Younger men have higher risk for mortality and cardiovascular disease for type 2 diabetes than type 1 diabetes; whereas for women type 1 diabetes outcomes are worse at all ages
2025-08-24
The first study of its kind to compare cardiovascular risk in type 1 diabetes (T1D) and type 2 diabetes (T2D) in both men and women shows that younger men with T2D have worse mortality and cardiovascular disease (CVD) outcomes than those with T1D, whereas for women of all ages, almost all outcomes are worse for T1D than for T2D. The study is by Dr Vagia Patsoukaki, Uppsala University, Uppsala, Sweden, and colleagues and is presented at this year’s Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September).
CVD is the leading cause of death and morbidity worldwide and individuals with ...
Freeze-framing the cellular world to capture a fleeting moment of cellular activity
2025-08-23
Osaka, Japan – Optical microscopy is a key technique for understanding dynamic biological processes in cells, but observing these high-speed cellular dynamics accurately, at high spatial resolution, has long been a formidable task.
Now, in an article published in Light: Science & Applications, researchers from The University of Osaka, together with collaborating institutions, have unveiled a cryo-optical microscopy technique that take a high-resolution, quantitatively accurate snapshot at a precisely selected timepoint in dynamic ...
Computer hardware advance solves complex optimization problems
2025-08-22
A line of engineering research seeks to develop computers that can tackle a class of challenges called combinatorial optimization problems. These are common in real-world applications such as arranging telecommunications, scheduling, and travel routing to maximize efficiency.
Unfortunately, today’s technologies run into limits for how much processing power can be packed into a computer chip, while training artificial-intelligence models demands tremendous amounts of energy.
Researchers at UCLA and UC Riverside have demonstrated a new approach that overcomes these ...
SOX2: a key player in prostate cancer progression and treatment resistance
2025-08-22
Prostate cancer remains a global health challenge, ranking as the second most common malignancy among men. While early-stage disease can be effectively managed, advanced forms—particularly metastatic castration-resistant prostate cancer (mCRPC)—pose significant therapeutic hurdles. A growing body of evidence highlights the pivotal role of SOX transcription factors, with SOX2 emerging as a central driver in tumor growth, spread, and resistance to therapy.
SOX2 is intricately linked to the fate of cancer stem/progenitor cells, influencing processes ...
Unlocking the potential of the non-coding genome for precision medicine
2025-08-22
The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark achievements of the Human Genome Project (HGP), scientists have increasingly focused on deciphering the non-coding regions of the human genome, which comprise approximately 98% of the genetic material. These regions, long overlooked due to their non-protein-coding nature, are now known to harbor ...
Chitinase-3-like protein 1: a novel biomarker for liver disease diagnosis and management
2025-08-22
The identification of Chitinase-3-like protein 1 (CHI3L1) as a crucial biomarker in liver disease is revolutionizing how clinicians approach the diagnosis, monitoring, and treatment of various liver conditions. As a member of the glycoside hydrolase family 18, CHI3L1 is recognized for its unique ability to bind to ligands and influence multiple pathophysiological processes, despite lacking enzymatic activity. This distinctive protein plays a key role in mediating cell proliferation, inflammation, fibrosis, and carcinogenesis.
Liver diseases, including hepatitis-related fibrosis, non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease ...
The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: August 22, 2025
2025-08-22
Reston, VA (August 22, 2025)—New research has been published ahead-of-print by The Journal of Nuclear Medicine (JNM). JNM is published by the Society of Nuclear Medicine and Molecular Imaging, an international scientific and medical organization dedicated to advancing nuclear medicine, molecular imaging, and theranostics—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.
Summaries of the newly published research articles are provided below.
Mapping Tiny Lifetimes ...
Charisma Virtual Social Coaching named a finalist for Global Innovation Award
2025-08-22
Center for BrainHealth® at The University of Texas at Dallas is proud to announce that one of its flagship programs, Charisma™ Virtual Social Coaching, has been selected as a Top 3 Finalist for the 2025 Global Innovation Management Institute (GIMI) Innovation Award in the category of Most Innovative Project – Social Sector/Non-Profit.
GIMI is the world’s largest certifying body and professional organization for innovation and innovation management. The Innovation Awards recognize projects that demonstrate exceptional creativity, measurable impact and scalable solutions across public, private and social sectors. With ten award categories, the competition ...
From the atmosphere to the abyss: Iron's role in Earth's climate history
2025-08-22
A new study published by researchers at the University of Hawai‘i (UH) at Mānoa sheds light on the critical role of iron in Earth’s climate history, revealing how its sources in the South Pacific Ocean have shifted over the past 93 million years. This groundbreaking research, based on the analysis of deep-sea sediment cores, provides crucial insights into the interplay between iron, marine life, and atmospheric carbon dioxide levels.
