A decade already passed from the first use of bioresorbable vascular scaffold in percutaneous coronary interventions. The first studies - by using surrogate endpoints - showed some superiority of BRS vs. metallic drug-eluting stent in terms of the so-called vascular restoration therapy with recovery of vasomotion and vascular pulsatility when the scaffold was absorbed. Nevertheless, after these first promising findings, larger and randomized clinical trials and subsequent meta-analyses, powered to hard clinical endpoints, showed that bioresorbable vascular scaffolds, made ...

Researchers at KU Leuven (Belgium) have developed a 3D printing technique that extends the possibilities of lateral flow testing. These tests are widespread in the form of the classic pregnancy test and the COVID-19 self-tests. With the new printing technique, advanced diagnostic tests can be produced that are quick, cheap, and easy to use. The COVID-19 pandemic has made everyone aware of the importance of rapid diagnosis. The sale of self-tests in pharmacies has been permitted in Belgium since the end of March. This self-test is a so-called lateral flow test. Using a ...

Analysis of The Autopsy, Toxicological, and Psychiatric Reports of Portugal's First Major Forensic Case: Part III https://doi.org/10.1080/20961790.2021.1898079 Announcing a new article publication for Forensic Sciences Research journal. In this review article the author Ricardo Jorge Dinis-Oliveira of the University Institute of Health Sciences (IUCS)-CESPU, Gandra, Portugal continues a three-part investigation of the "Crime of Flores Street" one of the most famous cases of poisoning which occurred in Portugal in the late 19th century. The case demonstrated the weaknesses of the Portuguese medicolegal system and attests to the importance of toxicological analysis. The first article ...

Most people who are infected with SARS-CoV-2 develop no or only mild symptoms. However, some patients suffer severe life-threatening cases of COVID-19 and require intensive medical care and a ventilator to help them breathe. Many of these patients eventually succumb to the disease or suffer significant long-term health consequences. To identify and treat these patients at an early stage, a kind of "measuring stick" is needed - predictive biomarkers that can recognize those who are at risk of developing severe COVID-19. First biomarker to predict severity of disease A team led by Professor Burkhard Becher at the Institute of Experimental Immunology at the University of Zurich, working with researchers from Tübingen, Toulouse and Nantes, has now discovered such ...

Due to the chaotic nature of the atmosphere, weather forecasts, even with ever improving numerical weather prediction models, eventually lose all skill. Meteorologists have a strong desire to better understand this process as they try to trace forecast error back to observational gaps and to provide a means for improvement. Root mean square error (rms, or its square, the variance distance) is often used to measure differences between simulated and observed fields. In this case, scientists measured the distance between a model forecast field within its grid and the verifying analysis field ...

A pioneering study by UCL scientists has discovered the presence of a harmful inflammatory protein in patients with symptomatic tuberculosis (TB). Researchers say, by targeting the IL-17 cytokine, a component produced naturally by the immune system in response to infection, excessive and damaging lung inflammation caused by TB may be significantly reduced to help speed up patient recovery. TB is an infection caused by the bacterium Mycobacterium tuberculosis and is the leading cause of death from infections worldwide. The World Health Organisation estimates that 1.4 million people died of TB disease worldwide in 2019. Explaining the experimental study, lead author Dr Gabriele Pollara (UCL Division of Infection & Immunity), ...

In a time of a global crisis such as the ongoing COVID-19 pandemic, it is easy to note how people move through different phases to buckle up for such unprecedented and arduous times. In the very beginning of the pandemic last year, we observed "an epidemic of fear", where it was all about the calamitous nature of a totally unknown virus and its worrying contagiousness and mortality rate. A few months later, with lockdown and restrictions already in place across the world, the fear was replaced by "an epidemic of explanations", where people even in their naivety, started to seek a sense of comfort by ...

Climate change, a pandemic or the coordinated activity of neurons in the brain: In all of these examples, a transition takes place at a certain point from the base state to a new state. Researchers at the Technical University of Munich (TUM) have discovered a universal mathematical structure at these so-called tipping points. It creates the basis for a better understanding of the behavior of networked systems. It is an essential question for scientists in every field: How can we predict and influence changes in a networked system? "In biology, one example is the modelling of coordinated neuron activity," says Christian Kühn, professor of multiscale and stochastic dynamics ...

