About The Study: In older patients with cancer and type 2 diabetes, glucagon-like peptide-1 receptor agonist (GLP-1RA) use was associated with lower all-cause mortality compared with dipeptidyl peptidase-4 inhibitor (DPP4i) use, with no significant difference relative to sodium-glucose cotransporter-2 inhibitor. The survival benefit over DPP4i persisted across age, sex, non-Hispanic white race, obesity status, and several cancer types (colorectal, lung, and breast).  Corresponding Author: To contact the corresponding author, Jingchuan Guo, MD, PhD, email guoj1@ufl.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.21887) Editor’s ...

About The Study: Over time, physician exit from traditional Medicare has increased. This result is consistent with earlier findings, but exits remained high even after the pandemic, which likely accelerated some physicians’ exit. The findings may reflect multiple factors, including the greater burden of new communication methods (e.g., portal messages) and demands for clinical documentation. Corresponding Author: To contact the corresponding author, Hannah T. Neprash, PhD, email hneprash@umn.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamahealthforum.2025.2267) Editor’s ...

Over the past decade, the advent of immune checkpoint blockade (ICB) therapy has transformed cancer treatment. Unlike conventional cytotoxic and targeted therapies, immunotherapy leverages both the innate and adaptive immune systems to target and eradicate tumors within the tumor microenvironment (TME). The TME is a highly organized ecosystem shaped by the intricate interactions between its diverse cellular and non-cellular components, which include tumor cells, immune cells, microbiota, endothelial cells, fibroblasts, and the extracellular matrix. Consequently, gaining a thorough ...

Researchers from the University of Tokyo in collaboration with Aisin Corporation have demonstrated that universal scaling laws, which describe how the properties of a system change with size and scale, apply to deep neural networks that exhibit absorbing phase transition behavior, a phenomenon typically observed in physical systems. The discovery not only provides a framework describing deep neural networks but also helps predict their trainability or generalizability. The findings were published in the journal Physical Review Research. In recent years, it seems no matter where we look, we come across artificial intelligence ...

Scientists at China Pharmaceutical University have launched GseaVis, a groundbreaking R package designed to transform how researchers visualize and interpret Gene Set Enrichment Analysis (GSEA) results in biomedical research. Gene Set Enrichment Analysis is a powerful computational method widely used to determine whether predefined sets of genes show statistically significant differences between biological states, such as healthy versus diseased conditions. However, effective visualization of GSEA results ...

“This case highlights that lipoleiomyomas can present many years after attaining menopause.” BUFFALO, NY — July 18, 2025 — A new case report was published in Volume 12 of Oncoscience on July 2, 2025, titled “Navigating diagnostic complexity: A case report on uterine lipoleiomyoma, unveiling its benign nature amidst characteristics resembling liposarcoma.” In this report, Seetu Palo, first corresponding author Mishu Mangla and colleagues from the All India Institute of Medical Sciences describe a rare case where a benign uterine tumor closely resembles a malignant tumor in an elderly patient. ...

Background and objectives Histopathology is the gold standard in cancer diagnosis. However, attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) spectroscopy has shown diagnostic potential in other settings. Therefore, this study aimed to investigate the sensitivity and specificity of the ATR-FTIR spectroscopy in evaluating breast lesions. Methods This study was conducted on formalin-fixed, paraffin-embedded biopsy blocks received at Ladoke Akintola University of Technology Teaching Hospital between ...

Age-related macular degeneration (AMD) remains a leading cause of vision loss globally, with significant advancements in treatment options for both dry and wet AMD. As highlighted by Huang and colleagues, "Current therapies for dry AMD have limited effectiveness in halting the progression of geographic atrophy (GA), underscoring the need for innovative approaches". One of the most notable breakthroughs is the FDA approval of pegcetacoplan and avacincaptad pegol, targeting the complement system to slow GA progression. Pegcetacoplan, a C3 inhibitor, reduced GA lesion growth by 19–22% ...

