SAN ANTONIO – Patients with intermediate-risk breast cancer had similar rates of 10-year overall survival whether or not they underwent chest wall irradiation (CWI) after mastectomy, according to results from the BIG 2-04 MRC SUPREMO clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024. “While post-mastectomy CWI is the standard of care for most patients with early-stage breast cancer who have four or more positive axillary lymph nodes, its role in patients with fewer positive lymph nodes or node-negative disease remains controversial,” ...

About The Study: Women with low-risk ductal carcinoma in situ randomized to active monitoring did not have a higher rate of invasive cancer in the same breast at 2 years compared with those randomized to guideline-concordant care.  Corresponding Author: To contact the corresponding author, E. Shelley Hwang, MD, MPH, email shelley.hwang@duke.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2024.26698) Editor’s Note: Please ...

About The Study: In this prespecified secondary analysis of the Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) prospective randomized trial, the overall lived experience of women randomized to undergo active monitoring for low-risk ductal carcinoma in situ was similar to that of women randomized to guideline-concordant care during the 2 years following diagnosis.  Corresponding Author: To contact the corresponding author, Ann H. Partridge, MD, MPH, email ann_partridge@dfci.harvard.edu. To access the embargoed study: Visit our For The Media website ...

Not only are they the smallest among us, premature children also face health and life challenges that make them the most vulnerable. Generally speaking, they have a slightly higher risk of mortality due to illness. It is now apparent that they also have a higher risk of unexpected death from so-called external causes: road traffic accidents, substance abuse and suicide. This has been revealed in a major Nordic study led by Professor Kari Risnes from the Faculty of Medicine and Health Sciences at the Norwegian University of Science and Technology (NTNU). The researchers have analyzed birth data and causes of death for nearly 37,000 individuals aged between 15 ...

Petrovax announced today the positive results from “Long-CoV-III-21,” a randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of bovhyaluronidase azoximer in adult patients with pulmonary sequelae of COVID-19. Bovhyaluronidase azoximer, marketed under the brand name Longidaza, is a polymer-conjugated hyaluronidase with an extended half-life. The study drug and placebo were administered for 71 days, with an observation period extending to Day 180. Longidaza demonstrated a statistically significant 62% reduction in the proportion of patients with exertional desaturation ...

Mosasaurs are extinct marine lizards, spectacular examples of which were first discovered in 1766 near Maastricht in the Netherlands, fueling the rise of the field of vertebrate palaeontology (the study of fossil remains of animals with backbones). Palaeontologist Michael Polcyn presented the most comprehensive study to date on the early evolution and ecology of these extinct marine reptiles. On 16 December, Polcyn will receive his PhD from Utrecht University for his research into the evolution of the mosasaurs. "Mosasaurs are a textbook example of macroevolution, ...

Genova (Italy), 12th December 2024 – A specific brain mechanism modulates how animals respond empathetically to others’ emotions. This is the latest finding from the research unit Genetics of Cognition, led by Francesco Papaleo, Principal Investigator at the Istituto Italiano di Tecnologia (IIT - Italian Institute of Technology) and affiliated with IRCCS Ospedale Policlinico San Martino in Genova. The study, recently published in Nature Neuroscience, provides new insights into psychiatric ...

The Korea Institute of Materials Science (KIMS) announced that Dr. Yong-Hun Kim from the Energy & Environment Materials Research Division and Dr. Kyung Song from the Material Characterization Center, in collaboration with Professor Hyun-Sang Hwang's team from POSTECH, have successfully developed a groundbreaking heterojunction technology. This technology integrates tungsten disulfide (WS₂), a two-dimensional (2D) material, with hafnium zirconium oxide (HZO), a ferroelectric material, achieving both interfacial stability and superior crystallinity. The results have been accepted by the International Electron Devices Meeting 2024 (IEDM 2024), ...

