Cancer-fighting antibody drugs are designed to penetrate tumor cells and release a lethal payload deep within, but too often they don’t make it that far. A new study shows how this Trojan Horse strategy works better by exploiting calcium differences outside and inside cells.  A research team led by Sophia Hober, professor at KTH Royal Institute of Technology, reported the development of a calcium activated delivery system they say could enable more precise treatment, with lower doses and less collateral damage to healthy tissue. In collaboration with Stanford University and Umeå University, ...

Researchers at the LSU LCMC Health Cancer Center have published groundbreaking findings in NPJ Breast Cancer that sheds new light on triple-negative breast cancer (TNBC), one of the most aggressive forms of breast cancer. The National Cancer Institute (NCI)-funded study, led by Dr. Lucio Miele, Director of the LSU LCMC Health Cancer Center, in collaboration with colleagues at LSU Health New Orleans, City of Hope Cancer Center (Duarte, CA), and the University of California, San Diego, examined tumors from more than 250 Black and White women across ...

A study led by University of Cincinnati Cancer Center researchers sheds new light on how pancreatic cancer cells resist treatment and points to potential new combination therapies to make treatments more effective. The research, led by corresponding author Andrew Waters, PhD, and co-first authors Haley Todd, Grace Goodheart and Szu-Aun Long, MD, was recently published in Cancer Research, a journal for the American Association for Cancer Research (AACR).   The research focuses on a gene called KRAS, the most frequently mutated oncogene in human cancer, which is mutated ...

As our society becomes more digital and interconnected, the systems that keep it running face growing vulnerability to cyber threats. Bahaa Eltahawy’s doctoral dissertation at the University of Vaasa, Finland, shows that safeguarding these networks requires a holistic approach. From power grids and transport to healthcare systems, the functioning of modern society relies on interconnected networks. When these systems fail, the consequences ripple quickly across sectors. In his doctoral dissertation in Computer Science, Bahaa Eltahawy argues that ensuring their security is not just a technical challenge but a ...

In a new JNeurosci paper, Tian-Ming Gao and colleagues, from Southern Medical University, explored how adenosine triphosphate (ATP) signaling relates to depression and anxiety using male mice. ATP is a molecule that not only provides energy but also supports communication between neurons. The researchers focused on ATP signaling in a brain region implicated in depression called the hippocampus.  Male mice that were more likely to acquire depressive- and anxiety-like symptoms following long-term stress had less ATP levels and ...

When people use a psychedelic called dimethyltryptamine (DMT), they experience a temporary loss of their sense of self. DMT interacts with a frequency of brain activity associated with self-referential processes (alpha waves), but it’s unclear how this activity relates to self-awareness. Christopher Timmerman, at University College London, and Marco Aqil, currently at the University of Miami, are among researchers who used DMT as a tool to explore the relationship between alpha waves and self-awareness.   As reported in their JNeurosci paper, the researchers discovered ...

Human emotional interaction relies heavily on CT afferents—unmyelinated nerves in hairy skin that convert gentle tactile stimuli into affective states. For robots to engage in similar empathetic communication, existing tactile sensing technologies fall short: most rely on segregated "sensation-transmission-processing" modules, which cause latency accumulation and high energy consumption due to repeated analog-to-digital conversion. "Current neuromorphic devices for touch either lack low-threshold sensitivity or separate ...

**EMBARGOED FOR RELEASE UNTIL NOV. 24 AT 12 NOON** Researchers at Johns Hopkins Medicine say they have used a “zap-and-freeze” technology to watch hard-to-see brain cell communications in living brain tissue from mice and humans. Findings from the new experiments, supported by the National Institutes of Health and published Nov. 24 in Neuron, could potentially help scientists find the root causes of nonheritable forms of Parkinson’s disease, the researchers say. Sporadic cases of Parkinson’s disease account for most ...

