Glucagon-like peptide 1 receptor agonists and mental health

JAMA Psychiatry

2025-05-14

(Press-News.org) About The Study: In patients with overweight/obesity and/or diabetes, glucagon-like peptide 1 receptor agonist (GLP1-RA) treatment is not associated with increased risk of psychiatric adverse events or worsening depressive symptoms relative to placebo and is associated with improvements in quality of life, restrained eating, and emotional eating behavior. These findings provide reassurance regarding the psychiatric safety profile of GLP1-RAs and suggest that GLP1-RA treatment contributes to both physical and emotional well-being.

Corresponding Authors: To contact the corresponding authors, email Aureliane C. S. Pierret, MBBChir (a.pierret@nhs.net) and Toby Pillinger, PhD (toby.pillinger@kcl.ac.uk).

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(10.1001/jamapsychiatry.2025.0679)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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