About The Study: In patients with symptomatic intracranial atherosclerotic stenosis, balloon angioplasty plus aggressive medical management, compared with aggressive medical management alone, statistically significantly lowered the risk of a composite outcome of any stroke or death within 30 days or an ischemic stroke or revascularization of the qualifying artery after 30 days through 12 months. The findings suggest that balloon angioplasty plus aggressive medical management may be an effective treatment for symptomatic intracranial atherosclerotic stenosis, although the risk of stroke or ...

About The Study: This cross-sectional study of commercially insured patients suggests that there may have been meaningful heterogeneous associations between cannabis policy and state and between cannabis policy and drug class (e.g., decreases in dispensing of benzodiazepines but increases in dispensing of antidepressants and antipsychotics). This finding suggests additional clinical research is needed to understand the association between cannabis use and mental health. The results have implications for patient substance use and mental health–related outcomes.  Corresponding Author: To ...

Researchers from Tokyo Medical and Dental University (TMDU) identify Mst1–FoxO1–C/EBP-ß signaling pathway that promotes heart cell survival Tokyo, Japan – Understanding the mechanisms behind cell death and survival is crucial when it comes to conditions like heart failure, which affects millions of people worldwide. Now, researchers from Japan have identified a mechanism which protects cardiac myocytes against ischemia, or a lack of blood supply. In this study published online on 25 July 2024 in Nature Communications, researchers from the Tokyo Medical and Dental ...

Tokyo Medical and Dental University (TMDU) researchers investigate the molecular mechanisms that link periodontal disease to rheumatoid arthritis Tokyo, Japan – Periodontal disease, which affects the gums and tissues that surround the teeth, is one of the most prevalent dental conditions worldwide. Most often caused by the formation and accumulation of bacterial biofilm around the teeth, periodontal disease can ultimately lead to tooth loss if left unattended. Interestingly, the inflammatory effects of periodontal bacteria can go well beyond the mouth, leading to systemic effects. Over the past few decades, clinical studies have revealed that the periodontal ...

Regenstrief Institute will host its semiannual LOINC® conference September 17-20, 2024, in Washington, D.C. LOINC, a global healthcare terminology standard, will be the subject of the three-day conference during which experts worldwide will collaborate during presentations across three points of emphasis: implementation and policy, innovation and mapping. Keynote presenters will be: Wednesday, September 18 – Jesse Ehrenfeld, M.D., MPH, the president of the American Medical Association. Thursday, September ...

Arthritis drugs already available for prescription have the potential to halt lingering lung problems that can last months or years after COVID-19 infections, new research from the University of Virginia School of Medicine and Cedars-Sinai suggests. By examining damaged human lungs and developing an innovative new lab model, the scientists identified faulty immune processes responsible for the ongoing lung issues that plague an increasing number of people after they’ve otherwise recovered from COVID-19. These lasting harms of COVID infection, ...

WASHINGTON—Women with higher levels of per- and polyfluoroalkyl substances (PFAS) during pregnancy may experience long-term weight gain and heart problems later in life, according to new research published in The Journal of Clinical Endocrinology & Metabolism. PFAS are manmade chemicals found in food packaging, cookware, clothes, drinking water, personal care products and many other consumer goods. These endocrine-disrupting chemicals (EDCs) can interfere with hormones and cause health issues such as obesity, infertility and cancer. “Our study supports the idea that pregnancy may be ...

Washington, D.C. — A common skin fungus, Malassezia globosa may invade deep tissues through the skin or by other means, then cause tumor growth, according to a new study. The study results were reported in mBio, an open access journal of the American Society for Microbiology. “It is important to take care of skin not only for beauty, but also for health,” said corresponding study author Qi-Ming Wang, Ph.D., a professor in the School of Life Sciences, Institute of Life Sciences and Green Development, Hebei University, Hebei, China. “As ...

PLYMOUTH MEETING, PA [September 5, 2024] — New research just-published online by JNCCN—Journal of the National Comprehensive Cancer Network finds that for many commonly used treatment regimens targeting metastatic gastrointestinal (GI) cancers, such as FOLFOX, FOLFIRI, or FOLFIRINOX, it is possible to administer 5-FU solely through continuous infusion, minus the bolus (quick-delivery via intravenous push) component, without negatively affecting patient outcomes. The study reviewed results from 11,765 patients across 280 cancer clinics who were diagnosed with ...

