All modern life is composed of cells, from single-celled bacteria to more complex organisms such as humans, which may contain billions or even trillions of cells, but how life came to be cellular remains uncertain. New research led by specially appointed assistant professor Tony Z. Jia at the Earth-Life Science Institute (ELSI) at Tokyo Institute of Technology, along with colleagues from around the world (Japan, Malaysia, France, Czech Republic, India and the USA), shows that simple chemical compounds known as hydroxy acids, which were likely common on primitive Earth, spontaneously link together ...

Scientists have begun the search for extraterrestrial life in the Solar System in earnest, but such life may be subtly or profoundly different from Earth-life, and methods based on detecting particular molecules as biosignatures may not apply to life with a different evolutionary history. A new study by a joint Japan/US-based team, led by researchers at the Earth-Life Science Institute (ELSI) at the Tokyo Institute of Technology, has developed a machine learning technique which assesses complex organic mixtures using mass spectrometry to reliably classify them as biological or abiological. In season 1, episode 29 ("Operation: Annihilate!") of Star Trek, which aired in 1966, the human-Vulcan hybrid character ...

PULLMAN, Wash. - Rush hour will likely return when pandemic lockdowns lift, but a new study suggests that congestion pricing--policies that charge tolls for driving during peak hours--could not only cure traffic jams but also convince motorists it is safe to buy smaller, more efficient cars. Researchers from Washington State University and the Brookings Institution studied a sample of nearly 300 households in the Seattle area over a six-year period, finding that the more congested their commutes, the more likely they would buy bigger cars which they perceive as safer and more ...

New research presented at this year's European Congress on Obesity (held online, 10-13 May) shows that the obesity drug semaglutide reduces appetite, food cravings and energy intake in people given a meal where they could eat as much as they liked. The study is by Dr Dorthe Skovgaard, Novo Nordisk A/S (the manufacturer of the drug), Søborg, Denmark, and colleagues. Semaglutide, in the glucagon-like peptide-1 (GLP-1) analogue drug class, is currently available at the dose of 1.0 mg injected once weekly for the treatment of type 2 diabetes and is under development for chronic weight management at the dose ...

An early study of a new experimental drug to treat obesity known as cagrilintide shows that, when combined with semaglutide 2.4 mg, the combination leads to more weight loss than semaglutide 2.4 mg alone and is well tolerated. This phase 1 study, which was recently published in The Lancet will be presented at this year's European Congress on Obesity (held online, 10-13 May) by Dr Lone Enebo, Novo Nordisk A/S, Denmark, on behalf of her colleagues. Novo Nordisk A/S is the manufacturer of both drugs in this study. Combining medications with different modes of action may provide more effective treatment options for people with obesity. Weekly injections of cagrilintide, ...

Two-thirds of California prisoners who were offered a COVID-19 vaccine accepted at least one dose, according to a new study by researchers at the Stanford University School of Medicine. "We found that many incarcerated people in California prisons were willing to be vaccinated for COVID-19," said Elizabeth Chin, the lead author of the study and a PhD candidate in biomedical data science. "This is an encouraging sign for other states at an early stage of rolling out vaccination programs in their prisons and jails." The researchers also found that nearly half of those who initially turned down a COVID-19 vaccine accepted it when it was offered to them again. The finding is an important indication that vaccine hesitancy is not necessarily fixed. Two-thirds ...

The 1949 letter by the physicist and Nobel laureate discusses bees, birds and whether new physics principles could come from studying animal senses. It's a position still being realised within physics to this day, with a growing body of research and understanding of how animals such as birds and bees find their way around. Now a study led by RMIT University in Melbourne, Australia, discusses how recent discoveries in migratory birds back up Einstein's thinking 72 years ago. The previously unpublished letter was shared with researchers by Judith Davys - Einstein had addressed ...

If you did not catch the flu this year -- and there is an overwhelming chance that you did not -- you have COVID-19 to thank. It's a small consolation, given the enormously disruptive scope of the pandemic. But it's the focus of a new paper published in the journal Frontiers in Public Health by two Concordia researchers and their colleagues that studies the 2020 influenza figures from Canada, the United States, Australia and Brazil. The authors show there is a clear relationship between the implementation of COVID-mitigation measures such as hand-washing, masking and social distancing and the spread of the annual flu. They write that these preventive measures all but eliminated ...