“Rich” and “full-bodied” are terms that people often use to describe the taste of wine. They are also the properties that kokumi compounds bring to foods like mature Gouda cheese, though scientists haven’t widely explored them in wines. In ACS’ Journal of Agricultural and Food Chemistry, researchers now connect the dots and report 11 probable kokumi compounds in sparkling wines. Kokumi is often confused with the better-known term umami. Umami is a savory, meaty flavor and is one of the basic five tastes, along with sweet, ...

Superconductors are materials which conduct electricity without any resistance when cooled down below a critical temperature. These materials have transformative applications in various fields, including electric motors, generators, high-speed maglev trains, and magnetic resonance imaging. Among these materials, CuO2 superconductors like Bi2212 stand out due to their high critical temperatures that surpass the Bardeen–Cooper–Schrieffer limit, a theoretical maximum temperature limit for superconductivity. However, ...

Artificial molecular machines, nanoscale machines consisting of a few molecules, offer the potential to transform fields involving catalysts, molecular electronics, medicines, and quantum materials. These machines operate by converting external stimuli, like electrical signals, into mechanical motion at the molecular level. Ferrocene, a special drum-shaped molecule composed of an iron (Fe) atom sandwiched between two five-membered carbon rings, is a promising foundational molecule for molecular machinery. Its discovery earned the Nobel Prize in Chemistry in 1973, and it has since ...

Plastic pollution is an ever-growing problem in today’s world, as most societies have become overly dependent on plastics for packaging, medical supplies, and general goods. Plastic litter accumulation in the ocean, either through deliberate dumping or by being transported from a river, poses significant environmental challenges. Additionally, this plastic eventually degrades into small fragments called microplastics, which then impact diverse marine and land ecosystems by working their way up the food chain and into most living organisms. Though their negative effects on cell health are still under study, many nations have taken a cautionary stance, ...

EUGENE, Ore. — Dec. 12, 2024 — Tiny implantable sensors are helping University of Oregon researchers optimize the process of recovery from severe bone injuries.  Scientists at the UO’s Phil and Penny Knight Campus for Accelerating Scientific Impact have developed miniature implantable sensors that transmit real-time data about what’s happening at an injury site. In a new study, they use the technology to show that a resistance-training rehabilitation program can significantly improve femur injuries in rats ...

Fusion energy research is being pursued around the world as a means of solving energy problems. Magnetic confinement fusion reactors aim to extract fusion energy by confining extremely hot plasma in strong magnetic fields. Its development is a comprehensive engineering project involving many advanced technologies, such as superconducting magnets, reduced-activation materials, and beam and wave heating devices. In addition, predicting and controlling the confined plasma, in which numerous charged particles and electromagnetic fields interact in complex ...

A new study led by investigators from Mass General Brigham has identified a unique brain network that links varied patterns of brain atrophy, or shrinkage, associated with schizophrenia. By combining neuroimaging data from multiple studies involving more than 8,000 participants, the research team found a specific connectivity pattern of atrophy that was present across different stages and symptoms of schizophrenia — and distinct from brain networks associated with other psychiatric disorders. The findings will help to guide a clinical trial that will start recruiting patients soon and will ...

Research has long shown that humans are susceptible to “social identity bias”—favoring their group, whether that be a political party, a religion, or an ethnicity, and disparaging “outgroups.” A new study by a team of scientists finds that AI systems are also prone to the same type of biases, revealing fundamental group prejudices that reach beyond those tied to gender, race, or religion.  “Artificial Intelligence systems like ChatGPT can develop ‘us versus them’ biases similar to humans—showing favoritism toward their perceived ‘ingroup’ while expressing ...

It has been known for nearly 20 years that slow, synchronous electrical waves in the brain during deep sleep support the formation of memories. Why that is was previously unknown. Now, writing in the journal Nature Communications, a team of researchers from Charité – Universitätsmedizin Berlin posits an explanation. According to the study, the slow waves make the neocortex, the location of long-term memory, especially receptive to information. The findings could help to optimize the treatment approaches that are intended to support memory formation from outside. How do permanent memories form? Experts believe that while we sleep, our brains replay the events of ...

