A monthly injection has helped 90% of severe asthma patients reduce daily steroid tablets, which are associated with long-term side effects. More than half of the participants who had received the injection were able to stop their daily steroid tablets entirely, without any impact on their symptoms. The clinical trial led by a King’s College London academic followed patients who had been injected with tezepelumab every four weeks for a year. Tezepelumab is a type of antibody which targets parts of the immune system, reducing lung inflammation. Treatment with tezepelumab was also shown to significantly improve asthma symptoms, lung function, and overall quality of life. During ...

A monthly injection for managing severe asthma could help patients safely reduce or even discontinue daily steroid medications, according to a new phase 3b clinical trial published in The Lancet Respiratory Medicine journal. Oral corticosteroids (OCS) are powerful medications that help control airway inflammation and asthma symptoms. In the most severe asthma patients, OCS are needed daily. However, long-term use can lead to serious health problems, including osteoporosis, diabetes, and increased vulnerability to infections. The ...

The most comprehensive review to date of ADHD treatments has found that medication for children and adults, and cognitive behavioural therapy for adults, remain the most effective approaches, backed by the strongest short-term trial evidence. Researchers led by the Université Paris Nanterre (France), Institut Robert-Debré du Cerveau de l'Enfant (France), and the University of Southampton (UK) analysed over 200 meta-analyses covering different treatment types, participant groups, and clinical outcomes in a study published today [27 November 2027] in The BMJ. The research was funded by public and peer-reviewed research ...

A satellite deployed to measure ocean surface heights was up to the challenge when a massive earthquake off the Kamchatka Peninsula triggered a Pacific-wide tsunami in late July. The Surface Water Ocean Topography or SWOT satellite captured the first high-resolution spaceborne track of a great subduction zone tsunami, researchers report in The Seismic Record. The track shows an unexpectedly complex pattern of waves dispersing and scattering across the ocean basin, one that could help tsunami scientists better understand how these events propagate and how they could threaten coastal communities. Angel Ruiz-Angulo at the University of Iceland and ...

Acid rain from fossil fuel pollution may be quietly training soil bacteria to become longer-lived, more transmissible, and more deadly, according to a new study in the journal New Contaminants that tracks how a notorious foodborne pathogen rapidly evolved under simulated acid deposition.​​ Acid deposition from burning coal, oil, and other fossil fuels has long been known to damage forests, lakes, and crops, but its impact on disease-causing microbes in soil has been largely overlooked. The new research shows that acid rain can destabilize the native soil microbiome in ways that make it easier for the pathogen Escherichia coli O157:H7 to invade and persist. In global soil metagenomic ...

Hereditary hemorrhagic telangiectasia (HHT) is the second most common inherited bleeding disorder worldwide, affecting 1 in 3,800 persons. HHT’s hallmark symptom is chronic nosebleeds, which often occur alongside other internal bleeding and vascular malformations that impact quality of life and longevity. A new study from Mass General Brigham tested the safety and efficacy of engasertib, a drug specifically designed to target the condition. This 75-participant, double-blind, placebo-controlled trial found engasertib ...

A speedy new scan could improve how millions of people with high blood pressure are treated, suggests a new study led by UCL (University College London) researchers. About a quarter of people with high blood pressure have been estimated to have a problem with their adrenal glands producing too much of the hormone aldosterone, which regulates levels of salt in the body. This problem is often missed, as the path to diagnosis is complex, involving multiple tests and, to guide treatment, an invasive procedure that is not always reliable. The new 10-minute scan, developed at UCL and described in a research letter in the New England Journal ...

The International Osteoporosis Foundation (IOF) announces that the 9th IOF Asia-Pacific Bone Health Conference will officially begin in just three weeks, taking place from December 11–13, 2025, in Tokyo, Japan. As the Asia-Pacific region faces a rapidly growing burden of osteoporosis and fracture-related health challenges, this major scientific congress will bring together healthcare professionals, researchers, and policymakers to exchange knowledge and shape the future of bone health across the ...

