Researchers at Pennington Biomedical Research Center have revealed critical insights into how impaired mitochondrial dynamics and quality control mechanisms in skeletal muscle influence insulin sensitivity in patients with Type 2 Diabetes, or T2D. The study, titled "Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients with Type 2 Diabetes," was recently published in the Journal of Cachexia, Sarcopenia and Muscle.​ The research team, led by Pennington Biomedical Executive Director Dr. John Kirwan, ...

ACM, the Association for Computing Machinery, today announced the recipients of three prestigious technical awards. This year’s awardees are recognized for groundbreaking innovations to autonomous systems, cryptography, and software for parallel computers. ACM will present these and other awards at its annual awards banquet on June 14 in San Francisco. Peter Stone, Professor, University of Texas at Austin, and Chief Scientist, Sony AI, receives the ACM - AAAI Allen Newell Award for significant contributions to the theory and practice ...

Taking place on 14 May 2025, in Copenhagen and online, the event will bring together leading European scientists, policymakers and civil society to address the urgent health and environmental threat from endocrine disrupting chemicals (EDCs).   The European Society of Endocrinology (ESE), the European Society for Paediatric Endocrinology (ESPE) and the Danish endocrine community will host a high-level event titled: “Minimising the impact of endocrine disrupting chemicals on health and environment: A scientific update following the joint congress of ESPE and ESE 2025.”   The ...

"This collection is published in memory of Professor Judith Campisi, a pioneering force in the field of cellular senescence whose groundbreaking work shaped the understanding of senescence in aging, cancer, and tissue homeostasis." BUFFALO, NY — May 1, 2025 — Aging (Aging-US) invites submissions for a Special Collection dedicated to the theme of cellular senescence, spanning its basic mechanisms, physiological and pathological functions, and clinical applications. This collection is published in memory of Professor ...

Washington, D.C. – May 2, 2025 – New research elevates the use of artificial intelligence (AI) for safer, accessible, and efficient detection and treatment for patients with heart failure and cardiac arrest. The data were presented today at the Society for Cardiovascular Angiography & Interventions (SCAI) 2025 Scientific Sessions. AI is rapidly transforming the medical industry, as many in healthcare may find themselves challenged to deliver effective, high-quality care and transform care at scale while simultaneously combating shortages in the workforce. AI algorithms are being developed specifically for the healthcare workforce. ...

Every year, Earth gets a bit bigger. Thousands of metric tons of space dust fall from the sky, while about 50 tons per year of meteorites crash land somewhere on the surface. Since the 1960s, space junk has also occasionally returned to Earth, falling from a hazy sphere of trash encircling the planet. Remnants of rockets, tools lost by space-walking astronauts, defunct satellites, and more fly through lower Earth orbit, reaching speeds of 18,000 miles per hour. When any item—whether space rock or space junk—enters the atmosphere, scientists try to track its path to estimate where it will land. Will the item in question plunk straight down, or will it fly along at an angle ...

As Europe increases its reliance on solar energy to meet climate and energy security targets, a growing atmospheric phenomenon is complicating the path forward: Saharan dust. New research presented at the European Geosciences Union General Assembly (EGU25) shows that mineral dust carried on the wind from North Africa is not only reducing photovoltaic (PV) electricity generation across Europe but also making it harder to predict. In their presentation at EGU25, The shadow of the wind: photovoltaic power generation under Europe’s dusty skies, Dr. György Varga and collaborators from Hungarian and European institutions reveal how dust-laden skies disrupt PV performance ...

A new analysis of a group of all-women extreme divers off the coast of Korea has uncovered genetic differences that could help them survive the intense physiological stresses of free-diving—and could ultimately lead to better treatments for blood pressure disorders. The results are published in Cell Reports. The researchers worked with the Haenyeo: women who have spent their whole lives diving in the waters off Jeju Island, 50 miles south of mainland South Korea. They free-dive up to 60 feet below the surface to harvest seaweed, abalone, and other food items from the seafloor, spending hours a day in the water all year round. For hundreds of years, Haenyeo diving was a staple ...

