With publicly funded correlative science in the nation’s Cancer Cooperative Groups reduced to a trickle, Group leaders propose implementing a long-standing National Academy of Medicine recommendation to bring new money to this area of research through public-private partnerships. They also recommend major process changes to remove significant barriers for researchers to access the biological samples contributed by patients. The current Journal of Clinical Oncology issue features ‘Correlative Science in the Cooperative Group System—Re-Engineering for Success.’ This Position Paper represents consensus among Evanthia Galanis, MD, DSc for the Alliance for Clinical ...

Kashif Nawaz, distinguished researcher and section head for Building Technologies Research at the Department of Energy’s Oak Ridge National Laboratory, has been named a Fellow of the American Society of Mechanical Engineers, or ASME. The Fellow grade recognizes outstanding engineering achievements for members with 10 or more years of active practice. Nawaz joined ORNL in 2016 as a research scientist in buildings equipment. He specializes in the heating, cooling and dehumidification systems of buildings including the development of novel heat exchangers and enhanced phase-change material ...

U2opia Technology has licensed Situ and Heartbeat, a package of technologies from the Department of Energy’s Oak Ridge National Laboratory that offers a new method for advanced cybersecurity monitoring in real time. Situ, which discovers and understands otherwise-undetectable events by analyzing security data, will go to the market through a commercial license. The company will continue to explore opportunities for Heartbeat, which detects cyber attacks by focusing on the physical behavior of a protected device, through a research and development license.  U2opia Technology, a woman- and minority- led company, is directed by Maurice Singleton III, chief executive officer, ...

Some of the most dramatic climatic events in our planet’s history are “Snowball Earth” events that happened hundreds of millions of years ago, when almost the entire planet was encased in ice up to 0.6 miles (1 kilometer) thick. These “Snowball Earth” events have happened only a handful of times and do not occur on regular cycles. Each lasts for millions of years or tens of millions of years and is followed by dramatic warming, but the details of these transitions are poorly ...

Wednesday, September 18, 2024, CLEVELAND: A clinical trial has demonstrated that the cancer drug pomalidomide is safe and effective in treating hereditary hemorrhagic telangiectasia (HHT), a rare bleeding disorder that impacts more than 1 in 5,000 people worldwide. The trial, led by Keith McCrae, M.D., of Cleveland Clinic and supported by the National Institutes of Health, was stopped early because of these successful findings, and has been published in the New England Journal of Medicine. The impetus for this trial was a single patient. About ...

A clinical trial supported by the National Institutes of Health (NIH) was stopped early after researchers found sufficient evidence that a drug used to treat bone marrow cancer and Kaposi sarcoma is safe and effective in treating hereditary hemorrhagic telangiectasia (HHT), a rare bleeding disorder that affects 1 in 5,000 people worldwide. The trial results, which are published in the New England Journal of Medicine, detail how patients with HHT given the drug, called pomalidomide, experienced a significant reduction in the severity of nosebleeds, needed fewer of the blood transfusions and iron infusions that HHT often demands, ...

A drug approved for treating the blood cancer multiple myeloma may offer a safe and effective way to reduce the risk of severe nosebleeds from a rare but devastating bleeding disorder. Hereditary hemorrhagic telangiectasia (HHT), the world's second-most-common inherited bleeding disorder, affects approximately 1-in-5,000 people and can have life-threatening complications, but there are currently no U.S. FDA-approved drugs to treat HHT. The PATH-HHT study, the first-ever randomized, placebo-controlled ...

Associate professor of chemical engineering Bryan Berger received funding from the Environmental Protection Agency to reduce the impact of per- and polyfluoroalkyl substances, known as PFAS, in food and farming communities. The award is part of the over $15 million the EPA granted to 10 institutions for PFAS reduction research, aimed at improving farm viability and increasing knowledge of PFAS accumulation.  Water sample collection for testing in Limestone, Maine. (Contributed photo) Known as forever chemicals, PFAS are man-made substances that have been used in industry ...

