By Leah Shaffer The process of biomanufacturing requires engineering microbes to produce useful chemicals and materials from carbon neutral processes. But current biomanufacturing cannot get beyond small production scale unless it can outcompete big oil. The petrochemical industry produces chemicals and material building blocks at a low cost because these processes can run nonstop. However, performing microbial biomanufacturing continuously faces numerous challenges and presents a significant hurdle for economically viable bioproduction. At the McKelvey School of Engineering at Washington University in St. Louis, researchers are ...

(MEMPHIS, Tenn. – August 13, 2025) A computational approach by St. Jude Children’s Research Hospital scientists promises to make designing T cell-based immunotherapies that target two cancer-related antigens at the same time far easier and faster. Chimeric antigen receptor (CAR) T cells are a type of immunotherapy that reprograms a patient’s immune cells to target a tumor-specific protein antigen. Targeting just one cell surface antigen often is not enough to eradicate the tumor. Thus, scientists ...

While we know much of the story of how humans evolved, the puzzle is still missing critical pieces. For example, fossil evidence for human evolution between 2 and 3 million years ago is patchy. It’s frustrating because we know that the branch of the hominin family tree that includes humans, or Homo sapiens, appears in the fossil record for the first time in this period.   Today, Homo sapiens (which anthropologists shorten to Homo), is the only hominin species alive. But in the past, Homo wasn’t alone. We coexisted and competed with other branches of the human family tree. Research ...

Researchers have controlled the evolution of E. coli bacteria in the lab in order to dramatically increase the amount of plasmid DNA (pDNA) these modified bacteria produce. The advance is significant because pDNA is an essential – and expensive – ingredient in many gene therapies, and the new technique could drive down the cost of these medical treatments. pDNA are found naturally in many bacteria and differ from other forms of DNA because the double helix shape most people are familiar with forms a circle, rather than the linear shape found in humans and most other organisms. “pDNA is relatively easy to work with in the lab – it’s stable and easy ...

Ultrasound AI, a pioneer in artificial intelligence applications for medical imaging, today announced the publication of groundbreaking findings from its PAIR (Perinatal Artificial Intelligence in Ultrasound) Study in The Journal of Maternal-Fetal & Neonatal Medicine. The study was performed in collaboration with researchers at the University of Kentucky and validates Ultrasound AI’s proprietary technology that more accurately predicts time to delivery using only standard ultrasound images. This technology offers a non-invasive, efficient, and scalable tool ...

Background: Ancient events in plant evolution have left behind large, duplicated regions in their genomes. New discovery: Salk Institute scientists found that deleting these large blocks of DNA can still lead to normal plants. The findings demonstrate that large chromosomal deletions are a viable strategy in plant genetic engineering, which could now accelerate the development of streamlined, minimal plant genomes—a major goal in industries looking to create new plant-based biotechnologies. The new study, led by Salk Research Professor Todd Michael and computational scientist Ashot Papikian, was published in Proceedings ...

As glaciers melt, huge chunks of ice break free and splash into the sea, generating tsunami-size waves and leaving behind a powerful wake as they drift away. This process, called calving, is important for researchers to understand. But the front of a glacier is a dangerous place for data collection.   To solve this problem, a team of researchers from the University of Washington and collaborating institutions used a fiber-optic cable to capture calving dynamics across the fjord of the Eqalorutsit Kangilliit Sermiat glacier in South Greenland. Data collected from the cable allowed them to document — without getting ...

EMBARGOED FOR RELEASE Wednesday, Aug. 13, 2025 11 a.m. Eastern Time   Media Contact: NIH Office of Communications 301-496-5787   A National Institutes of Health (NIH)-supported clinical trial has found that the outcome of treating complicated Staphylococcus aureus bloodstream infections with two intravenous (IV) doses of the antibiotic dalbavancin seven days apart is just as good as daily IV doses of conventional antibiotics over four to six weeks. Nearly 120,000 S. aureus bloodstream infections and 20,000 associated deaths occurred in the United States in 2017. The study results provide the clearest evidence to date for the safety and effectiveness ...

