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NIH-led team sets new bar in retinal imaging

NIH-led team sets new bar in retinal imaging
2021-03-11
A team led by scientists at the National Eye Institute (NEI) has noninvasively visualized the light-sensing cells in the back of the eye, known as photoreceptors, in greater detail than ever before. Published in Optica, the researchers report how they improved imaging resolution by a third by selectively blocking the light used to image the eye. NEI is part of the National Institutes of Health. The achievement is the latest in an evolving strategy to monitor cell changes in retinal tissue that, in turn, will help identify new ways to treat and prevent vision loss from diseases such as age-related macular degeneration, a leading cause of blindness in people age ...

Non-O blood type may increase stroke risk among women who smoke, take oral contraceptives

2021-03-11
DALLAS, March 11, 2021 -- Non-O blood type may increase the risk of stroke among women who smoke and take oral contraceptives, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. According to the most recent comprehensive data (January 2020) from the Centers for Disease Control and Prevention (CDC), stroke is the fifth leading cause of death in the United States and a major contributor to long-term disability. Some risk factors ...

The secrets of the best rainbows on Earth

The secrets of the best rainbows on Earth
2021-03-11
Rainbows are some of the most spectacular optical phenomena in the natural world and Hawai'i has an amazing abundance of them. In a new publication, an atmospheric scientist at the University of Hawai'i at Mānoa makes an impassioned case for Hawaii being the best place on Earth to experience the wonder of rainbows. He begins by highlighting the Hawaiian cultural significance of rainbows, he reviews the science of rainbows and the special combination of circumstances that makes Hawai'i a haven for rainbows. "The cultural importance of rainbows is reflected in the Hawaiian language, which has many words and phrases to describe the variety of manifestations in Hawai'i," said author Steven Businger, professor in the UH ...

Depression risk higher after stroke vs. heart attack and female vs. male stroke survivors

2021-03-11
DALLAS, March 11, 2021 -- Stroke patients were nearly 50% more likely than heart attack patients to develop depression, and female stroke patients had a higher risk of depression than their male counterparts, according to two preliminary studies by the same research group to be presented at the American Stroke Association's International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. In what researchers described as one of the largest ...

Fine structure revealed of potential alternative to lead compound used in sensors

Fine structure revealed of potential alternative to lead compound used in sensors
2021-03-11
Researchers in Japan have used a novel, ultra-fast technique to explore the fine structure of a potential alternative material to lead titanate, a ferroelectric material widely used for sensors in many everyday devices. Understanding this structure takes us a step closer to eliminating these remaining sources of lead pollution. The study appeared in the materials science journal Acta Materialia on 21 January. Ferroelectric materials are used in a wide range of practical applications, from capacitors to memory cells, medical ultrasound to data storage and displays. These materials have a spontaneous polarization, or direction, of their electrons that can be switched back and forth via the application of an electric field, called ferroelectricity. Worldwide, society is increasingly ...

Neuroprotectant delivered to brain in nanoparticles may improve stroke treatment, outcomes

2021-03-11
DALLAS, March 11, 2021 -- When NA1, a neuroprotectant, was delivered to the brain in nanoparticles, it reduced stroke severity and improved survival in a mouse model of stroke, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. In an earlier human trial (the ESCAPE-NA1 trial), NA1, a small peptide designed to save brain cells from death after stroke, showed mixed results when NA1 was administered to patients undergoing clot removal for severe ...

Stroke survivors may have higher suicide risk

2021-03-11
DALLAS, March 11, 2021-- Stroke survivors may be more likely to attempt or die by suicide than people who have not had a stroke, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. This study will be simultaneously published in the American Heart Association's journal Stroke. Rates of depression among stroke survivors range from 28% to 35%, and stroke is considered an independent risk factor for depression. Since depression after a stroke has been associated with increased suicidal ...

Risk of dementia rises significantly with severity and number of strokes

2021-03-11
Contains updated information not available in the abstract. DALLAS, March 11, 2021 -- Having an ischemic stroke increases dementia risk, and that risk escalates with the number and severity of strokes, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. Ischemic stroke is the most common stroke type, accounting for 87% of all strokes. It occurs when a vessel supplying blood to the brain is obstructed. Stroke is the leading preventable cause ...

Even short delays in the ER may reduce the lifespan of stroke survivors

2021-03-11
DALLAS, March 11, 2021 — For every 10-minute delay between arrival at the emergency room (ER) and starting stroke treatment, patients with severe strokes may lose eight weeks of healthy life, according to preliminary research to be presented at the American Stroke Association’s International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. Delays between the onset of stroke symptoms and arrival at the hospital have long been known to cost lives and brain cells. “Our study showed that delays in treatment at the hospital ...

