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What’s behind the enormous increase in early-onset gastrointestinal cancers?

2025-07-08
A new paper in BJS, published by Oxford University Press, indicates that early-onset gastrointestinal cancer rates are rising dramatically across the globe. In the United States, the age-standardized rate of colorectal cancer decreased from 66.2 cases per 100,000 people in 1985 to 35.7 cases per 100,000 people in 2018. In contrast, early-onset colorectal cancer has shown a marked increase in both men and women in the United States since the mid-1990s, with the age-adjusted incidence rising from 5.9 cases per 100,000 in 2000 to 8.4 cases per 100,000 in 2017. Compared with adults born in 1950, those born in 1990 have twice the risk of ...

Pharmacogenomics expert advances precision medicine for bipolar disorder

2025-07-08
CAGLIARI, Sardinia, Italy, 8 July 2025 – In a comprehensive Genomic Press Interview published today in Genomic Psychiatry, Dr. Mirko Manchia opens up about his transformative journey from a small Sardinian city to becoming a leading voice in psychiatric pharmacogenomics, revealing how personal family experiences with mental illness sparked a lifelong quest to understand why psychiatric medications work brilliantly for some patients while failing others. The Associate Professor of Psychiatry at the University of Cagliari has spent decades unraveling one of psychiatry's most perplexing puzzles: why does lithium, psychiatry's oldest mood stabilizer, ...

Brazilian researcher explores centenarian stem cells for aging insights

2025-07-08
SÃO PAULO, São Paulo, Brazil, 8 July 2025 – In a comprehensive Genomic Press Interview, postdoctoral researcher Dr. Mateus Vidigal de Castro shares his contributions to longevity research at the University of São Paulo. Working under the supervision of Professor Mayana Zatz at one of Brazil's leading genetics research centers, Dr. de Castro studies induced pluripotent stem cells (iPSCs) derived from centenarians, particularly those who demonstrated recovery from COVID-19. Research ...

Dr. Xuyu Qian's breakthrough analysis of 18 million brain cells advances understanding of human brain development

2025-07-08
PHILADELPHIA, Pennsylvania, USA – July 8, 2025 – Genomic Press today published in Genomic Psychiatry an in-depth interview with Dr. Xuyu Qian, Assistant Professor at the University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, whose pioneering research in brain organoid technology and spatial transcriptomics is transforming our understanding of human brain development and neurodevelopmental disorders. Dr. Qian's recent landmark study, published in Nature (2025), represents one of the ...

Gene networks decode human brain architecture from health to glioma

2025-07-08
SAN FRANCISCO, California, USA, 8 July 2025 – In a comprehensive Genomic Press Interview published in Brain Medicine, Dr. Michael C. Oldham shares his unconventional journey from advertising executive to computational neuroscientist and his groundbreaking contributions to understanding the human brain's cellular and molecular architecture through gene coexpression analysis. From Madison Avenue to molecular neuroscience Dr. Oldham's path to neuroscience was anything but direct. After graduating from Duke University at age 20 ...

How artificial light at night damages brain health and metabolism

2025-07-08
MORGANTOWN, West Virginia, USA, 8 July 2025 – In a comprehensive Genomic Press Innovators & Ideas interview published today, distinguished neuroscientist Dr. Randy J. Nelson shares insights from his pioneering research on how disrupted circadian rhythms affect brain function and overall health. The interview, published in Brain Medicine, traces Dr. Nelson's unconventional path from farm work and autopsy assistant to becoming one of the world's leading authorities on biological rhythms. Dr. Nelson, who chairs the Department of Neuroscience at West Virginia University, has spent the ...

For ultrasound, ultra-strength not always a good thing

2025-07-08
Osaka Metropolitan University researchers have solved a long-standing mystery in the field of sonochemistry: why do chemical reactions slow down when ultrasonic power becomes too strong? Their findings allow for smarter use of ultrasound in science and industry, such as for environmental cleanup or the creation of useful nanoparticles. Although ultrasound is inaudible to the human ear, it plays a powerful role in sonochemistry. When ultrasonic waves are applied to a liquid, they generate microscopic bubbles that rapidly ...

Matching your workouts to your personality could make exercising more enjoyable and give you better results

2025-07-08
Finding motivation to exercise can be the greatest challenge in working out. This might be part of the reason why less than a quarter of people achieve the activity goals recommended by the World Health Organization. But what if working out could be more enjoyable? One way of achieving this could be opting for types of exercise that fit our personalities. To this end, researchers in the UK now have examined how personality affects what types of exercise we prefer, and our commitment and engagement to them. The results ...

