Key Takeaways Vision scientists from the School of Veterinary Medicine at the University of Pennsylvania have developed new tools—four novel promoters—to address the challenge of treating advanced stages of inherited retinal diseases that cause vision loss. These promoters drive strong and specific gene expression in rod and cone photoreceptors even in mid-to-late stages of disease, outperforming most currently used promoters in retinal gene therapy. These novel promoters are ideally sized for effective adeno-associated virus (AAV)-mediated delivery.   Inherited retinal degenerations (IRDs) are a group of genetic disorders that lead ...

As the national debate intensifies around immigration, a new study from the University of California School of Global Policy and Strategy is challenging conventional wisdom about “brain drain”—the idea that when skilled workers emigrate from developing countries, their home economies suffer. Published in Science, the paper reveals high-skilled emigration from developing countries may actually boost economic development, human capital and innovation in migrants’ countries of origin.  With the U.S. undergoing sweeping immigration ...

LOS ANGELES — Researchers from City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States with its National Medical Center named Top 5 “Best Hospital” in the nation for cancer care by U.S. News & World Report, will present novel cancer treatment approaches and combinations, leading-edge targeted therapies, and supportive care interventions that could reduce cancer risk and improve survival at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting taking place May 30 ...

CAMBRIDGE, MA -- Separating crude oil into products such as gasoline, diesel, and heating oil is an energy-intensive process that accounts for about 6 percent of the world’s CO2 emissions. Most of that energy goes into the heat needed to separate the components by their boiling point. In an advance that could dramatically reduce the amount of energy needed for crude oil fractionation, MIT engineers have developed a membrane that filters the components of crude oil by their molecular size. “This is a whole new way of envisioning a separation process. Instead of boiling mixtures to purify them, why not separate ...

Groundbreaking Discovery What if the human body contained a natural bioreactor capable of regenerating vital organs? A collaborative team from ​Wenzhou Medical University, Nanjing University, and University of Macau has redefined the spleen’s potential, transforming it into a ​self-sustaining hub for organ regeneration, as published in Science Translational Medicine (May 21). This breakthrough could revolutionize treatments for type 1 diabetes and beyond. Redesigning the Spleen: From Filter to "Living Bioreactor" Confronting ...

A leading cardiovascular disease researcher from Simon Fraser University is ringing the alarm on universal recommendations intended to improve heart health around the globe. Cardiovascular disease (CVD) is the leading cause of death worldwide, with 80 per cent of deaths occurring in low- and middle-income countries. However, international heart-health guidelines are primarily based on research from high-income countries and often overlook upstream causes of CVD, says Scott Lear, a health sciences professor at SFU and the Pfizer/Heart & Stroke Foundation Chair in Cardiovascular Prevention Research. “The world extends beyond high-income countries when we think ...

A new study from UBC Okanagan says students appear to be using generative artificial intelligence (GenAI) responsibly, and as a way to speed up tasks, not just boost their grades. Dr. Meaghan MacNutt, who teaches professional ethics in the UBCO School of Health and Exercise Sciences (HES), recently published a study in Advances in Physiology Education. Published this month, the paper—titled Reflective writing assignments in the era of GenAI: student behaviour and attitudes suggest utility, not futility—contradicts ...

COLUMBUS, Ohio – Scientists aiming to advance cancer diagnostics have developed a machine learning tool that is able to identify metabolism-related molecular profile differences between patients with colorectal cancer and healthy people. The analysis of biological samples from more than 1,000 people also revealed metabolic shifts associated with changing disease severity and with genetic mutations known to increase the risk for colorectal cancer. Though there is more analysis to come, the resulting “biomarker discovery pipeline” shows promise as a noninvasive method of diagnosing colorectal cancer and monitoring disease progression, said Jiangjiang Zhu, ...

As the ocean warms across its temperate regions, kelp forests are collapsing and turf algae species are taking over. This shift from dense canopies of tall kelp to low-lying mats of turf algae is driving biodiversity loss and altering the flow of energy and nutrients through reef ecosystems. It’s also fundamentally altering the chemical ecology of coastal ecosystems. New research in Science, led by researchers at Bigelow Laboratory for Ocean Sciences, has shown for the first time how turf algae release ...

