In cancer, a lot of biology goes awry: Genes mutate, molecular processes change dramatically, and cells proliferate uncontrollably to form entirely new tissues that we call tumors. Multiple things go wrong at different levels, and this complexity is partly what makes cancer so difficult to research and treat. So it stands to reason that cancer researchers focus their attention where all cancers begin: the genome. If we can understand what happens at the level of DNA, then we can perhaps one day not just treat but even prevent cancers altogether. This drive has led a ...

In the last few years, several technology companies including Google, Microsoft, and IBM, have massively invested in quantum computing systems based on microwave superconducting circuit platforms in an effort to scale them up from small research-oriented systems to commercialized computing platforms. But fulfilling the potential of quantum computers requires a significant increase in the number of qubits, the building blocks of quantum computers, which can store and manipulate quantum information. But quantum signals can be contaminated by thermal noise generated by the movement of electrons. To prevent this, superconducting quantum systems must operate at ultra-low temperatures - less ...

NEW YORK, NY (May 10, 2021)--Scientists have discovered that many esophageal cancers turn on ancient viral DNA that was embedded in our genome hundreds of millions of years ago. "It was surprising," says Adam Bass, MD, the Herbert and Florence Irving Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center, who led the study published May 10 in Nature Genetics.  "We weren't specifically searching for the viral elements, but the finding opens up a huge new array of potential cancer targets that I think will be extremely exciting as ways to enhance immunotherapy." Fossil ...

DALLAS - May 10, 2021 - Scientists at UT Southwestern have discovered a key protein that helps the bacteria that causes Legionnaires' disease to set up house in the cells of humans and other hosts. The findings, published in Science, could offer insights into how other bacteria are able to survive inside cells, knowledge that could lead to new treatments for a wide variety of infections. "Many infectious bacteria, from listeria to chlamydia to salmonella, use systems that allow them to dwell within their host's cells," says study leader Vincent Tagliabracci, Ph.D., assistant professor of molecular biology at UTSW and member of the Harold C. Simmons Comprehensive Cancer Center. "Better understanding the tools they use to make this happen is teaching us some interesting biochemistry and ...

Many have assumed that the rates of major abdominal surgeries in adults over 65 is increasing over time as the U.S. population ages and as new technology renders surgical procedures safer for older adults. Contrary to this popular belief, a new study from the University of Chicago Medicine found the frequency of abdominal surgery in older adults is decreasing, especially among adults over the age of 85. The study, which examined data from 2002 to 2014, was published May 10 in the Journal of the American Geriatric Society. While the research was not able to determine the exact reasons for this shift, the results indicate that improvements ...

The relationship a dog has with its owner is related to its stress level. This is the conclusion of a newly published study from Linköping University, Sweden. The results, published in the journal Scientific Reports, also suggest that the link between stress and the owner's personality traits differs between dog breeds. Researchers at Linköping University have investigated whether the stress levels of dogs are affected by the people they live with. Stress levels for the past several months can be determined in both dogs and humans by measuring the levels of stress hormone stored in hairs as they grow. The researchers have collected hair from both dogs and owners, and measured levels of cortisol, the most important stress hormone, in them. They were interested in whether there ...

For organizations to reach their potential, they must leverage the expertise of their employees. However, research demonstrates that lower-status employees may not be heard because their "voices" are more likely to be ignored. New research from the University of Notre Dame is the first to show that peers can help boost marginalized voices, and at the same time benefit their own status, all while helping their organization realize the potential of its employees' diverse perspectives. Publicly endorsing -- or amplifying -- another person's contribution, while giving attribution to that person, enhances the status of both parties, according to "Amplifying Voice in Organizations," ...

Due to their complexity and microscopic scale, plant-microbe interactions can be quite elusive. Each researcher focuses on a piece of the interaction, and it is hard to find all the pieces let alone assemble them into a comprehensive map to find the hidden treasures within the plant microbiome. This is the purpose of review, to take all the pieces from all the different sources and put them together into something comprehensive that can guide researchers to hidden clues and new associations that unlock the secrets of a system. Like any good treasure map, there are still gaps in the knowledge and the searcher must be clever enough to fill in those gaps to find the "X". Without a map, there is only aimless wandering, but with a map, there is hope of finding the hidden ...

