What The Study Did: National COVID-19 registry data are used in this study to describe the epidemiology, clinical characteristics, complications, and hospital and postdischarge outcomes of pediatric patients with multisystem inflammatory syndrome in children (MIS-C) and to compare each in patients with severe COVID-19. Authors: Adrienne G. Randolph, M.D., of Boston Children's Hospital, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2021.2091) Editor's Note: The article includes conflict of ...

What The Study Did: This randomized clinical trial compares the effects of once-weekly subcutaneous semaglutide versussplacebo for weight management as an adjunct to intensive behavioral therapy with initial low-calorie diet in adults with overweight or obesity. Authors: Thomas A. Wadden, Ph.D., of the University of Pennsylvania in Philadelphia, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2021.1831) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions ...

Many genetic variants have been found to have a linkage with genetic diseases, but the understanding of their functional roles in causing diseases are still limited. An international research team, including a biomedical scientist from City University of Hong Kong (CityU), has developed a high-throughput biological assay technique which enabled them to conduct a systematic analysis on the impact of nearly 100,000 genetic variants on the binding of transcription factors to DNA. Their findings provided valuable data for finding key biomarkers of type 2 diabetes for diagnostics and treatments. And they ...

Long-term use of a medication used to treat kidney transplant patients may not be necessary in individuals with low-to-moderate risk of organ rejection, according to the results of a study led by a University of Cincinnati transplant researcher. The randomized clinical trial of 385 patients on immunosuppressive drugs tacrolimus and mycophenolate examined whether use of these medicines called corticosteroids could be eliminated at seven days after kidney transplantation. The study shows that 15 years after transplantation no difference in kidney transplant survival or patient survival rates were found between patients who received long-term corticosteroids versus those who had corticosteroid eliminated early, explains E. Steve Woodle, MD, the William ...

MEMPHIS, TN, FEBRUARY 24, 2021:- Early diagnosis of Alzheimer's disease has been shown to reduce cost and improve patient outcomes, but current diagnostic approaches can be invasive and costly. A recent study, published in the Journal of Alzheimer's Disease, has found a novel way to identify a high potential for developing Alzheimer's disease before symptoms occur. Ray Romano, Ph.D., RN, completed the research as part of his Ph.D. in the Nursing Science Program at the University of Tennessee Health Science Center (UTHSC) College of Graduate Health Sciences. Dr. Romano conducted the research through the joint laboratory ...

Plants and animals can rapidly respond to changes in their environment, such as a Venus flytrap snapping shut when a fly touches it. However, replicating similar actions in soft robots requires complex mechanics and sensors. Now, researchers reporting in ACS Applied Materials & Interfaces have printed liquid metal circuits onto a single piece of soft polymer, creating an intelligent material that curls under pressure or mechanical strain. Watch a video of the smart material here. Ideally, soft robots could mimic intelligent and autonomous behaviors ...

What The Article Says: This JAMA Insights review from Centers for Disease Control and Prevention COVID-19 Response team members presents data on the number of long-term care facilities and the numbers of residents and staff of those facilities who received first-dose vaccination through mid-January under the agency's public-private partnership with CVS, Walgreens and Managed Health Care Associates. Authors: Radhika Gharpure, D.V.M., M.P.H., of the COVID-19 Response at the CDC, is the corresponding author. To access the embargoed study: Visit ...

Coprolites, or fossilized dog feces, are often used to understand the dietary preferences of ancient civilizations. However, the samples are often contaminated, making the analysis difficult. A new study, published in END ...

PHILADELPHIA -- A second study of the injectable anti-obesity medication, semaglutide, has confirmed the large weight losses reported in a study earlier this month, establishing the reliability and robustness of this new drug. With obesity affecting more than 40 percent of American adults, the findings could have a major impact on weight management in primary care and other settings. The END ...

