Terpenoids are omnipresent in almost all living organisms. Prenylated indoles are prominent representatives that usually display potent medicinal properties (e.g. tryprostatin B). Therefore, significant efforts have been devoted to indole prenylation over the past decades. The known protocols often require a multi-step procedure and rely on the use of stoichiometric promoters. From the viewpoint of step- and atom-economy, developing a direct catalytic C2 prenylation of indoles is highly desirable yet challenging, because the nucleophilicity of C2 site is weaker than that of other two positions ...

Consuming large amounts of daily caffeine may increase the risk of glaucoma more than three-fold for those with a genetic predisposition to higher eye pressure according to an international, multi-center study. The research led by the Icahn School of Medicine at Mount Sinai is the first to demonstrate a dietary - genetic interaction in glaucoma. The study results published in the June print issue of Ophthalmology may suggest patients with a strong family history of glaucoma should cut down on caffeine intake. The study is important because glaucoma is the leading cause of blindness in the United States. It looks at the impact of caffeine intake on glaucoma, ...

Research Highlights: Rates of Kawasaki disease - a condition that creates inflammation in blood vessels in the heart and is more common in children of Asian/Pacific Island descent - have substantially decreased in South Korea during the COVID-19 pandemic. The decrease could be due to mask-wearing, hand-washing, school closures and physical distancing, suggesting Kawasaki disease may be prompted by infectious agents. The cause of Kawasaki disease is unknown, though it may be an immune response to acute infectious illness. DALLAS, June 7, 2021 -- The rate of Kawasaki disease in South Korea has substantially decreased during the COVID-19 pandemic, possibly due to pandemic prevention efforts, such as mask-wearing, ...

CAMBRIDGE, MA -- MIT engineers have discovered a new way of generating electricity using tiny carbon particles that can create a current simply by interacting with liquid surrounding them. The liquid, an organic solvent, draws electrons out of the particles, generating a current that could be used to drive chemical reactions or to power micro- or nanoscale robots, the researchers say. "This mechanism is new, and this way of generating energy is completely new," says Michael Strano, the Carbon P. Dubbs Professor of Chemical Engineering at MIT. "This technology is intriguing because all you have to do is flow a solvent through a bed of these particles. ...

Many modern fitness trackers and smartwatches feature integrated LEDs. The green light emitted, whether continuous or pulsed, penetrates the skin and can be used to measure the wearer's heart rate during physical activity or while at rest. These watches have become extremely popular. A team of ETH researchers now wants to capitalise on that popularity by using the LEDs to control genes and change the behaviour of cells through the skin. The team is led by Martin Fussenegger from the Department of Biosystems Science and Engineering in Basel. He explains the challenge to this undertaking: "No naturally occurring molecular ...

Levels of a protein called neurofilament light chain (NfL) in the blood can identify those who might have neurodegenerative diseases such as Down's syndrome dementia, motor neuron disease (ALS) and frontotemporal dementia, when clinical symptoms are not definitive. Published in Nature Communications and part-funded by the NIHR Maudsley Biomedical Research Centre, the research determined a set of age-related cut-off levels of NfL which could inform its potential use in primary care settings through a simple blood test. Joint Senior Author on the study, Dr Abdul Hye from the NIHR Maudsley Biomedical Research Centre at King's College London and South London and Maudsley NHS Foundation Trust said: 'For the first time we have shown ...

The first double-blind experiment analysing the role of human decision-making in climate reconstructions has found that it can lead to substantially different results. The experiment, designed and run by researchers from the University of Cambridge, had multiple research groups from around the world use the same raw tree-ring data to reconstruct temperature changes over the past 2,000 years. While each of the reconstructions clearly showed that recent warming due to anthropogenic climate change is unprecedented in the past two thousand years, there were notable differences in variance, amplitude and sensitivity, ...

NEW YORK, June 7, 2021--Recent studies suggest that new brain cells are being formed every day in response to injury, physical exercise, and mental stimulation. Glial cells, and in particular the ones called oligodendrocyte progenitors, are highly responsive to external signals and injuries. They can detect changes in the nervous system and form new myelin, which wraps around nerves and provides metabolic support and accurate transmission of electrical signals. As we age, however, less myelin is formed in response to external signals, and this progressive decline has been linked to the age-related cognitive and motor deficits detected in older people in the general population. Impaired ...

Just a few bacterial taxa found in ecosystems across the planet are responsible for more than half of carbon cycling in soils. These new findings, made by researchers at Northern Arizona University and published in END ...

