Insilico Medicine (“Insilico”), a generative artificial intelligence (AI)-driven clinical stage drug discovery company, today announced that the U.S. Food and Drug Administration (FDA) recently approved the initial investigational new drug (IND) application for ISM3091 for the treatment of patients with solid tumors. This is Insilico's first oncology program to advance to the clinical validation stage. The open-label, multicenter Phase I clinical trial of ISM3091 will be conducted simultaneously in the U.S. and China ...

Scientists in Finland have developed a nanodevice that can measure the absolute power of microwave radiation down to the femtowatt level at ultra-low temperatures – a scale trillion times lower than routinely used in verifiable power measurements. The device has the potential to significantly advance microwave measurements in quantum technology.     Measuring extremely low power  Quantum science takes place mostly at ultra-low temperatures using devices called dilution refrigerators. ...

An early advocate for the electronic health records now found in hospitals across the country has developed a plan to improve their use, lighten clinicians’ workload and enhance patient care. The University of Virginia School of Medicine’s Don Detmer, MD, MA, designed the improvement plan in collaboration with Andrew Gettinger, MD, of Dartmouth’s Geisel School of Medicine. Detmer oversaw UVA’s adoption of electronic physician order entry in the early 1990s while vice president ...

When we talk about defects, we generally think of flaws or impairments. However, as far as materials science is concerned, defects represent windows of opportunity. A new Collaborative Research Center (CRC) in the field of soft matter based at and administered by Johannes Gutenberg University Mainz (JGU) will explore these opportunities. The German Research Foundation (DFG) has approved CRC 1552 "Defects and Defect Engineering in Soft Matter" and will be providing funding of some EUR 8 million over the next four years. Also participating are the Max Planck Institute for Polymer Research and the Fraunhofer Institute for Microengineering and Microsystems ...

Scientists have made a significant advancement with quantum technologies that could transform complex systems modelling with an accurate and effective approach that requires significantly reduced memory. Complex systems play a vital role in our daily lives, whether that be predicting traffic patterns, weather forecasts, or understanding financial markets. However, accurately predicting these behaviours and making informed decisions relies on storing and tracking vast information from events in the distant past – a process which presents huge challenges. Current models using artificial intelligence see their ...

Key Takeaways Current cancer diagnoses compared with pre-pandemic rates: Researchers quantified missed diagnoses of lung, breast, and colorectal cancers by comparing observed cancer rates in 2020 with pre-pandemic cancer rates (2010-2019). Potential increase in undiagnosed disease: Incidence rates for all three types of cancer have significantly decreased, suggesting that many patients may currently harbor undiagnosed disease. Importance of screening: Study adds to the growing body of literature on pandemic-related disruptions and serves as a vital reminder to encourage all patients to stay up to date on their recommended cancer screenings. CHICAGO: ...

Nearly $13 million in federal grant funds to study treatments for traumatic brain injury, which kills an average of 190 people and hospitalizes another 600 in the U.S. every day, has been awarded to UTHealth Houston by the Department of Defense’s Office of Congressionally Directed Medical Research Programs (CDMRP). The funding marks a positive step forward for patients suffering from the medical condition, said Charles S. Cox Jr., MD, the George and Cynthia Mitchell Distinguished Chair in Neurosciences and the Glassell Family Distinguished Chair in the Department of Pediatric Surgery with McGovern ...

A group of Virginia Tech faculty who represent a variety of disciplines is bringing the principles of disability justice to Appalachia through educational workshops, cultural events, and technology research.  The team received a $502,000 grant from the Andrew Mellon Foundation to create local and regional programming for disability-led arts, culture, reflection, and technology guidance. The foundation is a nonprofit organization that funds arts and humanities work nationwide. With the three-year project, called “Just ...