Sepsis is a life-threatening condition caused by organ dysfunction resulting from the body's dysregulated response to infection. Annually, sepsis affects more than 31 million people worldwide, with a mortality rate of approximately 30%. The disease is characterized by rapid progression, poor prognosis, and high mortality, posing significant challenges in critical care medicine. Early diagnosis and intervention are crucial for improving patient outcomes. In a study published in the journal "Med Research," a team of researchers ...

Intratumoral microbiota—the microbial populations residing within solid tumors—have emerged as pivotal components of the tumor microenvironment (TME), influencing tumor initiation, progression, and therapeutic outcomes. In a comprehensive review published in Med Research, researchers from Southern Medical University and collaborating institutions systematically examine the heterogeneity of these microorganisms and their multifaceted roles in cancer biology. The authors categorize microbial heterogeneity at three distinct levels: among different ...

Differentiated thyroid carcinoma (DTC) is typically indolent, and some patients may be managed conservatively without immediate surgery. However, it remains a clinical challenge to determine who is suitable for active surveillance and to identify when disease progression may occur. A new study led by researchers at The First Affiliated Hospital of Zhengzhou University addresses this issue by developing an innovative dynamic biomarker system. Using an optimized dynamic network biomarker (DNB) algorithm, the team identified ...

Digestive system malignancies (DSMTs)—including oesophageal, gastric, colorectal, liver, and pancreatic cancers—represent a major public health challenge in China. A recent national epidemiological study by Hu et al., published in eGastroenterology, analysed trends from 2004 to 2021, revealing complex patterns of burden and survival. While progress has been made in reducing mortality from some cancers, the overall impact remains significant, with notable disparities across demographic and geographic lines. Below ...

Acute liver failure (ALF) represents a life-threatening condition marked by rapid deterioration of liver function, often necessitating urgent liver transplantation. In the United States, acetaminophen (APAP) overdose remains the most common cause of drug-induced ALF, accounting for nearly half of all cases. Given the scarcity of viable donor livers—worsened by the prevalence of steatotic liver disease—understanding and promoting the liver's intrinsic regenerative capacity has become an urgent priority ...

MINNEAPOLIS / ST. PAUL (07/18/2025) — Research from the University of Minnesota Twin Cities gives new insight into a material that could make computer memory faster and more energy-efficient. The study was recently published in Advanced Materials, a peer-reviewed scientific journal. The researchers also have a patent on the technology. As technology continues to grow, so does the demand for emerging memory technology. Researchers are looking for alternatives and complements to existing memory solutions that can perform at high levels with ...

COLUMBUS, Ohio – Chemists have developed a novel way to generate a variety of highly useful chemical building blocks by harnessing metal carbenes, suggests new research.   Typically used in chemical reactions essential for drug synthesis and materials development, carbenes are short-lived, highly reactive carbon atoms. In the lab, this can make carbenes especially tricky to create, as methods to form them are limited and often hazardous.  Now, for the first time, an approach discovered by researchers at The Ohio State University has made producing these ...

Lasers that are fabricated directly onto silicon photonic chips offer several advantages over external laser sources, such as greater scalability. Furthermore, photonic chips with these “monolithically” integrated lasers can be commercially viable if they can be manufactured in standard semiconductor foundries. III-V semiconductor lasers can be monolithically integrated with photonic chips by directly growing a crystalline layer of laser material, such as indium arsenide, on silicon substrate. However, photonic chips with such integrated laser source are challenging to manufacture due ...

Pain is an important physiological response in living organisms. While physical pain is an outcome of tissue damage, pain can manifest as diverse unpleasant sensory and emotional experiences. Many studies report that emotional or psychological stress enhances pain responses. Furthermore, mice housed with other mice experiencing inflammatory pain exhibit a ‘bystander effect’ with heightened pain sensitivity, or ‘hyperalgesia.’ However, the effects that underpin social pain transmission remain elusive.  Rodents emit ultrasonic vocalizations in the form of high-pitched squeaks in response to various stimuli, including pain, in ...

