SAN ANTONIO, Aug. 8, 2024 – A drug effective in treating breast cancer shows new promise in addressing breast cancer with brain metastases or recurrent glioblastoma, as reported by results of a prospective window-of-opportunity trial at the University of Texas Health Science Center at San Antonio (UT Health San Antonio). The window trial, in which patients agreed to receive a novel treatment before undergoing surgery, found that the drug Sacituzumab Govitecan was well-tolerated and showed signs of effectiveness for those whose breast cancer had progressed to brain tumors. About half of all women with ...

About The Article: This Viewpoint from the National Center for Health Statistics reports the leading causes of death in the U.S. from 2019 to 2023, including the emergence of COVID-19 and shifts in other top causes as pandemic deaths decreased. Corresponding Author: To contact the corresponding author, Farida Bhuiya Ahmad, MPH, email hhi0@cdc.gov. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2024.15563) Editor’s Note: Please see the ...

Scientists have made a significant breakthrough in agricultural biotechnology by using CRISPR/Cas9 to edit the potato genome, resulting in plants with increased resistance to both biotic and abiotic stresses. This innovation could lead to a new era of sustainable farming, where crops are naturally fortified against diseases and harsh environmental conditions, ensuring a stable food supply in the face of climate change and other global challenges. The global food system is under increasing pressure due to the compounding effects of climate change, which exacerbates the prevalence of pests and diseases in crops. Potatoes, being the third most important food crop worldwide, are ...

A recent review in the journal Sustainable Microbiology discusses how the use of biocides can promote well-being - but must only be used when there are clear benefits. Biocide use should be restricted to applications where there are tangible benefits but also not unnecessarily restricted where genuine benefits can be demonstrated, the new review suggests. The article ‘Sustainable application of biocides to promote hygiene and minimise antimicrobial resistance’ by scientists at the University of Manchester, UK, is published in Sustainable Microbiology, an Applied Microbiology International publication. Contribution to sustainability “We aimed to present ...

Amazonians are as genetically different from Andeans as Europeans are from East Asians when it comes to genetic variants that affect the response to certain drugs, according to a commentary published August 8 in the journal Cell. These genetic variations can affect what side effects an individual experiences and influence drug dosage recommendations. Taking the genetic diversity within indigenous groups as an example, the scientists highlight the need to address the diversity gap in genomics research. Historically, Native American populations have been viewed as ...

Physicians at an academic medical center completed surveys about climate change-focused educational modules related to health and sustainability in healthcare offered through an existing biannual quality incentive program. Most respondents thought that the modules were relevant or very relevant to their lives and clinical practices, and that their knowledge on these topics increased after completing the modules. Perceptions of the modules’ relevance varied by physicians’ demographics and specialties. An educational program emphasizing the relationship that climate change has with health and health care environmental sustainability was well-received by physicians, according ...

Toronto, ON, May 15, 2024 – Two classes of commonly prescribed oral antibiotics are associated with the greatest risk for severe drug rashes that can lead to emergency department visits, hospitalizations and even death, according to a new study.  Researchers from ICES, Sunnybrook Research Institute and the Department of Medicine at the University of Toronto’s Temerty Faculty of Medicine suggest that prescribers should consider using lower-risk antibiotics for their patients when clinically appropriate.  Serious cutaneous adverse drug reactions (cADRs), or severe drug rash, are ...

About The Study: Commonly prescribed oral antibiotics are associated with an increased risk of serious cutaneous adverse drug reactions compared with macrolides, with sulfonamides and cephalosporins carrying the highest risk. Prescribers should preferentially use lower-risk antibiotics when clinically appropriate. Corresponding Author: To contact the corresponding author, David N. Juurlink, M.D., Ph.D., email david.juurlink@ices.on.ca. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2024.11437) Editor’s Note: Please ...