Butterflies, bees, and even bats are celebrated as pollinators: creatures that travel from flower to flower to feed, and in the process, help fertilize the plants by spreading pollen. But some of nature’s most diverse pollinators often go unnoticed, even by scientists: long-snouted beetles called weevils. A new study in the journal Peer Community in Ecology provides a deep dive into the more than 600 species of weevils, including ones whose entire life cycles are interwoven with a specific plant that they help pollinate. “Even people who work on pollination don't usually consider weevils as one of the main pollinators, and people who ...

INDIANAPOLIS -- Even before the COVID-19 pandemic, more than 100 million hospital emergency department (ED) visits took place annually in the U.S. In two studies, Regenstrief Institute Research Scientist Sharmistha Dev, M.D., MPH, and colleagues characterize an ED visit as part of a continuum of care, exploring how an ED visit is a valuable arena to support care beyond the issue that motivated the visit. “Many people view a patient’s ED visit as a moment of acute care and a moment of dealing with just one issue and then the patient is either admitted or discharged. But ...

Teen girls who have greater difficulty effectively solving interpersonal problems when they experience social stress, and who experience more interpersonal stress in their lives, are at greater risk of suicidal behavior, suggests research published by the American Psychological Association. Suicide is the second-leading cause of death among teens, and rates of suicidal behavior are particularly high among girls. Previous research has found that interpersonal stressors – such as conflict with peers, friends and family – are related to suicidal behavior. Some theories of ...

May 25, 2023   Saving Our Soil: How to Extend US Breadbasket Fertility for Centuries New research from UMass Amherst shows that the rapid and unsustainable rate of topsoil erosion can be drastically reduced with no-till agricultural methods already in practice AMHERST, Mass. – The Midwestern United States has lost 57.6 billion tons of topsoil due to farming practices over the past 160 years, and the rate of erosion, even following the U.S. Department of Agriculture’s guidelines, is still 25 times higher than the rate at which topsoil ...

Aging often is accompanied by cognitive decline. Among the first structures of the brain affected are the hippocampus and adjacent cortices, areas essential for learning and memory. Deficits in cognitive ability are associated with reduced hippocampal volume and degradation of synaptic connectivity between the hippocampus and the (peri)-entorhinal cortex.  Increasing evidence indicates that physical activity can delay or prevent these structural and functional reductions in older adults. A new study by Florida Atlantic University and CINVESTAV, Mexico City, Mexico, provides novel insight into the benefits of exercise, which should motivate ...

Over 37 million Americans have diabetes, and 90-95% of that population are diagnosed with type 2 diabetes. Lifestyle interventions, such as a healthy diet and a regular physical activity program, are methods to manage diabetes. A new study from a collaboration of investigators at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, and Joslin Diabetes Center, part of Beth Israel Lahey Health, uses data from the Look AHEAD (Action for Health in Diabetes) study, a randomized controlled trial that compared an intensive lifestyle intervention with diabetes support and education in patients diagnosed ...

COLUMBUS, Ohio – The mental distress of cognitive dissonance – encountering information that conflicts with how we act or what we believe – can lead to added pressure on the neck and low back during lifting and lowering tasks, new research suggests. When study participants were told they were performing poorly in a precision lowering experiment in the lab, after initially being told they were doing well, their movements were linked to increased loads on vertebrae in their neck and low back. Results showed that the higher the cognitive dissonance score, the greater the extent of loading on the upper ...

The George Institute for Global Health today announced data from the phase III INTERACT3 study demonstrating that a new combination of treatments for stroke due to intracerebral haemorrhage (ICH) significantly improves the chances of surviving without major disability. Results were presented today at the European Stroke Organisation Conference in Munich, Germany, and simultaneously published in The Lancet. The INTERACT3 study is the first-ever randomised controlled trial to show a clearly positive outcome for the treatment of ICH. Timely administration of the new treatment protocol – known as a Care Bundle – centred on the rapid control of ...

In the past, it was considered unprofitable to electrify heavy goods vehicles that transport cargo over long distances. But now researchers at Chalmers University of Technology in Sweden have shown that it can be cheaper to run heavy goods vehicles on electricity than on diesel. ‘I myself am surprised by the results and hope that more haulage companies and heavy goods vehicle manufacturers will be willing to invest in electrification now that we have shown that it can be cost-effective,’ says Johannes Karlsson, Doctoral student in Automatic Control Engineering at Chalmers. The transition ...

