Herbal medicine is difficult to produce on an industrial scale. A team of Kobe University bioengineers manipulated the cellular machinery in a species of yeast so that one such molecule can now be produced in a fermenter at unprecedented concentrations. The achievement also points the way to the microbial production of other plant-derived compounds. Herbal medicinal products offer many beneficial health effects, but they are often unsuitable for mass production. One example is artepillin C, which has antimicrobial, anti-inflammatory, antioxidant, and anticancer action, but is only available as a bee culture product. The Kobe University bioengineer ...

The cybersecurity refrain when encountering phishing emails invariably advises: “don’t click on that link” and “report that email” — but new research from Drexel University and Arizona State University has revealed a problematic reality: Most major companies do little to support reporting and few take action to shut down phishing sites disguised as their own after they have been reported. Recently presented at the International Symposium on Research in Attacks, Intrusions and ...

Decoding Deception: The Psychology of Combating Misinformation, a short film produced by Proceedings of the National Academy of Sciences with support from the Pulitzer Center, addresses one of the most pressing issues of our time: the quest to stem the swelling tide of misinformation. Decoding Deception explores potential remedies to this growing societal problem. While social media acts as an accelerant for the rampant spread of misinformation on climate change, public health, and politics, the rise of generative AI risks worsening the problem. Left unchecked, disinformation and misinformation can inflict lasting damage on people, institutions, and society ...

A study links herbivory to phenology in the Arctic. Phenology is the study of the timing of events in the natural world. In recent decades, researchers have investigated how climate change is shifting many natural events. Eric Post and colleagues wanted to understand how a different variable—the presence or absence of herbivores—affects the timing of spring plant growth, or green-up, in Greenland. In an experiment lasting nine years, the authors excluded musk oxen and caribou from some areas, then compared the timing of the spring green-up of 9 tundra plant species in the areas with and without herbivores. Of the plants that showed altered green-up between the conditions, about ...

As many Americans prepare to gather with their families for the holidays, a new poll shows the importance of grandchildren in grandparents’ lives. The poll also suggests that having grandchildren and seeing them regularly may have a link to older adults’ mental health and risk of loneliness. Although the poll can’t show cause and effect, the findings suggest a need to study the role of grandparenting in older adults’ lives, as part of a broader effort to address social isolation. At ...

In the race to develop robust perception systems for robots, one persistent challenge has been operating in bad weather and harsh conditions. For example, traditional, light-based vision sensors such as cameras or LiDAR (Light Detection And Ranging) fail in heavy smoke and fog.  However, nature has shown that vision doesn't have to be constrained by light’s limitations — many organisms have evolved ways to perceive their environment without relying on light. Bats navigate using the echoes of sound waves, while sharks hunt by sensing electrical fields from their prey's movements. Radio waves, whose wavelengths are orders of magnitude ...

A Perspective suggests that “digital twins” are not simply tools for science but are an example of the integration of complexity science and data science into a new scientific field. A “digital twin” is a digital representation of a real-world object or system. The idea emerged from manufacturing but has been adopted by science, especially by the fields of medicine, immunology, and epidemiology. Digital twins are typically frequently or continuously updated and improved with real data from the real object the digital twin mirrors, allowing ...

Researchers at the Centre for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs" within the nucleus, orchestrating critical functions like cell division and DNA repair.   The discovery, reported across two separate research papers out today in Nature Communications, not only challenges longstanding biological paradigms in cellular biology but also opens new avenues for cancer therapies, particularly against aggressive tumours like triple-negative breast cancer (TNBC).  For decades, biology textbooks have neatly compartmentalised ...

Next-generation metagenomic sequencing test developed at UCSF proves its effectiveness in quickly diagnosing almost any kind of pathogen.  A genomic test developed at UC San Francisco to rapidly detect almost any kind of pathogen – virus, bacteria, fungus or parasite – has proved successful after a decade of use.   The test has the potential to vastly improve care for neurological infections that cause diseases like meningitis and encephalitis, as well as speed up the detection of new viral pandemic threats. It uses a powerful genomic sequencing ...