When a loved one dies, memories of that person become particularly valuable in connecting the mourners with the deceased. A new Weill Cornell Medicine online application, called Living Memory Home, offers a virtual and personal memorial space that allows mourners to deposit their memories and feelings about their loss and honor their loved one. Living Memory Home users are able to create a memorial space that they can personalize with photos and messages. They can customize a virtual cabin and choose an appropriate view. The curated set of questions prompt users to write memories ...

AMES, Iowa - New variants of the SARS-CoV-2 virus most likely will necessitate the development of more vaccine options in the years ahead, and a biomedical scientist at Iowa State University believes the "key" to that development lies in the way the virus binds to human cells. Michael Cho, a professor of biomedical sciences at Iowa State, is studying how to develop COVID-19 vaccines that target SARS-CoV-2's receptor-binding domain, or the part of the virus that docks with the host cellular receptor, angiotensin converting enzyme 2 (ACE2). This docking process allows the virus access to the host's cells, which leads to infection. Cho was the lead author of a study recently published in the peer-reviewed scientific journal Frontiers in Immunology detailing the ability of a vaccine ...

Unlike the oscillations of sound waves, the oscillations of light are so fast that extremely complex equipment is needed to observe them directly. However, it is possible to measure the frequencies of these oscillations indirectly with frequency combs. These combs are made up of a set of regularly spaced "teeth" where each tooth corresponds to a frequency. Used as a graduated ruler, they offer the possibility of measuring an optical frequency with great precision. This makes it possible, among other things, to measure variations in the distance between the Earth and the Moon with an accuracy ...

MADISON - By engineering a short chunk of protein, or peptide, that can prevent the attachment of human parainfluenza viruses to cells, researchers have improved a method in rodent models intended to help keep children healthy. Human parainfluenza viruses, or HPIVs, are the leading cause of childhood respiratory infections, responsible for 30% to 40% of illnesses like croup and pneumonia. The viruses also affect the elderly and people with compromised immune systems. To sicken people, HPIVs must latch onto cells and inject their genetic material to start making new viruses. HPIV3 is the most prevalent among these viruses. ...

Autistic people have far greater risks of long term physical health conditions than others, but the reasons for this remain unclear. New research from the University of Cambridge suggests that unhealthy lifestyle habits may be an important contributing factor. The results are published today in the journal Molecular Autism. Earlier research suggests that autistic people die 16-35 years younger than expected, and that greater health problems may contribute to this risk. The present study is the first to consider the diet, exercise, and sleep patterns of autistic adults and how these patterns may relate to health outcomes. The team at the Autism Research Centre in Cambridge developed an anonymous, online survey about lifestyle choices and daily habits, personal medical history, ...

The Covid-19 pandemic, like many other health crises, has had unequal effects on the U.S. population, with communities of color often hit the hardest. A new study co-authored by an MIT professor identifies a related challenge: Different social groups have different reactions to the fact that Covid-19 has generated those health inequities. More specifically, the study, based on a multilayered survey of U.S. residents, finds a divergence among racial groups when people are informed about the varying effects of the pandemic. Upon learning more about the social distribution of Covid-19, Black Americans tend to gain a better understanding of their risk. But among white Americans given the same information, ...

Australian photovoltaics researchers have made a 'cool' discovery: Singlet fission and tandem solar cells - two innovative ways to generate solar power more efficiently - also help to lower operating temperatures and keep devices running for longer. Tandem cells can be made from a combination of silicon - the most commonly used photovoltaics material - and new compounds like perovskite nanocrystals, which can have a larger bandgap than silicon and help the device to capture more of the solar spectrum for energy generation. Singlet fission, meanwhile, is a technique that produces twice the electronic charge carriers than normal for each photon of light that's absorbed. ...

A chemical that the NSW government has recently partially banned in firefighting has been found in the pups of endangered Australian sea lions and in Australian fur seals. The finding represents another possible blow to Australian sea lions' survival. Hookworm and tuberculosis already threaten their small and diminishing population, which has fallen by more than 60 percent over four decades. The new research - part of a long-term health study of seals and sea lions in Australia - identified the chemicals in animals at multiple colonies in Victoria and South Australia from 2017 to 2020. As well as in pups, the chemicals (Per- and polyfluoroalkyl substances - 'PFAS') were detected in juvenile ...

Despite the rapid and significant changes in consumption patterns witnessed during the initial months of the COVID-19 pandemic, Japanese households maintained their normal levels of greenhouse gases emissions. The "anthropause" -- reduction of human activity due to the pandemic -- made headlines last summer, but factory shutdowns and broken global supply chains did not translate into the adoption of eco-friendly lifestyles for the average household. "During the early COVID-19 period, we could witness lifestyle changes happening around us fast, so we decided to explore the environmental impacts of these lifestyle changes. Some other research at that period was showing that the production-side greenhouse gases emissions ...