The ability to engineer shapeshifting proteins opens new avenues for medicine, agriculture, and beyond.    Proteins catalyze life by changing shape when they interact with other molecules. The result is a muscle twitching, the perception of light, or a bit of energy extracted from food.   But this crucial ability has eluded the growing field of AI-augmented protein engineering.   Now, researchers at UCSF have shown it is possible to make new proteins that move and change shape like those in nature. This ability will help scientists engineer proteins in ...

Ancient sloths ranged in size from tiny climbers to ground-dwelling giants. Now, researchers report this body size diversity was largely shaped by sloths’ habitats, and that these animals’ precipitous decline was likely a result of increasing human pressures, which also triggered the extinction of the large-bodied ground-dwelling animals. Today’s small arboreal sloths are the last remnants of a once-diverse group, surviving likely because they inhabited secluded forest canopies and avoided direct human pressures, say the authors. While only two small, tree-dwelling genera survive today – confined largely to the tropical rainforests of South ...

As kelp forests decline in the warming coastal waters of the Gulf of Maine, turf algae – dense mats of red algae replacing kelp in many regions – may chemically interfere with kelp recovery, a new study reports. This complicates efforts to restore these crucial marine ecosystems. Kelp forests are ecologically and economically vital marine ecosystems that support diverse life forms and functions. However, despite their widely recognized importance, kelp forests worldwide are threatened with collapse due to climate change and/or overfishing. In many regions where kelp forests have disappeared, they have ...

Astronomers have identified a rare type of binary star system containing a rapidly spinning millisecond pulsar and a helium star companion, formed via common envelope evolution. Although such systems are rare, the authors of this new study predict that others do exist; they estimate there are 16 to 84 undiscovered examples in the Milky Way. Millisecond pulsars – rapidly spinning neutron stars that emit radio waves – achieve their extraordinary rotation rates by siphoning matter from a close stellar companion. The formation of these exotic binary systems is not fully understood, because it can involve a variety of complex processes. ...

Most relapsing fever bacteria that infect humans are spread by ticks, but Borrelia recurrentis is unique in being transmitted between humans via body lice. Now, new genomic evidence from ancient British remains suggests that B. recurrentis diverged from its tick-borne relatives and began adapting to transmission by lice between 6000 and 4000 years ago – coinciding with the widespread use of wool textiles by humans. The findings underscore how ancient DNA can illuminate the origins and evolution of infectious diseases and how pathogens like B. recurrentis have been shaped by human social transformations. Several pathogenic bacterial species that ...

Researchers at the Francis Crick Institute and UCL have analysed ancient DNA from Borrelia recurrentis, a type of bacteria that causes relapsing fever, pinpointing when it evolved to spread through lice rather than ticks, and how it gained and lost genes in the process. This transition may have coincided with changes in human lifestyles, like living closer together and the beginning of the wool trade. Borrelia recurrentis bacteria cause relapsing fever, an illness with many recurring episodes of fever, which is typically found ...

New standards in nuclear physics An international research team led by the Paul Scherrer Institute PSI has measured the radius of the nucleus of muonic helium-3 with unprecedented precision. The results are an important stress test for theories and future experiments in atomic physics. 1.97007 femtometre (quadrillionths of a metre): That’s how unimaginably tiny the radius of the atomic nucleus of helium-3 is. This is the result of an experiment at PSI that has now been published in the journal Science. More than 40 researchers from international institutes collaborated to develop and implement a method that ...

As legally required by the European Union, sustainable fisheries may not extract more fish than can regrow each year. Yet, about 70 per cent of commercially targeted fish stocks in northern EU waters are either overfished, have shrunken population sizes or have collapsed entirely. So why does the EU continue to miss its sustainable fisheries targets, despite a wealth of scientific data and policy instruments? Researchers at GEOMAR Helmholtz Centre for Ocean Research Kiel and Kiel University examined this question using the well-explored ...