Study shows people perceive biodiversity

2025-07-08
A new study published in People and Nature finds that both sight and sound influence perception of biodiversity, and participants were slightly more accurate when assessing forest biodiversity through sound alone than through sight alone. This interdisciplinary research, led by scientists from the German Centre for Integrative Biodiversity Research (iDiv), the Friedrich Schiller University Jena, the Helmholtz Centre for Environmental Research – UFZ, and Leipzig University, brings together methods from environmental psychology and forest and soundscape ecology.  In a lab-based sorting study, two groups of 48 participants examined either photographs ...

Personality type can predict which forms of exercise people enjoy

2025-07-08
The key to sticking to and reaping the rewards of exercise over the long term may be as simple as doing something you enjoy, say the authors of a new study from UCL. Previous research has shown that the personalities of people who engage in different types of organised sport tend to vary. But what is less clear is how personality affects the types of exercise people actually enjoy doing. The new study, published in Frontiers in Psychology, explored whether individual personality traits corresponded to the enjoyment of different types of exercise, whether participants completed a prescribed exercise programme, and the subsequent ...

People can accurately judge biodiversity through sight and sound

2025-07-08
People’s intuitive perception of biodiversity through visual and audio cues is remarkably accurate and aligns closely with scientific measures of biodiversity. This is according to new research published in the British Ecological Society journal, People and Nature. In a new study led by researchers at the German Centre for Integrative Biodiversity Research (iDiv), the Helmholtz Centre for Environmental Research (UFZ) and the Friedrich Schiller University Jena, participants with no ecological training were asked to sort ...

People diagnosed with dementia are living longer, global study shows

2025-07-08
A person diagnosed with dementia has improved survival outcomes in recent years amid significant progress in dementia diagnosis and care, according to a recent multinational study led by a University of Waterloo researcher.   The study analyzed data from more than 1.2 million people over the age of 60 living with dementia in eight global regions between 2000 and 2018. It found that in five of those regions, including Ontario, a lower risk of death exists today than in previous years.   “Dementia is a global public health priority,” said Dr. Hao Luo, assistant ...

When domesticated rabbits go feral, new morphologies emerge

2025-07-08
Originally bred for meat and fur, the European rabbit has become a successful invader worldwide. When domesticated breeds return to the wild and feralise, the rabbits do not simply revert to their wild form – they experience distinct, novel anatomical changes. Associate Professor Emma Sherratt, from the University of Adelaide’s School of Biological Sciences, led a team of international experts to assess the body sizes and skull shapes of 912 wild, feral and domesticated rabbits to determine how feralisation affects the animal. “Feralisation ...

Rain events could cause major failure of Waikīkī storm drainage by 2050

2025-07-08
Existing sea level rise models for coastal cities often overlook the impacts of rainfall on infrastructure. Researchers at the University of Hawai‘i at Mānoa discovered that by 2050, large rain events combined with sea level rise could cause flooding severe enough to disrupt transportation and contaminate stormwater inlets across 70% of Waikīkī on O‘ahu, Hawai‘i, due to interactions with water in the Ala Wai Canal. Their study was published recently in Scientific Reports. “We’ve known that sea level rise will reduce the capacity for our drainage system to handle surface runoff, however, including rainfall events in our models showed ...

Breakthrough in upconversion luminescence research: Uncovering the energy back transfer mechanism

2025-07-08
A recent study has made a breakthrough in the understanding of upconversion luminescent materials, particularly in revealing the energy back transfer (EBT) mechanism between Yb3+ and Er3+ ions. Researchers utilized Er3+-doped Yb3+-self-activated NaYb(MoO4)2 phosphor and crystal, as well as Yb3+/Er3+ codoped NaBi(MoO4)2 crystal as research subjects to investigate the effects of factors such as excitation power density and Yb3+ ion concentration on the EBT process. Through the study of various samples in different states (phosphors and crystals) and different doping conditions, they ...

Hidden role of 'cell protector' opens cancer treatment possibilities

2025-07-08
Landmark research on MCL-1, a critical protein that is an attractive target for cancer drug development, helps explain why some promising cancer treatments are causing serious side effects, and offers a roadmap for designing safer, more targeted therapies.  The WEHI-led discovery, published in Science, has uncovered a critical new role for MCL-1, revealing it not only prevents cell death but also provides cells with the energy they need to function.   The findings reshape our understanding ...

How plants build the microbiome they need to survive in a tough environment

2025-07-08
New research from Northern Arizona University points to the idea that under some conditions plants can “curate” their microbiomes—selecting good microbes and suppressing harmful ones—to adapt to their environments. The findings have significant implications for sustainable agriculture and offer a greater understanding of how complex ecosystems adapt in a changing environment.  Regents’ Professor Nancy Collins Johnson in the School of Earth and Sustainability at NAU and professor César Marín from Universidad Santo Tomás in Chile authored the paper, published in July in The ISME ...

