Coronary heart disease is the leading cause of adult death worldwide. The coronary angiography procedure provides the clinical standard diagnostic assessment for nearly all related clinical decision-making, from medications to coronary bypass surgery. In many cases, quantifying left ventricular ejection fraction (LVEF) at the time of coronary angiography is critical to optimize clinical decision-making and treatment decisions, particularly when angiography is performed for potentially life-threatening acute coronary syndromes (ACS). Since the left ventricle is the heart’s pumping center, measuring the ejection fraction in the chamber provides critical information about the percentage ...

Leesburg, VA, May 10, 2023—According to an accepted manuscript published in ARRS’ own American Journal of Roentgenology (AJR), frequencies of imaging-apparent and palpable hematoma were not significantly different between patients temporarily discontinuing versus maintaining antithrombotic therapy (AT). “The findings support safety of continuing AT during breast core-needle biopsy (CNB),” wrote lead researcher Melissa Reichman, MD, of Weill Cornell Medicine at New York-Presbyterian ...

COLUMBUS, Ohio - An Ohio State University astronomy professor has been elected to the National Academy of Sciences, one of the highest honors a scientist can receive in the U.S.  David Weinberg, Distinguished University Professor and chair of astronomy, is among 120 new members and 23 international members from 13 countries who were inducted this year in recognition of distinguished and continuing achievement in original research inside their chosen field. “I have been lucky to have great students and great colleagues throughout ...

CLEVELAND - Inhibiting a protein on the surface of immune cells could offer new strategies for treating severe asthma, Cleveland Clinic researchers found. Researchers discovered a new way a protein called MCEMP1 contributes to severe inflammation in the airway and lungs. The discovery, published in Nature Communications, provides critical information for developing therapeutic interventions to treat long-term lung conditions, including asthma, on a biological level.  The study was conducted in a lab led by Jae Jung, PhD, chair ...

A group of researchers led by Andreas Wallraff, Professor of Solid State Physics at ETH Zurich, has performed a loophole-free Bell test to disprove the concept of “local causality” formulated by Albert Einstein in response to quantum mechanics. By showing that quantum mechanical objects that are far apart can be much more strongly correlated with each other than is possible in conventional systems, the researchers have provided further confirmation for quantum mechanics. What’s special about ...

Philadelphia, May 10, 2023 – The dairy industry has seen a revolution over the past two decades in fertility success within herds. Widely adopted fertility programs are at the heart of this leap forward, along with the industry’s increased understanding—and optimization—of the holistic interactions among the body condition, overall health, and fertility of a dairy cow. In a recent mini-review appearing in a special fertility issue of JDS Communications®, published by Elsevier, researchers from the University of ...

Researchers have released a new high-quality collection of reference human genome sequences that captures substantially more diversity from different human populations than what was previously available. The work was led by the international Human Pangenome Reference Consortium, a group funded by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health.    The new “pangenome” reference includes genome sequences of 47 people, with the researchers pursuing the goal of increasing that number to 350 by mid-2024. With each person carrying a paired set of chromosomes, the current reference actually includes 94 distinct genome ...

Comparing individual cells across corn, sorghum, and millet reveals evolutionary differences among these important cereal crops, according to a new study led by New York University researchers.   The findings, published in Nature, bring researchers closer to pinpointing which genes control important agricultural traits such as drought tolerance, which will help scientists faced with a changing climate adapt crops to drier environments.   Corn, sorghum, and millet provide food for humans and animals around the world. Corn and sorghum are ancient relatives that evolved into two different species roughly 12 million years ago, and millet is a more distant relative.    Despite ...

EMBARGOED UNTIL WEDNESDAY, MAY 10, 2023, AT 11AM ET New York, NY (May 10, 2023)—Eimear Kenny, PhD, had just completed undergrad and was working in her first computational genomics job more than 20 years ago when scientists announced the first (nearly) complete sequencing of the human genome—what was considered at the time to be the fundamental blueprint for all humans. The Human Genome Project aimed to map the entire genome in an effort to accelerate the diagnosis and eventual treatment of common and rare diseases. Now, Dr. Kenny, ...

UC Santa Cruz scientists, along with a consortium of researchers, have released a draft of the first human pangenome—a new, usable reference for genomics that combines the genetic material of 47 individuals from different ancestral backgrounds to allow for a deeper, more accurate understanding of worldwide genomic diversity.  By adding 119 million bases—the “letters” in DNA sequences—to the existing genomics reference, the pangenome provides a representation of human genetic diversity that was not possible with a single reference genome. It is highly accurate, more complete and dramatically increases ...

New Haven, Conn. — When it was launched in April 2003, the Human Genome Project helped revolutionize biomedical research by providing scientists a reference map that allowed them to analyze DNA sequences for genetic clues to the origins of a host of diseases. Twenty years later, a team of researchers that includes Yale scientists has created a new “pangenome” that fills in missing sequencing gaps from the original genome project and greatly expands the diversity of genomes represented. The achievement is described in ...

One of the most important advances in palliative care in oncology over the past 15 years has been the recognition that palliative care specialists can improve cancer patients’ outcomes well before their end of life. Palliative care is specialized care provided to individuals with a serious illness that focuses on decision-making support, pain and symptom management, as well as psychosocial interventions to improve quality of life. Several past randomized clinical trials have shown palliative care specialists can improve the quality of life and lengthen the ...

About The Study: In this study, key thematic shifts and increases in language related to anxiety, anger, depression, and loneliness were identified in the content posted on social media by academic emergency medicine physicians and resident physicians during the pandemic. Social media may provide a real-time and evolving landscape to evaluate thematic content and linguistics related to emotions and sentiment for health care workers.  Authors: Anish K. Agarwal, M.D., M.P.H., M.S., of the ...