COLUMBUS, Ohio – Using a prebiotic to influence bacterial activity in the gut after a traumatic brain injury may help reduce impulsive behavior, one of the common symptoms to follow a moderate blow to the head, a new study in rats suggests. Following up on previous work showing a connection between negative changes to gut bacteria after a traumatic brain injury (TBI) and poor decision making, researchers at The Ohio State University are now exploring whether the gut problems may actually cause some long-term symptoms. They found that adding the prebiotic galacto-oligosaccharide (GOS) to rat diets before and after ...

About The Study: In a cohort composed primarily of women with obesity, glucagon-like peptide-1 receptor agonist (GLP-1RA) use with subsequent pre-pregnancy or early pregnancy discontinuation was associated with more gestational weight gain and a higher risk of preterm delivery, gestational diabetes, and hypertensive disorders of pregnancy. Corresponding Authors: To contact the corresponding authors, email Jacqueline Maya, MD, (jmaya@mgh.harvard.edu) and Camille E. Powe, MD, (camille.powe@mgh.harvard.edu). To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.20951) Editor’s Note: Please ...

About The Study: Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are increasingly used for postpartum weight loss since the introduction of semaglutide for weight loss in late 2022. Most users were overweight prior to pregnancy and only 23% had a documented diabetes diagnosis, suggesting that the primary indication for use was weight reduction. Corresponding Author: To contact the corresponding author, Mette Bliddal, PhD, email mbliddal@health.sdu.dk. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.20947) Editor’s Note: Please see the article for additional information, including ...

In a study led by researchers at Mass General Brigham, pregnant individuals who stopped taking popular weight loss GLP-1 medications before or early in their pregnancy tended to gain more weight and have higher risks of diabetes and hypertensive disorders during pregnancy, and experienced preterm delivery more so than people who had never taken GLP-1 drugs. The findings are published in JAMA. “The use of glucagon-like peptide-1 receptor agonists—or GLP-1RAs—has increased dramatically, but recommendations suggest their discontinuation before pregnancy ...

New research reveals that people with untreated obstructive sleep apnea have a higher risk of developing Parkinson’s disease. However, they can significantly reduce the risk by improving the quality of their sleep by using continuous positive airway pressure, or CPAP. The study, which published today in the journal JAMA Neurology, examined electronic health records covering more than 11 million U.S. military veterans who received care through the Department of Veterans Affairs between 1999 and 2022. The research was led by Oregon Health & Science University ...

About The Study: This cohort study found that the prevalence of avoidant/restrictive food intake in the general pediatric population was substantial, and affected children had an associated elevated risk of developmental difficulties across multiple domains. The findings suggest a need for broad support interventions and advance understanding of the genetic underpinnings of avoidant/restrictive food intake.  Corresponding Author: To contact the corresponding author, Ludvig Daae Bjorndal, PhD, email l.d.bjorndal@psykologi.uio.no. To ...

About The Study: In this post hoc analysis of the SURMOUNT-4 trial, among participants with obesity who achieved weight reduction with 36-week tirzepatide (a glucagon-like peptide-1 receptor agonist) treatment, withdrawing tirzepatide led to 25% or greater weight regain in most participants within 1 year and was associated with a greater reversal of their initial cardiometabolic parameter improvements compared with those who maintained weight reduction. These findings underscore the importance of continued obesity treatment.  Corresponding Author: To contact the corresponding author, Clare J. Lee, MD, MHS, ...

About The Study: This cross-sectional study of the Global Burden of Disease 2021 study data found that, among the U.S. population of 332.7 million, disorders affecting nervous system health impacted 180.3 million U.S. individuals and were the top cause of disability. Conditions with the greatest collective disability were stroke, Alzheimer disease and other dementias, diabetic neuropathy, and migraine. The U.S. should prioritize efforts to combat these conditions with development and implementation of new and effective prevention strategies, therapeutics, and focused rehabilitation. Corresponding ...

About The Study: In this cohort of young adults, reducing social media use for 1 week was associated with reductions in symptoms of depression, anxiety, and insomnia; however, the durability of these therapeutic outcomes and their associations with behavior warrant further study, particularly in more diverse populations.  Corresponding Author: To contact the corresponding author, John Torous, MD, MBI, email torous@bidmc.harvard.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.45245) Editor’s Note: Please ...