Highlights: Your driving habits could be a marker of your brain health. GPS trackers spotted cognitive issues better than age or memory tests alone. People with mild cognitive impairment started driving less, especially at night, and stuck to familiar routes. Adding driving data to the mix increased the accuracy in detecting cognitive decline to 87%. Watching how you drive could help catch brain changes early—before any crashes happen. MINNEAPOLIS — Using in-vehicle driving data may be a new way to identify people who are at risk of cognitive decline, according to a study published on November 26, 2025, in Neurology®, the medical ...

Researchers have unveiled a promising new method that could transform how uranium is recovered from challenging wastewater streams. By combining a specially engineered covalent organic framework with an indirect electrochemical process, the approach delivers high efficiency, long term stability, and strong tolerance to chemically complex environments. The findings provide fresh insight into how advanced functional materials and optimized operating conditions can work together to support cleaner and more sustainable nuclear energy development. Uranium is a vital resource ...

Soybean oil, the most widely consumed cooking oil in the United States and a staple of processed foods, contributes to obesity, at least in mice, through a mechanism scientists are now beginning to understand. In an experiment conducted at UC Riverside, most mice on a high-fat diet rich in soybean oil gained significant weight. However, a group of genetically engineered mice did not. These mice produced a slightly different form of a liver protein that influences hundreds of genes linked to fat metabolism. This protein also appears to change how the body processes linoleic acid, a major component of soybean oil. “This may be the first step toward understanding ...

The famous statues of Rapa Nui (Easter Island) were carved by numerous independent groups, according to a study published November 26, 2025 in the open-access journal PLOS One by Carl Philipp Lipo of Binghamton University, New York and colleagues. The island of Rapa Nui is famous for preserving hundreds of stone statues (moai) carved by Polynesian communities starting in the 13th century. Archaeological evidence consistently suggests that Rapa Nui society was not politically unified, consisting instead of small and independent family groups. ...

Captive male Asian elephants can live together peacefully and with little stress, if introduced slowly and carefully, per Laos case study of 8 unrelated males Article URL: https://plos.io/4oYWIwt Article title: Socializing a group of male Asian elephants in a semi-captive facility in Lao PDR Author countries: Thailand, Lao P.D.R., U.S. Funding: This research was supported by graduated school Faculty of Veterinary Medicine (Grant number;2562), Chiang Mai University, Thailand. The funders had no role in study design, data collection and analysis, ...

The Galapagos and other oceanic islands and Marine Protected Areas (MPAs) may be "critical" refuges for sharks in the Tropical Eastern Pacific, as predatory fish appear depleted in more coastal MPAs through fishing pressure Article URL: https://plos.io/3JOKoiY Article title: Relative abundance and diversity of sharks and predatory fishes across Marine Protected Areas of the Tropical Eastern Pacific Author countries: Ecuador, Colombia, U.S. Funding: We are grateful to the funding provided: To ...

Nature is brimming with colour in almost every season. While the majority of colours are matte, some are shiny. Evolutionary biologist Casper van der Kooi wondered why shiny colours are so rare. He researched how bees perceive glossy colours by using artificial flowers. The experiment showed that shiny objects can be easily seen from afar, but are more difficult to discern up close. ‘It’s a visual trade-off.’ Biologists do not merely admire the colours in nature, they also develop theories to explain them. Most colours, such as the feathers of a great tit, the petals of a daisy, or the skin of a frog, are matte. These colours look the same from every ...

Climate-vulnerable districts of India face significantly higher risks of adverse health outcomes, including 25% higher rates of underweight children, per large scale analysis highlighting the threat of climate change in undermining gains in Sustainable Development Goals Article URL: https://plos.io/3LCFo1n Article title: Health SDGs are at risk from climate change: Evidence from India Author countries: India Funding: This paper was written with support from the Wellcome Trust, UK [226740/Z/22/Z], for a research grant. PD is the principal investigator, WJ the co-principal investigator, while GS, MC and G are research staff on the study team. The authors are ...

A spatial analysis of crime in Chicago suggests that certain environmental and socioeconomic factors, such as building density, are linked with crime rates, but these relationships differ between neighborhoods. The study also reveals discrepancies between media coverage and actual crime patterns, with coverage disproportionately concentrated in certain areas. Yuxuan Cai of the University of Chicago, U.S., and colleagues present these findings in the open-access journal PLOS One on November 26, 2025. Numerous ...