Retinal damage may signal higher risk of stroke, dementia and early death

2021-03-11
DALLAS, March 11, 2021 — Pictures of the retina may someday provide early warning signs that a person is at an increased risk of stroke and dementia, making it possible to take preventive measures, according to preliminary research to be presented at the American Stroke Association’s International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. Studies have shown that people with severe retinopathy, damage to the light-sensing ...

Structural racism: Communities with higher redlining scores had higher rates of stroke

2021-03-11
DALLAS, March 11, 2021 -- Discriminatory housing policies that restricted the sale or purchase of homes by race in certain neighborhoods across the U.S., called 'redlining,' which were established nearly a century ago and outlawed by the Fair Housing Act of 1968, were associated with higher rates of stroke in the same neighborhoods in 2017, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. "Differences in stroke rates, whether we are studying ischemic or hemorrhagic stroke, ...

African American women experience higher risk of pregnancy-related stroke, death

2021-03-11
DALLAS, March 11, 2021 -- African American women have a significantly increased risk of stroke and death during pregnancy and childbirth or in the period right after birth, compared to the risk of stroke among white women, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. "Each year, thousands of American women have a stroke or die from a stroke during pregnancy. The risk of stroke is also high following childbirth," said lead study author Mohamed ...

Adding triglyceride-lowering Omega-3 based medication to statins may lower stroke risk

2021-03-11
DALLAS, March 11, 2021 — Taking the triglyceride-lowering medication icosapent ethyl cut the risk of stroke by an additional 36% in people at increased risk of cardiovascular disease who already have their bad cholesterol levels under control using statin medications, according to preliminary research to be presented at the American Stroke Association’s International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. “Icosapent ethyl is a new ...

Long-term stroke death rates are higher among Black Medicare patients

2021-03-11
DALLAS, March 11, 2021 — A long-term look at Medicare patients shows that Black patients who have an ischemic stroke (blocked blood flow to the brain) die at a higher rate than white patients, even after accounting for preexisting health conditions, according to preliminary research to be presented at the American Stroke Association’s International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. “So much of what we know is limited to the early or acute phase — the first two weeks after a stroke,” said lead study author Judith H. Lichtman, Ph.D., M.P.H., professor and chair of the department of epidemiology at the Yale ...

Life-saving role of mobile stroke units at risk due to reimbursement limitations

2021-03-11
DALLAS, March 11, 2021 -- Ambulances with specialized staff and equipment to provide rapid stroke treatment report financial difficulties due to limited reimbursement from health care insurers, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. According to the most recent comprehensive data from the Centers for Disease Control ...

More heart infections and strokes in the US linked to national opioid epidemic

2021-03-11
DALLAS, March 11, 2021 — The ongoing U.S. opioid epidemic may have led to an increase in the number of strokes due to more bacterial infections of the heart, or infective endocarditis, according to preliminary research to be presented at the American Stroke Association’s International Stroke Conference 2021. The virtual meeting is March 17-19, 2021 and is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health. According to the most recent comprehensive data (January 2020) from the Centers for Disease Control and Prevention (CDC), stroke is the fifth leading cause of death in the United States and a major contributor to ...

Pandemic-related anxiety in pregnancy

Pandemic-related anxiety in pregnancy
2021-03-11
Pregnant women in Japan who responded to an online survey early in the COVID-19 pandemic demonstrated higher levels of anxiety compared to women undergoing fertility treatments and to pregnant women in Iran. The findings were published in the Journal of Affective Disorders Reports. "The pandemic has changed the social environments of pregnant women and fertility patients," says Tohoku University clinical psychologist Koubon Wakashima. For example, restrictions in Japan meant that pregnant women have been unable to participate in group parenting classes or travel to their parents' homes to receive traditional childbirth assistance. Medical institutions in the country reported fewer women accessing infertility ...

Nano-micelle packaging CRISPR/Cas9 components enables brain genome editing

Nano-micelle packaging CRISPR/Cas9 components enables brain genome editing
2021-03-11
March 10, 2021 - Kawasaki, Japan: The research group of Deputy Principal Research Scientist Dr. Satoshi Uchida (Associate Professor, Kyoto Prefectural University of Medicine) at the Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki-Japan, Abbreviation: iCONM) reported that optimized nano-micelles can induce efficient genome editing in the mouse brain. The 2020 Chemistry Nobel Prize-winning technology CRISPR/Cas9 holds great promise for treating various diseases such as congenital disorders and viral infections, by correcting the disease-specific genomic ...

