Why do some lung transplant patients face higher rejection risk?
About one third of lung transplant recipients have a genetic variant that makes them more likely to develop chronic lung allograft dysfunction (CLAD), the primary cause of mortality after lung transplantation. However, it is unclear why some lung transplant recipients progress to CLAD while others do not. A study led by UCLA Health found that the cause could be a variant in the C3 gene, which makes it harder for the body to regulate the complement system, the part of the immune system that helps the body recognize and clear infections and debris, such as those occurring in the transplanted lung.
“Lung transplantation has the poorest long-term survival ...