Superintelligence — AI systems that surpass human intelligence — could be just a decade away, raising urgent questions about how to ensure their safety and alignment with human values, according to OpenAI.  These AI systems could be hugely beneficial, but more sophisticated systems create the possibility for unpredictability. Misinterpreting human values or intent, algorithmic biases and security risks are all cause for concern, especially with highly developed AI systems where the potential consequences are far greater. Yu Meng, assistant professor of computer science at ...

WASHINGTON, D.C.—A new website, AnimalMethodsBias.org, created by the Coalition to Illuminate and Address Animal Methods Bias (COLAAB), provides researchers guidance and resources aimed at helping them successfully publish nonanimal biomedical research by overcoming the preference some peer reviewers have for animal-based research methods. “We recently found that half of researchers surveyed had been asked by reviewers to add an animal experiment to their otherwise animal-free study,” says Catharine ...

MINNEAPOLIS – People whose diet more closely resembles the MIND diet may have a lower risk of cognitive impairment, according to a study published in the September 18, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. Results were similar for Black and white participants. These results do not prove that the MIND diet prevents cognitive impairment, they only show an association. The MIND diet is a combination of the Mediterranean and DASH diets. It includes green leafy vegetables like spinach, ...

MINNEAPOLIS – A class of drugs for diabetes may be associated with a lower risk of dementia and Parkinson’s disease, according to a study published in the September 18, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study looked at sodium-glucose cotransporter-2 (SGLT2) inhibitors, which are also known as gliflozins. They lower blood sugar by causing the kidneys to remove sugar from the body through urine. “We know that these neurodegenerative diseases like dementia and Parkinson’s disease are common and the number of cases is growing as the ...

SECORE International’s Coral Seeding approach utilizes assisted reproduction, the breeding of corals, for reef restoration. This approach is realized within a training and partner network throughout the Caribbean. Now, a peer-reviewed study shows that all the effort was worthwhile: during the devastating heatwave in the Caribbean in 2023, the young, bred corals out on the reef stayed healthy while most of the remaining wild corals bleached and many died in the aftermath. The summer of 2023 was deadly for many corals in the Caribbean Basin. An unprecedented heatwave, in intensity as well as in duration, hit the Caribbean with catastrophic ...

A mysterious tusked animal depicted in South African rock art might portray an ancient species preserved as fossils in the same region, according to a study published September 18, 2024 in the open-access journal PLOS ONE by Julien Benoit of the University of the Witwatersrand, Johannesburg, South Africa. The Horned Serpent panel is a section of rock wall featuring artwork of animals and other cultural elements associated with the San people of South Africa, originally painted between 1821 and 1835. Among the painted figures is ...

Climate change and a range of other human impacts are putting marine animals at risk of extinction – even those living in almost pristine marine habitats and diverse coastal regions – reports a new study by Casey O'Hara of the National Center for Ecological Analysis and Synthesis at the University of California, Santa Barbara, USA, and colleagues, published September 18, 2024 in the open-access journal PLOS ONE. Human activities on land and sea, in combination with climate change, are degrading coastal ...

Stuttgart – Scientists at the Max-Planck-Institute for Intelligent Systems (MPI-IS) have developed hexagon-shaped robotic components, called modules, that can be snapped together LEGO-style into high-speed robots that can be rearranged for different capabilities. The team of researchers from the Robotic Materials Department at MPI-IS, led by Christoph Keplinger, integrated artificial muscles into hexagonal exoskeletons that are embedded with magnets, allowing for quick mechanical and electrical connections. The team’s work, “Hexagonal electrohydraulic modules for rapidly reconfigurable high-speed robots” will be published in Science ...

RICHLAND, Wash.—After thousands of years as a highly valuable commodity, silk continues to surprise. Now it may help usher in a whole new direction for microelectronics and computing. While silk protein has been deployed in designer electronics, its use is currently limited in part because silk fibers are a messy tangle of spaghetti-like strands.  Now, a research team led by scientists at the Department of Energy’s Pacific Northwest National Laboratory has tamed the tangle.  They report in the journal ...

