WEST LAFAYETTE, Ind. - A neurotoxin called acrolein found in tobacco smoke that is thought to increase pain in people with spinal cord injury has now been shown to accumulate in mice exposed to the equivalent of 12 cigarettes daily over a short time period. One implication is that if acrolein is exacerbating pain its concentration in the body could be reduced using the drug hydralazine, which has been approved by the U.S. Food and Drug Administration for hypertension, said Riyi Shi (pronounced Ree Shee), a professor in Purdue University's Department of Basic Medical Sciences, ...

DURHAM, N.C. -- Citizens who get involved in science become more environmentally aware and willing to participate in advocacy than previously thought, according to a new study by researchers at Duke University's Nicholas School of the Environment. Citizen science projects can lead to broader public support for conservation efforts. The study, led by PhD student McKenzie Johnson, appeared in November in the journal Global Environmental Change. It surveyed 115 people who had recently participated in citizen science projects in India with the Wildlife Conservation Society ...

An enzyme that usually triggers strong allergic reactions now circulates in the veins of a group of mice without alerting the immune system. As INRS Énergie Matériaux Télécommunications Research Centre Professor Marc A. Gauthier explains in an article published in the journal Nature Communications, a polymer was used to camouflage the enzyme before it was injected into the rodents. This was achieved by coating the enzyme to avoid an immune response in a manner that does not compromise its activity. The first in vivo demonstration has opened the door ...

DURHAM, N.C. -- Scientists have developed a way to sniff out tiny amounts of toxic gases -- a whiff of nerve gas, for example, or a hint of a chemical spill -- from up to one kilometer away. The new technology can discriminate one type of gas from another with greater specificity than most remote sensors -- even in complex mixtures of similar chemicals -- and under normal atmospheric pressure, something that wasn't thought possible before. The researchers say the technique could be used to test for radioactive byproducts from nuclear accidents or arms control treaty ...

Alcohol use is a major risk factor for head and neck cancer. But an article published in the November issue of the journal Advances in Experimental Medicine and Biology shows that the chemical resveratrol found in grape skins and in red wine may prevent cancer as well. "Alcohol bombards your genes. Your body has ways to repair this damage, but with enough alcohol eventually some damage isn't fixed. That's why excessive alcohol use is a factor in head and neck cancer. Now, resveratrol challenges these cells - the ones with unrepaired DNA damage are killed, so they can't ...

West Orange, NJ. December 3, 2014. Brain injury researchers in New Jersey have identified retrieval practice as a useful strategy for improving memory among children and adolescents with traumatic brain injury (TBI). "Retrieval Practice as an Effective Memory Strategy in Children and Adolescents with TBI" (DOI: http://dx.doi.org/10.1016/j.apmr.2014.09.022) was published online ahead of print on October 10 by the Archives of Physical Medicine & Rehabilitation. This article is based on a collaborative study funded by Kessler Foundation and Children's Specialized Hospital. ...

As the two foolish pigs learned before running to their brother's solidly built house of bricks for safety, when the wolf comes calling, the quality of your shelter is everything. Animals in the wild have always instinctively known this. But changes to their habitat in the wake of human encroachment, climate change and a variety of environmental influences are affecting the predator-prey relationship and creating new "fearscapes" dotted with predation risks. To better understand what's happening, researchers are using innovative imaging techniques to map the properties ...

DETROIT - A common prostate cancer therapy should not be used in men whose cancer has not spread beyond the prostate, according to a new study led by researchers at Henry Ford Hospital. The findings are particularly important for men with longer life expectancies because the therapy exposes them to more adverse side effects, and it is associated with increased risk of death and deprives men of the opportunity for a cure by other methods. The research study has been published online in European Urology. The focus of the new study is androgen deprivation therapy (ADT), ...

Scientists have developed a novel treatment approach for persistent viral infections such as herpes. Using animal models of herpes simplex virus (HSV) infection, researchers show that blocking the activity of a host cell protein called LSD1 reduces HSV infection, shedding (release of viral particles) and recurrence. LSD1, which is essential for HSV's infectious cycle, modifies certain host proteins that control access to DNA. These modifications, known as "epigenetic" changes, help determine how and when genes are used. The collaborative effort, led by scientists at the ...

Kansas City, Mo. -- December 3, 2014 -- Results from more than 100 families with children affected by a broad range of neurologic and developmental disorders who underwent genomic testing to end their quest for a diagnosis, were published today in Science Translational Medicine. This is the first study to show that a genome-based diagnostic approach directly impacts patient care of both infants and older children with neurologic disorders. Forty-five percent of families received a diagnosis by exome or genome sequencing, fifty percent of those diagnosed had a change in ...

PULLMAN, Wash.--Washington State University researchers have found that it is counter-productive to kill wolves to keep them from preying on livestock. Shooting and trapping lead to more dead sheep and cattle the following year, not fewer. Writing in the journal PLOS ONE, WSU wildlife biologist Rob Wielgus and data analyst Kaylie Peebles say that, for each wolf killed, the odds of more livestock depredations increase significantly. The trend continues until 25 percent of the wolves in an area are killed. Ranchers and wildlife managers then see a "standing wave of livestock ...

Koala population distribution may be influenced by eucalyptus leaf toxin and nutrient content, especially in areas with low-quality food options, according to a study published December 3, 2014 in the open-access journal PLOS ONE by Eleanor Stalenberg from The Australian National University and colleagues. Scientists suspect that access to nutritious food plays a role in herbivore distribution and abundance, but there is still some debate over how variation in plant nutritional qualities may influence population distribution. Koalas predominantly eat eucalyptus leaves ...