The quest to create safer, more successful pregnancies is one of the top goals of modern science. While pregnancy is better understood today than ever before, with improvements in technology helping to lower the risk of negative outcomes, there is much researchers still don't know about a vital part of the pregnancy process: uterine fluid. Secreted by glands in the uterus during pregnancy, uterine fluid is believed to play an important role in supporting a developing embryo by sending information from the uterus to the embryo, along with a host ...

In 2020, stores sold out of garden seed, coops and rabbit cages. Now, we have an idea how much protein people can grow in their backyards. The 2020 meat shortages led many to wonder what to eat for protein when supply chains are disrupted. Some people turned to gathering eggs, raising animals and growing their own food. A team from Michigan Technological University and the University of Alaska Fairbanks found that the work is well worth it. In a new study published in Sustainability, the researchers looked at how a typical household with a typical backyard can raise chickens, rabbits or soybeans to meet its protein needs. People eat a lot of protein in the U.S. and the average person needs 51 grams of ...

MINNEAPOLIS/ST.PAUL (05/12/2021) -- In a study recently published in END ...

DURHAM, N.H.-- A national report from the University of New Hampshire shows close to one and a half million children each year visit a doctor, emergency room or medical facility as a result of an assault, abuse, crime or other form of violence. This is four times higher than previous estimates based only on data from U.S. emergency rooms for violence-related treatment. In their END ...

A portable, rapid testing platform can detect gonorrhea infections in patient samples in under 15 minutes, far faster than standard-of-care tests that can take hours or days. The platform accurately detected infections and determined resistance to a common antibiotic in 217 patient samples from sexual health clinics in Baltimore and Uganda. The technology's speed and low cost could empower quicker and more affordable gonorrhea testing in low-resource regions, as well as help combat the spread of drug-resistant strains. Rates of gonorrhea and other sexually transmitted ...

A new, noninvasive method for measuring brain blood flow with light has been developed by biomedical engineers and neurologists at the University of California, Davis, and used to detect brain activation. The new method, functional interferometric diffusing wave spectroscopy, or fiDWS, promises to be cheaper than existing technology and could be used for assessing brain injuries, or in neuroscience research. The work is published May 12 in Science Advances. "Now we can assess how well the brain regulates blood flow, and even detect brain activation noninvasively in adult humans, using principles similar to functional ...

MISSOULA - Only an anthropologist would treasure millennia-old human feces found in dry caves. Just ask Dr. Meradeth Snow, a University of Montana researcher and co-chair of UM's Department of Anthropology. She is part of an international team, led by the Harvard Medical School-affiliated Joslin Diabetes Center, that used human "paleofeces" to discover that ancient people had far different microorganisms living in their guts than we do in modern times. Snow said studying the gut microbes found in the ancient fecal material may offer clues to combat diseases like diabetes that afflict people living in today's industrialized societies. "We ...

Researchers used genetic engineering tools to create a virus that can enter specific neurons and insert into the prefrontal cortex a new genetic code that induces the production of modified proteins. In tests with mice, the alteration of these proteins was sufficient to modify brain activity, indicating a potential biomarker for the diagnosis of psychiatric disorders such as schizophrenia and autism. Sometimes referred to as the "executive brain", the prefrontal cortex is the region that governs higher-level cognitive functions and decision making. Studies of tissue from this brain region in patients with schizophrenia have detected alterations in two proteins: BDNF (brain-derived neurotrophic factor) and trkB (tyrosine receptor kinase B). The relationship ...

A new study by the University of Georgia revealed that more college students change majors within the STEM pipeline than leave the career path of science, technology, engineering and mathematics altogether. Funded by a National Institutes of Health grant and a National Science Foundation Postdoctoral Fellowship and done in collaboration with the University of Wisconsin, the study examined interviews, surveys and institutional data from 1,193 students at a U.S. midwestern university for more than six years to observe a single area of the STEM pipeline: biomedical fields of study. Out of 921 students ...

