About The Study: This study identifies growing healthspan (years lived in good health)-lifespan gaps around the globe, threatening healthy longevity across worldwide populations. Women globally exhibited a larger healthspan-lifespan gap than men.  Corresponding Author: To contact the corresponding author, Andre Terzic, MD, PhD, email terzic.andre@mayo.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.50241) Editor’s Note: Please see the article ...

Imagine a world in which a vaccine is a cream you rub onto your skin instead of a needle a health care worker pushes into your one of your muscles. Even better, it’s entirely pain-free and not followed by fever, swelling, redness or a sore arm. No standing in a long line to get it. Plus, it’s cheap. Thanks to Stanford University researchers’ domestication of a bacterial species that hangs out on the skin of close to everyone on Earth, that vision could become a reality. “We all hate needles — everybody does,” said Michael Fischbach, PhD, the Liu (Liao) Family Professor and a professor of bioengineering. “I haven’t found a single person ...

How can we explain the morphological diversity of living organisms?  Although genetics is the answer that typically springs to mind, it is not the only explanation. By combining observations of embryonic development, advanced microscopy, and cutting-edge computer modelling, a multi-disciplinary team from the University of Geneva (UNIGE) demonstrate that the crocodile head scales emerge from the mechanics of growing tissues, rather than molecular genetics. The diversity of these head scales observed in different crocodilian species therefore arises from the evolution of mechanical parameters, such as the growth ...

Investigators who previously found that a daily statin pill helps prevent heart attacks and strokes in people with HIV have now discovered a potential mechanism that may help to stabilize plaques and prevent their rupture in blood vessels. The research led by a team from Mass General Brigham is published in JAMA Cardiology. “Individuals with HIV tend to have an excess of noncalcified plaques that are vulnerable to rupture at a younger age, putting them at high risk for strokes, heart attacks, and sudden cardiac death,” said senior author Steven Grinspoon, MD, chief of the Metabolism Unit at Massachusetts General Hospital, a founding member of the Mass General Brigham healthcare ...

SAN FRANCISCO—Cells in the immune system don’t always fight; they often rest and wait for threats, like viruses or bacteria. When such threats emerge, the cells activate to defend the body. This delicate balance between rest and activation is crucial to our health—immune cells must be poised for activation to protect against threats, but if they’re overly active, autoimmune diseases can result. But what controls this important balance? In a new study published in Nature, scientists from Gladstone Institutes and UC San Francisco ...

HOBOKEN, N.J.—Wiley, one of the world’s largest publishers and a global leader in research and learning, today announced the release of the new version of its KnowItAll software, with numerous advances to accelerate spectral analysis and optimize workflows. KnowItAll 2025, the latest version of Wiley’s comprehensive software suite for spectral analysis and analytical data management, introduces a groundbreaking new tool to automate LC-MS analysis, enhanced data management, and numerous other features to streamline analysis across multiple ...

The arrival of Paxlovid in December 2021 marked another turning point in the COVID-19 pandemic—an effective antiviral that has since successfully treated millions. But like many antivirals before it, scientists know that at some point, Paxlovid is likely to lose some efficacy due to drug resistance. Researchers working to stay ahead of such emerging threats have now identified a wholly new way to treat SARS-CoV-2 infections—work that may have even broader implications. In fact, a new study by the Tuschl ...

The study presents the journey of designing and optimizing novel gut-restricted PHD inhibitors using the comprehensive generative chemistry engine Chemistry42. From initiation to preclinical candidate nomination, the program spanned only 12 months, during which approximately 115 molecules were synthesized and screened. Preclinical studies demonstrate ISM5411 to be gut-restricted and PHD-specific, thus reducing cardiovascular and systematical tumorigenic risks. Two Phase 1 clinical trials of ISM5411 for IBD are currently being conducted in parallel in Australia and China, with the last subject out in both ...

