VIEW EMBARGOED ARTICLE “Pharmacotherapy can help people living with obesity improve overall health, not just lose weight,” says Dr. Sue D. Pedersen, MD, endocrinologist and obesity medicine specialist in Calgary, and lead author of this guideline. “The goal of obesity medications is to improve metabolic, mechanical, and/or mental health, and improve quality of life, incorporating treatment goals that are important to each individual patient.” The guideline includes 6 new and 7 revised recommendations, reflecting the latest evidence since the 2022 and 2020 versions of the guideline. It takes the ...

VIEW EMBARGOED ARTICLE Cannabis potency is increasing — The concentration of tetrahydrocannabinol (THC) has increased fivefold in the last 20 years in Canada from about 4% to 20% in most legal dried cannabis. High-potency and regular cannabis use is linked to increased risk of psychosis — The risk of psychosis is increased in people using high-potency THC (more than 10% THC), people using it frequently, and those who are younger and male. A history of mental disorders (depression, anxiety, etc.) also appears to increase ...

People who practised blowing through a conch shell regularly for six months experienced a reduction in their symptoms of obstructive sleep apnoea (OSA), according to a small randomised controlled trial published today (Monday) in ERJ Open Research [1].   OSA is a common sleep disorder where breathing repeatedly stops during the night due to a blocked airway. It leads to loud snoring, restless sleep and daytime sleepiness. It also increases the risk of high blood pressure, heart disease, and stroke.   Blowing ...

Research by sports scientists reveals that high-performance athletes face unique mental health challenges despite the well-established benefits of physical activity for depression prevention and treatment. While moderate exercise is widely recognized for its positive impact on mental health, elite athletes experience specific pressures that can contribute to depression, including performance nerves, injury concerns and identity crises. These findings are detailed in the comprehensive new book, Physical ...

Tokyo, Japan – Researchers from Tokyo Metropolitan University have discovered a new pathway by which cells counteract the action of alovudine, an important antiviral and anticancer drug. The protein flap endonuclease-1 (Fen1) was found to improve cell tolerance by counteracting the toxic accumulation of another protein, 53BP1. A renewed spotlight on the underappreciated role of Fen1 promises not only new cancer treatments, but a way to gauge the efficacy of existing treatments.   Chain-terminating nucleoside analogs (CTNAs) are molecules which closely resemble nucleosides, the building blocks of DNA. They have been used as antiviral and cancer treatments ...

A paper published in BMJ Open today (Friday 8 August) led by researchers from the University of Birmingham highlights how few studies conducted into athlete help-seeking for mental health have looked into support provided by semi-formal sources such as coaches, with the majority of research conducted on formal sources. The team reviewed 104 relevant studies conducted around the world and found that while many athletes experience mental health issues, they face unique sport-specific barriers when seeking help and ...

A blink of an eye seems natural and instantaneous, but is it? Without a functioning eyelid, the eye can become dry, irritated and eventually lose the ability to see clearly. Now, a team of UCLA biomechanical engineers and ophthalmologists has uncovered new details about the muscle that controls blinking, offering a pathway toward developing blink-assisting prostheses. Published in the Proceedings of the National Academy of Sciences, the study found that the orbicularis oculi — the muscle that controls eyelid movement — contracts in complex patterns that vary by action and move the eyelid in more than just a simple up-and-down motion. The researchers studied how ...

(Santa Barbara, Calif.) — Touchdown airbursts — a type of cosmic impact that may be more common than the crater-forming, dinosaur-killing kind — remain somewhat less understood. UC Santa Barbara Earth Science Emeritus Professor James Kennett and collaborators continue to make the case that these high-energy events deserve closer attention.  “Touchdown events can cause extreme damage through very high temperatures and pressures,” Kennett said. “And yet they don’t necessarily form a crater, or they form ephemeral surface disturbances, but they’re ...