University of B.C. researchers have developed a groundbreaking coating that could make medical devices safer for millions of patients, reducing the risks associated with blood clots and dangerous bleeding. The new material, designed to mimic the natural behavior of blood vessels, could allow for safer use of blood-contacting devices like catheters, stents, blood-oxygenation machines and dialysis machines—especially in cases where blood clots are a significant concern. “This discovery could be a transformative step in the development of safer medical devices,” said Dr. Jayachandran Kizhakkedathu, ...

In an emerging red flag for the digital era, sleep experts have warned us to avoid screen time in bed, sounding the alarm that light emitted from phones and other electronic devices can disrupt our sleep patterns. That’s one way that science is waking up to the broad range of health and disease implications related to circadian biology and our daily sleep-wake cycles. Now, researchers at the University of California San Diego have found that light disruption is not only a health concern for humans. A new study led by PhD candidate Ashley Kim and Professor James Nieh in the School of Biological Sciences has found that artificial light disrupts the circadian rhythms of ...

New study from deCODE genetics/Amgen highlights the importance of BMI in pathogenesis of disease, suggesting that reducing BMI alone could lower the risk of several diseases. Scientists at deCODE genetics, subsidiary of Amgen, published a study today in Nature Communications that sheds light on how Body Mass Index (BMI) influences the risk of various diseases that are comorbid with obesity. The study, which used genetic data from Iceland and the UK Biobank, looked at whether disease risk associated with BMI-related sequence variants are explained completely or partially by their effect on BMI. The results showed that for some conditions, such as fatty liver disease, glucose intolerance, ...

What role do dogs play in today’s world? For many, they are more than just pets. New findings from the Department of Ethology at Eötvös Loránd University show that whether seen as friends, family members, children or guardians, these roles affect the way dogs are cared for, suggesting shifting dynamics in human-animal bonds shaped by societal trends and individual owner profiles. In Western cultures, more and more people see their dogs as their best friends, family members or even their furry children. In fact, ...

All animals, large or small, have to move at an incredible precision to interact with the world. Understanding how the brain controls movement is a fundamental question in neuroscience. For larger animals, this is challenging because of the complexity of their brains and nervous systems. But the fruit fly, Drosophila melanogaster, has a smaller and therefore more easily mappable brain, allowing scientists to gain detailed insights into how its nervous system drives behavior. To understand how the nervous system controls actions, researchers at the group of Pavan Ramdya at EPFL created a simulated reality where a virtual fly can operate ...

Researchers have found evidence that mangrove forests – which protect tropical and subtropical coastlines – are drowning in the Maldives. Their findings, published today (Tuesday 12 December) in Scientific Reports, indicate that rising sea level and a climate phenomenon known as the Indian Ocean Dipole have led to some Maldivian islands losing over half of their mangrove cover since 2020. The research team, led by Northumbria University, warn that the findings have implications not only for the Maldives, but also for other island nations and coastal ecosystems around the world. In 2020, more than a quarter of the Maldivian islands containing mangrove forests saw their trees experiencing ...

There’s no doubt that exercise does a body good. Regular activity not only strengthens muscles but can bolster our bones, blood vessels, and immune system.  Now, MIT engineers have found that exercise can also have benefits at the level of individual neurons. They observed that when muscles contract during exercise, they release a soup of biochemical signals called myokines. In the presence of these muscle-generated signals, neurons grew four times farther compared to neurons that were not exposed to myokines. These cellular-level experiments suggest that exercise can have a significant biochemical effect on nerve growth.  Surprisingly, the researchers also ...

A new paper in Nicotine and Tobacco Research, published by Oxford University Press, finds that people who switch from smoking cigarettes to vaping see improved respiratory health, but people who begin consuming electronic cigarettes while continuing to smoke regular cigarettes do not report improved respiratory symptoms. Adults increasingly use electronic cigarettes to try to quit smoking because of the perceived reduced risk. But while vaping reduces exposure to toxic chemicals, it has been unclear whether switching from cigarettes to e-cigarettes results in a reduction of the respiratory problems—like wheezing and coughing—common in regular cigarette ...