EMBARGOED FOR RELEASE AT 11 A.M. ET, MONDAY, NOVEMBER 24, 2025 Highlights: A new systematic analysis shows more than half the people living in the U.S., 54%, are affected by a neurological disease or disorder. Disorders of the nervous system impacted more than 180 million of the nearly 333 million Americans in 2021 and were the top cause of health loss in the U.S. The nervous system includes the brain, spinal cord and nerves. The most prevalent conditions were tension-type headache affecting 122 million Americans, migraine affecting 58 million and diabetic neuropathy affecting 17 million. The leading causes of health loss were stroke, Alzheimer’s disease and ...

LMU researchers uncover the mechanism by which ribosomes raise alarms in the cell. Ribosomes, the protein factories of the cell, are essential for all living organisms. They bind to mRNA and move along the messenger molecule, reading the genetic code as they go. Using this information, they link amino acids to make proteins. But their function goes far beyond pure production: Ribosomes are also important sensors for cellular stress and initiate protective reactions when problems arise. An international team led by Professor Roland Beckmann from LMU’s Gene Center ...

A new Doctoral Network coordinated by Tampere University has secured €4.4 million in funding from the European Union’s Marie Skłodowska-Curie Actions (MSCA) programme. The High-Power Optical Vortices (HiPOVor) project will train 15 doctoral researchers in the generation, amplification and application of high-power optical vortex beams. The consortium has set an ambitious goal: to establish optical vortex beams as a key enabling technology for advanced light-matter interaction. Optical vortices – light beams carrying orbital angular momentum – open up unique possibilities for ultra-precise material processing, particle acceleration, high-capacity ...

WASHINGTON, D.C. — Eating a vegan diet increases consumption of plant-based foods—including those defined as “unhealthy” by the plant-based diet index—leading to greater weight loss than the Mediterranean diet, finds a new analysis by the Physicians Committee for Responsible Medicine published in Frontiers in Nutrition.  Avoiding animal products; eating foods like potatoes and refined grains, which are defined as “unhealthy” by the plant-based diet index; and avoiding added oils and nuts, which are defined as “healthy” by the plant-based diet ...

(Toronto, November 24, 2025) JMIR Publications, a leading publisher of academic journals dedicated to digital health and open science, today announced that it has joined the International Association of Scientific, Technical and Medical Publishers (STM), the global trade association for academic and professional publishers. In addition, JMIR Publications is integrating STM Integrity Hub into routine operations to further support the integrity and high quality of scholarly publishing and the published scientific record. STM Integrity Hub is a platform ...

The National Center for Supercomputing Applications was recognized for its outstanding achievements in two different domains in the annual HPCwire Readers’ and Editors’ Choice Awards announced at Supercomputing Conference 2025 (SC25) in St. Louis on November 17. It’s the 15th consecutive year NCSA has been honored with an HPCwire award. Both awards centered around research that utilized NCSA’s premier supercomputing systems Delta and DeltaAI. The first team published novel research on using artificial intelligence to monitor inaccessible locations of nuclear energy systems, enhancing their ...

New York, NY (November 24, 2025)—Researchers at the Icahn School of Medicine at Mount Sinai have uncovered a new way to understand how children fare after liver transplantation: by focusing not on medical test results, but on how differently parents and children perceive the child’s well-being. The findings, published in The Journal of Pediatrics, come from the first multisite prospective trial to evaluate real-time discrepancies in patient-reported outcomes for pediatric liver transplant recipients. The study included 140 parent-child pairs across seven transplant centers in the United States ...

Some tumors are almost impossible to treat. That’s especially true for carcinomas, which don’t behave like other malignancies. Some of these tumors act as shapeshifters and start to resemble cells from other organs of the human body, such as skin. This bizarre behavior presents a challenge for existing therapies. “The tumors are notoriously plastic in their cellular identity,” says Cold Spring Harbor Laboratory (CSHL) Professor Christopher Vakoc. Some may even change to escape cancer treatment. Recent ...