In order to fight pathogens, mast cells regulate inflammatory reactions of the immune system. Both mast cells and neutrophils are white blood cells and are critical for the body's immune defense. A team of scientists around the immunologist Prof. Dr. Anne Dudeck and the bioengineer Jan Dudeck has discovered a crucial aspect of the communication between mast cells and neutrophils. These new findings may allow for developing innovative, targeted therapeutic strategies to dampen allergic responses and inflammatory reactions. The results have been published ...

ADELPHI, Md. -- A new quantum sensor can analyze the full spectrum of radio frequency and real-world signals, unleashing new potentials for soldier communications, spectrum awareness and electronic warfare. Army researchers built the quantum sensor, which can sample the radio-frequency spectrum--from zero frequency up to 20 GHz--and detect AM and FM radio, Bluetooth, Wi-Fi and other communication signals. The Rydberg sensor uses laser beams to create highly-excited Rydberg atoms directly above a microwave circuit, to boost and hone in on the portion of the spectrum being measured. The Rydberg atoms are sensitive to the circuit's voltage, enabling the device to be used as a sensitive probe for the wide range of signals in the RF spectrum. "All ...

People traditionally think that lungs and limbs are key innovations that came with the vertebrate transition from water to land. But in fact, the genetic basis of air-breathing and limb movement was already established in our fish ancestor 50 million years earlier. This, according to a recent genome mapping of primitive fish conducted by the University of Copenhagen, among others. The new study changes our understanding of a key milestone in our own evolutionary history. There is nothing new about humans and all other vertebrates having evolved from fish. The conventional understanding has been that certain fish shimmied landwards roughly ...

A global team of researchers has developed a new strategy for fast and reliable antibody tests, which can quantify the immune response induced by vaccination and reveal the timeline and stage of pathogen infection. Led by Professor Martin Hegner, Principal Investigator in CRANN and Trinity College Dublin's School of Physics, the team's one-step quantitative antibody tests are conducted using (blood) serum and are on a par with the gold-standard, enzyme-linked immunosorbent assay (ELISA) technique. The major advantage of the newly developed nano technique with respect to ELISA tests is that it is equally ...

ATLANTA - Researchers at Yerkes National Primate Research Center, Emory University, have developed a COVID-19 vaccine that has proven safe and effective in mice and monkeys. Results from this National Institute of Allergy and Infectious Diseases (NIAID)-funded study are published online today in Immunity. The Emory MVA COVID-19 vaccine approaches inducing protective immunity via modified vaccinia Ankara (MVA), a harmless version of a poxvirus that is well-known for its use in HIV/AIDS vaccines. Like the Moderna and Pfizer COVID-19 vaccines, the Emory MVA COVID-19 vaccine ...

New research carried out by City, University of London data scientist, Dr Andrea Baronchelli, and colleagues into the dark web marketplace (DWM) trade in products related to COVID-19, has revealed the need for the continuous monitoring of dark web marketplaces (DWMs) especially in light of the current shortage and availability of coronavirus vaccines. In their paper, Dark Web Marketplaces and COVID-19: before the vaccine published in the EPJ Data Science, Dr Baronchelli and his colleagues analysed 851,199 listings extracted from 30 DWMs between January 1, 2020 and November 16, 2020 before the advent of the availability of the coronavirus vaccine. They identify 788 listings directly related to COVID-19 ...

In data gathered and analyzed over 13 years, the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) Physics Frontiers Center (PFC) has found an intriguing low-frequency signal that may be attributable to gravitational waves. NANOGrav researchers - including a number from West Virginia University's (WVU's) Department of Physics and Astronomy and the Center for Gravitational Waves and Cosmology - measure the times of arrival of radio pulses from exotic stars called pulsars with large radio telescopes, including the Green Bank Telescope (GBT) in Pocahontas County, ...

Researchers have developed a new technique to protect rice seeds against fungal infections that can ruin up to half of all rice crops in the world. The biocontrol method, which involves inoculation of flowers with a different fungus that doesn't cause disease and using seeds harvested from the flower to grow crops, is even better at protecting rice plants from diseases than existing fungicide approaches, and could also be used against similar pathogens that affect other staple crops. The extremely destructive seedborne bakanae disease, which affects rice plants everywhere in the world that the staple crop is grown, is currently typically combatted with either chemical fungicides or ...

