About The Study: Cryopreserved platelets did not meet the predefined threshold for noninferiority in hemostatic effectiveness at 24 hours after intensive care unit admission. Additional predefined end points consistently indicated diminished hemostatic effectiveness, although prespecified adverse events were comparable. Corresponding Author: To contact the corresponding author, Michael C. Reade, MBBS, DPhil, email m.reade@uq.edu.au. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.23355) Editor’s Note: Please see the article for additional information, including other authors, ...

About The Study: In this economic evaluation, cryopreserved platelets were dominated by liquid-stored platelets for managing bleeding in cardiac surgery. Further research is needed to assess the potential economic benefits of cryopreserved platelets in broader populations, particularly in regional and remote hospitals where platelet availability is limited.  Corresponding Author: To contact the corresponding author, Alisa M. Higgins, PhD, email lisa.higgins@monash.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.54363) Editor’s Note: Please see ...

Precise Point Positioning (PPP) is widely used for high-accuracy navigation, but broadcast ephemeris from the BDS-3 system still suffers from hourly discontinuities that degrade real-time performance. This study introduces a new PPP strategy that integrates a covariance-adaptive Kalman filter to compensate for sudden orbit and clock jumps during each ephemeris update. By incorporating systematic parameters and dynamically scaling process noise, the algorithm better captures unexpected changes in satellite signals. Tests using one week of static global data and a 10-hour marine kinematic dataset show significant gains in accuracy, demonstrating that the proposed ...

Patients who receive T-cell redirecting therapies are typically hospitalized for several days after treatment to watch for side effects. Now new research by Fox Chase Cancer Center physicians shows that these patients can safely be monitored at home. The study, presented today at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition, showed that a structured outpatient model significantly reduced the number of days patients spent in the hospital, with no negative outcomes. Fewer Hospital Days, No Safety Compromises “There are multiple benefits to our approach,” ...

A researcher at the Department of Physics at Tohoku University has uncovered a surprising quantum phenomenon hidden inside ordinary crystals: the strength of interactions between electrons and lattice vibrations - known as phonons - is not continuous, but quantized. Even more remarkably, this strength is universally linked to one of physics' most iconic numbers: the fine-structure constant. What makes this dimensionless number (α ≈ 1/137) so iconic is its ability to explain electromagnetic interactions, ...

The Institute for Frontier Science and Engineering at Okayama University of Science (OUS) is developing various international collaboration projects with the aim of forming a research hub where international talents gather. Based on the education and research agreement between OUS and Mapúa University (MU) in the Philippines, a joint colloquium was held to foster exchanges among researchers and students from both universities. This was the third time the colloquium was held. Three professors — Haruo Akashi (Institute for Frontier Science and ...

Young adolescents, especially boys, who participated in organized sports between ages 6 and 10 are less likely to defy their parents, teachers and other authority figures, a new study by researchers in Canada and Italy suggests. “Oppositional-defiant disorder (ODD) is often under-diagnosed and can co-occur with other developmental disorders," said the study's lead author Matteo Privitera, a doctoral student at the University of Pavia (UofP), supervised by Linda Pagani, a professor at Université de Montréal's School of Psycho-Education. "Symptoms of the disorder include persistent patterns of irritability, defiance and hostility toward ...

LOS ANGELES — Researchers from City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States with its National Medical Center ranked among the nation’s top cancer centers by U.S. News & World Report, presented scientific results on novel therapies, treatment strategies, and approaches to managing side effects and complications for blood cancer patients at the 2025 American Society of Hematology (ASH) conference in Orlando, Florida, held Dec. 6 to 9. City of Hope was involved in one ASH plenary. In addition, its scientists ...

FOR IMMEDIATE RELEASE  EMBARGOED UNTIL DECEMBER 8, 2025  Research Aims to Strengthen the Security of In-Person Voting Machines  New study on election security evaluates potential vulnerabilities  in widely used Precinct Count Optical Scanners    Washington, D.C., December 8, 2025 – About 70% of Americans voted in person in the 2024 presidential election, their ballots counted by machines called Precinct Count Optical Scanners (PCOS). Researchers at Towson University have systematically analyzed thousands ...

