Between 11% to 40% of adults in the United States experience chronic pain, and primary care physicians may feel ill-equipped to effectively and safely care for patients with chronic pain, addiction or both. Researchers from Tufts University conducted a study to evaluate the effectiveness of an interdisciplinary consultation service that supports primary care physicians who care for patients experiencing chronic pain and addiction. The goal was to identify new and effective strategies that clinics can use to support PCPs. From that interdisciplinary consultation service, the researchers collected ...

Bacteria that move around live on the edge. All the time. Their success, be it in finding nutrients, fending off predators or multiplying depends on how efficiently they navigate through their confining microscopic habitats. Whether these habitats are in animal or plant tissues, in waste, or in other materials. In a recent paper published in PNAS, a team of researchers led by McGill University, has described a number of factors affecting how five, very different, species of bacteria search and navigate through varied microfluidic environments which pose various decisional challenges. This increased understanding of the bacterial space searching and navigational 'strategies' has implications ...

Antibiotics: Patient Expectations and Doctors' Prescribing Habits May Contribute to Antimicrobial Resistance Inappropriate antibiotic prescribing for upper respiratory tract infections contributes to antibiotic resistance, making some bacterial infections difficult to treat. This often leads to higher medical costs, prolonged hospital stays and increased mortality. Still, many physicians report prescribing antibiotics at their patients' request. To address patients' expectations for antibiotic prescribing for URTIs, researchers conducted an experiment in which study participants were assigned brief educational videos to watch on a tablet immediately prior to their appointment. The authors randomized patients into three groups - one that viewed a presentation about ...

Skoltech scientists have created a new monitoring system for agricultural applications that performs real-time image segmentation on board the drone to identify hogweed. The research was published in a high-profile journal, IEEE Transactions on Computers. Sosnovsky's hogweed is equally hazardous for farming, local ecosystems, and human health. Direct contact with human skin, especially if aggravated by exposure to the Sun, causes severe burns that require continuous medical care and take weeks to heal. The rampant spread of Sosnovsky's hogweed has become a real environmental disaster that extends across the whole of ...

Individuals with diabetes are at greater risk of developing oral health issues, like gum disease, yet care for these linked health issues are usually disconnected, split between primary care and dental care. A research team from the University of Amsterdam developed an intervention that provided primary care-based oral health information and dental referrals for patients with diabetes. In a cluster randomized controlled trial, 764 patients from 24 primary care practices received either the oral health support or standard primary care. Participants were asked to rate their oral health quality of life, as well as their general health and any oral health complaints, at the start and end of the study. Analysis showed that individuals who received the primary care-based oral health support ...

Though different fabrication approaches exist, two-step deposition is one of the main experimental techniques now used to make efficient, stable PSCs, especially on the industrial scale. The process involves first depositing lead iodide (PbI2) and then adding halide salts of monovalent cations such as methylammonium iodide (MAI) and formamidinium iodide (FAI) to convert it to perovskite. While this two-step deposition is better than other options, it is difficult to maintain reproducible high performance and long-term stability when scaling up, mostly because of a lack ...

EAST LANSING, Mich. - An acute loss of smell is one of the most common symptoms of COVID-19, but for two decades it has been linked to other maladies among them Parkinson's disease and dementia. Now, a poor sense of smell may signify a higher risk of pneumonia in older adults, says a team of Michigan State University researchers. "About a quarter of adults 65 years or older have a poor sense of smell," said Honglei Chen, a professor in the Department of Epidemiology and Biostatistics within MSU's College of Human Medicine. "Unlike vision or hearing impairment, this sensory deficit has been largely neglected; more than two-thirds of people with a poor sense of smell do not know they have it." In a first-of-its-kind study, Chen and his team found a possible link ...

Simon Fraser University researchers have designed a remarkably fast engine that taps into a new kind of fuel -- information. The development of this engine, which converts the random jiggling of a microscopic particle into stored energy, is outlined in research published this week in the END ...

Scientists now better understand early bacterial evolution, thanks to new research featuring University of Queensland researchers. Bacteria comprise a very diverse domain of single-celled organisms that are thought to have evolved from a common ancestor that lived more than three billion years ago. Professor Phil Hugenholtz, from the Australian Centre for Ecogenomics in UQ's School of Chemistry and Molecular Biosciences, said the root of the bacterial tree, which would reveal the nature of the last common ancestor, is not agreed upon. "There's great debate about the root of this bacterial tree of life and indeed whether bacterial evolution should even be described as a tree has been contested," Professor ...