The new therapeutic approach is based on shutting down the viral hepatitis B genome located in the nucleus of infected liver cells. Upon infection of the liver cell, the viral genome is transformed inside the nucleus into a closed circular DNA molecule. This deoxyribonucleic acid is a stable molecule known as covalently closed circular DNA (cccDNA) and serves as the template for the production of new viruses. The cccDNA represents the central reservoir of the hepatitis B viruses and enables their persistence in the liver. The virologist Prof. Dr. Maura Dandri and her team at the UKE managed to prevent the HBV-cccDNA from producing further viruses in the animal model. The point of attack of their ...

Treating equine donor stem cells with a growth factor called TGF-β2 may allow them to avoid "tripping" the immune response in recipients, according to new research from North Carolina State University. The work could simplify the stem cell treatment process for ligament and tendon injuries in horses, and may also have implications for human stem cell therapies. Mesenchymal stem cell therapy is a promising avenue for treating musculoskeletal injuries - particularly tendon and ligament injuries - in horses. Mesenchymal stem cells are adult stem cells found in bone marrow that act as repair directors, producing secretions that recruit paracrine, or healing, factors to the site of injury. Just as blood cells have "types," ...

Gels are formed by mixing polymers into fluids to create gooey substances useful for everything from holding hair in place to enabling contact lenses to float over the eye. Researchers want to develop gels for healthcare applications by mixing in medicinal compounds, and giving patients injections so that the gel releases the active pharmaceutical ingredient over a period of months to avoid weekly or daily needle sticks. But standing in the way is a problem that's as easily understandable as the difference between using hair gel on a beach versus in a ...

Virtual 'exergaming' has become a popular way to exercise - especially among younger people - since the release of virtual reality (VR) fitness games on consoles such as Nintendo and Playstation. But while VR is undoubtedly raising fitness games to a whole new level, researchers at the University of South Australia are cautioning players about the potential side effects of VR, particularly in the first hour after playing. In a new study published in the Journal of Medical Internet Research, UniSA researchers investigated the consequences of playing one of the most popular VR exergames - Beat Saber* - finding that one in seven players still ...

Catalysts are key materials in modern society, enabling selective conversion of raw materials into valuable products while reducing waste and saving energy. In case of industrially relevant oxidative dehydrogenation reactions, most known catalyst systems are based on transition metals such as Iron, Vanadium, Molybdenum or Silver. Due to intrinsic drawbacks associated with the use of transition metals, such as rare occurrence, environmentally harmful mining processes, and toxicity, the fact that pure carbon exhibits catalytic activity in this type of reaction and thus has high potential as a sustainable substitution material is of high interest. To date, the development of carbon-based catalysts for oxidative dehydrogenation reactions may be divided into two ...

UCC palaeontologists have discovered new evidence that the fate of vertebrate animals over the last 400 million years has been shaped by microscopic melanin pigments. This new twist in the story of animal evolution is based on cutting-edge analyses of melanin granules - melanosomes - in many different fossil and modern vertebrates, including fish, amphibians, reptiles, birds and mammals. Melanin and melanosomes have traditionally been linked to outermost body tissues such as skin, hair and feathers, with important roles in UV protection and stiffening of tissues. Analyses of where different animals store melanin in the body, however, show that different vertebrate groups concentrate melanin in different organs, revealing ...

Ultrasound is not only used as an imaging technique but targeted pulses of ultrasound can be used as a highly accurate treatment for a range of brain diseases, for which there were previously only limited treatment options. Over the last few years, several revolutionary techniques of this kind have been developed, primarily in Toronto but also at MedUni Vienna. The Viennese technique improves brain functions by externally activating neurons that are still functional. Improvements can be expected in various neuropsychiatric brain diseases such as Alzheimer's, Parkinson's, stroke, Multiple Sclerosis, and neuralgia. A review jointly written by ...

Researchers at NUI Galway have identified genomic signatures in women developing the most common type of breast cancer that can be associated with long-term survival. The NUI Galway team analysed the genomes of breast cancer patients to look for associations with survival rates using advanced statistical techniques. Carried out by Lydia King during her studies in NUI Galway's MSc in Biomedical Genomics programme, the research has been published in the international journal PLOS ONE. Early detection by national screening programmes and timely treatment for patients diagnosed with "luminal" types of breast cancer have resulted in excellent prognoses with survival rates of over 80% within five years of treatment. The challenge of long-term survival ...