Can expert commissions develop solutions for controversial issues that will enjoy broad democratic support? A team of researchers from the Institute for Advanced Sustainability Studies (IASS) has analysed the work of Germany's "Coal Exit Commission" using a set of new criteria. While the authors view positively the Commission's success in reaching a compromise, they criticise its failure to deliver an outcome that promotes the common good, particularly with respect to the high cost of the coal exit and its unambitious contribution towards Germany's climate goals, as well as the lack of public participation. On 29 April 2021, Germany's Federal Constitutional Court ruled that the provisions of the Climate Protection Act (2019) are incompatible ...

Only one in three fertilizations leads to a successful pregnancy. Many embryos fail to progress beyond early development. Cell biologists at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen (Germany), together with researchers at the Institute of Farm Animal Genetics in Mariensee and other international colleagues, have now developed a new model system for studying early embryonic development. With the help of this system, they discovered that errors often occur when the genetic material from each parent combines immediately after fertilization. This is due to a remarkably inefficient process. Human somatic cells typically have 46 chromosomes, which together carry ...

Ophthalmologists at New York Eye and Ear Infirmary of Mount Sinai have created a new technique to evaluate patients with sickle cell retinopathy and assess the disease before it progresses and leads to permanent vision loss. Using optical coherence tomography (OCT) angiography--an advanced imaging system that captures the motion of red blood cells in blood vessels non-invasively--the researchers discovered that sequential imaging of affected retinal blood flow in sickle cell patients can help assess how the disease is progressing and how effective their treatment is for reducing focal vascular strokes. Their study was published ...

Porcupines are frequently traded across Asia, and Indonesia, home to five species, is no exception. They are targeted for a number of reasons: their meat as an alternative source of protein, their bezoars consumed as traditional medicine, and their quills used as talismans and for decorative purposes. A new study examining seizure data of porcupines, their parts and derivatives in Indonesia found a total of 39 incidents from January 2013 to June 2020 involving an estimated 452 porcupines. The research was published in the open-access, peer-reviewed journal Nature Conservation. There are no harvest quotas for any porcupine species in Indonesia, which makes all hunting and trade in porcupines illegal. Of the five species found in the country, only the Sunda porcupine (Hystrix javanica) ...

COLUMBUS, Ohio - The symptoms of grief people feel for a loved one facing a life-limiting illness fluctuate over time, a new study found - suggesting that individuals can adjust to their emotional pain, but also revealing factors that can make pre-loss grief more severe. Researchers examined changes in the severity of pre-loss grief symptoms in people whose family members had either advanced cancer or dementia. The study is the first to document pre-loss grief at two points in time, and found that about 70% of participants' symptoms decreased over a month. However, compared to initial symptoms reported by participants, ...

An analysis of historical medical records found that men who were prenatally exposed during early gestation to the Dutch famine of 1944-1945 were 30 percent more likely to be overweight with a Body Mass Index of 25 or over at age 19, compared to a similar group not exposed to the famine. Professor L. H. Lumey at Columbia University Mailman School of Public Health led the study, which is published in the International Journal of Obesity. The study confirms evidence on the health risks of prenatal famine exposure, which also includes diabetes and schizophrenia. The mechanism by which famine exposure raises the risk for later excess weight is still unknown. The researchers speculate that famine exposure could lead to changes in DNA methylation that stimulate being overweight. Or that surviving ...

MRSA skin infections are often treated with intravenous injection of antibiotics, which can cause significant side effects and promote the development of resistant bacterial strains. To solve these problems, researchers at Karolinska Institutet in Sweden are developing a microneedle patch that delivers antibiotics directly into the affected skin area. New results published in Advanced Materials Technologies show that the microneedle patch effectively reduces MRSA bacteria in the skin. MRSA (methicillin resistant Staphylococcus aureus) skin infections are potentially lethal, ...

A new approach to tackling viruses by targeting the 'control centre' in viral RNA could lead to broad spectrum anti-viral drugs and provide a first line of defence against future pandemics, according to new research at the University of Birmingham. In a new study, published in Angewandte Chemie, researchers have shown how this approach could be effective against the SARS-CoV-2 virus responsible for the COVID-19 pandemic. Earlier modelling and in vitro analysis by the team and published in Chemical Science has also shown effectiveness against the HIV virus. Professor Mike Hannon, from the University of Birmingham's School of Chemistry, is co-lead author ...

Captive pelicans that are free to choose their own friendships are more likely to breed successfully on repeated occasions, new research suggests. Social network analysis on captive great white pelicans, led by the University of Exeter, found that providing social choice within the flock and allowing partnerships to form naturally led to improved breeding success. The study revealed that the pelicans chose their specific social relationships, and that there was a social structure across the flock, in which sub-adults (the equivalent of teenagers) spent more time with each other than with adult birds. Zoo-housed pelicans are common, but their breeding record is poor and they receive little ...

