TALLAHASSEE, Fla. -- Florida State University researchers have taken a big step forward in the fight against cancer with a discovery that could open up the door for new research and treatment options. Fanxiu Zhu, the FSU Margaret and Mary Pfeiffer Endowed Professor for Cancer Research, and his team uncovered a viral protein in the cell that inhibits the major DNA sensor and thus the body's response to viral infection, suggesting that this cellular pathway could be manipulated to help a person fight infection, cancer or autoimmune diseases. They named the protein KicGas. "We ...

Brief intervals of exercise during otherwise sedentary periods may offset the lack of more sustained exercise and could protect children against diabetes, cardiovascular disease and cancer, according to a small study by researchers at the National Institutes of Health Children who interrupted periods of sitting with three minutes of moderate-intensity walking every half hour had lower levels of blood glucose and insulin, compared to periods when they remained seated for three hours. Moreover, on the day they walked, the children did not eat any more at lunch than on ...

Washington, DC--People who developed Type 2 diabetes tended to take more antibiotics in the years leading up to the diagnosis than people who did not have the condition, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. A person develops diabetes, which is characterized by high blood sugar levels, when the individual cannot produce enough of the hormone insulin or insulin does not work properly to clear sugar from the bloodstream. More than 29 million Americans have diabetes, according to the Society's Endocrine ...

Washington, DC--Taking 3-minute breaks to walk in the middle of a TV marathon or other sedentary activity can improve children's blood sugar compared to continuously sitting, according to a new National Institutes of Health (NIH) study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). A sedentary lifestyle can put children at risk of developing pediatric obesity and metabolic health problems such as diabetes. Nearly 17 percent of children and teens nationwide are obese, according to the Society's Endocrine Facts and Figures report. ...

Washington, DC--For years after it was administered, growth hormone continued to reduce the risk of fractures and helped maintain bone density in postmenopausal women who had osteoporosis, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. Osteoporosis is a progressive condition that causes the bones to become weak and more likely to break. More than 10 million American adults have osteoporosis, and 80 percent of the people being treated for the condition nationwide are women, according to the Society's Endocrine ...

NASA's Aqua satellite and NOAA's GOES-West satellite provided temperature and cloud data on newborn Tropical Storm Jimena in the Eastern Pacific Ocean. Data from both satellites show the storm continues to consolidate. Tropical Depression 13E formed about 865 miles (1,390 km) south-southwest of the southern tip of Baja California, Mexico at 5 p.m. EDT (2100 UTC) on August 26. Six hours later, the depression strengthened into Tropical Storm Jimena at 11 p.m. EDT. A false-colored infrared image from Aug. 27 at 09:47 UTC (4:57 a.m. EDT) showed high, cold, strong thunderstorms ...

A molecular system that holds great promise for the capture and storage of carbon dioxide has been modified so that it now also holds great promise as a catalyst for converting captured carbon dioxide into valuable chemical products. Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have incorporated molecules of carbon dioxide reduction catalysts into the sponge-like crystals of covalent organic frameworks (COFs). This creates a molecular system that not only absorbs carbon dioxide, but also selectively reduces ...

Researchers reporting in the Cell Press journal Current Biology on August 27 have evidence in support of a clearly defined depth limit for deep-sea fishing in Europe. The findings come just as the European Union considers controversial new legislation to manage deep-sea fisheries, including a ban on trawling below 600 meters. "The most notable thing to consider about our findings is that the trend in catch composition over the depth range of 600 to 800 meters shows that collateral ecological impacts are significantly increasing while the commercial gain per unit effort ...

Isaac Newton was a classic neurotic. He was a brooder and a worrier, prone to dwelling on the scientific problems before him as well as his childhood sins. But Newton also had creative breakthroughs--thoughts on physics so profound that they are still part of a standard science education. In a Trends in Cognitive Sciences Opinion paper published August 27, psychologists present a new theory for why neurotic unhappiness and creativity go hand-in-hand. The authors argue that the part of the brain responsible for self-generated thought is highly active in neuroticism, which ...

Researchers at the Virginia Bioinformatics Institute at Virginia Tech have uncovered key cellular functions that help regulate inflammation -- a discovery that could have important implications for the treatment of allergies, heart disease, and certain forms of cancer. The discovery, to be published in the Oct. 6 issue of the journal Structure, explains how two particular proteins, Tollip and Tom1, work together to contribute to the turnover of cell-surface receptor proteins that trigger inflammation. "The inflammatory response can be a double-edged sword," said Daniel ...

Mobility between different physical environments in the cell nucleus regulates the daily oscillations in the activity of genes that are controlled by the internal biological clock, according to a study that is published in the journal Molecular Cell. Eventually, these findings may lead to novel therapeutic strategies for the treatment of diseases linked with disrupted circadian rhythm. So called clock-controlled - or circadian - genes are part of the internal biological clock, allowing humans and other light-sensitive organisms to adjust their daily activity to the cycle ...

Cold Spring Harbor, NY - When a large combat unit, widely dispersed in dense jungle, goes to battle, no single soldier knows precisely how his actions are affecting the unit's success or failure. But in modern armies, every soldier is connected via an audio link that can instantly receive broadcasts - reporting both positive and negative surprises - based on new intelligence. The real-time broadcasts enable dispersed troops to learn from these reports and can be critical since no solider has an overview of the entire unit's situation. Similarly, as neuroscientists at Cold ...

LA JOLLA--Every organism--from a seedling to a president--must protect its DNA at all costs, but precisely how a cell distinguishes between damage to its own DNA and the foreign DNA of an invading virus has remained a mystery. Now, scientists at the Salk Institute have discovered critical details of how a cell's response system tells the difference between these two perpetual threats. The discovery could help in the development of new cancer-selective viral therapies and may help explain why aging and certain diseases seem to open the door to viral infections. "Our ...

Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system "virus alert" that may one day boost cancer patients' response to immunotherapy drugs. An increasingly promising focus of cancer research, the drugs are designed to disarm cancer cells' ability to avoid detection and destruction by the immune system. In a report on the work published in the Aug. 27 issue of Cell, the Johns Hopkins-led research team says it has found a core group of genes related to both ...

Understanding exactly what is taking place inside a single cell is no easy task. For DNA, amplification techniques are available to make the task possible, but for other substances such as proteins and small molecules, scientists generally have to rely on statistics generated from many different cells measured together. Unfortunately, this means they cannot look at what is happening in each individual cell. Now, thanks to seven years of work done at the RIKEN Quantitative Biology Center and Hiroshima University, scientists can take a peek into a single plant cell and--within ...

In experiments with mouse tissue, UC San Francisco researchers have discovered that the adaptive immune system, generally associated with fighting bacterial and viral infections, plays an active role in guiding the normal development of mammary glands, the only organs--in female humans as well as mice--that develop predominately after birth, beginning at puberty. The scientists say the findings have implications not only for understanding normal organ development, but also for cancer and tissue-regeneration research, as well as in the highly active field of cancer immunotherapy, ...

Philadelphia, PA, Aug 27, 2015 - Having twins accounts for only 1.5% of all births but 25% of preterm births, the leading cause of infant mortality worldwide. Successful strategies for reducing singleton preterm births include prophylactic use of progesterone and cervical cerclage in patients with a prior history of preterm birth. To investigate whether the use of a cervical pessary might reduce premature births of twins, an international team of researchers conducted a large, multicenter, international randomized clinical trial (RCT) of approximately 1200 twin pregnancies. ...

DURHAM, N.H. - Researchers at the University of New Hampshire are turning to an unusual source --otoliths, the inner ear bones of fish -- to identify the nursery grounds of winter flounder, the protected estuaries where the potato chip-sized juveniles grow to adolesence. The research, recently published in the journal Transactions of the American Fisheries Society, could aid the effort to restore plummeting winter flounder populations along the East Coast of the U.S. In addition to showing the age of a fish, much like the rings in the cross-section of a tree, otoliths ...

When cloud top temperatures get colder, the uplift in tropical cyclones gets stronger and the thunderstorms that make up the tropical cyclones have more strength. NASA's Aqua satellite passed over Hurricane Ignacio and infrared data revealed cloud top temperatures had cooled from the previous day. Ignacio strengthened to a hurricane at 11 p.m. EDT on August 26. It became the seventh hurricane of the Eastern Pacific Ocean hurricane season. A false-colored infrared image of Hurricane Ignacio was made at NASA's Jet Propulsion Laboratory in Pasadena California, using data ...

Researchers from the Gladstone Institutes have revealed that HIV does not cause AIDS by the virus's direct effect on the host's immune cells, but rather through the cells' lethal influence on one another. HIV can either be spread through free-floating virus that directly infect the host immune cells or an infected cell can pass the virus to an uninfected cell. The second method, cell to cell transmission, is 100 to 1000 times more efficient, and the new study shows that it is only this method that sets off a cellular chain reaction that ends in the newly infected cells ...

At a time when cancer drug prices are rising rapidly, an innovative new study provides the framework for establishing value-based pricing for all new oncology drugs entering the marketplace. Using a highly sophisticated economic model, researchers from Winship Cancer Institute of Emory University and Georgia Institute of Technology used an example of a new lung cancer drug. The study findings will be published August 27, 2015 in JAMA Oncology. Researchers focused their investigation on a drug called necitumumab, which is awaiting approval from the U.S. Food and Drug ...

Use of the 21-gene recurrence test score was associated with lower chemotherapy use in high-risk patients and greater use of chemotherapy in low-risk patients compared with not using the test among a large group of Medicare beneficiaries, according to an article published online by JAMA Oncology. National Comprehensive Cancer Network (NCCN) guidelines recommend considering chemotherapy in estrogen receptor (ER)-positive, node-negative breast cancer for all but the smallest tumors. Several studies have suggested the 21-gene recurrence score assay (testing) is cost-effective ...

Microfocused ultrasound (MFU) treatment to tighten and lift skin on the face and neck appeared to be safe for patients with darker skin types in a small study that resulted in only a few temporary adverse effects, according to a report published online by JAMA Facial Plastic Surgery. Normal aging results in changes in the skin and underlying connective tissue. A system that uses MFU together with ultrasound visualization was developed to treat lax, aging skin. Previous clinical trials have shown the system to be a safe and effective noninvasive aesthetic treatment, according ...

PITTSBURGH, Aug. 27, 2015 - Researchers have identified in an animal model the molecular mechanisms behind resilience to noise-induced tinnitus and a possible drug therapy that could reduce susceptibility to this chronic and sometimes debilitating condition. The findings by a team from the University of Pittsburgh School of Medicine were published online in the journal eLife. Tinnitus is typically induced by exposure to loud noise and causes whistling, clicking, roaring and other phantom sounds. It is estimated that 5 to 15 percent of Americans suffer from tinnitus, said ...

Each spring, powerful dust storms in the deserts of Mongolia and northern China send thick clouds of particles into the atmosphere. Eastward winds sweep these particles as far as the Pacific, where dust ultimately settles in the open ocean. This desert dust contains, among other minerals, iron -- an essential nutrient for hundreds of species of phytoplankton that make up the ocean's food base. Now scientists at MIT, Columbia University, and Florida State University have determined that once iron is deposited in the ocean, it has a very short residence time, spending ...