The Tokyo Tech InfoSyEnergy Research and Education Consortium, the Tokyo Tech Academy of Energy and Informatics (Head of Consortium and Academy Director Manabu Ihara, Prof.), and several companies such as Toshiba Corporation and Toshiba Energy Systems & Solutions Corporation are jointly developing a platform "100 kW hydrogen fuel cell - digital twin" for optimizing the design and control of a 100 kw hydrogen fuel cell that seeks to balance carbon neutrality and economic advantage by mixing renewable energy hydrogen/waste ...

A new study published in the journal Child Development from researchers at Boston College in Massachusetts, USA and the University of Queensland in Australia explores whether four- to nine-year-old-children consider past choices when making moral judgements of others. The findings showed that from the age of six, children considered what characters could have done when making judgement of how nice or mean they are behaving and that four and five- year-olds’ moral judgements were influenced only by ...

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) shows an association between type 2 diabetes (T2D) and developing dementia in later life – with the risk of dementia increasing the earlier a person develops T2D. The study is by PhD student Jiaqi Hu and Professor Elizabeth Selvin of the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, and colleagues. Their study investigated the association between prediabetes and dementia. Prediabetes is an intermediate stage of high blood sugar, where blood sugar is high but has not yet crossed the threshold for T2D. Prediabetes ...

Avocado oil has become a popular choice for many people in recent years because of its heart-healthy benefits and versatility in cooking. However, not all avocado oil products on store shelves are created equal. Some products are labeled as “pure” avocado oil when they contain other oils or additives. No enforceable standards defining the chemical and physical characteristics of avocado oil exist yet. Researchers at the University of California, Davis, analyzed samples of 36 private label avocado oil products and graded them based on quality and purity. Private label products are made by a third-party processor and sold under a grocery store or retailer brand label. Their ...

A new study led by investigators from Mass General Brigham has found that subanesthetic intravenous ketamine was effective and not inferior to electroconvulsive therapy (ECT) for the treatment of non-psychotic, treatment-resistant depression. Their results are published in the New England Journal of Medicine. “ECT has been the gold standard for treating severe depression for over 80 years,” said Amit Anand, MD, director of Psychiatry Translational Clinical Trials at Mass General Brigham and Professor of Psychiatry at Harvard Medical School. “But it is also a controversial treatment because it can cause memory ...

Animals using the most of efficient methods of searching for resources may well pay with their lives, scientists at the University of Bristol have discovered. The findings, published today in Behavioural Ecology, reveal why animals may not always use a searching strategy that maximises results. How animals move through their habitat, particularly in search for food, is a major question in biology, and has application in how animals will respond to environmental change. Numerous studies have demonstrated that a special kind of movement, known as Lévy motion, increases the ability to find resources because it includes long-distance moves ...

EMBARGO:  00.01 BST (London time) on THURSDAY, MAY 25, 2023 / 19.01 US EDT on WEDNESDAY, MAY 24, 2023 Heavy drinkers risk muscle loss, new study finds Peer reviewed – observational study - humans Heavy drinkers could be putting themselves at risk of muscle loss and frailty in later life, according to new research from the University of East Anglia. A new study published today shows with statistical modelling that people with the lowest amount of muscle were drinking 10 units or more a day – about ...

Vegetarian and vegan diets are linked to lower levels of cholesterol and fats in your blood, according to an analysis of all the evidence from randomised trials published since 1982.   The authors of the study, which is published in the European Heart Journal [1] today (Thursday), say this means that plant-based diets can play a significant role in reducing blocked arteries, thereby lowering the risk of heart and blood vessel diseases, such as stroke and heart attacks.   The researchers looked at 30 randomised trials with a total of 2,372 participants, published between 1982 and 2022, that quantified the effect of vegetarian or vegan diets versus omnivorous diets on levels ...