A new UCLA-led study found that cardiovascular disease risk among Chinese American immigrants increases with length of residence and varies by location in the U.S. The study, which leveraged data from the MESA (Multi-Ethnic Study of Atherosclerosis) cohort, sponsored by the National Heart, Lung, and Blood Institute (NHLBI), observed the heart health of 746 Chinese Americans in both Los Angeles and Chicago over a period of roughly 18 years. The study found that participants who resided in Chicago showed lower mortality levels from heart disease compared to those who lived in Los Angeles. “This is the first long-term prospective study in nearly two decades to investigate the effects of ...

Research Highlights: In the first study, nearly 23% of young adults (ages 18-39 years) included in the NHANES 2017-2020 datasets had high blood pressure (130/80 mm Hg or greater). In addition, they were more likely to self-report being uninsured, food insecure and low-income compared to older adults. The second study, which also used the 2017-2020 NHANES datasets, found that among 2,600 youths ages 8-19, 8.7% had elevated blood pressure and 5.4% had high blood pressure, as defined by age-sex-height percentiles in accordance with guidelines from the American Academy of Pediatrics. These two studies point to the need for policies and programs to support youth and young adults ...

Research Highlights: A new study finds that up to 74% of participants with resistant or difficult-to-control high blood pressure, including those with chronic kidney disease, were able to improve control of their blood pressure within 12 months after using a Bluetooth-enabled remote monitoring system coupled with pharmacist interactions. Two-thirds of patients had interacted with pharmacists who co-managed their blood pressure via telehealth, often making medication adjustments and addressing medication adherence, which was associated with ...

Research Highlights: An analysis of at-home blood-pressure monitors estimates that the arm cuffs for 10 of the most popular potentially do not fit up to 18 million adults in the U.S. and nearly 12% of Black adults. To ensure accurate blood pressure monitoring, the researchers suggest that manufacturers and retailers be aware of the disparities and improve access and selection of diverse blood pressure cuff sizes for consumers. Note: The studies featured in this news release are research abstracts. Abstracts ...

There are some pretty strange ingredients in cosmetics and skin care products. One example is snail mucin — also known as snail slime — which is used for its moisturizing and antioxidant properties. But researchers reporting in ACS Omega might have found something even weirder to put on your face: molecules made by fish gut bacteria. In cultured cells, the compounds had skin-brightening and anti-wrinkle properties, making them potential ingredients for your future skin care routine. Though fish guts might seem like the absolute last place to look for cosmetic compounds, it’s not a completely far-fetched idea. Many important drugs have ...

How does your dip in a local watering hole affect the stream’s chemistry? Researchers who previously analyzed the impact of people swimming and tubing on a Colorado creek report updated observations in ACS ES&T Water. They find that these recreational activities over a busy Labor Day weekend have a short-term effect, increasing the levels of metals, human gut-associated microbes and substances from personal care products. Researchers James Ranville, Carsten Prasse, John Spear, Noor Hamden, Carmen Villarruel and colleagues studied how recreational ...

Hong Kong (5 September 2024) – The Asian Fund for Cancer Research Limited (AFCR) is pleased to announce the winners of the 2024 BRACE Award Venture Competition: the First Prize goes to Concarlo Therapeutics, led by Founder and CEO Stacy Blain, Ph.D., and the Second Prize goes to Orphagen Pharmaceuticals, led by its Founder and CEO Scott Thacher, Ph.D. AFCR’s BRACE (Bridging Research from Academia to Cancer Entrepreneurship) Award Venture Competition is designed to support and accelerate oncology innovations on their path toward commercialization, aiming to improve outcomes for patients affected by cancer globally. ...

Research Highlights: In an analysis of 18 randomized clinical trials, people with obesity and high blood pressure who underwent bariatric (weight-loss) surgery were almost three times more likely to achieve blood pressure remission, defined as reducing to less than 140/90 mm Hg and no longer taking antihypertensive medication, and keep it under control in comparison to peers treated with medication and healthy lifestyle adjustments. Over a 1-to-5-year follow-up period, people with obesity who ...

