Two clinical studies demonstrate high response rates by patients with two hard-to-treat and aggressive blood cancers   Pivekimab sunirine (PVEK) targets the CD123 antigen, which is overexpressed in both diseases  Frontline triplet regimen including PVEK shows promise for hard-to-treat AML in patients who are not eligible for intensive chemotherapy  PVEK monotherapy demonstrates strong responses, enables stem cell transplant for high-risk subgroup of BPDCN patients   ORLANDO, DECEMBER 8, 2025 – Researchers from The ...

Alexandria, VA, USA – Members of the International Association for Dental, Oral, and Craniofacial Research (IADR) have elected George Belibasakis, Karolinska Institutet, Stockholm, Sweden to serve as Vice-president. His term will commence at the conclusion of the 104th General Session of the IADR, which will be held in conjunction with the 55th Annual Meeting of the AADOCR and the 50th Annual Meeting of the Canadian Association for Dental Research, from March 25-28, 2026 in San Diego, CA, USA. Belibasakis is currently Professor of Clinical Oral Infection Biology, Head of the Division of Oral Health and Periodontology, and Head of Research at the Department of Dental Medicine, ...

Quantum technologies from ultrasensitive sensors to next-generation information processors depend on the ability of quantum bits, or qubits, to maintain their delicate quantum states for a sufficiently long time to be useful.  One of the most important measures of this stability is the spin coherence time. Unfortunately, qubits may lose coherence because their environment is “noisy,” for example, due to the presence of nuclear isotopes or other interference that disturbs the qubit. Two-dimensional (2D) materials—or atomically thin sheets—can offer quiet environments for qubits, as their reduced thickness naturally lowers the number of isotopes that interact ...

University of Phoenix College of Doctoral Studies announces a new white paper, “Leadership Opportunities for Increasing Employee Value through Artificial Intelligence,” authored by Andrew C. Lawlor, PhD, and Pamayla E. Darbyshire, DHA, MSN/CNS, both Fellows at the Center for Educational and Instructional Technology Research (CEITR). The paper examines how leaders can use AI, especially generative AI, to address skills gaps, restore worker autonomy, and shift employees from repetitive tasks to higher-value activities.   The authors draw upon the University’s Career Optimism Index® study and other current research, ...

MIAMI, FLORIDA (EMBARGOED UNTIL DEC. 8, 2025, AT 4:30 P.M. EST) – A new clinical trial suggests that pairing bispecific antibodies and antibody-drug conjugates with CAR T-cell therapy may sharply boost one-year progression-free survival for people with aggressive lymphoma. In just a few years, treatment options for aggressive lymphoma have rapidly advanced. However, many patients show a consistent pattern: powerful new therapies act quickly but often fail to keep the lymphoma at bay permanently, says Jay Spiegel, M.D., a transplant and cellular therapy physician at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine. Spiegel ...

A groundbreaking new treatment using genome-edited immune cells, developed by scientists at UCL (University College London) and Great Ormond Street Hospital (GOSH), has shown promising results in helping children and adults fight a rare and aggressive form of blood cancer called T-cell acute lymphoblastic leukaemia (T-ALL). The world-first gene therapy (BE-CAR7) uses base-edited immune cells to treat previously untreatable T-cell leukaemia and help patients achieve remission, offering new hope for families facing this aggressive cancer. Base-editing is an advanced version of CRISPR technology, that can precisely change single ...

An international team led by the University of Michigan has introduced new methods that reveal which regions of the brain were active throughout the day with single-cell resolution. Using mouse models, the researchers developed an experimental protocol and a computational analysis to follow which neurons and networks within the brain were active at different times. Published in the journal PLOS Biology, the study provides new insights into brain signaling during sleep and wakefulness, which hints at the bigger questions and goals that motivated the work. "We undertook this difficult study to understand fatigue," ...