Boston, Massachusetts, 12 November 2024 – Environmental exposure to air pollutants during critical developmental periods may significantly impact autism risk, according to a groundbreaking Emerging Topic review published 12 November 2024, in Brain Medicine. The study reveals how common air pollutants, including fine particulate matter and nitrogen oxides, can trigger complex biological cascades affecting brain development. "Different kinds of neurological disorders, including autism spectrum disorder, can be associated ...

Boston, Massachusetts, 12 November 2024 – The complex interplay between nitric oxide and brain disorders takes center stage in the latest Genomic Press Interview, published November 12, 2024, in Brain Medicine. Professor Haitham Amal, head of the Laboratory of Neuromics, Cell Signaling, and Translational Medicine at the Hebrew University of Jerusalem, shares insights into his groundbreaking research and personal motivation. “Meeting families and children with autism in Boston during my time at MIT inspired me to focus on a single goal: to help develop biological diagnostics ...

Destructive winds during storms and cyclones often cause tree failures, especially through uprooting and stem breakage. However, how trees respond to wind under various forest configurations and weather conditions remains unclear. A recent study on Cryptomeria japonica plots shows that trees dissipate wind energy by switching between two swaying behaviors at specific wind speeds, offering insights that may help in improved forest management to minimize damage caused by storms. Extreme weather events, such as tropical and extratropical cyclones and tornadoes, can cause widespread damage to forests, leading to environmental and financial ...

Bioprinting is a technology used to create three-dimensional structures, such as human tissues or organs, using bio-inks made of cells and hydrogels. However, conventional inkjet technology has difficulty dispensing bio-inks that are sensitive to temperature due to the heat generated during operation. Furthermore, conventional 3D bioprinting mainly utilizes simple syringe-type printing devices with a single needle, making it time-consuming to produce artificial organs like the brain, lungs, and heart. The Bionics Research Center team, led by Dr. Byung Chul Lee at the Korea Institute of Science and Technology (KIST, President Sang-Rok Oh), in ...

La version française suit Opioid use disorder: updated clinical practice guideline An updated evidence-based guideline aimed at helping clinicians and other health care providers manage patients with opioid use disorder recommends buprenorphine and methadone as first-line treatments. The guideline is published in CMAJ (Canadian Medical Association Journal). https://www.cmaj.ca/lookup/doi/10.1503/cmaj.241173 Opioid use and opioid use disorder are the leading causes of drug-related deaths worldwide, and Canada ...

The rapid advancement in personalized healthcare has driven the development of wearable biomedical devices for real-time biomarker monitoring and diagnosis. Traditional invasive blood-based diagnostics are painful and limited to sporadic health snapshots. To address these limitations, microneedle-based sensing platforms have emerged, utilizing interstitial fluid (ISF) as an alternative biofluid for continuous health monitoring in a minimally invasive and painless manner. The team led by Wei Gao from California Institute of Technology providea a comprehensive overview of microneedle sensor technology, covering microneedle design, fabrication methods, ...

Research by scientists at the University of Sydney has identified a constituent in the cannabis plant that improves sleep. Their report is the first to use objective measures to show the component, known as cannabinol (CBN), increases sleep in rats.  The study has been published in the leading journal Neuropsychopharmacology. “For decades, cannabis folklore has suggested that aged cannabis makes consumers sleepy via the build-up of CBN, however there was no convincing evidence for this,” said lead author on the study Professor Jonathon Arnold, ...

A team of clinicians, scientists, and engineers at Mount Sinai trained a deep learning pose-recognition algorithm on video feeds of infants in the neonatal intensive care unit (NICU) to accurately track their movements and identify key neurologic metrics. Findings from this new artificial intelligence (AI)-based tool, published November 11 in Lancet’s eClinicalMedicine, could lead to a minimally invasive, scalable method for continuous neurologic monitoring in NICUs, providing critical real-time insights into infant health that have not been possible before. Every year, more than 300,000 ...