In a white ocean, well above sea level, the algae thrive. Normally invisible to the naked eye, they are often spotted by hikers trekking through the mountains in late spring as strikingly coloured stretches of snow, in shades of ochre, orange and red. Known as "glacier blood", this colouring is the result of the punctual multiplication (or bloom) of the microalgae that inhabit the snow. But apart from this impressive phenomenon, the life and organisation of mountain microalgae communities remains a secret. It is this still unknown ecosystem, now threatened by global warming, that needs to be explored. The ALPALGA* consortium aims to meet this challenge by organising and pooling research efforts on snow microalgae, and it has already received support from the Agence nationale ...

Mental health visits for new mothers were 30% higher during the COVID-19 pandemic than before the pandemic, particularly in the first 3 months after giving birth, found new research in CMAJ (Canadian Medical Association Journal). https://www.cmaj.ca/lookup/doi/10.1503/cmaj.210151 "Increased visit rates began in March 2020, although the state of emergency was declared only midway through the month, suggesting that distress related to the pandemic translated into an increased need for care very quickly," writes Dr. Simone Vigod, chief of psychiatry, senior scientist and interim vice president of academics at Women's College Hospital (WCH), and senior adjunct scientist at ...

New research indicates that patients hospitalized with active cancer were more likely to die from COVID-19 than those with a history of cancer or those without any cancer diagnosis. The findings published by END ...

A traditional Vietnamese meat snack could hold the key to developing a safe and natural food preservative, addressing the twin global problems of food waste and food-borne illnesses. Key Points Bacteria-killing compound discovered in Nem Chua, a fermented pork snack Toxic to bacteria but safe for humans, it's a natural alternative to artificial food preservatives New study reveals ideal growth conditions to potentially make the bacteria-killer at industrial scales The fermented pork snack, Nem Chua, is eaten raw but does not cause food poisoning when prepared correctly. This is because friendly bacteria that thrive in the fermented meat make a special compound that destroys more dangerous bacteria. Now ...

Once viewed merely as a producer of the cerebrospinal fluid (CSF) bathing the brain and spinal cord, the choroid plexus is now known to be a key player in brain development and immunity. These fronds of brain tissue, located in the CSF-filled brain cavities known as ventricles, secrete instructive cues into the CSF to regulate brain development. They also function as an important barrier between the brain and the rest of the body. Maria Lehtinen, PhD, of Boston Children's Hospital has done much of the pioneering work in understanding this once-obscure tissue. In new work published in Cell, Lehtinen, Neil Dani, PhD, and other colleagues at Boston Children's and the Broad Institute created ...

The friendship paradox is the observation that the degrees of the neighbors of a node within any network will, on average, be greater than the degree of the node itself. In other words: your friends probably have more friends than you do. While the standard framing of the friendship paradox is essentially about averages, significant variations occur too. In the Journal of Complex Networks, Santa Fe Institute and University of Michigan researchers George Cantwell, Alec Kirkley, and Mark Newman address this by developing the mathematical theory ...

Carried like stowaways in the guts of international travelers, new and potentially deadly strains of antimicrobial resistant superbugs may be coming to a community near you, suggests new research from Washington University School of Medicine in St. Louis. "Even before the COVID-19 pandemic, we knew that international travel was contributing to the rapid global increase and spread of antimicrobial resistance," said Alaric D'Souza, an MD/PhD student at Washington University and a co-first author of the study to be published June 6 in Genome Medicine. "But what's new here is that we've found numerous completely novel genes associated with antimicrobial ...

Climate experts warn that, without urgent action, climate change will continue to cause an increase in the intensity of extreme rainfall that can lead to severe flooding. An international research team have concluded that increases in extreme rainfall and associated flooding are projected to continue as global temperatures continue to rise. Efforts to limit warming to +1.5C will help limit changes in extreme rainfall, though some societal adaptations will still be required. Sharing their findings in a new ScienceBrief Review, published today (7 June), scientists ...

Niigata, Japan - A comprehensive investigation on cells and colony motion offers new insight into the proliferative and epithelial regenerative capacities of human primary oral keratinocyte cultures with implications for quality control of engineered cells used in regenerative medicine. Dr. Kenji Izumi and his colleagues, Dr. Emi Hoshikawa and Dr. Taisuke Sato, modified the optical flow (OF) protocol originally presented in their 2019 paper to add the capacity to determine the threshold of the cells/colony motion speed required to differentiate substandard oral keratinocyte populations before manufacturing a tissue-engineered oral mucosa tissue construct. ...