UCLA life scientists have identified six "words" that specific immune cells use to call up immune defense genes -- an important step toward understanding the language the body uses to marshal responses to threats. In addition, they discovered that the incorrect use of two of these words can activate the wrong genes, resulting in the autoimmune disease known as Sjögren's syndrome. The research, conducted in mice, END ...

A new study from North Carolina State University finds that greenhouse gas (GHG) emissions from standing dead trees in coastal wetland forests - colloquially called "tree farts" - need to be accounted for when assessing the environmental impact of so-called "ghost forests." In the study, researchers compared the quantity and type of GHG emissions from dead tree snags to emissions from the soil. While snags did not release as much as the soils, they did increase GHG emissions of the overall ecosystem by about 25 percent. Researchers say the findings show snags are important for understanding the total environmental impact of the spread of dead trees in coastal wetlands, known as ghost forests, ...

The immune system's main job is identifying things that can make us sick. In the language of immunology, this means distinguishing "self" from "non-self": The cells of our organs are self, while disease-causing bacteria and viruses are non-self. But what about the billions of bacteria that live in our guts and provide us with benefits like digesting food and making vitamins? Are they friend or foe? This isn't only a philosophical question. An immune system that mistakes our good gut bacteria for an enemy can cause a dangerous type of inflammation in the intestines called colitis. An immune system that looks the other way while gut microbes spill past their assigned borders is equally dangerous. Understanding ...

Our body's relationship with bacteria is complex. While infectious bacteria can cause illness, our gut is also teaming with "good" bacteria that aids nutrition and helps keep us healthy. But even the "good" can have bad effects if these bacteria end up in tissues and organs where they're not supposed to be. Now, research published in END ...

COLUMBUS, Ohio - Neighborhoods without opioid treatment providers likely serve as a widespread barrier to care for those who are ready to seek help, a new study has found. The study, led by researchers at The Ohio State University, appears today (May 12, 2021) in the journal PLOS ONE. "The study identified clear opioid treatment deserts that undoubtedly stand in the way of access to needed care and that likely exist throughout the state and the nation. These are areas where treatment providers should be setting up shop - we need a surge of resources into these areas," said Ayaz Hyder, an assistant professor in Ohio State's College of Public Health ...

Elephant Seals' Extreme Diving Allows Them to Exploit Deep Ocean Niche Using data captured by video cameras and smart accelerometers attached to female elephant seals, Taiki Adachi and colleagues show that the animals spend at least 80% of their day foraging for fish, feeding between 1,000 and 2,000 times per day. The unique glimpse at elephant seal foraging strategy shows how these large marine mammals exploit a unique ocean niche filled with small fish. The findings also may offer a way to monitor the health of the mesopelagic zone, the dark and cold ocean "twilight zone" ecosystem at 200 to 1,000 meters deep. Small mesopelagic fish dominate the world's ocean ...

A Johns Hopkins University-led team has created an inexpensive portable device and cellphone app to diagnose gonorrhea in less than 15 minutes and determine if a particular strain will respond to frontline antibiotics. The invention improves on traditional testing in hospital laboratories and clinics, which typically takes up to a week to deliver results--time during which patients can unknowingly spread their infections. The team's results appear today in Science Translational Medicine. "Our portable, inexpensive testing platform has the potential to change the game when it comes to diagnosing and enabling rapid treatment of sexually transmitted infections," said team leader Tza-Huei Wang, a professor of mechanical engineering ...

People who are genetically more likely to suffer from cardiovascular diseases may benefit from boosting a biomarker found in fish oils, a new study suggests. In a genetic study in 1,886 Asian Indians published in PLOS ONE today (Wednesday 12 May), scientists have identified the first evidence for the role of adiponectin, an obesity-related biomarker, in the association between a genetic variation called omentin and cardiometabolic health. The team, led by Professor Vimal Karani from the University of Reading, observed that the role of adiponectin was linked to cardiovascular disease markers that were independent of common and central obesity among the Asian Indian population. ...