Just a few changes to an enzyme's amino acids can be enough to dramatically change its function, enabling microbes to inhabit wildly different environments. University of Queensland microbiologist Associate Professor Ulrike Kappler, led by an international team of researchers, made this discovery when investigating how Haemophilus influenzae bacteria colonise the human respiratory system. "This disease-causing bacterium is supremely adapted to living in humans, so much so that they cannot survive anywhere else," Dr Kappler said. "It turns out that one enzyme, MtsZ, is the key player in this adaptation. "But, surprisingly, ...

Researchers have been able to reduce scarring by blocking part of the healing process in research that could make a significant difference for burns and other trauma patients. University of Queensland Professor Kiarash Khosrotehrani said scars had been reduced by targeting the gene that instructs stem cells to form them in an animal study. "The body's natural response to trauma is to make plenty of blood vessels to take oxygen and nutrients to the wound to repair it," Professor Khosrotehrani said. "Once the wound has closed, many of these blood vessels become fibroblast cells which produce the collagens forming the hard materials found in scar tissue. "We found that vascular stem cells determined whether a blood vessel was retained or gave rise to scar material ...

CORVALLIS, Ore. - A team of Oregon State University scientists has discovered a new class of anti-cancer compounds that effectively kill liver and breast cancer cells. The findings, recently published in the journal Apoptosis, describe the discovery and characterization of compounds, designated as Select Modulators of AhR-regulated Transcription (SMAhRTs). Edmond Francis O'Donnell III and a team of OSU researchers conducted the research in the laboratory of Siva Kolluri, a professor of cancer research at Oregon State. They also identified the aryl hydrocarbon receptor (AhR) as a new molecular target ...

Researchers looking to help people suffering from addiction, depression, and pain are studying how certain brain neurons operate to see if they can be controlled. In a paper published May 11 in Neuron, researchers at the University of Washington School of Medicine and Washington University in St. Louis, along with several other universities, successfully used a protein called parapinopsin to turn off brain circuits. This protein is found in lamprey - an ancient lineage of jawless fish similar to eel. Reserachers said the ability to inhibit neurons could eventually lead to turning ...

BUFFALO, N.Y. - Americans are in chronic pain, and a comprehensive new study exploring trends in this major public health concern reveals that what has been a long-standing and under-acknowledged problem is getting substantially worse. The findings, published in the latest issue of the journal Demography, suggest blanket increases across multiple measures, with pain rising in every adult age group, in every demographic group, and at every site of pain for which data exists. People today are experiencing more pain than individuals of the same age in earlier decades. In fact, each subsequent birth group is in greater pain than the one that came before it. "We ...

BOSTON - It's a real-life plot worthy of a classic spy novel: Researchers at Massachusetts General Hospital (MGH), the Dana-Farber Cancer Institute and other Boston-area research centers are turning the tables on glioblastomas, the most devastating and aggressive form of brain cancer, by transforming a type of cell that normally protects tumors and inhibits effective drug therapy into a stone-cold glioblastoma killer. Glioblastoma, a type of brain tumor, is rapidly fatal: Most patients die within two years of diagnosis despite aggressive therapies such as brain surgery, whole-brain radiation and chemotherapy. Despite hopes that a class of drugs known as immune checkpoint blockers (ICBs) - drugs that have revolutionized the treatment ...

DURHAM, N.C. -- With mosquito season upon us, people are stocking up on repellents to prevent itchy bites. Bug repellents are important because they don't just protect against the buzzing, blood-sucking little pests -- they also safeguard against the diseases they carry, which kill some 700,000 people worldwide each year. Surprisingly, despite widespread use, no one understood exactly how most mosquito repellents keep the insects away. Now researchers are starting to uncover the first pieces of the puzzle. A new study has identified a scent receptor in mosquitoes that helps them sniff out and avoid trace amounts of pyrethrum, a plant extract used for centuries to repel biting insects. One ...

INFORMS Journal Manufacturing & Service Operations Management Study Key Takeaways: The study looked at archival data on 240 U.S. federal government technology programs across 24 federal agencies. Researchers found that the practice of moving baseline targets is a key driver in continually increasing budgets for federal government technology programs. The componentization of a program into smaller work units and increasing the level of competency in program management can dampen this increase, resulting in significant cost savings. CATONSVILLE, MD, May 11, 2021 ...