Washington, D.C. December 8, 2025 -- A new statewide spatial analysis of Alzheimer’s disease and related dementias (ADRD) has uncovered significant disparities in Maryland’s rural communities, offering a striking example of how healthcare accessibility is shaping health outcomes across the United States.   More than 90% of larger hospitals are located in urban areas, leaving rural hospitals with fewer resources and very small operating margins. One of the biggest challenges is the shortage of doctors, nurses, and specialists trained in Alzheimer's and dementia care, who are concentrated in urban centers. As a result, ...

MIAMI, FLORIDA (EMBARGOED UNTIL DEC. 8, 2025, AT 6 P.M. EST) – A new national study shows for the first time that people exposed to Agent Orange face a higher risk of developing myelodysplastic syndrome (MDS), tend to develop it earlier, and often have more aggressive disease that is more likely to progress to acute myeloid leukemia. The study was co-led by researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine. Many veterans and doctors have long questioned whether Agent Orange exposure ...

Two clinical studies demonstrate high response rates by patients with two hard-to-treat and aggressive blood cancers   Pivekimab sunirine (PVEK) targets the CD123 antigen, which is overexpressed in both diseases  Frontline triplet regimen including PVEK shows promise for hard-to-treat AML in patients who are not eligible for intensive chemotherapy  PVEK monotherapy demonstrates strong responses, enables stem cell transplant for high-risk subgroup of BPDCN patients   ORLANDO, DECEMBER 8, 2025 – Researchers from The ...

Alexandria, VA, USA – Members of the International Association for Dental, Oral, and Craniofacial Research (IADR) have elected George Belibasakis, Karolinska Institutet, Stockholm, Sweden to serve as Vice-president. His term will commence at the conclusion of the 104th General Session of the IADR, which will be held in conjunction with the 55th Annual Meeting of the AADOCR and the 50th Annual Meeting of the Canadian Association for Dental Research, from March 25-28, 2026 in San Diego, CA, USA. Belibasakis is currently Professor of Clinical Oral Infection Biology, Head of the Division of Oral Health and Periodontology, and Head of Research at the Department of Dental Medicine, ...

Quantum technologies from ultrasensitive sensors to next-generation information processors depend on the ability of quantum bits, or qubits, to maintain their delicate quantum states for a sufficiently long time to be useful.  One of the most important measures of this stability is the spin coherence time. Unfortunately, qubits may lose coherence because their environment is “noisy,” for example, due to the presence of nuclear isotopes or other interference that disturbs the qubit. Two-dimensional (2D) materials—or atomically thin sheets—can offer quiet environments for qubits, as their reduced thickness naturally lowers the number of isotopes that interact ...

University of Phoenix College of Doctoral Studies announces a new white paper, “Leadership Opportunities for Increasing Employee Value through Artificial Intelligence,” authored by Andrew C. Lawlor, PhD, and Pamayla E. Darbyshire, DHA, MSN/CNS, both Fellows at the Center for Educational and Instructional Technology Research (CEITR). The paper examines how leaders can use AI, especially generative AI, to address skills gaps, restore worker autonomy, and shift employees from repetitive tasks to higher-value activities.   The authors draw upon the University’s Career Optimism Index® study and other current research, ...

MIAMI, FLORIDA (EMBARGOED UNTIL DEC. 8, 2025, AT 4:30 P.M. EST) – A new clinical trial suggests that pairing bispecific antibodies and antibody-drug conjugates with CAR T-cell therapy may sharply boost one-year progression-free survival for people with aggressive lymphoma. In just a few years, treatment options for aggressive lymphoma have rapidly advanced. However, many patients show a consistent pattern: powerful new therapies act quickly but often fail to keep the lymphoma at bay permanently, says Jay Spiegel, M.D., a transplant and cellular therapy physician at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine. Spiegel ...