Australian researchers have for the first time pinpointed specific genetic changes that increase the risk of severe, sight-threatening forms of age-related macular degeneration (AMD). A new study, published today in Nature Communications, reveals the specific genetic factors linked to the presence of reticular pseudodrusen - deposits which drive vision loss and are found on the retina of up to 60 per cent of people with advanced AMD. The research, led by the Centre for Eye Research Australia, WEHI and the University of Melbourne, offers a promising new target for treatments aimed at the most severe ...

Embargoed for release until 5:00 p.m. ET on Monday 8 December 2025    Follow @Annalsofim on X, Facebook, Instagram, Bluesky, and Linkedin              Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization ...

About The Study: Among patients with sepsis, precision immunotherapy targeting macrophage activation–like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared with placebo. Corresponding Author: To contact the corresponding author, Evangelos J. Giamarellos-Bourboulis, MD, PhD, email egiamarel@med.uoa.gr. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2025.24175) Editor’s Note: Please see the article for additional information, including other ...

The topics of human-level artificial general intelligence (AGI) and artificial superintelligence (ASI) have captivated researchers for decades. Interest has surged with the rapid progress and deployment of large language models (LLMs), which now handle tasks such as coding, scientific explanation, creative writing, and multimodal reasoning. “Solve AI and it will solve everything” remains a popular, if contested, credo—driving large-scale investment, shaping public narratives, and motivating optimism about transformative advances. Applying this vision to the healthcare and pharmaceutical industries, ...

FOR IMMEDIATE RELEASE  EMBARGOED UNTIL DECEMBER 8, 2025  Study Finds Most People Trust Doctors More than AI But See Its Potential for Cancer Diagnosis  Nationally representative surveys measure public attitudes toward AI in healthcare  Washington, D.C., December 8, 2025– New research on public attitudes toward AI indicates that most people are reluctant to let ChatGPT and other AI tools diagnose their health condition, but see promise in technologies that use AI to help diagnose cancer. These and other results of two nationally representative surveys will be presented at the ...

Embargoed for release: Monday, December 8, 2025, 4:00 PM ET Key points: Children whose schools reopened during the COVID-19 pandemic had significantly decreased mental health diagnoses relative to children whose schools remained closed, according to a new study of schools across California. This included fewer diagnoses of depression, anxiety, and ADHD. Girls’ mental health benefited the most. Mental health care spending decreased by up to 11% by the ninth month after a school’s reopening. The study is among the largest and most data-rich examinations of how school closures impacted ...

SARS‑CoV‑2, the virus that causes COVID-19, continues to mutate, with some newer strains becoming less responsive to current antiviral treatments like Paxlovid. Now, University of California San Diego scientists and an international team of researchers have identified several promising molecules that could lead to new medications capable of combating these resistant variants. Instead of looking for antiviral candidates from scratch, the research team screened 141 previously synthesized compounds that had originally been designed between 1997 and 2012 to inhibit a key enzyme called cruzain. ...

Reston, VA (December 8, 2025) As nuclear medicine theranostics expands rapidly across clinical practice worldwide, a new supplement to the Journal of Nuclear Medicine Technology (JNMT) explores how nuclear medicine technologists are embracing their growing role within the field. Titled, Building the Future of Theranostics: Advancing Practice, Education, and Innovation Worldwide, the supplement brings together voices from across the globe, offering perspectives that span clinical lessons, educational frameworks, operational strategies, advocacy, equity, and biology. From the early use of ...

Hoboken, N.J., December 8, 2025 — On Saturday December 6, 2025 Alaska was rocked by a 7.0 magnitude quake. Though not always so forceful, earthquakes happen every day. On average, about 55 of them strike daily, according to the United States Geological Survey (USGS), totaling some 20,000 annually worldwide. About once a year, one reaches 8.0 points or greater and 15 others hit within the magnitude 7 range on the Richter scale, which measures earthquakes by the energy they release. For example, in just 2025 an 8.8 earthquake offshore from the Kamchatka Peninsula in Russia, ...

MIAMI, FLORIDA (EMBARGOED UNTIL DEC. 8, 2025, AT 2:45 P.M. EST) – Most patients with a rare and aggressive form of large B-cell lymphoma can safely receive a less toxic treatment than the intensive chemotherapy often used, according to new research from Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine. Lead researcher Juan Alderuccio, M.D., a hematologist and lymphoma specialist at Sylvester, will present this research Dec. 8 at the American Society of Hematology ...