Embargoed for Release  Wednesday, August 13, 2025  11 a.m. EDT     Contact:  NIH Office of Communications  301.496.5787    Adults who smoke cigarettes and are addicted to alcohol or other drugs were more likely to achieve sustained remission of their substance use disorder symptoms if they also quit smoking, according to scientists at the National Institutes of Health (NIH).  Based on their analysis of data from a large U.S. study of smoking and health, researchers believe the results clearly show the benefit of pairing ...

In Nature, 21 leading scientists today prescribe ways to use food systems to halt and reverse land degradation, underlining that doing so must become a top global priority to mitigate climate change and stop biodiversity loss.  The article breaks new ground by quantifying the impact by 2050 of reducing food waste by 75% and maximising sustainable ocean-based food production, measures that alone could spare an area larger than Africa.   According to the paper: “Food systems have not yet been fully incorporated into intergovernmental agreements, nor do they receive ...

A team of international scientists has discovered new fossils at a field site in Africa that indicate Australopithecus, and the oldest specimens of Homo, coexisted at the same place in Africa at the same time — between 2.6 and 2.8 million years ago. The paleoanthropologists discovered a new species of Australopithecus that has never been found anywhere.     The Ledi-Geraru Research Project is led by scientists at Arizona State University and the site has revealed the oldest member of the genus Homo and the earliest Oldowan stone tools on the planet.  The research team concluded ...

Around the world, about 2 billion people suffer from iron deficiency, which can lead to anemia, impaired brain development in children, and increased infant mortality.  To combat that problem, MIT researchers have come up with a new way to fortify foods and beverages with iron, using small crystalline particles. These particles, known as metal-organic frameworks, could be sprinkled on food, added to staple foods such as bread, or incorporated into drinks like coffee and tea. “We’re ...

About The Study: This study found a nearly two-fold higher cervical cancer incidence, late-stage diagnosis, and mortality in counties with repeatedly low vs high cervical cancer screening coverage. Most counties with repeat low coverage were rural and lower income. Corresponding Author: To contact the corresponding author, Trisha L. Amboree, PhD, MPH, email amboree@musc.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.26709) Editor’s Note: Please see the article for additional information, including other authors, author ...

About The Study: In this study, a considerable proportion of patients with high-grade serous cancer missed opportunities for risk assessment with genetic testing and for surgical prevention. Given the lack of effective screening and limited treatment options for high-grade serous cancer, eradicating it requires addressing the full spectrum of missed opportunities.  Corresponding Author: To contact the corresponding author, Rebecca L. Stone, MD, email rstone15@jhmi.edu. To access the embargoed study: Visit ...

Women in counties with repeatedly lower cervical cancer screening rates suffer nearly double the rate of cervical cancer diagnoses, particularly of late-stage disease, and death from cervical cancer, according to a new analysis from researchers at MUSC Hollings Cancer Center.   Trisha Amboree, Ph.D., is part of a team of researchers that has previously shown that cervical cancer incidence and death rates are higher in low-income and rural U.S. counties. Those papers analyzed the numbers but couldn’t explore the reasons why incidence and death were higher.   “We ...

(Santa Barbara, Calif.) — On May 12, 2008, the magnitude 7.9 Wenchuan Earthquake shook central China, its destructive tremors spreading from the flank of the Longmen Shan, or Dragon's Gate Mountains, along the eastern margin of the Tibetan Plateau. Over 69,000 people died in the disaster, nearly a third are thought to be from geohazards like the more than 60,000 landslides that rushed down the slopes of the Longmen Shan. After more than a decade and a half of work, scientists finally have an account of the fate of the landslide debris. Surveys of a reservoir downstream of the epicenter revealed how and how quickly the region’s ...

The discovery of new fossils and a new species of ancient ancestor may help shift the perception of human evolution from linear evolution to that of a tree with many branches, new UNLV research published today in the journal Nature shows. UNLV anthropologist Brian Villmoare and a team of international scientists discovered new fossils at a field site in Ethiopia that indicate Australopithecus, and the oldest specimens of Homo, coexisted between 2.6 and 2.8 million years ago at the same place in Africa. The ...