Railways, the most climate-friendly mode of transport bar long-distance buses, are bound to play an important role in the fight for net zero. The total emissions of railway travel are currently 31 grams of CO2 equivalents (CO2e) per passenger kilometer, half the amount as for the most economical electrical vehicles. But the carbon emissions of railway traffic can be further reduced, shows a new study in Frontiers in Sustainability by authors in Finland. This is because typical construction materials such as steel and concrete are energetically costly to produce, transport, handle, and maintain. Even on the ...

Food poisoning is a common, yet unpleasant, illness caused by eating contaminated items. It is sometimes caused by Clostridium perfringens, a pathogen widely found in soil and the intestinal tracts of animals. The pathogen multiplies in environments with little oxygen, for example, curry stored in a pot. After ingestion of the pathogen, they form spores in the small intestinal tracts. The toxins produced during spore formation cause diarrhea and abdominal pain, but the underlying mechanism of spore formation has not been fully understood. Associate Professor Mayo Yasugi’s team at Osaka Metropolitan University’s ...

A new study from Karolinska Institutet shows that long-term exposure to air pollution contributes to millions of deaths in India. The research, published in The Lancet Planetary Health, emphasises the need for stricter air quality regulations in the country. Air pollution consisting of particles smaller than 2.5 micrometres in diameter, PM2.5, can enter the lungs and bloodstream and is a major health risk in India. Researchers have now examined the link between these particles and mortality over a ten-year ...

Inequalities in childhood vaccination are widening in England, with uptake rates of five key vaccines consistently lower in young children living in areas of higher deprivation from 2019 to 2023, finds a study published by The BMJ today.  The researchers say vaccine uptake was below the World Health Organization’s recommended 95% target for all vaccinations studied and call for urgent action to strengthen systems for childhood vaccination. Protecting children from vaccine preventable diseases ...

An investigation published by The BMJ today raises new concerns over the landmark clinical trial (PLATO) that was used to gain worldwide approval for the anti-platelet drug ticagrelor (Brilinta in the US and Brilique in Europe), manufactured by AstraZeneca. Peter Doshi, senior editor at The BMJ, reveals new details that show problems in data reporting after obtaining primary PLATO trial records and unpublished data through a freedom of information request. The PLATO trial was published in the New England Journal of Medicine (NEJM) in 2009. Assessing over 18,000 patients in 43 countries, investigators reported that ticagrelor ...

A simple change to the chemotherapy regimen for people with Hodgkin lymphoma could reduce the long-term health impacts that can result from treatment, according to researchers in Cambridge. The findings could lead to the national guidance on chemotherapy treatment for these patients being revised. The study, published today in The Lancet Oncology was led by Cambridge University Hospitals NHS Foundation Trust (CUH) and the Wellcome Sanger Institute. It compares the lasting effects of two chemotherapy regimens used to treat Hodgkin lymphoma in younger adults. Hodgkin lymphoma ...

ATLANTA, December 11, 2024 — A new study led by American Cancer Society (ACS) researchers shows that early-onset colorectal cancer (CRC) incidence rates are rising in 27 of 50 countries/territories worldwide, 20 of which have either exclusive or faster increases for early-onset disease. In 14 countries, including the United States, rates are increasing in young adults while stabilizing in those 50 years and older. The research is published today in the journal The Lancet Oncology. “The ...

EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, DECEMBER 11, 2024 MINNEAPOLIS – Older adults whose blood pressure fluctuates over time may be more likely to have problems with thinking and memory skills, according to a study published in the December 11, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. The association was found in Black participants but not in white participants in the study.   The study does not prove that fluctuations in blood pressure cause problems with thinking skills; it only shows an association. “These results suggest ...