About The Study: This cohort study highlights an association between cannabis-related disorder and the development of head and neck cancer in adult patients. Given the limitations of the database, future research should examine the mechanism of this association and analyze dose response with strong controls to further support evidence of cannabis use as a risk factor for head and neck cancers.  Corresponding Author: To contact the corresponding author, Niels C. Kokot, MD, email niels.kokot@med.usc.edu. To ...

About The Study: In this cohort study of Canadian children and adolescents, childhood and adolescent depression symptoms were associated with impaired adult psychosocial functioning. Interventions should aim to screen and monitor children and adolescents for depression to inform policymaking regarding young adult mental health and psychosocial outcomes.  Corresponding Author: To contact the corresponding author, Marilyn N. Ahun, PhD, email marilyn.ahun@mcgill.ca. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.25987) Editor’s ...

Parents shopping with their children in Berkeley, California, can now breathe a sigh of relief when they get to the checkout lane. Likewise, Berkeley shoppers looking for an impulse snack purchase now have healthy options at the checkout. That is because in March 2021, Berkeley became the world’s first city to implement a healthy checkout policy, which sets nutritional standards for store checkouts. Berkeley, located in the San Francisco Bay Area, has been followed by Perris, a small city in Southern California, as well the United Kingdom.  According to Berkeley’s policy, only the following products can be placed at checkout: ...

LOS ANGELES — A study from the USC Head and Neck Center, part of Keck Medicine of USC and the USC Caruso Department of Otolaryngology – Head and Neck Surgery, suggests that cannabis, the most commonly used illicit substance worldwide, is associated with an increased occurrence of head and neck cancer.   A large, multicenter study published in JAMA Otolaryngology – Head & Neck Surgery revealed that adults with cannabis dependence, known as cannabis use disorder, are 3.5 to 5 times more likely to develop head and neck cancer than those who do not use the substance.  “This ...

KTU M-Lab, the Centre of Experimental and Prototyping Laboratories at Kaunas University of Technology, Lithuania, in cooperation with the company Nando Droid, is constructing first-person view (FPV) kamikaze drones, which are being sent to Ukraine and used in the war field. These drones are fitted with explosives that are activated when they hit an obstacle. Kaunas University of Technology students assembling the drones say that they are built to have a long flight range and the ability to carry a large payload. “The war in Ukraine is already being called a drone war. Without them, this war would be unimaginable. It saves many lives,” says the representative ...

As climate change continues to advance, the need for low-carbon, clean energy alternatives has become more urgent than ever. A research team at City University of Hong Kong (CityUHK) has developed a new generation of printable perovskite solar cells that offer higher efficiency and stability, lower cost and scalability, with a minimal carbon footprint. With funding support from the inaugural Research, Academic and Industry Sectors One-plus Scheme (RAISe+ Scheme) of the Innovation and Technology Commission of the HKSAR government, the team aims to establish ...

Beijing (China) and Berlin (Germany) August 8, 2024 – Tsinghua University Press (TUP), the leading university press in China, and ResearchGate, the professional network for researchers, are delighted to announce a new Journal Home partnership that aims to increase the readership and visibility of TUP’s open access research. The agreement is the first of its kind with a Chinese publisher.   The agreement covers five fully open-access journals published by TUP through their platform, SciOpen, including research published in Artificial Intelligence, Energy, Materials, and Construction. In ...

INDIANAPOLIS -- Romantic relationships play an important part in adolescent development. Most young people have had at least one romantic relationship by middle adolescence (ages 14 to17). However, successful promotion of healthy sexual behavior to reduce risk of unintended pregnancies and sexually transmitted infections in this teen population has proven difficult. Regenstrief Institute and Indiana University Research Scientist Arthur Owora, PhD, MPH, a quantitative epidemiologist and applied biostatistician, is the first author of a new multi-site ...