FOOD SCIENCE Sweden takes first, Denmark second and Norway lags at the bottom when it comes to how much organic food is served in canteens, kindergartens and other public sector workplaces across the three Nordic nations. This, according to the results of a new report by the University of Copenhagen. The report details plenty of potential for expanding the conversion to organic food service in the Danish public sector--a topic of discussion across the EU at the moment. Plate with potatoes and beef The governments of Denmark, Norway and Sweden are all keen on ramping up the amount of organic food ...

The FinnBrain research of the University of Turku has demonstrated for the first time that the stress the father has experienced in his childhood is connected to the development of the white matter tracts in the child's brain. Whether this connection is transmitted through epigenetic inheritance needs further research. Evidence from multiple new animal studies demonstrates that the changes in gene function caused by environment can be inherited between generations through gametes. In particular, nutrition and stress have been proven to cause these types of changes. However, these do not alter the nucleic acid sequence of ...

Today's digital world generates vast amounts of data every second. Hence, there is a need for memory chips that can store more data in less space, as well as the ability to read and write that data faster while using less energy. Researchers from the National University of Singapore (NUS), working with collaborators from the University of Oxford, Diamond Light Source (the United Kingdom's national synchrotron science facility) and University of Wisconsin Madison, have now developed an ultra-thin material with unique properties that could eventually achieve some of these goals. Their ...

A study published in the journal Pediatrics expands validation evidence for a new screening tool that directly engages preschool-age children during clinic visits to assess their early literacy skills. The tool, which is the first of its kind, has the potential to identify reading difficulties as early as possible, target interventions and empower families to help their child at home, according to researchers at Cincinnati Children's Hospital Medical Center. The Reading House (TRH) is an assessment for ages 3-5 based on a specially designed children's book, which was developed by John Hutton, MD, and his team at Cincinnati Children's. Screening takes five minutes and gauges performance levels ...

An inexpensive, long-lasting and easy-to-administer vaccine against malaria could be a game-changer for millions of people living in countries where the mosquito-borne disease is endemic. Lucie Jelinkova, a graduate student in the laboratory of Bryce Chackerian, PhD, professor in The University of New Mexico Department of Molecular Genetics & Microbiology, has identified a method that could make that dream into reality. In research recently published in the journal NPJ Vaccines, Jelinkova and colleagues at Johns Hopkins and Flinders University in Australia report ...

Tuberous sclerosis complex (TSC) afflicts as many as two million people around the world, affecting multiple organs, including lungs, brain, skin and kidneys. In about 80 percent of cases, it causes cysts and benign tumors to form in the kidney, eventually resulting in kidney failure. It's known that the disease is triggered by genetic mutations, but how these mutations lead to the formation of kidney cysts has been poorly understood - until now. Nephrologist Manoocher Soleimani, MD, a professor in The University of New Mexico Department of Internal Medicine, led a team that solved the puzzle and pointed the way toward potential ...

Twitter has long provided a short, sharp take on the community's fears, anxieties and experiences. Now, data scientists have analysed 94 million tweets from the first months of the pandemic to track COVID-19's effect on mental health in NSW. The research team used machine learning to develop a model able to capture data indicating depression, stress, anxiety and suicidal thoughts among users of the social media platform. The aim was to tap into popular technology to help public health experts identify changes in community levels of depression over time. The World Health Organisation highlighted early in 2020 that the pandemic would likely have a negative impact on mental health, with the disease affecting many facets of life including work, health and relationships. Researchers from ...

Senescent cells accumulate in organs during aging, promote tissue dysfunction, and cause numerous aging-related diseases like cancer. The cells arise through a process called "cellular senescence," a permanent cell cycle arrest resulting from multiple stresses. A collaborative research group led by Professor Makoto Nakanishi of the Institute of Medical Science, The University of Tokyo (IMSUT), and co-researchers has identified an inhibitor of the glutamate metabolic enzyme GLS1(*1) so that its administration selectively eliminates senescent cells in vivo. They confirmed that the GLS1 inhibitor eliminated senescent cells from various organs and tissues in aged mice, ameliorating age-associated tissue dysfunction and the symptoms of obese diabetes, arteriosclerosis, and ...

While scientists and historians have long surmised that etchings on stones and bones have been used as a form of symbolism dating back as early as the Middle Paleolithic period (250,000-45,000 BCE), findings to support that theory are extremely rare. A recent discovery by archeologists from the Hebrew University and the University of Haifa alongside a team from the Le Centre National de la Recherche Scientifique in France have uncovered evidence of what may be the earliest-known use of symbols. The symbols were found on a bone fragment in the Ramle region in central ...