The sense of smell is vital for animals, as it helps them find food, protect themselves from predators and interact socially. An international research team led by Dr Quentin Martinez and Dr Eli Amson from State Museum of Natural History Stuttgart has now discovered that certain areas of the brain skull allow conclusions to be drawn about the sense of smell in mammals. Particularly significant is the volume of the endocast of the olfactory bulb, a bony structure in the skull that is often well preserved even in very old fossils. This volume is closely related to the number of intact odour receptor genes – an important ...

One of the most important steps in the evolution of modern mammals was the development of highly sensitive hearing. The middle ear of mammals, with an eardrum and several small bones, allows us to hear a broad range of frequencies and volumes, which was a big help to early, mostly nocturnal mammal ancestors as they tried to survive alongside dinosaurs.  New research by paleontologists from the University of Chicago shows that this modern mode of hearing evolved much earlier than previously thought. Working with detailed CT scans of the skull and jawbones of Thrinaxodon liorhinus, a 250-million-year-old mammal predecessor, they used engineering methods to simulate ...

The negative health impacts from contamination by so called "forever chemicals" in drinking water costs the contiguous U.S. at least $8 billion a year in social costs, a University of Arizona-led study has found. The study, published in the Proceedings of the National Academy of Sciences, builds on previous research into how PFAS – per- and polyfluoroalkyl substances – can negatively impact health when the chemicals contaminate drinking water. The research team studied all births in New Hampshire from 2010-2019, focusing on mothers living ...

A new advance from Carnegie Mellon University researchers could reshape how clinicians identify the brain regions responsible for drug-resistant epilepsy. Surgery can be a life-changing option for millions of epilepsy patients worldwide, but only if physicians can accurately locate the epileptogenic zone, the area where seizures originate. Bin He, professor of biomedical engineering, and his team have developed a unified, machine learning-based approach called spatial-temporal-spectral imaging (STSI) to assist. It is the first technology capable of analyzing every major type of epileptic ...

Irvine, Calif., Dec. 8, 2025 — With a $50 million lead gift from the Quilter family and approximately $30 million in new commitments, the University of California, Irvine’s Institute for Memory Impairments and Neurological Disorders will begin planning to build a state-of-the-art research and care facility to enhance its position as a global leader in Alzheimer’s disease and related dementias research and patient care.   UC Irvine alumni Charles Quilter, M.A. ’06, Ph.D. ’10, and Ann Quilter, M.S. ’79, and their family members Patrick, Chris, Matt and Patty made the generous contribution ...

URBANA, Ill. -- To meet ambitious U.S. Department of Energy targets for sustainable aviation fuel (SAF), production of purpose-grown energy crops must ramp up significantly. Although researchers have made substantial progress in understanding the management and conversion of these crops, key knowledge gaps hold the industry back. Now, two new studies from the University of Illinois Urbana-Champaign help fill in the blanks for Miscanthus and switchgrass management.  “We have come a long way in our understanding of purpose-grown energy crops for SAF, but we still ...

In the Middle Ages, a plague killed a third of Europe’s population. Fleas carried the plague bacterium, Yersinia pestis, transmitting the Black Death from infected rats to millions of people.  Another, earlier strain of Y. pestis emerged 5,000 years ago in the Bronze Age. It infected people throughout Eurasia for 2,000 years and then vanished. Unlike the Middle Age plague bacterium, this earlier Bronze Age strain could not be transmitted by fleas. How the plague circulated for so long across a vast area has long been a mystery.  Now, ...

December 8, 2025 — Millions of people already chat about their mental health with large language models (LLMs), the conversational form of artificial intelligence. Some providers have integrated LLM-based mental healthcare tools into routine workflows. John Torous, MD, MBI and colleagues, of the Division of Digital Psychiatry at Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, urge clinicians to take immediate action to ensure these tools are safe and helpful, not wait for ideal evaluation methodology to be developed. In the November issue ...