The Haenyeo, a group of all-female divers from the Korean island of Jeju, are renowned for their ability to dive in frigid waters without the aid of breathing equipment — even while pregnant. A study publishing on May 2 in the Cell Press journal Cell Reports shows that the divers’ remarkable abilities are due to both training and genetic adaptation, including gene variants associated with cold tolerance and decreased blood pressure. The divers also showed pronounced bradycardia, or slowing of the heart rate, when they dived, but this trait is likely due to a lifetime of training, not genetics.   “The ...

By using antibodies from a human donor with a self-induced hyper-immunity to snake venom, scientists have developed the most broadly effective antivenom to date, which is protective against the likes of the black mamba, king cobra, and tiger snakes in mouse trials. Described May 2 in the Cell Press journal Cell, the antivenom combines protective antibodies and a small molecule inhibitor and opens a path toward a universal antiserum. How we make antivenom has not changed much over the past century. Typically, it involves immunizing ...

About The Study: Despite similar access to health insurance, lesbian, gay, bisexual, transgender, queer, and other sexual and gender minority (LGBTQ+) people had large inequities in unmet health care needs and cost-related medication nonadherence in the postpartum year. Results suggested LGBTQ+ people receive lower-quality care in the postpartum period. Although use of pregnancy-related care was comparable, LGBTQ+ individuals used more primary and specialist care and were nearly twice as likely to use the emergency department compared with ...

The massive national effort to return the Medicaid enrollment process to its pre-pandemic rules starting in April 2023 may have disrupted the care of people receiving treatment for opioid addiction, a new University of Michigan study suggests.   The researchers call this finding concerning, because the disruption may increase the risk of overdose or other negative impacts from opioid use disorder in states that were most aggressive in removing people from Medicaid coverage during the “unwinding” process in 2023.   The study has implications for the current debate over the future of Medicaid funding, which may result in further changes ...

About The Study: In this cross-sectional study, tax policy was associated with increased state-level cancer screening rates, as well as decreased cancer mortality rates, which mostly benefited white populations, suggesting that state-level policies may contribute to bridging ongoing cancer care gaps. Corresponding Author: To contact the corresponding author, Timothy M. Pawlik, MD, PhD, MPH, MTS, MBA, email tim.pawlik@osumc.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.8455) Editor’s ...

Lactate mediates training of our innate defenses A link between metabolism and epigenetics forms the basis for trained immunity   The BCG vaccine protects against tuberculosis, but by inducing trained immunity it also protects against many more respiratory infections. International research led by the Radboudumc shows how this process works. Lactate, a product of scaled-up energy production, appears to play a leading role.   The immune system protects people in two ways. Innate immunity protects us from birth against many bacteria and viruses, while adaptive immunity ...

SACRAMENTO, Calif. (May 2, 2025) – Researchers at Sutter Health, led by Cheryl Stults, Ph.D., found that an innovative ambient artificial intelligence platform showed promising results in easing the burden of clinical documentation for healthcare providers. The study, published today in JAMA Network Open, revealed significant reductions in documentation time and improved overall clinician satisfaction. It also highlights the technology’s potential to address long-standing challenges in the medical ...

Late Jurassic and Early Cretaceous oceans are known for enormous and fierce predators like pliosaurids with 2-meter-long jaws, toothy thalattosuchia crocodyliforms, and fast, fish-like ichthyosaurians. Then, during the middle Cretaceous, the fossil record shows an abrupt change . Ichthyosaurs, thalattosuchians, and pliosaurids disappeared. Meanwhile, mosasaurs, plesiosaurs, and sharks diversified and expanded. What changed to cause species that had ruled the oceans for millions of years to suddenly die out and new species to ...

Embargoed until 02 May 2025 Researchers from the Institute for Environmental Sciences (IVM) at Vrije Universiteit Amsterdam have unveiled DYNAMO-M, a groundbreaking global agent-based model that projects how farmers across the world’s coasts may respond to the growing threat of coastal flooding and salt intrusion due to sea level rise (SLR). The model, which will be presented at the EGU General Assembly 2025 in Vienna, offers new insights into the challenges faced by 13 million farming households globally. Using decision-making logic rooted in discounted expected ...