ANN ARBOR—Two University of Michigan faculty members have been elected to the National Academy of Inventors, the highest professional distinction awarded solely to inventors. Robert Bartlett, professor emeritus of surgery at the Medical School, and Zhen Xu, professor of biomedical engineering at the College of Engineering and professor of radiology and neurosurgery at the Medical School, were elected this month to the academy. Bartlett and Xu were nominated for being innovative researchers with extensive work translating discoveries into ...

“Monoclonal antibodies (mAb) have emerged as a promising tool in advancing personalized medicine.” BUFFALO, NY – December 11, 2024 – A news feature on the research paper “Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition” by Rackear et al. was published in Oncotarget’s Volume 15 on November 22, 2024, titled “Advancements in cell-penetrating monoclonal antibody treatment.“ This new publication by Sai Pallavi Pradeep and Raman Bahal from the  Department of Pharmaceutical Sciences at the University of Connecticut highlights significant advancements in ...

“These initial results suggest that individuals with SCD have a significantly higher cellular senescence burden which may contribute to premature aging, physiological decline, and excess morbidities.”  BUFFALO, NY- December 11, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 21 on November 14, 2024, entitled, “Adolescents and young adults with sickle cell disease exhibit accelerated aging with elevated T-cell p16INK4a expression.” Researchers Samuel R. Wilson, Natalia Mitin, ...

One of the great ambitions in the scientific world is to use tiny objects—such as molecules, viruses, and nanoparticles—as building blocks to construct essential macromolecules and materials, much like constructing intricate designs with LEGO bricks. However, achieving this requires overcoming significant challenges. Molecules in liquid environments move randomly and at extraordinary speeds—approximately many times faster than Usain Bolt at peak velocity—making precise manipulation extraordinarily challenging. To ...

Advancing the energy transition requires more than just technological innovation – it demands a joint effort between public and private actors. Giovanna Pinilla De La Cruz’s doctoral dissertation at the University of Vaasa, Finland, explores the mechanisms that foster collaboration in the energy sector, highlighting the Vaasa region’s energy cluster as a successful example. The transition to sustainable energy systems is one of the most pressing challenges of our time. Successfully navigating this transition requires coordinated ...

The TIME is a dynamic network composed of cancer cells, immune cells, and stromal components. During the early stages of tumorigenesis, the TIME attempts to eliminate abnormal cells through immune surveillance. However, as tumors evolve, they exploit the TIME to evade immune responses and promote tumor progression. Exosomes play a central role in this transformation by transporting bioactive molecules such as proteins, lipids, and nucleic acids, thereby influencing processes like immune escape, angiogenesis, and metastasis. HCC is particularly adept ...

(Toronto, December 11, 2024) JMIR Publications is proud to announce that JMIR Aging has been accepted for inclusion in the Science Citation Index Expanded (SCIE) and the Social Sciences Citation Index (SSCI). This accomplishment follows a selective re-evaluation process, where a limited number of  Emerging Sources Citation Index (ESCI) journals were considered for inclusion. To be eligible, journals needed to rank among the top three in their respective categories based on the latest Journal Citation Reports (JCR) data. JMIR Aging’s acceptance into SCIE and SSCI underscores its exceptional quality and impact, demonstrated by its outstanding performance ...

The majority of children who started smoking tobacco at age 10 years or in their later teens continued to smoke until their mid-twenties. Continuous smoking from childhood significantly increased the risk of premature heart damage, a new study shows. The study was conducted in collaboration between the Universities of Bristol and Exeter in the UK, and the University of Eastern Finland, and the results were published in the prestigious Journal of the American College of Cardiology (JACC). In the present study, 1,931 children drawn from the University of Bristol’s Children of the 90s cohort were followed up from age 10 until 24 years. ...

Cigarette smoking from childhood into early adulthood is associated with an increased risk of premature cardiac injury, according to a study published today in JACC, the flagship journal of the American College of Cardiology. This early damage to the structure and function of the heart can also significantly increase the chance of future cardiovascular (CVD) mortality in mid-life. “Our goal is to provide data for policymakers, clinicians, and public health practitioners on crucial timing for preventing smoking and its early consequences in youth,” ...