PROVIDENCE, R.I. [Brown University] — Providing year-round access to RSV immunization would minimize the risk of large seasonal outbreaks across the nation, including in both urban and rural areas. That’s according to a new study, published in Science Advances, which examined differences in viral spread in areas with different population density. The study showed that in urban areas, higher rates of interpersonal contact led to a higher proportion of hospitalizations in infants under age 1 and a more prolonged, lower-intensity RSV outbreak. Rural areas, on the other hand, saw shorter, spikier outbreaks. The ...

Located in the middle of the South Pacific, thousands of miles from the nearest continent, Easter Island (Rapa Nui) is one of the most remote inhabited places on Earth. To visit it and marvel at the quarries where its iconic moai statues were created is a luxury few get to experience – until now. You can now explore Rano Raraku, one of the major quarries on Easter Island, from the comfort of your home. A research team including faculty at Binghamton University, State University of New York has created the first-ever high-resolution 3D model of the quarry, providing people ...

Researchers at the Department of Mechanical Engineering, Seoul National University, led by Professor Kyu-Jin Cho—Director of the Human-Centered Soft Robotics Research Center and a founding member of the SNU Robotics Institute (SNU RI)—have applied the principle of interlacing to an origami-inspired structure and developed a “Foldable-and-Rollable corruGated Structure (FoRoGated-Structure)” that can be smoothly folded and rolled up for compact storage while maintaining very high strength when deployed. The study ...

Nerve damage is one of the most common and burdensome complications of diabetes. Millions of patients worldwide suffer from pain, numbness, and restricted movement, largely because damaged nerve fibres do not regenerate sufficiently. The reasons for this are unclear. A research team led by Professor Dr Dietmar Fischer, Professor of Pharmacology at the University of Cologne’s Faculty of Medicine, and Director of the Center for Pharmacology at University Hospital Cologne, has now identified a central mechanism that explains limited regeneration ...

What if a robot could show us how the brain keeps us balanced? UBC scientists built one – and their discovery could help shape new ways to reduce fall risk for millions of people. A towering ‘body-swap’ robot built by University of British Columbia researchers is giving scientists an unprecedented look at how the brain keeps us standing—a skill we barely notice until affected by age or disease. Their findings, published today in Science Robotics with collaborators at Erasmus Medical Clinic, reveal that to stay balanced, the brain treats delays in sensory feedback almost the same way it handles changes in body mechanics. ...

Puerto Ayora, Galapagos | 26 November, 2025 – One of the most comprehensive surveys to date of shark and other large predator fish in the Eastern Tropical Pacific (ETP) ocean finds that  remote Marine Protected Areas (MPAs)—including the Galapagos, Malpelo, Clipperton, and Revillagigedo islands—support some of the largest numbers of sharks reported globally, including the critically endangered scalloped hammerhead, while coastal MPAs are showing signs of severe depletion.  “The oceanic islands of the Eastern Tropical ...

A new study of adolescents and young adults (AYAs) with seven common cancers reveals that nearly one in ten patients diagnosed with non-metastatic disease later develop metastatic recurrence — a condition associated with significantly worse survival outcomes. Metastasis is when cancer cells spread from the initial or primary site to other parts of the body. It comes with significantly worse survival outcomes. UC Davis Comprehensive Cancer Center scientists led the research. The findings highlight the urgent need to identify and address survivorship needs for young cancer survivors. “As treatments improve survival, young patients with cancer face unique challenges,” ...

Tampa, FL, USA, November 26, 2025: The Global Virus Network (GVN), a coalition of leading human and animal virologists in more than 40 countries dedicated to advancing pandemic preparedness through research, education and training, and global health solutions, today issued a statement on the newly confirmed outbreak of Marburg virus disease (MVD) in southern Ethiopia. This represents the country’s first documented outbreak of Marburg virus and raises urgent public health, research, and surveillance imperatives. According to the World Health Organization ...