As millions of people know firsthand, the most common side effect of mRNA vaccines like the COVID-19 shot is inflammation: soreness, redness and a day or two of malaise. But what if mRNA vaccines could be redesigned to sidestep that response altogether? In a new paper in Nature Biomedical Engineering, researchers at the University of Pennsylvania show that tweaking the structure of the ionizable lipid, a key component of the lipid nanoparticles (LNPs) that deliver mRNA, not only reduces inflammation but also boosts vaccine effectiveness for preventing or treating a range of diseases, from COVID-19 to cancer. The ...

An experimental mRNA vaccine boosted the tumor-fighting effects of immunotherapy in a mouse-model study, bringing researchers one step closer to their goal of developing a universal vaccine to “wake up” the immune system against cancer. Published today in Nature Biomedical Engineering, the University of Florida study showed that like a one-two punch, pairing the test vaccine with common anticancer drugs called immune checkpoint inhibitors triggered a strong antitumor response. A surprising element, researchers said, was that they achieved the promising results not by attacking a specific target protein expressed in the tumor, but by simply revving ...

Vitamin D is not only an essential nutrient, but also the precursor of the hormone calcitriol, indispensable for health: it regulates the uptake of phosphate and calcium necessary for bones by the intestines, as well as cell growth and the proper function of muscles, nerve cells, and the immune system. Now, researchers have shown for the first time in Frontiers in Endocrinology that a particular gene, called SDR42E1, is crucial for taking up vitamin D from the gut and further metabolizing it – a discovery with many possible applications in precision medicine, including ...

A study led by a scientist at the University of California San Diego offers new warnings on the dangers of human interactions with wildlife. Assistant Professor Shermin de Silva of the School of Biological Sciences studies endangered Asian elephants and has reported on their shrinking habitats, a downturn that has resulted in territorial conflicts between people and elephants. Along with her study coauthors, de Silva now provides fresh evidence in the journal Ecological Solutions and Evidence on ...

A major international collaboration between researchers in China and the U.S. has successfully synthesized a novel two-dimensional magnetic material (indium-based chromium telluride, CIT) using chemical vapor transport. A compound that exhibits robust ferromagnetism and magnetocaloric effect at room temperature with intriguing phase transition behavior and complex magnetic interaction. This discovery paves the way for novel applications in high-performance spintronics, magnetic refrigeration, and advanced electronic devices. The realm of 2D materials has intrigued researchers due to their distinctive physical properties and promising technological ...

Bioengineered organs are no longer just structural substitutes. A new review published in Trends in Biotechnology introduces a groundbreaking concept: biohybrid-engineered tissue (BHET) platforms—living constructs integrated with electronics that can monitor, modulate, and even autonomously control their own functions. The review, authored by Dr. Uijung Yong (Future IT Innovation Laboratory, Pohang University of Science and Technology (POSTECH)), Jihwan Kim (Department of Mechanical Engineering, POSTECH), and Prof. Jinah Jang (Department of Mechanical Engineering, Convergence IT Engineering, and School of Interdisciplinary Bioscience and Bioengineering, POSTECH), ...

Alliance researchers and partners, including Embrapa, Brazil’s largest agricultural research organization, launched a rapid response plan to slow the spread and mitigate potentially devastating consequences for food security and livelihoods. In 2023, cassava farmers in remote French Guiana watched in shock as their crops withered. They pulled dilapidated stems from the ground. Instead of unearthing massive root bunches, which are cornerstones of diets across South America, they found nothing larger ...

New research has shown that a world-first system of rubber shock absorbers made from recycled tyres can significantly protect railway tracks from damage, addressing the dual challenges of high maintenance costs and national tyre waste. The technology was validated over a two-year period by a collaborative team from the University of Technology Sydney (UTS), Sydney Trains, Transport for NSW, and industry partners EcoFlex and Bridgestone, following extensive monitoring at a live Sydney Trains freight line in Chullora. Researchers installed track ...