NEW YORK, NY (September 18, 2024)—Columbia University will award the 2024 Louisa Gross Horwitz Prize to Scott Emr and Wesley Sundquist for discovering the ESCRT (Endosomal Sorting Complexes Required for Transport) pathway and revealing how it works. ESCRT (pronounced “escort”) complexes deform the cell membrane and bend parts of it away from the cytoplasm, the space that houses all material inside a cell. This unique process plays an essential role in keeping cells healthy by packaging and sorting molecules, removing waste, and regulating important functions such as cell division, neuron remodeling, ...

Images A set of knee exoskeletons, built with commercially available knee braces and drone motors at the University of Michigan, has been shown to help counteract fatigue in lifting and carrying tasks. They helped users maintain better lifting posture even when tired, a key factor in defending against on-the-job injuries, the researchers say.   "Rather than directly bracing the back and giving up on proper lifting form, we strengthen the legs to maintain it," said Robert Gregg, U-M professor of robotics and corresponding author of the study in Science Robotics. "This differs from what's more commonly done in industry."   Already ...

Researchers at the National Institutes of Health (NIH) and their collaborators have identified a protein, known as RNF114, that reverses cataracts, a clouding of the eye’s lens that occurs commonly in people as they age. The study, which was conducted in the 13-lined ground squirrel and rats, may represent a possible surgery-free strategy for managing cataracts, a common cause of vision loss.  The study published in the Journal of Clinical Investigation. “Scientists have long searched for an alternative to cataract surgery, which is effective, but not without risk. Lack of access to cataract surgery is a barrier to care in some ...

Tomorrow’s workplace will be run on mind-boggling amounts of data. To make sense of it all, businesses, developers and individuals will need better artificial intelligence (AI) systems, better trained AI workers and more efficient number-crunching servers. While big tech companies have the resources and expertise to meet these demands, they remain beyond the reach of most small and medium-sized enterprises and individuals. To respond to this need, a Concordia-led international team of researchers has developed a new framework to make complex AI tasks more accessible ...

BUFFALO, N.Y. — A University at Buffalo psychiatrist who has played a critical role in getting mental health screening and treatment integrated into routine care for adults and adolescents with cystic fibrosis (CF) has been awarded $3 million from the Cystic Fibrosis Foundation to focus on the mental health of children with the disease.   Led by UB and launched this summer, the new study is an outgrowth of The International Depression Epidemiological Study (TIDES), which began in 2014 and was the largest study of mental health in adolescents and adults with CF. As a result of TIDES, ...

The Universidad Carlos III de Madrid (UC3M) is one of 22 institutions that have been selected by the Ministry for Digital Transformation and the Civil Service to create an ENIA Chair to further the development of artificial intelligence (AI)-based applications. The AImpulsa UC3M-Universia Chair, as it is called, will be the only one of its kind in Spain in the area of Data Economy and will collaborate with Universia-Banco Santander, through Santander Universities. The ENIA Chairs' objectives, which depend on the Secretary of State for Digitalisation and Artificial Intelligence of the Ministry for Digital Transformation and ...

Anyone who has ever pet a cat or shuffled their feet across the carpet knows that rubbing objects together generates static electricity. But an explanation for this phenomenon has eluded researchers for more than two millennia. Now, Northwestern University scientists have finally uncovered the mechanics at play.  When an object slides, the front and back parts of that object experience different forces, researchers found. This difference in forces causes different electrical charges to build up on the front and back parts of the object. And the difference in electrical charges creates a current, leading to a light zap. The study was published yesterday (Sept. 17) in the journal ...

UC San Diego Health has been honored as a top performer for Vizient’s 2024 Bernard A. Birnbaum, MD, Quality Leadership Performance Award, marking the sixth consecutive year the health system has achieved this prominent distinction. This award places UC San Diego Health among the top academic medical centers in the nation, highlighting its exceptional commitment to delivering high-quality, patient-centered care. This sustained excellence recognizes the region’s only academic medical center’s mission of advancing health care standards and outcomes at the highest level. “Being named a Vizient top performer for the sixth year in a row underscores ...