UNSW medical researchers have found a way to starve pancreatic cancer cells and 'disable' the cells that block treatment from working effectively. Their findings in mice and human lab models - which have been 10 years in the making and are about to be put to the test in a human clinical trial - are published today in Cancer Research, a journal of the American Association for Cancer Research. "Pancreatic cancer has seen minimal improvement in survival for the last four decades - and without immediate action, it is predicted to be the world's second biggest ...

The Indian public blamed foreigners, minority groups and doctors for the rapid spread of COVID-19 across the country during the first wave, due to misinformation, rumour and long-held discriminatory beliefs, according to an international study led by Monash University. This resulted in people refusing to get tested for fear of humiliation or public reprisals, which included attacks on Muslims and health care workers. However, when presented with accurate and reliable information about the virus spread, the Indian public back-pedalled on those negative sentiments and were more likely to get tested and seek medical help, highlighting the importance of health advice from credible sources. A ...

World-first nanotechnology developed by the University of South Australia could change the lives of thousands of people living with cystic fibrosis (CF) as groundbreaking research shows it can improve the effectiveness of the CF antibiotic Tobramycin, increasing its efficacy by up to 100,000-fold. The new technology uses a biomimetic nanostructured material to augment Tobramycin - the antibiotic prescribed to treat chronic Pseudomonas aeruginosa lung infections in severe cases of CF - eradicating the infection in as little as two doses. In Australia, cystic fibrosis (CF) affects one in 2500 babies - or one baby born every four days - causing severe impairments to a person's ...

Cancer death rates have fallen dramatically in the United States, but factor in obesity, as researchers did at the University of North Carolina Gillings School of Global Public Health, and the picture changes. In a study published May 10 in JAMA Network Open, researchers showed that obesity-related cancer deaths are improving, but at a slowing pace. Based on mortality data for 50 million people, deaths from cancers not associated with obesity -- that's lung cancer and skin cancer, among others - are declining at a rate almost three times faster than cancers linked to obesity, such as stomach, colorectal, uterine, thyroid and postmenopausal breast cancer. "These are cancers where we could see even larger mortality improvements with creative and practical tools to combat ...

Compared with the superresolution microscopy that bases on squeezing the point spread function in the spatial domain, the superresolution microscopy that broadens the detection range in the spatial frequency domain through the spatial-frequency-shift (SFS) effect shows intriguing advantages including large field of view, high speed, and good modularity, owing to its wide-field picture acquisition process and universal implementation without using special fluorophores labeling. To enable spatial-frequency-shift microscopy with a superresolution at the subwavelength scale, it is essential to use the near-field evanescent wave with a larger wave vector than the far-field propagation wave for illumination, which can be built on the integrated photonics, paving the way for compact ...

Researchers from Tokyo Medical and Dental University (TMDU), collaborating with scientists from the Marine Biological Laboratory (MBL) and RIKEN, develop a novel technique for live-cell fluorescent imaging which leads them to discover a new actin structure in starfish early embryos. Tokyo, Japan - Monitoring alignments of the building blocks of cells is important to understand how the cells are built. By collaborating with imaging scientists at the MBL, researchers from Japan have developed a new probe which they call POLArIS, allowing real-time imaging of molecular orientations in live cells. A fluorophore emits polarized light as it glows. The orientation of polarized fluorescence ...

It is difficult for us to succeed in whatever we set out to do if we lack motivation. We usually need it as a driving force to achieve both short- and long-term goals, from household chores to getting a degree. However, because of the ongoing pandemic, our lifestyles have been subjected to drastic and dynamic changes, and many work- and study-related activities are now carried out online exclusively. This, among other complex factors, have made it difficult for some people to stay focused and motivated, and psychology researchers are trying to find effective and widely applicable solutions to address such problems. In a END ...

COLUMBUS, Ohio - A new study's findings dispel the misconception that patients and providers are at high risk of catching COVID-19 at the dentist's office. SARS-CoV-2 spreads mainly through respiratory droplets, and dental procedures are known to produce an abundance of aerosols - leading to fears that flying saliva during a cleaning or a restorative procedure could make the dentist's chair a high-transmission location. Ohio State University researchers set out to determine whether saliva is the main source of the spray, collecting samples from personnel, equipment and other surfaces reached by aerosols during a range ...