The world is one step closer to ultimately secure conference calls, thanks to a collaboration between Quantum Communications Hub researchers and their German colleagues, enabling a quantum-secure conversation to take place between four parties simultaneously. The demonstration, led by Hub researchers based at Heriot-Watt University and published in Science Advances, is a timely advance, given the global reliance on remote collaborative working, including conference calls, since the start of the C19 pandemic. There have been reports of significant escalation of cyber-attacks on popular teleconferencing platforms in the last year. This advance in quantum secured communications could lead to conference calls with inherent unhackable security measures, underpinned by the principles of ...

In the Kumano Sea, off the southeast coast of Japan, an evolutionary mystery lay in wait. Researchers collected samples from the muddy sea floor, including hermit crabs, mollusks and discarded shells. Here, in and on these shells, they found scale worms living mostly in pairs with a striking difference compared to the almost 900 already known species of scale worms: one was a quarter the size of its mate. The discovery was published on March 29 as the cover of the Journal of Zoological Systematics and Evolutionary Research. "The species is characterized by males being dwarf, with their minute bodies always riding on the dorsal side of females," said paper author Naoto Jimi, postdoctoral researcher at the National Institute of Polar Research, Research ...

(Geneva, 5 June 2021) Mass screening of school age children has led to significantly higher numbers of coeliac disease cases being diagnosed, according to a new study presented today at the 6th World Congress of Paediatric Gastroenterology, Hepatology and Nutrition. Researchers in Italy found double the number of cases of the autoimmune disease - where the body produces antibodies to gluten, a protein found in wheat, barley, and rye - in school children compared to a similar study by the same group 25 years ago. A new screening programme of 7,760 children aged from five ...

(Geneva, 5 June 2021) Procedures to prevent the direct transmission of hepatitis B virus (HBV) from mother to child, particularly during and after pregnancy, have significant fragmentation and gaps, a new survey presented at the 6th World Congress of Paediatric Gastroenterology, Hepatology and Nutrition has shown. The results, based on 76 delivery hospitals from ten major European countries*, identified significant variances in maternal HBV screening frequency during pregnancy: 53% in the first trimester, 1% in the second trimester and 46% in the third trimester. Alarmingly, only 38% of those women who tested positive with high HBV-DNA levels were treated ...

MADISON, Wis. -- If you're wearing gold jewelry right now, there's a good chance it came from an illegal mining operation in the tropics and surfaced only after some rainforest was sacrificed, according to a team of University of Wisconsin-Madison researchers and alumni who studied regulatory efforts to curb some of these environmentally damaging activities in the Amazon. The researchers, including UW-Madison geography Professor Lisa Naughton, investigated mining-related deforestation in a biodiverse and ecologically sensitive area of the Peruvian Amazon to see whether formalizing and legalizing these mining operations might curb some of their negative effects. Their study, published June 2 in the journal Environmental Research Letters, was co-authored by a group including UW-Madison ...

In a large, international retrospective study, men at high risk for death from prostate cancer had a significant reduction in all-cause mortality if treated with radiation shortly after surgery. Prostate cancer is one of the most common forms of cancer among men, and about 1-in-8 of them will be diagnosed with it during their lifetime. While most men are cured with available treatment, there remains a group at high risk for death. In the United States in 2020, 33,330 men died from the disease, making prostate cancer the second leading cause of cancer death for men in this country. Therefore, among those at highest risk of recurrence, metastasis, and death from prostate cancer, understanding what steps can be taken to lower these risks could save and extend lives. Early ...

Oak Brook, IL - The June edition of SLAS Discovery features the cover article, "A Perspective on Synthetic Biology in Drug Discovery and Development--Current Impact and Future Opportunities" by Florian David, Ph.D. (Chalmers University of Technology, Gothenburg, Sweden), Andrew M. Davis, Ph.D. (AstraZeneca, Cambridge, England, UK). Michael Gossing, Ph.D., Martin A. Hayes, Ph.D., and Elvira Romero, Ph.D., and Louis H. Scott, Ph.D. (AstraZeneca, Gothenburg, Sweden), and Mark J. Wigglesworth, Ph.D. (AstraZeneca, London, England, UK). In January 2021, a survey of immunologists, infectious-disease researchers and virologists found that 90% of respondents believe SARS-CoV-2 will become endemic, continuing to circulate in pockets of the global population ...