To become climate neutral by 2050, the European Union launched two ambitious programmes: "Green Deal" and "DigitalStrategy". As a key component of their successful implementation, climate scientists and computer scientists launched the "Destination Earth" initiative, which will start in mid-?2021 and is expected to run for up to ten years. During this period, a highly accurate digital model of the Earth is to be created, a digital twin of the Earth, to map climate development and extreme events as accurately as possible in space and time. Observational data will be continuously incorporated into the digital ...

SAN ANTONIO -- Feb. 24, 2021 -- A Southwest Research Institute® (SwRI®) scientist examined 11 Mars years of image data to understand the seasonal processes that create linear gullies on the slopes of the megadune in the Russell crater on Mars. In early spring images, captured by two different cameras on the Mars Reconnaissance Orbiter, SwRI's Dr. Cynthia Dinwiddie noticed airborne plumes of dusty material associated with the linear dune gullies on the sand dune's downwind slope. These clues point to active processes involving chunks of frozen CO2, or dry ice, sliding down the sand dune, kicking up sand and dust along the way. Russell crater, on Mars, ...

Meat alternatives are officially mainstream. To wit, Burger King added the plant-based Impossible Burger to its menu nationwide in 2019, and McDonald's plans to unveil its own McPlant in 2021. Alongside these vegetarian options, many companies are also working to culture meat outside of animals grown from cell lines. Proponents highlight a range of potential environmental and health benefits offered by this emerging industry, and several companies believe that these benefits could also play out with seafood. A multidisciplinary team of researchers has taken a good, hard look at what it would take for cell-based seafood to deliver conservation benefits. They have ...

Immunologists at St. Jude Children's Research Hospital have discovered that tumors use a unique mechanism to switch on regulatory T cells to protect themselves from attack by the immune system. Surprisingly, the mechanism does not affect regulatory T cell function outside the tumor and may therefore limit the immune-associated toxicities of targeting regulatory T cells. The finding offers the promise of drug treatment to selectively shut down regulatory T cells in a tumor, rendering the tumor vulnerable to cancer immunotherapies that activate the immune ...

BROOKLYN, New York, Wednesday, February 24, 2021 -The Governance Lab (The GovLab) at the NYU Tandon School of Engineering released a report, "The Power of Virtual Communities," which examines the role online groups play in creating opportunities for people to build new kinds of meaningful communities they often could not form in real space. This first-of-its-kind research was built on interviews with 50 Facebook community leaders in 17 countries, 26 global experts from academia and industry, unique access to Facebook's underlying research and an original global survey conducted by YouGov of 15,000 people in 15 countries who are currently members of online and ...

Aged cheeses pack a punch of nutty, sharp flavor. Before they're fully mature, aged cheeses are either waxed or placed in brine for weeks to create a natural rind. However, the high salt content in brined cheeses deters some consumers. Now, researchers reporting in ACS Food Science & Technology present a shortened brining time for Parmigiano Reggiano that results in a less salty product, while still potentially maintaining the cheese's distinctive texture and flavor compounds. Parmigiano Reggiano is a lactose-free, crumbly and hard cheese. Manufactured ...

Scientists have made a pivotal breakthrough in the quest to understand how single-cell green algae are able to keep track of the light as they swim. A team of researchers from the University of Exeter's flagship Living Systems Institute has discovered how the model alga Chlamydomonas is seemingly able to scan the environment by constantly spinning around its own body axis in a corkscrewing movement. This helps it respond to light, which it needs for photosynthesis. The tiny alga, which is found abundantly in fresh-water ponds across the world, swims by beating its two flagella, hair-like structures that adopt a whip-like movement to move the cell. These flagella beat in much the same way as the cilia in the human respiratory ...

NEW YORK (February 24, 2021) -- Nearly half of women with uncomplicated urinary tract infections received the wrong antibiotics and almost three-quarters received prescriptions for longer than necessary, with inappropriately long treatment durations more common in rural areas, according to a study of private insurance claims data published today in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America. "Inappropriate antibiotic prescriptions for uncomplicated urinary tract infections are prevalent and come with serious patient- and society-level consequences," said Anne Mobley Butler, PhD, lead author of the study and assistant professor ...