Iron is a vital nutrient for marine life and plays a significant role in regulating atmospheric carbon dioxide by influencing the growth of phytoplankton, which absorb carbon dioxide. Although the importance of iron ...
US oil and gas air pollution causes unequal health impacts
2025-08-22
UCL Press Release
Peer-reviewed | modelling study | people
Under embargo until Friday 22 August 2025, 19:00 UK time / 14:00 US Eastern time
US oil and gas air pollution causes unequal health impacts
Air pollution from oil and gas is causing 91,000 premature deaths and hundreds of thousands of health issues across the United States annually, with Black, Asian, Native American and Hispanic groups consistently the most affected, finds a major new study led by researchers at UCL and the Stockholm Environment Institute (SEI).
The research, published in Science Advances, is the first to comprehensively quantify the health impacts of outdoor air pollution across ...
Scientists reveal how microbes collaborate to consume potent greenhouse gas
2025-08-22
Methane — a potent greenhouse gas — constantly seeps from the ocean floor and can rise into the atmosphere. Now, an international team led by scientists with the USC Dornsife College of Letters, Arts and Sciences has uncovered how tiny microorganisms work together as a living electrical network to consume some of this gas before it escapes, acting as a powerful living filter.
By revealing how these microbes naturally reduce methane emissions, the findings could lead to innovative strategies ...
UMass Amherst kinesiologist receives $2 million ‘outstanding researcher’ award from NIH
2025-08-22
A University of Massachusetts Amherst kinesiologist has received a five-year, $2 million grant from the National Institutes of Health (NIH) to advance his research on how myosin molecules—molecular motors crucial for muscle contraction— work together to drive different processes within cells.
This multi-pronged research will lead to a better understanding of many important myosin-related functions, from how our muscles and heart contract to how the ear’s stereocilia facilitate hearing. The long-term goal is to use these findings to pinpoint the causes of dysfunction in myosin-associated diseases and to identify ...
Wildfire peer review report for land Brandenburg, Germany, is now online
2025-08-22
From November 18-22, 2024, four peers from Spain, Portugal, and Italy, selected by the European Commission, carried out an on-site mission in Land Brandenburg under the Union Civil Protection Mechanism (UCPM) Peer Review Programme. Requested by the authorities of Land Brandenburg in cooperation with the Federal Office of Civil Protection and Disaster Assistance (BBK), the review assessed wildfire risk governance and practice to provide actionable pathways for strengthening capabilities.
CMCC experts served as facilitators, leveraging experience from previous disaster risk management and wildfire peer reviews in Romania (2022), Moldova (2023), ...
Wired by nature: Precision molecules for tomorrow's electronics
2025-08-22
Organic chemistry, the chemistry of carbon compounds, is the basis of all life on Earth. However, metals also play a key role in many biochemical processes. When it comes to “marrying” large, heavy metal atoms with light organic compounds, nature often relies on a specific group of chemical structures: porphyrins. These molecules form an organic ring; in its center, individual metal ions such as iron, cobalt, or magnesium can be “anchored”.
The porphyrin framework forms the basis for hemoglobin in human blood, photosynthetic chlorophyll in plants, and numerous ...
New study finds hidden body fat is linked to faster heart ageing
2025-08-22
Excessive amounts of visceral fat — the hidden fat surrounding organs — is linked with faster ageing of the heart, a new study has found.
Ageing is the biggest risk factor for heart disease, but why some people age faster than others isn’t fully understood. The scientists leading the research say that visceral body fat could play an important role in accelerating ageing of the heart and blood vessels. This type of fat is known to be harmful to health and this study now links it to faster heart ageing.
The study, led by scientists from the Medical Research Council (MRC) Laboratory ...
How a gift card could help speed up Alzheimer’s clinical research
2025-08-22
Offering a modest gift card significantly increased enrollment of low-income individuals in a patient registry designed to accelerate Alzheimer’s disease clinical trials, a new USC study finds.
Why it matters: Effective strategies are needed to improve representation of marginalized groups in Alzheimer’s clinical trials. Despite ongoing debate among researchers about the ethics of financial incentives for clinical trial enrollment, there has been little consensus on the appropriate use and size of incentives.
About the experiment: Nearly 50,000 adults 50 and older without a dementia diagnosis were invited over ...