Depression due to politics and its quiet danger to democracy addressed in new book 'The Sad Citizen'

2025-07-07
On laptop screens, televisions and social media feeds across the nation, images and words fueled by a fractured political landscape spout anger, frustration and resentment. Clashing ideologies burst forth in public demonstrations, family gatherings and digital echo chambers. Red-hot rhetoric and finger-pointing memes are open expressions of emotions generated by engaging in politics. But there is another set of emotions far less incendiary but just as damaging to democracy. These feelings can push people to the sidelines and drive them to silence. Disappointment. Grief. Loss. The reasons for this phenomenon, along with its effects on mental health, are the subject of “The ...

International experts and patients unite to help ensure all patients are fully informed before consenting to new surgical procedures

2025-07-07
Leading global doctors, researchers, and lawyers have joined forces with patient representatives and created the first-ever information guide to better support and protect patients across the world who are considering pioneering, but also potentially risky, surgery. The comprehensive seven-step set of essential information, co-led by the National Institute for Health and Care Research (NIHR) Bristol Biomedical Research Centre (BRC) and the University of Bristol, was published today in the British Journal of Surgery. It sets out clearly what patients must be told by their surgeon or clinician before undergoing innovative procedures and coincides with the fifth anniversary ...

Melting glaciers could trigger more explosive eruptions globally, finds research

2025-07-07
Melting glaciers may be silently setting the stage for more explosive and frequent volcanic eruptions in the future, according to research on six volcanoes in the Chilean Andes. Presented today [Tuesday 8 July] at the Goldschmidt Conference in Prague, the study suggests that hundreds of dormant subglacial volcanoes worldwide – particularly in Antarctica – could become more active as climate change accelerates glacier retreat. The link between retreating glaciers and increased volcanic activity has been known in Iceland since the 1970s, but this ...

Nearly half of U.S. grandchildren live within 10 miles of a grandparent

2025-07-07
ITHACA, N.Y. — New, more precise estimates show most American grandchildren live close to a grandparent, with implications for families’ well-being and for how much time and money generations share. Cornell researchers’ analysis found that nearly half of U.S. grandchildren (47%) live within 10 miles of a grandparent. Of those, significant numbers live even closer: 21% live between 1 and 5 miles, and 13% live within a walkable distance of 1 mile. As many grandchildren live within 1 mile of their grandparents as live 500 miles or more away. Families living closer to grandparents tend to have lower socioeconomic status, the researchers found, ...

Study demonstrates low-cost method to remove CO₂ from air using cold temperatures, common materials

2025-07-07
Researchers at Georgia Tech’s School of Chemical and Biomolecular Engineering (ChBE) have developed a promising approach for removing carbon dioxide (CO₂) from the atmosphere to help mitigate global warming. While promising technologies for direct air capture (DAC) have emerged over the past decade, high capital and energy costs have hindered DAC implementation. However, in a new study published in Energy & Environmental Science, the research team demonstrated techniques for capturing CO₂ more efficiently and affordably using extremely cold air and widely available porous sorbent materials, expanding future ...

Masonic Medical Research Institute (MMRI) welcomes 13 students to prestigious Summer Fellowship program

2025-07-07
UTICA, NY – MMRI is thrilled to welcome 13 undergraduate students to its highly esteemed 2025 Summer Fellowship program. For ten weeks, these Summer Fellows will study in the laboratories of MMRI’s principal investigators (PI) gaining invaluable scientific research experience. This rigorous and competitive program selects students based on academic excellence and demonstrated drive to partake in cutting-edge research programs that include areas of cardiovascular disease biology, autoimmunity and autism. “We ...

Mass timber could elevate hospital construction

2025-07-07
Picture a hospital and you might imagine concrete, stainless steel or plastic. But University of Oregon researchers hope to make wood — often overlooked in health care facilities — more commonplace in those settings. Exposed wood, they’ve found, can resist microbial growth after it briefly gets wet. During their study, wood samples tested lower for levels of bacterial abundance than an empty plastic enclosure used as a control. “People generally think of wood as unhygienic ...

A nuanced model of soil moisture illuminates plant behavior and climate patterns

2025-07-07
(Santa Barbara, Calif.) — Any home gardener knows they have to tailor their watering regime for different plants. Forgetting to water their flowerbed over the weekend could spell disaster, but the trees will likely be fine. Plants have evolved different strategies to manage their water use, but soil moisture models have mostly neglected this until now. Researchers at UC Santa Barbara and San Diego State University sought a way to move beyond simple on/off models to capture the nuanced ways that plants manage water stress. To ...
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