Nearly a quarter of children with recurrent wheezing have “silent” lung infections that would be better treated with antiviral medications than commonly prescribed steroids that can carry lifelong side effects, new research from the University of Virginia School of Medicine reveals. Pediatric pulmonologist W. Gerald Teague, MD, was inspired to investigate after noting large numbers of children with stubborn wheezing cases referred from community providers and through the UVA Health Emergency Department.  Knowing that rhinoviruses – the main cause of the common cold – can trigger wheezing episodes, Teague wanted to see if there ...

A new research paper published in the scientific journal Nature Conservation has uncovered concerning activities within South Africa's captive lion industry, shedding light on the urgent need for comprehensive governmental action. The study by World Animal Protection, conducted through direct interviews with workers at two closed-access lion facilities in South Africa’s North West Province, reveals disturbing practices. These include: The use of legal activities such as commercial captive lion breeding and canned hunting to mask involvement in the illegal international trade of lion and tiger bones. Animal welfare violations including ...

Researchers at the Texas A&M School of Veterinary Medicine and Biomedical Sciences (VMBS) have discovered that parents who struggle with alcohol use disorders can pass along symptoms of early aging to their children, affecting them well into adulthood.  These accelerated aging effects — including high cholesterol, heart problems, arthritis, and early onset dementia — can be passed down from either mom or dad individually, but they become worse when both parents have an issue with alcohol abuse, especially in male offspring. “Scientists have wondered what causes children who grow up in homes where there is alcohol ...

An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases can predict which melanoma patients are likely to have severe side effects from immunotherapy designed to treat the most deadly skin cancer, a new study shows. Led by researchers at NYU Langone Health and its Perlmutter Cancer Center, the latest experiments focused on checkpoint inhibitors, drugs that have in the last decade become a mainstay of treating melanoma. This form of skin cancer kills nearly 10,000 Americans annually. The drugs work by blocking molecules ...

WASHINGTON — Researchers have shown that a fluorescence detection system that doesn’t contain any lenses can provide highly sensitive detection of deadly microorganisms in drinking water. With further development, the new approach could provide a low-cost and easy-to-use way to monitor water quality in resource-limited settings such as developing countries or areas affected by disasters. It could also be useful when water safety results are needed quickly, such as for swimming events, a concern highlighted during the Paris Olympics. “In developing countries, unsafe water sources ...

For decades, researchers have worked to develop therapies that can prime the immune system to recognize and attack proteins on the surface of tumor cells. However, success has been limited due to the technological challenge of engineering therapies that provide specific enough “training” to the immune system to identify a given patient’s neoantigens. Now, investigators from Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, have evaluated an ...

WASHINGTON—Women with the common reproductive and metabolic condition polycystic ovary syndrome (PCOS) face a greater risk of developing bulimia, binge eating disorder and disordered eating, according to new research published in The Journal of Clinical Endocrinology & Metabolism. PCOS affects roughly one in eight women. Women who have the condition face an increased risk of developing metabolic problems such as diabetes, reproductive issues such as infertility, and psychological issues including anxiety and depression. Women are diagnosed when they have at least two of the three ...

A Korean research team has presented the first universal design principles for solid-state batteries, signaling a paradigm shift in battery design research that previously lacked standard benchmarks. Dr. Jinsoo Kim from the Ulsan Advanced Energy Technology R&D Center of the Korea Institute of Energy Research (KIER) and Professor Sung-Kyun Jung's research team from the Ulsan National Institute of Science and Technology (UNIST) have jointly developed a design principles and a versatile design toolkit for implementing high-energy-density solid-state batteries and have completed performance verification. With ...

Nationally, falls remain the leading cause of both fatal and non-fatal injuries in older adults and are the leading cause of traumatic brain injury. In 2021, falls led to the deaths of 36,500 older adults in the United States and 3,805 older Floridians. While some studies have hypothesized that alcohol use contributed to these outcomes, there are few studies which have examined this issue.  As such, little is known about the association between the frequency of alcohol use and the severity of injuries sustained after a fall in older adults. A study by Florida Atlantic University’s Schmidt College of Medicine and collaborators, is one of the first to examine the relationship ...