The Cluster of Excellence "The Politics of Inequality" at the University of Konstanz will continue to receive funding through the German Excellence Strategy for another seven years. The German Research Foundation (DFG) and the German Council of Science and Humanities (WR) made the announcement on 22 May 2025. The Cluster of Excellence applied for around 52 million euros in funding. Clusters of Excellence are large, transdisciplinary research networks that study relevant research topics at the highest level internationally; they are one of the funding lines of the Excellence Strategy. "Our Cluster of Excellence 'The Politics ...

Using a novel lab method they developed, McGill University researchers have identified nine molecules in the blood that were elevated in teens diagnosed with depression. These molecules also predicted how symptoms might progress over time. The findings of the clinical study could pave the way for earlier detection, before symptoms worsen and become hard to treat. “Alarmingly, more and more adolescents are being diagnosed with depression, and when it starts early, the effects can be long-lasting and severe,” said senior author Cecilia Flores, James ...

Research confirms that social isolation and loneliness significantly impact health and mortality, even if not listed on death certificates. BYU psychology and neuroscience professor, Julianne Holt-Lunstad, has published extensively on the topic, including a landmark 2010 meta-analysis and a 2023 framework on assessment and treatment. She also served as lead scientist on the 2023 Surgeon General Advisory and is advising the World Health Organization on an upcoming report that addresses the pressing health threat of loneliness and isolation and a global agenda on social connection. Social connection is now a legitimate health factor, but Holt-Lunstad ...

The University of Cologne is once again highly successful in the Excellence Strategy: Five Clusters of Excellence will be funded in the next funding period. This was announced today by the German Research Foundation (DFG) and the German Science and Humanities Council. The following Clusters will be funded for seven years: CECAD for aging research, CEPLAS for plant sciences, DYNAVERSE for astrophysics, ECONtribute for economics and ML4Q for quantum research. These Clusters reflect the academic fields of the natural sciences, life sciences, humanities and social sciences represented at the University of Cologne. “We ...

The global impact of Universidad Nacional Autónoma de México (UNAM) research is set to increase under a new open access (OA) agreement with publisher Taylor & Francis. The three-year partnership will enable UNAM researchers to publish OA articles in more than 2,400 journals. OA publishing supports UNAM's ambition to be a leading international hub of excellence in research and innovation, through fostering collaboration and ensuring the latest work can be freely accessed by researchers, policymakers, and practitioners worldwide. Taylor & Francis’ first ‘read & publish’ agreement in Mexico maintains the academic community’s reading ...

What: National Institutes of Health (NIH) scientists have developed a new surgical technique for implanting multiple tissue grafts in the eye's retina. The findings in animals may help advance treatment options for dry age-related macular degeneration (AMD), which is a leading cause of vision loss among older Americans. A report about the technique published today in JCI Insight.   In diseases such as AMD, the light-sensitive retina tissue at the back of the eye degenerates. Scientists are testing therapies for restoring damaged retinas with grafts of tissue ...

Most people have encountered the black, grey, or pink stains of bacterial biofilms built up on the bathroom tiles or kitchen sink. Even with vigorous scrubbing and strong cleaning chemicals, this grime can be difficult to remove and often returns with vengeance. A new study, published in Chemical Engineering Journal, reports a novel, two-step method to effectively dismantle bacterial biofilms and prevent regrowth. “Biofilms are everywhere, from bathrooms to food factories,” said Hyunjoon Kong (M-CELS leader/EIRH/RBTE), a professor of chemical and biomolecular engineering. “Biofilms are also responsible for cross contamination ...

A new study from researchers at Aarhus University and Aarhus University Hospital found no increased risk of neurodevelopmental disorders in children whose fathers were treated with valproate during spermatogenesis. The results have just been published in JAMA Network Open and cast new light on the European Medicines Agency’s (EMA's) recent recommendation for precautionary measures. In January 2024, EMA recommended precautionary measures for treating male patients with valproate, based on ...