In the first few months of their lives, babies cry, babble, gurgle and make a variety of other peculiar sounds. It can be difficult to imagine that they are actually laying the foundations for later speech with these utterances. However, there is a determining element that proves that even their cries can be assigned to a particular language: the speech melody - or, more accurately: prosody. "Every language is characterised by specific musical elements, which we call prosody," says Kathleen Wermke. Prosody, in simple terms, is the combination of intonation (melody) and rhythm. Earlier studies have shown that even newborns are able to distinguish different languages, like German ...

Everyone knows 2 + 2 = 4, but what about mosquitoes plus malaria? Lauren Childs, an assistant professor in the Department of Mathematics at Virginia Tech, says there's an equation for that too. Childs recently co-authored a report with a team from Harvard University on the role of natural mosquito behavior on transmission of a disease that threatens half the world's population. The study, "Multiple blood feeding in mosquitoes shortens the Plasmodium falciparum incubation period and increases malaria transmission potential," was published in the December 2020 issue of PLOS Pathogens. "Worldwide there are about 400,000 deaths and 200 million cases each year from malaria," said Childs, a faculty member with the Virginia Tech College ...

Prisons with more green space have lower levels of violence and self-harm, according to new research at the University of Birmingham and Utrecht University. The study is the first to attempt large-scale mapping of green space within prison environments and link it to well-being in a robust, statistically significant way. The results are published in Annals of the American Association of Geographers. The researchers used GIS mapping to identify the percentages of green space (such as trees, lawns and shrubbery) within prisons in England and Wales. They ...

A new report shows that British citizens who are missing abroad were more than twice as likely to be found by UK police as police in the country of disappearance. Research by the Centre for the Study of Missing Persons (CSMP) at the University of Portsmouth also shows they were likely to be missing for much longer than if they'd disappeared in the UK. The study found that British people who vanish abroad tend to be missing for extended periods, on average 134 days. This compares with 88 percent of people who go missing in the UK being found within the first 48 hours. Dr Karen Shalev-Greene, Director of the ...

Extreme weather driven by climate change is making power outages more commonplace even as the need for electricity-dependent home health equipment grows. In this context, battery storage can help protect medically vulnerable households, according to researchers at Columbia University Mailman School of Public Health. The article is published in the journal Futures. For the millions reliant on electricity for home medical equipment, even short-term power outages can lead to a potentially life-threatening situation. Society's most vulnerable populations--elders, ...

Heads or tails? If we toss two coins into the air, the result of one coin toss has nothing to do with the result of the other. Coins are independent objects. In the world of quantum physics, things are different: quantum particles can be entangled, in which case they can no longer be regarded as independent individual objects, they can only be described as one joint system. For years, it has been possible to produce entangled photons - pairs of light particles that move in completely different directions but still belong together. Spectacular results have been achieved, for example in the field of quantum teleportation or quantum cryptography. Now, a new method has been ...

Knowing the environmental and human-related variables that characterize the favorable areas for the incidence of the West Nile virus, a flavivirus that is transmitted from birds to humans by mosquitoes, is essential to identify those places in Europe at high risk of experiencing outbreaks, even before these are registered, thus enabling preventive measures to be taken. Researchers of the Biogeography, Diversity and Conservation Group of the University of Malaga have developed risk models for West Nile Fever, the disease caused in humans by this virus, which, based on historical incidence data, may predict areas of future outbreaks a year in advance, as well as detect their intensity. Artificial intelligence to develop risk ...

Leesburg, VA, February 24, 2021--An open-access article in ARRS' American Journal of Roentgenology (AJR) describes the clinical and imaging features of axillary adenopathy detected during screening or diagnostic breast imaging after recent coronavirus disease (COVID-19) vaccination to inform the development of follow-up recommendations. Shabnam Mortazavi of the University of California at Los Angeles reviewed electronic medical records to identify women with post-COVID-19 vaccination adenopathy found from December 2020 to February 2021. For mammography, Mortazavi considered a node abnormal when its size, shape, or density was deemed disproportionate to other axillary nodes (ipsilateral or contralateral). On ultrasound, she deemed ...