HERSHEY, Pa. -- Over the past year, studies have revealed that certain pre-existing conditions, such as cancer, diabetes and high blood pressure, can increase a person's risk of dying from COVID-19. New research shows that individuals living with human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) -- an estimated 38 million worldwide, according to the World Health Organization -- have an increased risk of SARS-CoV-2 infection and fatal outcomes from COVID-19. In a new study, published in Scientific Reports, Penn State College of Medicine researchers found that people living ...

A newly described horned dinosaur that lived in New Mexico 82 million years ago is one of the earliest known ceratopsid species, a group known as horned or frilled dinosaurs. Researchers reported their find in a publication in the journal PalZ (Paläontologische Zeitschrift). Menefeeceratops sealeyi adds important information to scientists' understanding of the evolution of ceratopsid dinosaurs, which are characterized by horns and frills, along with beaked faces. In particular, the discovery sheds light on the centrosaurine subfamily of horned dinosaurs, of which Menefeeceratops is believed to be the oldest member. Its remains offer a clearer picture of the group's evolutionary path ...

Researchers have developed a global earthquake monitoring system that uses the Global Navigational Satellite System (GNSS) to measure crustal deformation. The monitoring system within seconds can rapidly assess earthquake magnitude and fault slip distribution for earthquakes of magnitude 7.0 and larger, making it a potentially valuable tool in earthquake and tsunami early warning for these damaging events, Central Washington University geophysicist Timothy Melbourne and colleagues report in the Bulletin of the Seismological Society of America. GNSS can potentially characterize a large earthquake much more rapidly than the global seismic network, ...

Covid-19 patients who receive oxygen therapy or experience fever show reduced gray matter volume in the frontal-temporal network of the brain, according to a new study led by researchers at Georgia State University and the Georgia Institute of Technology. The study found lower gray matter volume in this brain region was associated with a higher level of disability among Covid-19 patients, even six months after hospital discharge. Gray matter is vital for processing information in the brain and gray matter abnormality may affect how well neurons function and communicate. The study, published in the May 2021 issue of Neurobiology ...

A new approach to road safety that relies on design and engineering principles--the "Safe System" approach--could lead to dramatic reductions in vehicle-related deaths and injuries if implemented in the U.S., according to a report from a consortium of experts convened by researchers at Johns Hopkins Bloomberg School of Public Health and the Institute of Transportation Engineers. The Safe System approach engineers road systems so that they are safe when used intuitively, the way people tend to use them. A Safe System minimizes the chances for mistakes by drivers, pedestrians, and bicyclists, and reduces the intensity ...

Marie-Claude Bourgeois-Daigneault and her team at the CRCHUM are using mice to show how a combination of peptides and oncolytic viruses, used as an adjuvant, can provide effective immunization against cancer. In her laboratoryat the University of Montreal Hospital Research Centre (CRCHUM), Marie-Claude Bourgeois-Daigneault and a team of scientists usually modify viruses to make them specific to the cells of a tumour. Once in the patient's body, these viruses, called oncolytic viruses, infect and specifically destroy the cancer cells without touching healthy cells. These viruses can even stimulate the immune system so that it is better armed to recognize and kill malignant cells. This is immunotherapy. In a study published in Nature Communications, the scientific team at the University ...

NEW YORK (May 11, 2021) - A group of scientists say now is the time to talk about reintroducing jaguars (Panthera onca) into the U.S. In a study published today in the journal Conservation Science and Practice, the authors provide a prospective framework for this effort and describe "righting a wrong" done to "America's Great Cat" in the Southwest more than 50 years ago. The big cats lived for hundreds of years in the central mountains of Arizona and New Mexico but were driven to local extinction by the mid-20th century, in part because of killing by government hunters. Authors of the study include a diverse set ...

Amsterdam, May 11, 2021 - It is projected that up to 152 million people worldwide will be living with Alzheimer's disease (AD) by 2050. To date there are no drugs that have a substantial positive impact on either the prevention or reversal of cognitive decline. A growing body of evidence finds that targeting lifestyle and vascular risk factors have a beneficial effect on overall cognitive performance. A new review in the Journal of Alzheimer's Disease, published by IOS Press, examines research that finds spiritual fitness, a new concept in medicine that centers on psychological and spiritual wellbeing, and Kirtan Kriya, a simple 12-minute meditative practice, may reduce multiple risk factors for AD. "The key point of this review is that making a commitment ...