Supramolecular chemistry involves the study of self-assembly of discrete molecules that are used to build functional large structures. Often, these molecules are allowed to self-assemble into one-dimensional polymeric structures (supramolecular polymers or SPs) in a suitable environment, and the dynamic molecular interactions are noted for tweaking the environment and improving the features of the resulting SPs. They are being explored as the next-generation polymeric materials with applications in electronics, soft-robotics, ...

Liquid biopsy is increasingly recognized as a promising tool for cancer detection and treatment monitoring, yet its effectiveness is often limited by the extremely low levels of tumor-derived DNA circulating in the blood. To address this challenge, researchers led by Professor Junseok W Hur from Korea University College of Medicine, in collaboration with multiple partners, have developed MUTE-Seq, a highly sensitive CRISPR-based method designed to detect cancer mutations present at exceptionally low frequencies while simultaneously reducing sequencing costs and background error noise. The study was first made available ...

Philadelphia, PA, USA, December 9, 2025, First Patient Enrolled in GOG-3133/ FRAmework-01 Phase 3 Study Evaluating Sofetabart Mipitecan (LY4170156), a Novel ADC Targeting Folate Receptor Alpha (FRα), in Recurrent Ovarian Cancer The GOG Foundation, Inc. is proud to announce the enrollment of the first patient in GOG-3133, a pivotal Phase 3 clinical trial titled FRAmework-01: A Two-Part Phase 3 Study of LY4170156 versus Chemotherapy or Mirvetuximab Soravtansine in Platinum-Resistant Ovarian Cancer, and LY4170156 plus Bevacizumab versus Platinum-Based Chemotherapy plus Bevacizumab in Platinum-Sensitive Ovarian Cancer. The study is sponsored by Eli ...

The Hebrew University of Jerusalem proudly congratulates two of its esteemed researchers on receiving the prestigious European Research Council (ERC) Consolidator Grant for 2025. Both awardees, who lead groundbreaking work in applied physics and international relations, were selected for one of Europe’s most competitive grants, awarded to researchers 7–12 years after their doctorates. These grants support the establishment of independent research groups, the development of new laboratories, and innovative projects across the natural sciences, social sciences, and humanities. This recognition continues the university’s ...

University of Tartu Associate Professor in Climate Physics Velle Toll received the Consolidator Grant from the European Research Council (ERC) to quantify the extent to which air pollution particles cool the Earth’s climate. The results of Toll’s work would help fill a gap in our detailed understanding of human-induced climate change and improve the accuracy of climate projections.  The main cause of anthropogenic climate change is the greenhouse gases released by burning fossil fuels, and the ...

The brain-chemical surge that comes with running may bolster coordination and speed in the old and young alike, a new study of middle-aged mice shows. Such physical activity may help restore ease of movement and agility, which often decline as humans and animals get older, the study authors said. Led by NYU Langone Health researchers, the investigation explored how aerobic exercise can boost the release of dopamine, a brain chemical involved in movement, reward, and memory. The team built upon its earlier work, which revealed that young (10-week-old) male rodents had a lasting increase in dopamine release after voluntarily running on an exercise wheel for 30 days. The new findings showed ...

Doctors and researchers try to understand what medications a person has taken by asking patients directly or by looking at medical records. But this information is often incomplete. People may forget what they took, use over-the-counter drugs, take leftover prescription drugs, buy medicines online, or be exposed unintentionally through food and the environment. As a result, significant drug exposures can be missed. Knowing what drugs are present is important because they can have unexpected effects on biology ...

Humans live in a world abundant in salt, but this everyday seasoning is a luxury for wild herbivores, and it’s far from clear how these animals get enough.    A new study published today in Nature Ecology and Evolution and authored by Northern Arizona University researchers and collaborators found the density and distribution of Earth’s largest land animals, including elephants, giraffes and rhinos, appear to be limited by this kitchen essential. There are only a few areas ...

WASHINGTON –   A new finding from researchers at Georgetown University Medical Center shows that the learning process of associating cues with rewards can be altered by increased or decreased activity of a specific protein in the brain. Knowing when to respond positively to cues that result in beneficial outcomes or rewards vs. ignoring cues that result in bad habits, such as smoking addiction, is an essential part of learned behaviors. “Our ability to link certain cues or stimuli ...

Researchers have discovered that not all atoms in a liquid are in motion and that some remain stationary regardless of the temperature, significantly impacting the solidification process, including the formation of an unusual state of matter—a corralled supercooled liquid.   The formation of solids is essential in various natural processes, including mineralisation, ice formation, and the folding of protein fibrils. It also plays a significant role in technological applications such as pharmacy and industries ...

A new study has developed a powerful computational method that can detect how genes interact with each other to influence complex traits in humans at a scale previously impossible. The new method was applied to massive datasets that pair individual genomes and traits to find evidence for such interactions. The findings, published in Nature Genetics, show that a person's genetic background can substantially modify how individual genetic variants affect their traits. Why it matters Understanding how genes interact to influence complex traits, such as Body Mass Index or total ...

Herbivores require a steady intake of sodium to keep their metabolism running smoothly. This is why farm animals have long been given salt or mineral licks. Animals in the wild, however, need to get their salt from sources in their habitats. In some areas, plants and other natural sources of salt provide sufficient sodium, while in others sodium levels are scarce. These differences can influence where certain species settle or how far they will migrate to find natural salt licks. A new study conducted in collaboration with the University ...

When cell division (mitosis) takes too long, it can be a sign that something is wrong with the cells, for example DNA damage or chromosomal instability. That’s why our cells come with an innate ability to tell the time, with a stress response known as the mitotic stopwatch pathway activating after prolonged mitosis, and triggering cell cycle arrest, or even cell death. Now, researchers at the Okinawa Institute of Science and Technology (OIST) have found that certain cancers can ‘lose their sense of time’ to avoid cellular stress responses, revealing new insights that could shape future anti-cancer therapeutics. The research published in Nature Communications ...