PULLMAN, Wash. —  A new application that uses artificial intelligence may revolutionize the way scientists study hair and could lead to the development of health diagnostics based solely on hair. The AI model speeds up and streamlines the hair quantification process, allowing a microscope to scan slides and collect images of hundreds of hairs at a time. In a matter of seconds, it can capture an abundance of high-resolution data that is then processed with a deep learning algorithm that collects the color, shape, width and length of each individual hair. Researchers tested it using mouse fur, but it could be ...

A combined 4.8 million euros in ERC Starting Grants will go to scientists at the Institute of Science and Technology Austria (ISTA). Awarded to early career researchers by the European Research Council (ERC), Starting Grants help researchers launch and develop projects, build capable teams, and pursue cutting-edge research. All three of ISTA’s ERC winners wholly embody the Institute’s curiosity-driven mission: they aim to find out how cells keep time, improve the way we date our stars, and optimize the extraction of relevant information from our ever-growing data. ERC Starting Grants ...

Drs Johanna Vos has won a highly prestigious European Research Council (ERC) Starting Grants to pursue research aimed at better understanding weather patterns in extrasolar worlds deep in the galaxy. Dr Vos’ project: Exometeorology: Probing Extrasolar Atmospheres (Exo-PEA) Over the past 30 years, astronomers have uncovered thousands of new extrasolar planets, which vary from small, rocky worlds, to giant planets like Jupiter. Additionally, lots of isolated or free-floating worlds have been discovered. We have already learned that the atmospheres of these strange worlds are highly complex, hosting a range of weather processes.  The launch of the James Webb Space Telescope ...

Iliana Ivanova, Commissioner for Innovation, Research, Culture, Education and Youth, said: “The European Commission is proud to support the curiosity and passion of our early-career talent under our Horizon Europe programme. The new ERC Starting Grants winners aim to deepen our understanding of the world. Their creativity is vital to finding solutions to some of the most pressing societal challenges. In this call, I am happy to see one of the highest shares of female grantees to date, a trend that I hope will continue. Congratulations to all!”  President of the European Research Council, Prof. ...

Dr Michael-John Dolan has won a highly prestigious European Research Council (ERC) Starting Grants to pursue research aimed at uncovering the secrets of brain disorders and repair. Dr Dolan’s project: MICRODISSECT: Dissection of Microglial State Biology in Brain Repair Dr Dolan’s research will focus on microglia, the brain's resident immune cells, which can form distinct subtypes, or “states” – especially during brain damage, disease, or repair. While microglia are crucial for regulating neuroinflammation and brain repair, these states are poorly understood ...

If you upset one bee, what determines whether the entire hive decides to avenge her grievance? A $1.2 million grant will support UC Riverside scientists in answering questions like these about how honeybees communicate. Every third bite of food you eat has been pollinated by a bee. They are central to worldwide food production, but there have been an alarming number of die-offs recorded since 2006.  One solution to this issue is the use of special survivor bees that are more resistant to pests and diseases that are killing managed honeybees.  Commonly found in ...

“We are extremely happy about the freshly granted ERC project for Hannah Schneider. Thereby, the European Research Agency distinguished a highly talented young researcher, who develops new ideas and approaches to explore anatomical roots traits that are highly relevant for stress tolerance and resource efficiency of crops”, says Prof. Dr. Nicolaus von Wirén, Managing Director at IPK. “The new ERC project of the scientist from Minnesota, whom we allured to IPK just last October, follows the two previous ERC-Starting Grant holders Martin Mascher and Stefan Heckmann and will bring great international visibility to root research at IPK.”  “The ...

A study published in Nature Communications provides new insight into how damaged cells interact within disease-promoting microenvironments following acute kidney injury, or AKI. With limited treatment options, AKI frequently progresses to chronic kidney disease (CKD), which affects more than 1 in 7 U.S. adults—an estimated 37 million people. The new findings may contribute to future efforts to prevent CKD, which can lead to kidney failure.  The study brought together scientists from Andy McMahon’s lab at USC and Long Cai’s lab at Caltech, with support from a USC Broad Innovation Award that funded the cross-institutional research collaboration.  In ...