Using human cells and cutting-edge technology, the team created a three-dimensional (3D) model that accurately simulates the brain invaded by aggressive cancer. Published in Biofabrication, the study combines frontier science, advanced technology, and international collaboration — while also carrying a personal story: part of the team is formed by a couple of scientists who quite literally bring their work home. Brain metastasis occurs when cancer cells migrate from the original tumor — in this case, the skin — to the brain. This stage of the disease is among the most challenging to treat, and it is associated with over 90% of cancer-related deaths. “When melanoma ...

CAMBRIDGE, MA -- In an MIT classroom, a professor lectures while students diligently write down notes they will reread later to study and internalize key information ahead of an exam. Humans know how to learn new information, but large language models can’t do this in the same way. Once a fully trained LLM has been deployed, its “brain” is static and can’t permanently adapt itself to new knowledge. This means that if a user tells an LLM something important today, it won’t remember ...

Everyday life on the internet is insecure. Hackers can break into bank accounts or steal digital identities. Driven by AI, attacks are becoming increasingly sophisticated. Quantum cryptography promises more effective protection. It makes communication secure against eavesdropping by relying on the laws of quantum physics. However, the path toward a quantum internet is still fraught with technical hurdles. Researchers at the Institute of Semiconductor Optics and Functional Interfaces (IHFG) at the University of Stuttgart have now made a decisive breakthrough in one of the most technically challenging components, the ‘quantum repeater’. They report their results in Nature Communications ...

Yi Du and colleagues from the Chinese Academy of Sciences published an article in the open access journal PLOS Biology on November 18th detailing their findings about a new way our bodies naturally respond to music. Given a steady beat, our eyes blink in synchrony. The neurological process that helps us move with the music is known as auditory-motor synchronization. This describes the way you tap your foot along with the radio or bob your head at a concert, or why some runners listen to songs with a specific number of beats per minute ...

An analysis of data from almost two dozen long-term studies finds that even low-intensity smokers have a substantially higher risk of heart disease and death compared to people who never smoked, even years after they quit. Michael Blaha of the Johns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease, USA, and colleagues report these findings November 18th in the open-access journal PLOS Medicine. Previous research has shown that smoking cigarettes increases a person’s risk of developing cardiovascular disease, but the exact relationship between how heavily a ...

Researchers have developed a high-fidelity 13-degree-of-freedom nonlinear model and an intelligent algorithm for wind turbine dynamic analysis. This framework accurately captures complex tower-blade interactions, including often-neglected torsional effects, achieving a remarkable agreement with high-fidelity benchmarks. Published in Smart Construction, this work provides a powerful and efficient tool for structural assessment and future optimization of large-scale wind energy systems. The global push for sustainable energy has cemented wind power's role in the renewable transition. However, designing safe and cost-effective ...

A combination blood stem cell and pancreatic islet cell transplant from an immunologically mismatched donor completely prevented or cured Type 1 diabetes in mice in a study by Stanford Medicine researchers. Type 1 diabetes arises when the immune system mistakenly destroys insulin-producing islet cells in the pancreas. None of the animals developed graft-versus-host disease — in which the immune system arising from the donated blood stem cells attacks healthy tissue in the recipient — and the destruction of islet cells by the native host immune system was halted. After the transplants, the animals did not require the use of the immune suppressive drugs ...

Researchers from the Plant Genetics team of the Regional Service for Agri-Food Research and Development of the Principality of Asturias (Serida) have just published a first version of the genome of the Faba Granja Asturiana variety. This advance is key for the genetic improvement and conservation of one of Asturias’ most emblematic legumes. The work has been published in the journal Data in Brief under the title “Chromosome-level dataset from de novo assembly of a Fabada common bean genotype using Illumina and PacBio ...

Gestational diabetes can cause a multitude of complications in the offspring, but to date, the reasons are incompletely understood. A new study, exploring a foundational step in the process of building proteins from genetic material, called splicing, reveals that this process is affected, altering how the placenta reads and processes genetic instructions. Researchers found that in pregnancies affected by gestational diabetes, hundreds of genetic messages are assembled incorrectly, potentially disrupting how the placenta functions. ...