Magnonics is an emerging engineering subfield that targets high-speed, high-efficiency information encoding without the energy loss that burdens electronics. This energy loss occurs when electrons flowing through a circuit generate heat, but magnonic systems don’t involve any electron flow at all. Instead, an external magnetic field is applied to a magnet, upsetting the magnetic orientation (or ‘spin’) of the magnet’s electrons. This upset enables a tailored collective excitation called a spin wave (magnon), which travels through ...

Leading X-ray space telescopes XMM-Newton and XRISM have spotted a never-seen-before blast from a supermassive black hole. In a matter of hours, the gravitational monster whipped up powerful winds, flinging material out into space at eye-watering speeds of 60 000 km per second. The gigantic black hole lurks within NGC 3783, a beautiful spiral galaxy imaged recently by the NASA/ESA Hubble Space Telescope. Astronomers spotted a bright X-ray flare erupt from the black hole before swiftly fading away. As it faded, fast winds emerged, raging at one-fifth of the speed of light. “We’ve not watched a black ...

A new study from City St George’s, University of London has found that people’s newspaper reading habits are a reliable predictor of their attitudes towards autism, even when many other factors such as age, education, political views and personal experiences are taken into account. The research, published in the journal Autism, reveals that around 10% of the differences in automatic, unconscious bias were linked to what newspapers people read. People who read right-leaning tabloid papers more ...

Artificial turf football pitches are better than natural turf from a sustainability perspective – at least as long as the artificial turf material is recycled and the natural turf is cut using fossil fuel-powered lawn mowers. This is demonstrated by researchers at Linköping University in a new study comparing the environmental impact of the different pitches with the help of life cycle analyses. “The Nordic climate is tough on football pitches and there isn’t much research on the subject. But there is a great deal of interest from the municipalities as regards sustainability and weighing artificial turf against natural ...

A new study shows that in 2023, substance use disorders led to nearly $93 billion in lost productivity in the United States from missed work, reduced job performance, inability to work, and lost household productivity. The novel analysis appearing in the American Journal of Preventive Medicine, published by Elsevier, highlights the need for prevention and treatment strategies to reduce harm and costs. “Substance use disorders can impair cognitive and behavioral functioning, resulting in productivity losses,” said the team of investigators from the Centers for Disease Control and Prevention. “While ...

More than half of psychologists experimented with artificial intelligence tools in their practices in the past year, but almost all cite concerns about how the technology may affect their patients and society, according to the American Psychological Association’s 2025 Practitioner Pulse Survey. This annual survey, conducted by APA and its companion organization, APA Services, Inc., was completed by 1,742 psychologists in September 2025. It found that 56% of psychologists reported using AI tools ...

Ammonia fuels agriculture, supports industry, and is increasingly viewed as a key player in future clean-energy systems. Yet producing it is heat and pressure intensive. A research team has developed an electrocatalyst that helps turn nitrate--a common pollutant found in groundwater and agricultural runoff--into ammonia under far milder conditions. Details of their findings were published in the journal Advanced Functional Materials on November 4, 2025. "Our new catalyst has two main benefits: first, it reduces the emissions linked to fertilizer and chemical manufacturing, ...

Background and Motivation In recent years, the rise of common institutional ownership—where large institutional investors hold significant shares in multiple competing firms within the same industry—has sparked intense debate among scholars and regulators. While some argue it fosters information sharing and improves governance, others warn it may reduce competition and encourage collusion. Despite growing attention, little research has examined how this ownership structure affects overall business strategy. This study investigates whether common institutional ownership makes companies more or less aggressive in ...

Background and Motivation China’s national carbon market has grown rapidly in recent years, emerging as one of the world’s largest Emissions Trading Systems (ETS). Carbon price volatility not only affects market stability and pricing credibility but also influences corporate investment and emissions strategies. While prior research has identified various factors affecting carbon price fluctuations, most studies focus on a narrow set of variables and rarely compare broader potential drivers across regions. This leaves a gap in understanding which factors are truly critical in explaining volatility ...

Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), and NHG Health’s Institute of Mental Health (IMH) have mapped how brain networks differ in individuals at Clinical High Risk (CHR) for psychosis, providing a new perspective on the mechanisms underlying the disease onset. Published in Molecular Psychiatry, the study utilised advanced neuroimaging methods to identify early, network-level changes in more than 3,000 individuals at varying levels of risk.   The study – led by Dr Siwei Liu, Senior Research Scientist, and Associate Professor Juan Helen Zhou, Director, both at the Centre for Translational Magnetic Resonance Research ...

About The Study: Cryopreserved platelets did not meet the predefined threshold for noninferiority in hemostatic effectiveness at 24 hours after intensive care unit admission. Additional predefined end points consistently indicated diminished hemostatic effectiveness, although prespecified adverse events were comparable. Corresponding Author: To contact the corresponding author, Michael C. Reade, MBBS, DPhil, email m.reade@uq.edu.au. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.23355) Editor’s Note: Please see the article for additional information, including other authors, ...

About The Study: In this economic evaluation, cryopreserved platelets were dominated by liquid-stored platelets for managing bleeding in cardiac surgery. Further research is needed to assess the potential economic benefits of cryopreserved platelets in broader populations, particularly in regional and remote hospitals where platelet availability is limited.  Corresponding Author: To contact the corresponding author, Alisa M. Higgins, PhD, email lisa.higgins@monash.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.54363) Editor’s Note: Please see ...