Iceberg calving occurs when masses of ice break away from the edge of glaciers and crash into the ocean. This process is one of the major drivers of the rapid mass loss currently affecting the Greenland ice sheet. An international research team led by the University of Zurich (UZH) and the University of Washington (UW) has now used fiber-optic technology to measure for the first time how the impact of falling ice and its subsequent drift is driving the mixing of glacial melt with warmer subsurface seawater. “The warmer water increases seawater-induced melt erosion and eats away at the base of the vertical wall of ice at the glacier’s edge. This, in turn, ...

AMHERST, Mass. — An international team of researchers led by the University of Massachusetts Amherst has tracked changes in more than 114,000 rivers in High-mountain Asia over a 15-year period. The paper, published in AGU Advances, reported that nearly 10% of these rivers saw an increase in flow, with an increasing proportion of that water coming from glacial ice melt compared to precipitation.     This water serves billions of people from China, India and Southeast Asia to Turkmenistan; is sensitive to climate change; and plays a key role in the sustainable development of this region through ...

“The ability of PCAIs to mitigate various cancer hallmarks in the various cancer cell lines has been well established.” BUFFALO, NY – August 13, 2025 – A new research paper was published in Volume 16 of Oncotarget on July 29, 2025, titled “PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion.” In this study, led by first author Jassy Mary ...

INDIANAPOLIS -- Regenstrief Institute’s latest LOINC® content update on August 12, introduces two new linguistic variants: Arabic, for users in Jordan, and Czech, for users in the Czech Republic. With these additions, LOINC is now available in 22 languages. “Expanding the number of supported languages improves the accessibility and adoption of LOINC around the world,” said Marjorie Rallins, DPM, M.S., executive director of Health Data Standards (HDS) at Regenstrief. “Making LOINC content available in more languages strengthens interoperability by enabling users to work with data in ...

LOS ANGELES — A new drug-releasing system, TAR-200, eliminated tumors in 82% of patients in a phase 2 clinical trial for individuals with high-risk non-muscle-invasive bladder cancer whose cancer had previously resisted treatment.   In the majority of cases, the cancer disappeared after only three months of treatment, and almost half the patients were cancer-free a year later.  “Traditionally, these patients have had very limited treatment options. This new therapy is the most effective one reported to date for the most common form of bladder cancer,” said Sia Daneshmand, MD, director of urologic oncology with Keck ...

A public-private partnership between Commonwealth Fusion Systems (CFS), the U.S. Department of Energy’s (DOE) Princeton Plasma Physics Laboratory (PPPL) and Oak Ridge National Laboratory has led to a new artificial intelligence (AI) approach that is faster at finding what’s known as “magnetic shadows” in a fusion vessel: safe havens protected from the intense heat of the plasma.  Known as HEAT-ML, the new AI could lay the foundation for software that significantly speeds up the design of future fusion systems. Such software could also enable good decision-making during fusion operations by adjusting the plasma so that ...

Late nights, alcohol, and smoking on weekends may be doing more than disrupting your Monday mornings, they could be triggering a newly identified sleep health concern known as ‘social apnea’, warn researchers from Flinders University. Published in the prestigious American Journal of Respiratory and Critical Care Medicine, the international study introduces social apnea as a novel trend in sleep medicine referring to the weekend spike in Obstructive Sleep Apnea (OSA) severity, driven by lifestyle choices and irregular sleep patterns. The research, which analysed data from over 70,000 people worldwide, found a consistent ...

Florida Atlantic University’s Charles E. Schmidt College of Science has been awarded a $700,000 grant from the United States Environmental Protection Agency Gulf of America Division to support a novel research project aimed at advancing water quality monitoring in one of Florida’s most critical freshwater ecosystems. Led by Natalia Malina, Ph.D., principal investigator and an assistant professor in FAU’s Department of Chemistry and Biochemistry within the Charles E. Schmidt College of Science, the three-year project titled, “Developing ...