KEY TAKEAWAYS Among 11,600 youth in Massachusetts who started buprenorphine, only 1 in 4 maintained high adherence for a full year Those who remained adherent for 12 months had almost half the risk of overdose, and fewer emergency department visits and hospitalizations, compared with those who discontinued early Findings suggest that longer, more consistent treatment could be lifesaving for youth amid the ongoing fentanyl crisis   New research from Mass General Brigham finds that adolescents and young adults who ...

WASHINGTON, Nov. 18, 2025 — The average global temperature has risen by 1.5 C since the pre-industrial era due to climate change, and it is poised to continue increasing. In response, the Intergovernmental Panel on Climate Change has developed the Global Warming Potential (GWP) metric, a unit of measurement that compares a specific gas’s contribution to climate change to that of carbon dioxide. Nitrogen trifluoride (NF3) is particularly bad, with a GWP about 17,000 times higher than carbon dioxide. But NF3 is critical in the semiconductor industry for etching and cleaning, and its use has increased more than twentyfold over the past 30 years. Though NF3 is often viewed as ...

About The Study: In this cohort study of Supplemental Nutrition Assistance Program (SNAP) participants, the 50% incentive, automatic enrollment in the Eat Well, Be Well program, the first state-level SNAP fruit and vegetable incentive program launched in Rhode Island, was not associated with significant relative changes in fruit and vegetable intake, but was associated with benefits among participants already consuming more fruits and vegetables. Enhanced implementation, including broader retail ...

WASHINGTON, Nov. 18, 2025 — Aggressive cancer cells are masters of movement. When they spread through the body, they cause metastasis, which significantly reduces a person’s chance of survival. For this spreading to take place, they can switch between different cell states — behaviors of cells — that move with different strategies. A previous study revealed two specific metastatic cancer lines — MV3 (melanoma) and HT1080 (fibrosarcoma) — are capable of making a similar switch when the gaps in tissue are very tight. However, the study found that only one of the cell lines did so by switching motility modes in response ...

Our body’s “blood factory” consists of specialized tissue made up of bone cells, blood vessels, nerves and other cell types. Now, researchers have succeeded for the first time in recreating this cellular complexity in the laboratory using only human cells. The novel system could reduce the need for animal experiments for many applications. The bone marrow usually works quietly in the background. It only comes into focus when something goes wrong, such as in blood cancers. In these cases, understanding exactly how blood production in our body works, and how this process fails, becomes critical. Typically, bone marrow research relies heavily ...

Professor Gideon Wasserberg at UNC Greensboro has been awarded a prestigious $3.7 million National Institutes of Health R01 grant to advance his research on controlling sand flies, the vectors of the parasitic disease leishmaniasis. Leishmaniasis affects more than 1 million people each year and is found in approximately 90 countries in tropical and arid regions of the world, putting approximately 1 billion people at risk. The most common form, cutaneous leishmaniasis, typically causes skin ulcers, which can last months or even years and leave significant scars. The more serious visceral form of the disease, which attacks internal organs, often affects children ...

Anion exchange membrane (AEM) water electrolysis is widely recognized as a key technology for next-generation green hydrogen production. Currently, most AEM systems rely on alkaline supporting electrolytes such as potassium hydroxide, which can cause issues including bipolar plate corrosion, shunt current, and accelerated membrane degradation. Achieving stable operation with pure water feed is the goal for AEM water electrolysis. However, obstacles remain such as the instability of the membrane-electrode three-phase interface, limited current density, and poor durability. In a study published ...

“Glycation-lowering strategies may serve as effective treatments for alleviating GH-induced metabolic and inflammatory disruptions in the liver, offering a promising avenue for addressing age-related metabolic diseases associated with GH dysregulation.” BUFFALO, NY — November 18, 2025 — A new research paper was published in Volume 17, Issue 10 of Aging-US on October 3, 2025, titled “Growth hormone excess drives liver aging via increased glycation stress.” In this study, led by first author Parminder Singh ...