Biological differences between females, males need to be considered in scientific studies

2021-03-11
WASHINGTON--Biological differences between females and males affect virtually every aspect of medicine and biomedical research. In a new Scientific Statement released today, the Endocrine Society called for sex differences to be studied thoroughly to improve public health. "When we understand the ways sex differences operate at baseline in health, which can either worsen the course of a disease to amplify differences in health outcomes, or protect against it, we can more effectively prevent and treat medical conditions," said Aditi Bhargava, Ph.D., of the University of California, San Francisco in San Francisco, Calif., and the chair of the writing group that authored the Society's Scientific Statement. For instance, SARS CoV-2 infection, cause of the COVID-19 pandemic, disproportionately ...

Lifestyle intervention is beneficial for most people with type 2 diabetes, but not all

2021-03-11
WINSTON-SALEM, N.C. - March 11, 2021- For people who are overweight or obese and have type 2 diabetes, the first line of treatment is usually lifestyle intervention, including weight loss and increased physical activity. While this approach has cardiovascular benefit for many, it can be detrimental for people who have poor blood sugar control, according to a study conducted by researchers at Wake Forest School of Medicine. In the study, published in the current issue of the journal Diabetes Care, the researchers re-evaluated the National Institutes of Health Action ...

The world's oldest crater from a meteorite isn't an impact crater after all

2021-03-11
Several years after scientists discovered what was considered the oldest crater a meteorite made on the planet, another team found it's actually the result of normal geological processes. During fieldwork at the Archean Maniitsoq structure in Greenland, an international team of scientists led by the University of Waterloo's Chris Yakymchuk found the features of this region are inconsistent with an impact crater. In 2012, a different team identified it as the remnant of a three-billion-year-old meteorite crater. "Zircon crystals in the rock are like little ...

Unhealthy weight gains, increased drinking reported by Americans coping with pandemic stress

Unhealthy weight gains, increased drinking reported by Americans coping with pandemic stress
2021-03-11
WASHINGTON -- As growing vaccine demand signals a potential turning point in the global COVID-19 pandemic, the nation's health crisis is far from over. One year after the World Health Organization declared COVID-19 a global pandemic, many adults report undesired changes to their weight, increased drinking and other negative behavior changes that may be related to an inability to cope with prolonged stress, according to the American Psychological Association's latest Stress in America™ poll. APA's survey of U.S. adults, conducted in late February 2021 by The Harris Poll, shows that a majority of adults (61%) experienced undesired weight changes - weight gain ...

New report reveals how the U.S. can renew its leadership in global health R&D

2021-03-11
The U.S. Congress and Biden-Harris administration have a clear opportunity to supercharge global health research and development (R&D) in the wake of a pandemic that has revealed both the sector's chronic neglect and amazing potential, according to a detailed agency-by-agency action plan released today by the nonprofit Global Health Technologies Coalition (GHTC). "The same core capabilities instrumental to defeating COVID-19 can also defeat diseases that have plagued humanity for generations--such as AIDS, tuberculosis, malaria and Ebola--while targeting emerging pathogens of pandemic potential," said GHTC Director Jamie Bay Nishi. "Developing vaccines in ...

Mapping the best places to plant trees

Mapping the best places to plant trees
2021-03-11
Reforestation could help to combat climate change, but whether and where to plant trees is a complex choice with many conflicting factors. To combat this problem, researchers reporting in the journal One Earth on December 18 have created the Reforestation Hub, an interactive map of reforestation opportunity in the United States. The tool will help foresters, legislators, and natural resource agency staff weigh the options while developing strategies to restore lost forests. "Often the information we need to make informed decisions about where to deploy reforestation already exists, it's just scattered across a lot of different locations," says author Susan Cook-Patton, a Senior Forest Restoration Scientist at the Nature Conservancy. "Not everybody has the ...

Lifestyle research studies to reduce risk of Alzheimer's respond to COVID-19 challenges

2021-03-11
The impact of the COVID-19 pandemic on public health is staggering; more than one hundred million cases and two million deaths worldwide. In response, most countries and local governments have taken substantial measures -- such as travel restrictions and physical distancing -- to keep their citizens safe. Both the pandemic and related protective measures pose challenges for ongoing clinical research studies seeking to treat and prevent the world's greatest public health emergencies including COVID-19, but also Alzheimer's disease and other dementia. In a new paper from the World-Wide FINGERS network in Alzheimer's ...
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