The promise of a quantum internet depends on the complexities of harnessing light to transmit quantum information over fiber optic networks. A potential step forward was reported today by researchers in Sweden who developed integrated chips that can generate light particles on demand and without the need for extreme refrigeration. Quantum computing today relies on states of matter, that is, electrons which carry qubits of information to perform multiple calculations simultaneously, in a fraction of the time it takes with classical computing. The co-author of the research, Val Zwiller, Professor ...

Cerebral aneurysms are malformations caused by abnormalities on the walls of blood vessels in the brain. When these blood vessels rupture, about 30% of the sufferers die on the spot, giving these the rightful label of 'ticking bombs in the head'. Recently, a research team at POSTECH has come up with a new treatment that can disassemble these time bombs by filling the aneurysm in blood with a new method. In order to overcome the shortcomings of coil embolization, POSTECH's joint research team (Professor Joonwon Kim and Dr. Jongkyeong Lim of the Department of Mechanical Engineering with Professor ...

The skin, which covers the surface of the human body, is its largest organ. It is the first organ to show changes stemming from organ or physiological activity. It is especially common for diabetic patients to suffer from skin diseases or infections. Recently, a POSTECH research team has succeeded in creating a 3D artificial skin that enables observation of skin diseases of diabetic patients. A research team led by Professor Dong-Woo Cho and Minjun Ahn of POSTECH's Department of Mechanical Engineering and Professor Byoung Soo Kim of School of Biomedical Convergence Engineering at Pusan National University has ...

A decade already passed from the first use of bioresorbable vascular scaffold in percutaneous coronary interventions. The first studies - by using surrogate endpoints - showed some superiority of BRS vs. metallic drug-eluting stent in terms of the so-called vascular restoration therapy with recovery of vasomotion and vascular pulsatility when the scaffold was absorbed. Nevertheless, after these first promising findings, larger and randomized clinical trials and subsequent meta-analyses, powered to hard clinical endpoints, showed that bioresorbable vascular scaffolds, made ...

Researchers at KU Leuven (Belgium) have developed a 3D printing technique that extends the possibilities of lateral flow testing. These tests are widespread in the form of the classic pregnancy test and the COVID-19 self-tests. With the new printing technique, advanced diagnostic tests can be produced that are quick, cheap, and easy to use. The COVID-19 pandemic has made everyone aware of the importance of rapid diagnosis. The sale of self-tests in pharmacies has been permitted in Belgium since the end of March. This self-test is a so-called lateral flow test. Using a ...

Analysis of The Autopsy, Toxicological, and Psychiatric Reports of Portugal's First Major Forensic Case: Part III https://doi.org/10.1080/20961790.2021.1898079 Announcing a new article publication for Forensic Sciences Research journal. In this review article the author Ricardo Jorge Dinis-Oliveira of the University Institute of Health Sciences (IUCS)-CESPU, Gandra, Portugal continues a three-part investigation of the "Crime of Flores Street" one of the most famous cases of poisoning which occurred in Portugal in the late 19th century. The case demonstrated the weaknesses of the Portuguese medicolegal system and attests to the importance of toxicological analysis. The first article ...

Most people who are infected with SARS-CoV-2 develop no or only mild symptoms. However, some patients suffer severe life-threatening cases of COVID-19 and require intensive medical care and a ventilator to help them breathe. Many of these patients eventually succumb to the disease or suffer significant long-term health consequences. To identify and treat these patients at an early stage, a kind of "measuring stick" is needed - predictive biomarkers that can recognize those who are at risk of developing severe COVID-19. First biomarker to predict severity of disease A team led by Professor Burkhard Becher at the Institute of Experimental Immunology at the University of Zurich, working with researchers from Tübingen, Toulouse and Nantes, has now discovered such ...

Due to the chaotic nature of the atmosphere, weather forecasts, even with ever improving numerical weather prediction models, eventually lose all skill. Meteorologists have a strong desire to better understand this process as they try to trace forecast error back to observational gaps and to provide a means for improvement. Root mean square error (rms, or its square, the variance distance) is often used to measure differences between simulated and observed fields. In this case, scientists measured the distance between a model forecast field within its grid and the verifying analysis field ...