SAN ANTONIO —December 11, 2024 — Southwest Research Institute seeks support from residents or visitors of countries worldwide to assist with an international oil sampling program. Selected participants will be paid to purchase prequalified oil samples from retail stores and ship them to SwRI’s headquarters in San Antonio. Prequalification for the program will occur via an emailed photo exchange. Participants will purchase four 1-quart or 1-liter containers, or one 1-gallon container, of specified brands ...

Statistical and Engineering Approaches to Federated Learning: Comprehensive Benchmarking for Healthcare Applications   A groundbreaking study conducted by Duke-NUS Medical School evaluates federated learning (FL) methods to guide healthcare researchers in choosing privacy-preserving algorithms tailored to their clinical goals. This comprehensive benchmark compared statistical and engineering FL frameworks, offering actionable insights to balance predictive accuracy and interpretability in medical research.   Federated learning (FL) has emerged as a powerful tool in healthcare, enabling collaboration across institutions without compromising patient ...

Drug addiction has been one of America’s growing public health concerns for decades. Despite the development of effective treatments and support resources, few people who are suffering from a substance use disorder seek help. Reluctance to seek help has been attributed to the stigma often attached to the condition. So, in an effort to address this problem, researchers at Drexel University are raising awareness of the stigmatizing language present in online forums and they have created an artificial intelligence tool to help educate users and offer alternative language. Presented at the recent ...

Religious believers are no more generous than atheists – at least as long as they don’t know what the recipient believes in. Finding this out increases generosity significantly, mainly because people give more to those who share their religion. This is the conclusion of a study carried out at Linköping University, Sweden.  Nathalie Hallin is an atheist. Her colleague Hajdi Moche is a Christian. They both have a postdoc position at the Department of Behavioural Sciences and Learning at Linköping. Together they wanted to find out if a religious belief makes a person more generous, which research has so far disagreed on and they themselves have ...

SAN ANTONIO – Patients with high-risk, BRCA-positive breast cancer who received olaparib (Lynparza) after standard treatment continued to have better survival outcomes than those who received placebo after a median follow-up of 6.1 years, according to the latest results from the phase III OlympiA clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024. “The OlympiA trial examines adding one year of the oral PARP inhibitor olaparib after completion of standard treatment ...

SAN ANTONIO – Patients with germline BRCA mutations who were diagnosed with breast cancer at or before age 40 and who underwent a bilateral risk-reducing mastectomy (RRM) and/or a risk-reducing salpingo-oophorectomy (RRSO) had lower rates of recurrence, secondary breast and/or ovarian malignancies, and death than those who did not undergo these surgeries, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024. “The benefits of RRM and RRSO have been shown for BRCA-mutation carriers without a prior history of cancer, but their impact for BRCA-mutation carriers with a history of early-onset breast cancer is less clear,” ...

SAN ANTONIO – Imlunestrant, an investigational next-generation selective estrogen receptor degrader (SERD), improved progression-free survival in patients with endocrine therapy-pretreated, ER-positive, HER2-negative advanced breast cancer—as monotherapy in patients with ESR1 mutations and as combination therapy with abemaciclib (Verzenio) in all patients, regardless of ESR1 mutation status—according to results from the phase III EMBER-3 clinical trial presented at the San Antonio ...

Carnegie Mellon University Africa and Challenger Center Collaborate to Deliver STEM Programs Partnership Will Promote STEM Education and Careers to Secondary School Students in Africa Carnegie Mellon University Africa, CMU’s College of Engineering location in Kigali, Rwanda, and Challenger Center, will partner to deliver Challenger Center’s Virtual Missions to hundreds of secondary school students on the continent. This project will help grow the population of African students who are motivated to pursue higher education and careers in science, technology, engineering, and math (STEM) fields. Challenger Center’s Virtual Missions are space-themed experiences for students ...