About The Study: In this secondary analysis of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, overweight and obese body mass index (BMI) in early and middle adulthood was associated with an elevated risk of colorectal cancer and non-colorectal gastrointestinal cancers. The results of the current study prompt further exploration into the mechanistic role of obese BMI in carcinogenesis.  Authors: Holli A. Loomans-Kropp, Ph.D., M.P.H., of Ohio State University in Columbus, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2023.10002) Editor’s ...

UW Medicine genome experts made significant scientific contributions to a National Institutes of Health Human Genome Research Institute reference collection that better represents the genetic diversity of the world’s populations. Called the Human Pangenome Reference Consortium, the multi-institutional effort expands and updates earlier work that started as the Human Genome Project. That original project, with drafts reported in 2001 and 2003, was based on a more limited sampling of human DNA. The goal then was to create an entire sequence of a human genome to use as a reference. ...

For more than 20 years, scientists have relied on the human reference genome, a consensus genetic sequence, as a standard against which to compare other genetic data. Used in countless studies, the reference genome has made it possible to identify genes implicated in specific diseases and trace the evolution of human traits, among other things. But it has always been a flawed tool. One of its biggest problems is that about 70 percent of its data came from a single man of predominantly African-European background whose DNA was sequenced during ...

For more than a decade, astronomers have been trying to get a closer look at GJ 1214b, an exoplanet 40 light-years away from Earth. Their biggest obstacle is a thick layer of haze that blankets the planet, shielding it from the probing eyes of space telescopes and stymying efforts to study its atmosphere. NASA’s new James Webb Space Telescope (JWST) solved that issue. The telescope’s infrared technology allows it to see planetary objects and features that were previously obscured ...

A ‘Matter Arising’ paper published in Nature today refutes the findings of a paper by Sala et al on the amount of CO2 released from the seabed by bottom trawling. The paper made significant headlines around the world on release in 2021, as it equated the carbon released by bottom trawling to be of a similar magnitude to the CO2 created by the global airline industry. In their paper quantifying the carbon benefits of ending bottom trawling, Prof Jan Hiddink of Bangor University’s world-renowned School of Ocean Science and others, explain that the methodology ...

Implantable bioelectrodes are electronic devices that can monitor or stimulate biological activity by transmitting signals to and from living biological systems. Such devices can be fabricated using various materials and techniques. But, because of their intimate contact and interactions with living tissues, selection of the right material for performance and biocompatibility is crucial. In recent times, conductible hydrogels have attracted great attention as bioelectrode materials owing to their flexibility, compatibility, and excellent interaction ability. However, the absence ...

FOR IMMMEDIATE RELEASE With a $35 million gift from researcher, philanthropist and race car driver Theodore Giovanis, scientists at Johns Hopkins Medicine will study the biological roots of the most fatal aspect of cancer: how it metastasizes, or spreads, through the body. The contribution, a 15-year commitment, will establish the Giovanis Institute for Translational Cell Biology, dedicated to studying metastasis. The institute’s researchers aim to make discoveries that reveal common features of metastasis across cancer types, ...

WASHINGTON (May 10, 2023) – Elevated maternal stress during the COVID-19 pandemic changed the structure, texture and other qualities of the placenta in pregnant mothers – a critical connection between mothers and their unborn babies – according to new research from the Developing Brain Institute at Children’s National Hospital.    Published in Scientific Reports, the findings spotlight the underappreciated link between the mental health of pregnant mothers and the health of the placenta – a critical organ ...

A newly piloted program from the Society for Cardiovascular Angiography & Interventions (SCAI), the leading society representing interventional cardiology, hopes to increase access and encourage interest in interventional cardiology early in students' medical careers. SCAI's Ready to Launch - Careers in Cardiology program is designed to introduce future physicians to the field of interventional cardiology through a half-day program where attendees will get the opportunity to have impactful conversations with nationally recognized interventional cardiologists, learning about training paths, barriers to care and solutions for the future, the importance of health ...

CORVALLIS, Ore. – A fossil arthropod entombed in 100-million-year-old Burmese amber has been identified as a new genus and species of froghopper, known today as an insect with prodigious leaping ability in adulthood following a nymphal stage spent covered in a frothy fluid. Oregon State University researcher George Poinar Jr., an international expert in using plant and animal life forms preserved in amber to learn about the biology and ecology of the distant past, and his co-author, Alex E. Brown, published ...

HOUSTON ― The James P. Allison Institute at The University of Texas MD Anderson Cancer Center today announced the appointment of its first members, James P. Allison, Ph.D., Padmanee Sharma, M.D., Ph.D., Jennifer Wargo, M.D., Sangeeta Goswami, M.D., Ph.D., and Kenneth Hu, Ph.D. In addition, Garry Nolan, Ph.D., will join the Allison Institute as an adjunct member. These members include pioneering researchers who have made notable contributions to science as well as rising stars on the path toward important breakthroughs. This group ...

St. Jude Children’s Research Hospital scientist Madan Babu Mohan, Ph.D., Center of Excellence in Data-Driven Discovery director and member of the Department of Structural Biology, has been elected a Fellow of the Royal Society of London. The Royal Society is the oldest scientific academy in continuous existence. Babu was selected to join the Royal Society for his pioneering data science-based strategies to reveal fundamental principles in biological systems. His scientific accomplishments include determining the molecular mechanisms governing G-protein-coupled receptor (GPCR) signaling, uncovering the roles of disordered protein regions in biology and disease, ...