Twenty-seven years ago, more than 1 million Rwandans were killed during the genocide against the Tutsi in Rwanda from April 7 to July 4, 1994. It is estimated that 100,000 to 250,000 women were raped during the 100-day genocide, and that 10,000 children were born as a result. A new study finds that Rwandans who were conceived by mothers who survived the 1994 genocide against the Tutsi have poorer adult health outcomes than those who were conceived by Rwandan mothers living outside the country at that time. In addition, those who were conceived through genocidal rape have poorer adult health ...

DALLAS, May 13, 2021 -- Higher body mass index (BMI) in adolescence is associated with a significantly higher risk of first ischemic stroke in adults under age 50 regardless of whether they had Type 2 diabetes, according to new research published today in Stroke, a journal of the American Stroke Association, a division of the American Heart Association. While rates of adolescent obesity and stroke among adults under the age of 50 years continue to rise around the world, the precise link between the two conditions is still not fully understood. "Adults who survive stroke earlier in life face poor functional outcomes, which can lead to unemployment, depression and anxiety," said study co-author Gilad Twig, M.D., M.P.H., Ph.D., an ...

It's a tough time to be a shark. Pollution, industrialized fishing, and climate change threaten marine life, and the populations of many top ocean predators have declined in recent years. In addition to studying sharks in the wild, scientists working to save sharks rely on ones living in zoos and aquariums so that they can help build breeding programs and learn more about the conditions sharks need to thrive. One important way the scientists do that is by playing matchmakers to the sharks, pairing up individuals in ways that increase genetic diversity. In a new study in Scientific Reports, scientists undertook the largest-ever effort to artificially inseminate sharks.Their work resulted in 97 new baby sharks, ...

Wild orangutans are known for their ability to survive food shortages, but scientists have made a surprising finding that highlights the need to protect the habitat of these critically endangered primates, which face rapid habitat destruction and threats linked to climate change. Scientists found that the muscle mass of orangutans on the island of Borneo in Southeast Asia was significantly lower when less fruit was available. That's remarkable because orangutans are thought to be especially good at storing and using fat for energy, according a Rutgers-led study in the journal Scientific Reports. The findings highlight ...

All modern life is composed of cells, from single-celled bacteria to more complex organisms such as humans, which may contain billions or even trillions of cells, but how life came to be cellular remains uncertain. New research led by specially appointed assistant professor Tony Z. Jia at the Earth-Life Science Institute (ELSI) at Tokyo Institute of Technology, along with colleagues from around the world (Japan, Malaysia, France, Czech Republic, India and the USA), shows that simple chemical compounds known as hydroxy acids, which were likely common on primitive Earth, spontaneously link together ...

Scientists have begun the search for extraterrestrial life in the Solar System in earnest, but such life may be subtly or profoundly different from Earth-life, and methods based on detecting particular molecules as biosignatures may not apply to life with a different evolutionary history. A new study by a joint Japan/US-based team, led by researchers at the Earth-Life Science Institute (ELSI) at the Tokyo Institute of Technology, has developed a machine learning technique which assesses complex organic mixtures using mass spectrometry to reliably classify them as biological or abiological. In season 1, episode 29 ("Operation: Annihilate!") of Star Trek, which aired in 1966, the human-Vulcan hybrid character ...

PULLMAN, Wash. - Rush hour will likely return when pandemic lockdowns lift, but a new study suggests that congestion pricing--policies that charge tolls for driving during peak hours--could not only cure traffic jams but also convince motorists it is safe to buy smaller, more efficient cars. Researchers from Washington State University and the Brookings Institution studied a sample of nearly 300 households in the Seattle area over a six-year period, finding that the more congested their commutes, the more likely they would buy bigger cars which they perceive as safer and more ...

New research presented at this year's European Congress on Obesity (held online, 10-13 May) shows that the obesity drug semaglutide reduces appetite, food cravings and energy intake in people given a meal where they could eat as much as they liked. The study is by Dr Dorthe Skovgaard, Novo Nordisk A/S (the manufacturer of the drug), Søborg, Denmark, and colleagues. Semaglutide, in the glucagon-like peptide-1 (GLP-1) analogue drug class, is currently available at the dose of 1.0 mg injected once weekly for the treatment of type 2 diabetes and is under development for chronic weight management at the dose ...