Depression and anxiety symptoms in adults displaced by natural disasters
2025-08-22
About The Study: This study found that, in U.S. adults, disaster-induced displacement from home was associated with increased odds of depression and anxiety symptoms, with the highest odds among those who never returned home. There is an urgent need to address mental health care for populations displaced by natural disasters, particularly socially vulnerable populations.
Corresponding Author: To contact the corresponding author, Ther W. Aung, PhD, email twa21@case.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2025.28546)
Editor’s ...
Cardiovascular health at the intersection of race and gender in Medicare fee for service
2025-08-22
About The Study: This cross-sectional study found that Asian and Pacific Islander, Black, and Hispanic transgender and gender diverse beneficiaries had a high prevalence of cardiovascular-related conditions and had an elevated prevalence of several conditions, attributable to the intersection of gender, race, and ethnicity. Medicare should use the tools at its disposal to support the health of transgender and gender diverse beneficiaries.
Corresponding Author: To contact the corresponding author, Gray Babbs, MPH, ...
World’s first observation of the transverse Thomson effect
2025-08-22
For the first time in the world, a joint research team from NIMS, Nagoya University and The University of Tokyo has successfully observed the transverse Thomson effect—a phenomenon in which metals or semiconductors release or absorb heat when a heat current, charge current and magnetic field are applied orthogonally to each other. This achievement may contribute to advances in physics and materials science related to the conversion between heat, electricity and magnetism, as well as to the development of new thermal management technologies. The research was published in Nature ...
Powerful nodes for quantum networks
2025-08-22
Quantum networks are often described as the future of the internet — but instead of transmitting classical information in bits, they send quantum information carried by photons. These networks could enable ultra-secure communication, link together distant quantum computers into a single, vastly more powerful machine, and create precision sensing systems that can measure time or environmental conditions with unprecedented accuracy.
To make such a network possible, so-called quantum network nodes — that can store ...
Mapping fat: How microfluidics and mass spectrometry reveal lipid landscapes in tiny worms
2025-08-22
Understanding how fat molecules are distributed and function in living organisms is key to uncovering mechanisms of aging, disease, and metabolism. Caenorhabditis elegans, a transparent roundworm, is a widely used model for studying fat storage due to its genetic similarity to humans and well-defined anatomy. However, visualizing lipids at high resolution in such a small organism has posed a major technical challenge.
A research team at Okayama University, Japan, led by Professor Masazumi Fujiwara and his PhD student Ms. Sara Mandic, in collaboration with Professor Ron M. A. Heeren of ...
ATOX1 promotes hepatocellular carcinoma carcinogenesis via activation of the c-Myb/PI3K/AKT signaling pathway
2025-08-22
Background and Aims
Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality. Antioxidant-1 (ATOX1) has been implicated in oncogenic processes across various cancer types; however, its specific role in HCC remains unclear. This study aimed to investigate the function of ATOX1 and its underlying molecular mechanisms in HCC.
Methods
Immunohistochemical analysis was conducted to assess ATOX1 expression in HCC tissues. Cell Counting ...
Colibactin-producing E. coli linked to higher colorectal cancer risk in FAP patients
2025-08-22
Researchers from Kyoto Prefectural University of Medicine and collaborating Japanese institutions found that patients carrying colibactin-producing Escherichia coli (pks+ E. coli) in their colon polyps were more than three times as likely to have a history of colorectal cancer compared to those without the bacterium.
The findings, published in eGastroenterology, highlight a potential role for gut microbes in accelerating cancer risk in people with a strong genetic predisposition.
Study Details
Between 2018 and 2019, the team studied 75 FAP patients who had not yet undergone colon surgery, preserving their natural gut microbiota. Tissue samples ...
Animal protein not linked to higher mortality risk, study finds
2025-08-22
Hamilton, ON, Aug. 22, 2025–Eating animal-sourced protein foods is not linked to a higher risk of death and may even offer protective benefits against cancer-related mortality, new research finds.
The study, published in Applied Physiology, Nutrition, and Metabolism, analyzed data from nearly 16,000 adults aged 19 and older using the National Health and Nutrition Examination Survey (NHAMES III).
Researchers examined how much animal and plant protein people ...
Satellite insights into eutrophication trends on the Qinghai–Tibet plateau
2025-08-22
This research investigates chlorophyll-a (Chla) variations in lakes across the Qinghai-Tibet Plateau (QTP), a region facing rapid warming. Using Landsat satellite data from 1986 to 2023, the study explores how climate change and human activities, such as grazing and fertilizer use, affect lake water quality. The analysis of 1,069 lakes reveals significant changes in Chla concentrations, indicating increasing eutrophication, particularly in smaller and shallower lakes. The study forecasts future Chla trends until 2100, offering valuable insights for ...
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