Radiation-induced brain injury (RIBI) is a serious and often delayed complication of cranial radiotherapy, which remains a cornerstone in the treatment of brain tumors such as gliomas, metastases, and lymphomas. While modern radiotherapy techniques have improved survival rates, they have also led to an increased incidence of RIBI, adversely affecting patients' neurological function and quality of life. This review synthesizes recent advances in multimodal imaging and emerging therapeutic strategies for RIBI, highlighting the shift from conventional symptomatic management to mechanism-driven, precision interventions. Pathophysiological Mechanisms ...

Chronic subdural hematoma (CSDH) is one of the most common neurosurgical conditions, particularly among the elderly, with an annual incidence ranging from 1.7 to 20.6 per 100,000 people. As the global population ages and the use of antiplatelet and anticoagulant therapies increases, the incidence of CSDH is projected to rise significantly. Despite its clinical prevalence, treatment options have seen limited breakthroughs over the past two decades, largely due to an incomplete understanding of its pathophysiology. This review provides a comprehensive overview ...

A Japanese research team has studied the variations in beryllium-7 concentrations in the surface air over the Antarctic regions of Southern Ocean. Beryllium-7 is a radioactive isotope of beryllium produced by cosmic rays in the atmosphere. The team explored, over space and time, how the beryllium-7 is transported from the atmosphere to the Earth’s surface. Their goal was to better understand the mechanisms of atmospheric mixing on Earth. Their research is published in the Journal of Geophysical Research: Atmospheres on October 14, 2025. “We aimed to clarify where and by what atmospheric flows the radioactive isotope beryllium-7, produced in the stratosphere ...

SAN ANTONIO — November 18, 2025 — Southwest Research Institute identified a security vulnerability in a standard protocol governing communications between electric vehicles (EV) and EV charging equipment. The research prompted the Cybersecurity & Infrastructure Security Agency (CISA) to issue a security advisory related to the ISO 15118 vehicle-to-grid communications standard. Through internal research, a team of SwRI engineers spoofed signal measurements between an EV and EV supply equipment (EVSE), leading to CISA’s publication of a Common ...

Operating a new device named the Fusion Z-pinch Experiment 3, or FuZE-3, Zap Energy has now achieved plasmas with electron pressures as high as 830 megapascals (MPa), or 1.6 gigapascals (GPa) total, comparable to the pressures found deep below Earth’s crust. The results are the highest-pressure performance to date in a sheared-flow-stabilized Z pinch and an important marker on the path to scientific energy gain, or Q>1. FuZE-3 is Zap’s first device to incorporate a third electrode to separate the forces that drive plasma acceleration and compression. Details of the preliminary results were presented today at the American Physical Society’s Division of Plasma ...

Washington, November 18, 2025—Students who enroll in short-term, job-focused training through community college noncredit programs experience modest but meaningful earnings gains and a greater likelihood of being employed after training, according to a new study published today in Educational Evaluation and Policy Analysis, a peer-reviewed journal of the American Educational Research Association. The study, conducted by Peter Riley Bahr of the Strada Institute for the Future of Work and Rooney Columbus of E&E Analytics, finds that workers earn about $2,000 more per year, on average, within two years of ...

November 18, 2025 – The American Pediatric Society (APS) is pleased to announce Tara O. Henderson, MD, MPH, as the recipient of the 2026 Norman J. Siegel New Member Outstanding Science Award, in recognition of her significant contributions to pediatric science. The award will be presented to Dr. Henderson during the APS Presidential Plenary at the Pediatric Academic Societies 2026 Meeting, taking place in Boston, MA, April 24-27. Established in honor of renowned nephrologist Norman J. Siegel, MD, FASN, the award celebrates early-career APS members whose scientific work demonstrates ...

Alzheimer’s disease (AD) is a devastating cause of memory loss and cognitive decline, for which no curative treatment is available. Among lifestyle factors, physical activity stands out as possibly one of the strongest defenders of brain health. Growing evidence links skeletal muscle function to cognitive health. Pioneering research from Florida Atlantic University and its collaborators at the Novo Nordisk Foundation Center for Basic Metabolic Research takes this evidence to the next level, revealing that the key to fighting AD may lie not just in the brain – but also in our muscles. At the center of this discovery is Cathepsin ...