(SACRAMENTO, Calif.) — A new study in the International Journal of Hygiene and Environmental Health finds parents’ workplace chemical exposure may be linked to a range of behavioral challenges and developmental delays in their children with autism. Autism is a neurodevelopmental condition that is marked by challenges with social skills, communication struggles and repetitive behaviors. Autism traits can vary widely in how mild or strong they are. “Past research explored the impact of environmental factors on the likelihood of a child developing autism,” said Irva ...

Yale Study: Mobile Phone App Reduced Suicidal Behavior Among High-Risk Patients August 08, 2025 by Christopher Gardner   A mobile phone app designed to deliver suicide-specific therapy reduced suicidal behavior among high-risk psychiatric inpatients, according to a new study by scientists at Yale School of Medicine and The Ohio State University Wexner Medical Center and College of Medicine. The study, published Aug. 8, 2025 in JAMA Network Open, found that the app, OTX-202, reduced the recurrence ...

‘A tipping point’: An update from the frontiers of Alzheimer’s disease research    One-third of people older than 85 in the United States are estimated to live with Alzheimer’s disease today, according to the National Institute on Aging. The condition’s characteristic long, slow decline places an enormous burden on families and on society. While the need for new treatments is urgent, Alzheimer’s is a complex disease that requires multidisciplinary research across a wide range of specialties.   In a new article led by Yale’s Amy Arnsten, researchers from across numerous disciplines share an ...

Key takeaways Heavy use of antibiotics has led to bacterial strains that resist them, making some infections difficult to treat. Copper antimicrobials are increasingly used to reduce the emergence of resistant strains. New research shows that heavy use of copper leads to the evolution of copper-resistant E. coli bacteria that can also resist antibiotic drugs. Fortunately, when the use of copper is stopped, bacteria quickly revert to a less-resistant state, suggesting that alternating copper with other antimicrobials could be as effective without driving resistance.​​​ Copper has emerged as an ally in the battle against antibiotic-resistant bacteria. Copper sulfate ...

UNIVERSITY PARK, Pa. — New computer simulations that model every atom of a protein as it folds into its final three-dimensional form support the existence of a recently identified type of protein misfolding. Proteins must fold into precise three-dimensional shapes — called their native state — to carry out their biological functions. When proteins misfold, they can lose function and, in some cases, contribute to disease. The newly spotted misfolding results in a change to a protein’s structure — either a loop that traps another section of the protein ...

For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells. Similar to the instant kung fu education Keanu Reeves downloaded in “The Matrix,” MYOD plugs into muscle stem cell DNA and reprograms the cells to build muscle. MYOD also comes to the rescue when muscle tissue needs to be repaired after injury or to restore minor damage that occurs with athletic training or other physical activity. The transcription factor rallies nearby muscle stem cells to expand in number and become muscle ...

COLUMBUS, Ohio – People’s perceptions of the world are easily impacted by the angle at which they view objects in it, suggests a new study.   This finding, made by researchers from The Ohio State University, was revealed by testing people’s ability to estimate the steepness of a hill. The study, recently published in the journal Perception, showed that most people, regardless of their visual orientation — or line of sight  — will consistently overestimate its steepness.  Dennis Shaffer, lead author of the study and a professor of psychology at The Ohio State University’s Mansfield campus, said his team’s research aimed to understand ...

In the wake of a wildfire, there’s often an assumption that burned landscapes will be more susceptible to landslides. But new research from the University of Oregon suggests it’s not always that simple.   An analysis of the Columbia River Gorge, which runs along the border between Oregon and Washington, shows that steep, rocky watersheds in that area have been prone to debris flows and rockfall for thousands of years. Those events didn’t measurably increase after the Eagle Creek Fire, which scorched 47,000 acres of the gorge over the course of three months in 2017.  UO ...

Once viewed only as infectious invaders, bacteria are now understood to play an important role in overall health. For example, the gut microbiome—the community of microorganisms that inhabit the human gastrointestinal tract—has garnered much attention recently as studies have explored its relationship with health and disease. But what about the mouth? The mouth is the second most diverse human microbial system and, as the start of the digestive system, is directly and frequently exposed to the external environment. However, it has been vastly overshadowed by the focus on the gut. Now, a collaborative team including Modupe O. Coker of Penn ...