Laundry is a major source of microplastic pollution into the environment, and in-line washing machine filters are one potential solution for preventing fibers from entering waterways. But how likely would people be willing to pay for them?  Portland State researchers surveyed a sample of registered voters and environmental interest groups in Oregon to gauge respondents' general knowledge and concerns surrounding microplastics, as well as their willingness to pay for high-efficiency washing machine filters. ...

DALLAS, May 2, 2025 — About 6.7 million adults in the U.S. are living with heart failure, and that number is expected to increase to more than 8 million by 2030.[1] A new analysis published in Circulation: Heart Failure shows hospitals participating in the American Heart Association’s multiregional IMPLEMENT-HF™ initiative significantly improved adherence to guideline-directed medical therapy for patients hospitalized with heart failure with reduced ejection fraction (HFrEF), the most common type of heart failure. The American Heart Association, a global force changing the future of health for all, launched the three-year ...

Two studies at Hospital for Special Surgery (HSS) focused on advancing pain management have received President’s Choice Awards from the American Society of Regional Anesthesia and Pain Medicine (ASRA). The awards recognize innovative research with significant potential to improve patient care, highlighting HSS’s leadership in developing safer, more effective approaches to pain control. Study: Prevalence of cannabidiol use in patients undergoing sports medicine procedures on the knee, shoulder, or hip: A survey study Researchers set out to determine the ...

Washington, D.C. – May 1, 2025 – New technology shows promise for restoring blood flow and advancing care for patients with pulmonary embolism (PE) and carotid artery stenosis (CAS). The data were presented today at the Society for Cardiovascular Angiography & Interventions (SCAI) 2025 Scientific Sessions. Over the past 30 years, deaths from cardiovascular diseases have increased by 60%. There is a growing need for cardiovascular innovation with a focus on patient outcomes, whether that’s through advancements in technology, the use of digital therapeutics, or the research and development of revolutionary devices.  “Constant innovation ...

Washington, D.C. – May 2, 2025 – New analysis from the EARLY TAVR trial showed patients between the age of 65 and 70 years old derived the most benefits of a strategy of early intervention with transcatheter aortic valve replacement (TAVR) compared to other age groups, especially in regards to stroke risk, and in regards to the composite of death, stroke, and heart failure hospitalization. The late-breaking results were presented today at the Society for Cardiovascular Angiography & Interventions (SCAI) 2025 Scientific ...

Washington, D.C. – MAY 2, 2025 – New data from a large, international registry showed balloon-assisted anterior mitral leaflet modification (BATMAN) was safe, effective, and resulted in shorter procedure times among patients undergoing transcatheter mitral valve replacement (TMVR). The data were presented today as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2025 Scientific Sessions. An estimated four million people in the U.S. have mitral valve regurgitation (the most common form of heart ...

Background and Aims Heme oxygenase 1 (HO-1) has an influential yet insufficiently investigated effect on Sirtuin 1 (SIRT1), a histone deacetylase activated by nicotinamide adenine dinucleotide, which may impact the transforming growth factor-β (TGF-ß)/Smad3 pathway in nonalcoholic fatty liver disease (NAFLD)-related liver fibrosis. This study aimed to elucidate the regulation of NAFLD-related liver fibrosis induced by HO-1 through the SIRT1/TGF-ß/Smad3 pathway. Methods HO-1 induction and inhibition were established in C57BL/6J mice fed a methionine- and choline-deficient (MCD) diet. Additionally, wild-type mice were fed either ...

Mitochondrial diseases affect approximately 1 in 5,000 people worldwide, causing debilitating symptoms ranging from muscle weakness to stroke-like episodes. Some of these conditions result from mutations in mitochondrial DNA (mtDNA), the genetic material housed in these organelles. For patients with the common m.3243A>G mutation, which can cause MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) and diabetes mellitus, treatments remain limited. A fundamental challenge in mitochondrial disease research is that patients typically have a mix of both normal and mutated mtDNA within their cells. This ...