FRANKFURT. The virostatic agent remdesivir was developed to disrupt an important step in the propagation of RNA viruses, to which SARS-CoV-2 also belongs: the reproduction of the virus's own genetic material. This is present as RNA matrices with which the host cell directly produces virus proteins. To accelerate the production of its own proteins, however, RNA viruses cause the RNA matrices to be copied. To do so, they use a specific protein of their own (an RNA polymerase), which is blocked by remdesivir. Strictly speaking, remdesivir does not do this itself, but rather a substance that is synthesized from remdesivir in five steps when remdesivir penetrates a cell. In ...

A new Dartmouth-led study, published this week in the journal Pediatrics, has found that the disproportionate use of premiums within child-targeted TV advertising for children's fast-food meals is deceptive. The researchers examined thousands of advertisements from 11 fast-food restaurants, but one company--McDonald's--accounted for nearly all the airtime and, as a result, the findings. The researchers report that these ads often overemphasize premiums such as toy giveaways and games relative to the primary product being sold, the fast food itself. This marketing practice violates the industry's own guidelines--put in place to ensure that the use of premiums in ads is not deceptive or unfair--as young children lack the cognitive ability ...

Announcing a new article publication for BIO Integration journal. In this review the authors Yuheng Bao, Jifan Chen, Pintong Huang and Weijun Tong from Zhejiang University, Hangzhou, China discuss the synergistic effects of acoustics-based therapy and immunotherapy in cancer treatment. Cancer immunotherapy to enhance the autogenous immune response to cancer tissue is reported to be a promising method for cancer treatment. After the release of damage-associated molecular patterns, dendritic cells mature and recruit activated T cells to induce immune response. To trigger the release of cancer associated antigens, cancer acoustics-based therapy has various prominent advantages and has been reported in various research. ...

In a retrospective study of trauma patients over 65 years of age attended by KSS, it was found that, although a number of these patients had sustained a minor injury through seemingly innocuous mechanisms, a high proportion of this group required advanced clinical interventions and subsequent tertiary level care at a major trauma centre. The study also identified that dispatch time to these patients was typically longer, in particular in instances when KSS's critical care was requested by an ambulance crew already in attendance. With response time often critical to patient outcomes, the ...

Soon after E.L. James's Fifty Shades of Grey appeared in 2015, the book market was inundated with a flood of erotic bestsellers. People from all corners began wondering what this type of novel's secret of success could be. Now, a research team at the Max Planck Institute for Empirical Aesthetics (MPIEA) in Frankfurt/Main, Germany, has taken a closer look at the readership of erotic novels and investigated the causes of this literary predilection. In the media as well as the academy, contemporary erotica is typically dismissed as being of low literary value. Critics and scholars tend to classify its readers as having mediocre to poor taste, without, however, examining ...

Twenty dollars a month might not seem like a lot to pay for health insurance. But for people getting by on $15,000 a year, it's enough to make some drop their coverage - especially if they're healthy, a new study of Medicaid expansion participants in Michigan finds. That could keep them from getting preventive or timely care, and could leave their insurance company with a sicker pool of patients than before, say the researchers from the University of Michigan and University of Illinois Chicago. They have published their findings as a working paper through the National Bureau of Economic Research, ahead of publication in the American Journal of Health Economics. The study has implications for other states that require ...

DURHAM, N.C. - A potential new vaccine developed by members of the Duke Human Vaccine Institute has proven effective in protecting monkeys and mice from a variety of coronavirus infections -- including SARS-CoV-2 as well as the original SARS-CoV-1 and related bat coronaviruses that could potentially cause the next pandemic. The new vaccine, called a pan-coronavirus vaccine, triggers neutralizing antibodies via a nanoparticle. The nanoparticle is composed of the coronavirus part that allows it to bind to the body's cell receptors and is formulated with a chemical booster called an adjuvant. ...

A Flinders University researcher has finally fathomed why large numbers of killer whales gather at a single main location off the Western Australian southern coastline every summer. In a new paper published in Deep Sea Research, physical oceanographer Associate Professor Jochen Kampf describes the conditions which have produced this ecological natural wonder of orcas migrating to the continental slope near Bremer Bay in the western Great Australian Bight from late austral spring to early autumn (January-April). "The aggregation is connected to the local marine food web that follows from the upwelling of benthic particulate organic matter (POM) ...