities and an annual retreat with past winners. For Dr. Simon, the prize will allow him to apply his knowledge as a neuroscientist to cancer research. “I'm not a traditional cancer biologist,” said Dr. ...

A team from the University of Michigan Rogel Cancer Center and School of Dentistry, led by Yu Leo Lei, D.D.S., Ph.D., have identified a mechanism in mice for how obesity affects some oral cancers’ ability to escape from the immune system. This study, published in Cell Reports, found that obesity helps to establish a type of tumor microenvironment that promotes tumor progression. How exactly this happens lies in the relationship between the saturated fatty acids, the STING-type-I interferon pathway, and NLRC3. “We tend to think about the increased risks for gastrointestinal tumors, breast cancer, pancreatic cancer, and ovarian cancer when it comes to obesity,” ...

If you are a third grader, your chances of growing up to be a computer scientist is likely to heavily depend on your gender — a situation Allison Master says is just plain wrong. How can Master be certain? Because third grade girls are telling her so. “Our new research addresses a big, longstanding issue in STEM education, that women are highly under-represented in fields like computer science. It’s actually one of the most challenging fields for women’s representation. Only about 20% of people who major in computer science are women,” said Master, assistant professor ...

Researchers at the University of Michigan Rogel Cancer Center and the School of Dentistry identified a new metric to articulate the relationship between nerve density and oral cancer. The study, published in Clinical Cancer Research, a journal of the American Association for Cancer Research, investigated normalized nerve density to translate previous mechanistic studies into a context that could be used in the clinic. “We are recognizing more and more that there's a very dynamic interaction between nerves and cancer cells in the tumor microenvironment,” said Nisha D’Silva, B.D.S., M.S.D, Ph.D., Donald Kerr Endowed Collegiate ...

SEATTLE – (May 16, 2023) – Patients with cancer whose immune systems are being supported or rebuilt by bone marrow transplantation should begin receiving vaccines for protection against SARS-CoV-2 three months post-transplant, according to a large, prospective, observational study led collaboratively by the Center for International Blood and Marrow Transplant Research, the Blood & Marrow Transplant Clinical Trials Network and Fred Hutchinson Cancer Center. The research, involving 22 cancer centers and research institutions in the United States and focusing on mRNA-based vaccines, published in The Lancet journal ...

Online workflow systems for off-site radiologists are one reason for health care delays that cost hospitals money and test the patience of patients, according to West Virginia University research. Bernardo Quiroga, associate professor of supply chain management at the WVU John Chambers College of Business and Economics, and his coauthors analyzed a radiology workflow platform, used by thousands of U.S. hospitals, which allows radiologists working from home to log in, view a pool of tasks such as X-rays or CT and MRI scans that are available for processing, and choose which of those radiological studies to read and report on. The radiologists’ ...

Contact: Shelby Cefaratti-Bertin, Baylor University Media & Public Relations, 254-327-8012 Follow us on Twitter: @BaylorUMedi WACO, Texas (May 15, 2023) – For most of U.S. history, tattoos have been associated with sailors and bikers, but not church-going people. As tattoos have become more popular, with nearly one-third of U.S. adults sporting at least one tattoo, religious-themed tattoos have also increased. A recent study examined the behaviors of college students with tattoos, including religious tattoos. Jerome R. Koch, Ph.D., professor of sociology at Texas Tech University, and Kevin D. Dougherty, Ph.D., professor of sociology at ...

An old antibiotic may provide much-needed protection against multi-drug resistant bacterial infections, according to a new study publishing May 16th in the open access journal PLOS Biology by James Kirby of Harvard Medical School, US, and colleagues. The finding may offer a new way to fight difficult-to-treat and potentially lethal infections. Nourseothricin is a natural product made by a soil fungus, which contains multiple forms of a complex molecule called streptothricin. Its discovery in the 1940s generated high hopes ...

“The end of modern medicine as we know it.” That’s how the then-director general of the World Health Organization characterized the creeping problem of antimicrobial resistance in 2012. Antimicrobial resistance is the tendency of bacteria, fungus and other disease-causing microbes to evolve strategies to evade the medications humans have discovered and developed to fight them. The evolution of these so-called “super bugs” is an inevitable natural phenomenon, accelerated by misuse of existing drugs and intensified by the lack of new ones in the development ...

Students at the University of Warwick are leading social prescribing research for dementia, highlighting the benefits of this innovative approach during Dementia Action Week.   The ground-breaking dementia café project, led by students from Warwick Medical School, is a shining example of the power of social prescribing in dementia care. By regularly connecting people with dementia to community activities, groups, and services, the project aims to meet practical, social, and emotional needs of people living with dementia while improving their overall health and well-being.   Social prescribing ...

About The Article: This Viewpoint from the Centers for Disease Control and Prevention discusses the prevalence of dengue infection in U.S. territories and opportunities to combat it, such as vaccines and novel vector control methods. Authors: Alfonso C. Hernandez-Romieu, M.D., M.P.H., of the Centers for Disease Control and Prevention in San Juan, Puerto Rico, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2023.8567) Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict ...

Question: In your book you argue the suicidal are oppressed by structural suicidism, a hidden oppression. Alexandre Baril: “I coined the term suicidism to refer to an oppressive system in which suicidal people experience multiple forms of injustice and violence. Our society is replete with horrific stories of suicidal individuals facing inhumane treatment after expressing their suicidal ideations. The intention is to save their lives at all costs and interventions range from being hospitalized and drugged ...

WASHINGTON, May 16, 2023 – For gummy candies, texture might be even more important than taste. Biting into a hard, stale treat is disappointing, even if it still carries a burst of sweetness. Keeping gummies in good condition depends on their formulation and storage, both of which alter how the molecules in the candies link together. In Physics of Fluids, by AIP Publishing, researchers from Ozyegin University and Middle East Technical University conducted a series of experiments that explore how changing key parts of the gummy-making process affects the final product, as well as how the candies ...

About The Study: According to two data sources, in 2018, the economic burden of health inequities for racial and ethnic minority populations (American Indian and Alaska Native, Asian, Black, Latino, and Native Hawaiian and Other Pacific Islander populations) was $421 billion or $451 billion and the economic burden of health inequities for adults without a 4-year college degree was $940 billion or $978 billion. The economic burden of health inequities is unacceptably high and warrants investments in policies and interventions to promote health equity for racial and ethnic minorities and adults with less than a 4-year college degree.  Authors: Darrell ...