A groundbreaking new treatment using genome-edited immune cells, developed by scientists at UCL (University College London) and Great Ormond Street Hospital (GOSH), has shown promising results in helping children and adults fight a rare and aggressive form of blood cancer called T-cell acute lymphoblastic leukaemia (T-ALL). The world-first gene therapy (BE-CAR7) uses base-edited immune cells to treat previously untreatable T-cell leukaemia and help patients achieve remission, offering new hope for families facing this aggressive cancer. Base-editing is an advanced version of CRISPR technology, that can precisely change single ...

An international team led by the University of Michigan has introduced new methods that reveal which regions of the brain were active throughout the day with single-cell resolution. Using mouse models, the researchers developed an experimental protocol and a computational analysis to follow which neurons and networks within the brain were active at different times. Published in the journal PLOS Biology, the study provides new insights into brain signaling during sleep and wakefulness, which hints at the bigger questions and goals that motivated the work. "We undertook this difficult study to understand fatigue," ...

Australian researchers have for the first time pinpointed specific genetic changes that increase the risk of severe, sight-threatening forms of age-related macular degeneration (AMD). A new study, published today in Nature Communications, reveals the specific genetic factors linked to the presence of reticular pseudodrusen - deposits which drive vision loss and are found on the retina of up to 60 per cent of people with advanced AMD. The research, led by the Centre for Eye Research Australia, WEHI and the University of Melbourne, offers a promising new target for treatments aimed at the most severe ...

Embargoed for release until 5:00 p.m. ET on Monday 8 December 2025    Follow @Annalsofim on X, Facebook, Instagram, Bluesky, and Linkedin              Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization ...

About The Study: Among patients with sepsis, precision immunotherapy targeting macrophage activation–like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared with placebo. Corresponding Author: To contact the corresponding author, Evangelos J. Giamarellos-Bourboulis, MD, PhD, email egiamarel@med.uoa.gr. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.24175) Editor’s Note: Please see the article for additional information, including other ...

The topics of human-level artificial general intelligence (AGI) and artificial superintelligence (ASI) have captivated researchers for decades. Interest has surged with the rapid progress and deployment of large language models (LLMs), which now handle tasks such as coding, scientific explanation, creative writing, and multimodal reasoning. “Solve AI and it will solve everything” remains a popular, if contested, credo—driving large-scale investment, shaping public narratives, and motivating optimism about transformative advances. Applying this vision to the healthcare and pharmaceutical industries, ...

FOR IMMEDIATE RELEASE  EMBARGOED UNTIL DECEMBER 8, 2025  Study Finds Most People Trust Doctors More than AI But See Its Potential for Cancer Diagnosis  Nationally representative surveys measure public attitudes toward AI in healthcare  Washington, D.C., December 8, 2025– New research on public attitudes toward AI indicates that most people are reluctant to let ChatGPT and other AI tools diagnose their health condition, but see promise in technologies that use AI to help diagnose cancer. These and other results of two nationally representative surveys will be presented at the ...

Embargoed for release: Monday, December 8, 2025, 4:00 PM ET Key points: Children whose schools reopened during the COVID-19 pandemic had significantly decreased mental health diagnoses relative to children whose schools remained closed, according to a new study of schools across California. This included fewer diagnoses of depression, anxiety, and ADHD. Girls’ mental health benefited the most. Mental health care spending decreased by up to 11% by the ninth month after a school’s reopening. The study is among the largest and most data-rich examinations of how school closures impacted ...

SARS‑CoV‑2, the virus that causes COVID-19, continues to mutate, with some newer strains becoming less responsive to current antiviral treatments like Paxlovid. Now, University of California San Diego scientists and an international team of researchers have identified several promising molecules that could lead to new medications capable of combating these resistant variants. Instead of looking for antiviral candidates from scratch, the research team screened 141 previously synthesized compounds that had originally been designed between 1997 and 2012 to inhibit a key enzyme called cruzain. ...