An early study of a new experimental drug to treat obesity known as cagrilintide shows that, when combined with semaglutide 2.4 mg, the combination leads to more weight loss than semaglutide 2.4 mg alone and is well tolerated. This phase 1 study, which was recently published in The Lancet will be presented at this year's European Congress on Obesity (held online, 10-13 May) by Dr Lone Enebo, Novo Nordisk A/S, Denmark, on behalf of her colleagues. Novo Nordisk A/S is the manufacturer of both drugs in this study. Combining medications with different modes of action may provide more effective treatment options for people with obesity. Weekly injections of cagrilintide, ...

Two-thirds of California prisoners who were offered a COVID-19 vaccine accepted at least one dose, according to a new study by researchers at the Stanford University School of Medicine. "We found that many incarcerated people in California prisons were willing to be vaccinated for COVID-19," said Elizabeth Chin, the lead author of the study and a PhD candidate in biomedical data science. "This is an encouraging sign for other states at an early stage of rolling out vaccination programs in their prisons and jails." The researchers also found that nearly half of those who initially turned down a COVID-19 vaccine accepted it when it was offered to them again. The finding is an important indication that vaccine hesitancy is not necessarily fixed. Two-thirds ...

The 1949 letter by the physicist and Nobel laureate discusses bees, birds and whether new physics principles could come from studying animal senses. It's a position still being realised within physics to this day, with a growing body of research and understanding of how animals such as birds and bees find their way around. Now a study led by RMIT University in Melbourne, Australia, discusses how recent discoveries in migratory birds back up Einstein's thinking 72 years ago. The previously unpublished letter was shared with researchers by Judith Davys - Einstein had addressed ...

If you did not catch the flu this year -- and there is an overwhelming chance that you did not -- you have COVID-19 to thank. It's a small consolation, given the enormously disruptive scope of the pandemic. But it's the focus of a new paper published in the journal Frontiers in Public Health by two Concordia researchers and their colleagues that studies the 2020 influenza figures from Canada, the United States, Australia and Brazil. The authors show there is a clear relationship between the implementation of COVID-mitigation measures such as hand-washing, masking and social distancing and the spread of the annual flu. They write that these preventive measures all but eliminated ...

The quest to create safer, more successful pregnancies is one of the top goals of modern science. While pregnancy is better understood today than ever before, with improvements in technology helping to lower the risk of negative outcomes, there is much researchers still don't know about a vital part of the pregnancy process: uterine fluid. Secreted by glands in the uterus during pregnancy, uterine fluid is believed to play an important role in supporting a developing embryo by sending information from the uterus to the embryo, along with a host ...

In 2020, stores sold out of garden seed, coops and rabbit cages. Now, we have an idea how much protein people can grow in their backyards. The 2020 meat shortages led many to wonder what to eat for protein when supply chains are disrupted. Some people turned to gathering eggs, raising animals and growing their own food. A team from Michigan Technological University and the University of Alaska Fairbanks found that the work is well worth it. In a new study published in Sustainability, the researchers looked at how a typical household with a typical backyard can raise chickens, rabbits or soybeans to meet its protein needs. People eat a lot of protein in the U.S. and the average person needs 51 grams of ...

MINNEAPOLIS/ST.PAUL (05/12/2021) -- In a study recently published in END ...

DURHAM, N.H.-- A national report from the University of New Hampshire shows close to one and a half million children each year visit a doctor, emergency room or medical facility as a result of an assault, abuse, crime or other form of violence. This is four times higher than previous estimates based only on data from U.S. emergency rooms for violence-related treatment. In their END ...

A portable, rapid testing platform can detect gonorrhea infections in patient samples in under 15 minutes, far faster than standard-of-care tests that can take hours or days. The platform accurately detected infections and determined resistance to a common antibiotic in 217 patient samples from sexual health clinics in Baltimore and Uganda. The technology's speed and low cost could empower quicker and more affordable gonorrhea testing in low-resource regions, as well as help combat the spread of drug-resistant strains. Rates of gonorrhea and other sexually transmitted ...