When several wildfires ignited in Los Angeles in early January of 2025, Miriam Marlier’s friends and neighbors came to her with questions about how to find reliable air quality information. Marlier is a UCLA scientist and a member of the Western Fire and Forest Resilience Collaborative (WFFRC), a program of Cary Institute of Ecosystem Studies led by Cary forest ecologist Winslow Hansen. Guided by decision makers, the collaborative conducts research to inform solutions to the Western US fire crisis. During the January fires, “people were urgently trying ...

Fukuoka, Japan—Researchers at Kyushu University have developed a novel organic molecule that simultaneously exhibits two highly sought-after properties: efficient light emission suitable for advanced displays and strong light absorption for deep-tissue bioimaging. This breakthrough addresses a long-standing challenge in molecular design, paving the way for next-generation multifunctional materials. Their study, published online in the journal Advanced Materials on July 29, 2025, was conducted in collaboration with ...

Tropical cyclone cluster events over the North Atlantic. This image from NOAA's GOES-16 satellite on September 14, 2020, shows five tropical systems spinning in the Atlantic basin at one time. From left to right: Hurricane Sally in the Gulf of Mexico, Hurricane Paulette east of the Carolinas, the remnants of Tropical Storm Rene in the central Atlantic, and Tropical Storms Teddy and Vicky in the eastern Atlantic. A total of 10 named storms formed in September 2020 — the most for any month on record. (Image credit: NOAA) Tropical cyclones, commonly known as typhoons or hurricanes, can form in clusters and impact coastal regions ...

Fighting off pathogens is a tour de force that must happen with speed and precision. A team of researchers at CeMM and MedUni Vienna led by Christoph Bock and Matthias Farlik has investigated how macrophages—immune cells that are the body’s first responders—master this challenge. Their study, published in Cell Systems (DOI: 10.1016/j.cels.2025.101346), offers a time-resolved analysis of the molecular processes that unfold when these cells encounter various pathogens. They developed a new method that combines gene editing and machine learning, which identified key regulators of ...

About The Study: In this cohort study of adults prescribed semaglutide, initiation was associated with reductions in weight and cardiovascular risk factors but increases in health care expenditures, excluding semaglutide costs. These findings suggest potential clinical benefits in routine practice, while highlighting the need to evaluate the long-term impact of semaglutide on economic outcomes. Corresponding Authors: To contact the corresponding authors, email Jason Abaluck, PhD, (jason.abaluck@yale.edu) ...

About The Study: In this cross-sectional study of 143 health conditions among persons in 50 states and Washington, DC, per capita pharmaceutical use was highest among white populations and lowest among Asian or Pacific Islander and Hispanic populations. However, after standardizing for age and disease prevalence (for 52 conditions with available data), prescription fills were substantially lower for Black populations relative to the all-population mean. These patterns varied by state, highlighting the need for local- and condition-specific ...

COLUMBUS, Ohio – A mobile phone app designed to deliver suicide-specific therapy reduced suicidal behavior among high-risk psychiatric inpatients, according to a new study by scientists at Yale School of Medicine and The Ohio State University Wexner Medical Center and College of Medicine. The study, published Aug. 8, 2025 in JAMA Network Open, found that the app, OTX-202, reduced the recurrence of post-discharge suicide attempts by 58.3% among patients who had previously attempted suicide. This reduction is a critical achievement for a group that is particularly vulnerable to repeated suicidal behaviors, the researchers said. Users of the app also experienced ...

Seoul National University College of Engineering announced that a research team led by Professor Seung Hwan Ko of the Wearable Soft Electronics Lab, Department of Mechanical Engineering, has developed a wearable electronic device that attaches to the skin like a bandage and enables real-time, continuous monitoring of blood pressure over extended periods.   Unlike conventional cuff-based blood pressure monitors that use an inflatable air bladder to apply pressure to the arm, this new technology continuously measures blood pressure with a compact, flexible electronic patch, garnering ...