A population of humpback whales that resides in the Arabian Sea may have been isolated for ~70,000 years, according to a study published December 3, 2014 in the open-access journal PLOS ONE by Cristina Pomilla, Ana Rita Amaral, Howard Rosenbaum, and Tim Collins of the Wildlife Conservation Society, the American Museum of Natural History, and their colleagues. The small, non-migratory population of Arabian Sea humpback whales is currently classified as "Endangered" on the IUCN Red List of Threatened Species. Scientists have limited data on the difficult-to-study population, ...

Aspects of the culture of research in UK higher education institutions (HEIs) can encourage poor research practices and hinder the production of high quality science, according to scientists who took part in a project exploring the ethical consequences of the culture of research led by the Nuffield Council on Bioethics. The findings of the project, which included a survey of almost 1000 scientists and others, suggest that scientists are motivated in their work to find out more about the world and benefit society, and that they believe collaboration, multidisciplinarity, ...

Birds learn new foraging techniques by observing others in their social network, 'copycat' behaviour that can sustain foraging 'traditions' that last years, according to a study of how innovations spread and persist in wild great tits (Parus major). The study involved experiments with eight local populations of great tits in Wytham Woods, Oxfordshire (UK). In five of the populations two male birds were trained to slide a puzzle box door either to the left or to the right. In three control groups two males were captured but not trained. The birds were then released back ...

Whether stubbing a toe or stroking a cat, the sensation of touch starts out as a mechanical force that is then transformed into an electrical signal conveying pain or other sensations. Tiny channels in neurons act as translators by helping to formulate that signal to the brain. However, scientists know little about the fine details of how these channels work. New work at Rockefeller University has revealed that one such channel in humans responds to mechanical force using a never-before-seen mechanism. Researchers led by Roderick MacKinnon, John D. Rockefeller Jr. Professor ...

A team of biomedical engineers at Washington University in St. Louis, led by Lihong Wang, PhD, the Gene K. Beare Distinguished Professor of Biomedical Engineering, has developed the world's fastest receive-only 2-D camera, a device that can capture events up to 100 billion frames per second. That's orders of magnitude faster than any current receive-only ultrafast imaging techniques, which are limited by on-chip storage and electronic readout speed to operations of about 10 million frames per second. Using the Washington University technique, called compressed ultrafast ...

VIDEO: NIH-funded scientists developed a promising new drug that may lead to spinal cord injury treatments. Click here for more information. Injections of a new drug may partially relieve paralyzing spinal cord injuries, based on indications from a study in rats, which was partly funded by the National Institutes of Health The results demonstrate how fundamental laboratory research may lead to new therapies. "We're very excited at the possibility that millions of people ...

Case Western Reserve scientists have developed a new chemical compound that shows extraordinary promise in restoring function lost to spinal cord injury. The compound, which the researchers dubbed intracellular sigma peptide (ISP), allowed paralyzed muscles to activate in more than 80 percent of the animals tested. The remarkable study, partly funded by the National Institutes of Health, appears in the December 3 edition of the journal Nature. Case Western Reserve University School of Medicine Professor of Neurosciences Jerry Silver, PhD, the senior author, led an international ...

Pilots are trained to guard against vertigo: a sudden loss of the sense of vertical direction that renders them unable to tell "up" from "down" and sometimes even leads to crashes. Coming up out of a subway station can produce similar confusion: For a few moments, you are unsure which way to go, until regaining your sense of direction. In both cases, the disorientation is thought to be caused by a temporary malfunction of a brain circuit that operates as a three-dimensional (3D) compass. Weizmann Institute scientists have now for the first time demonstrated the existence ...

Extensive areas of the world's deltas -- which accommodate major cities such as Shanghai, Dhaka and Bangkok -- will be drowned in the next century by rising sea levels, according to a Comment piece in this week's Nature. In the article, Dr. Liviu Giosan, a geologist with the Woods Hole Oceanographic Institution (WHOI), and colleagues call for maintenance efforts to be started now to avert the loss of vast expanses of coastline, and the consequent losses of ecological services, economic and social crises, and large-scale migrations. Problems start upstream: deltas are built ...

HOUSTON - (Dec. 3, 2014) - A novel mechanism - similar to how normal tissue stem cells respond to wounding - might explain why bladder cancer stem cells actively contribute to chemo-resistance after multiple cycles of chemotherapy drug treatment. Targeting this "wound response" of cancer stem cells can potentially provide a novel approach for therapeutic invention, said researchers from the National Cancer Institute-designated Dan L. Duncan Cancer Center at Baylor College of Medicine. The results of their study appear online in the journal Nature today. "Treatment ...

LA JOLLA, CA--December 3, 2014--A team led by biologists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in neuroscience by identifying the "mechanoreceptor" protein that mediates the sense of touch in mammals. Mice that lack the Piezo2 ion-channel protein in their skin cells and nerve endings lose nearly all their sensitivity to ordinary light touch, but retain a mostly normal sensitivity to painful mechanical stimuli. "We can say with certainty that Piezo2 is the principal touch sensor in mammals," said Ardem Patapoutian, professor at TSRI ...

Researchers from the African Genome Variation Project (AGVP) have published the first attempt to comprehensively characterise genetic diversity across Sub-Saharan Africa. The study of the world's most genetically diverse region will provide an invaluable resource for medical researchers and provides insights into population movements over thousands of years of African history. These findings appear in the journal Nature. "Although many studies have focused on studying genetic risk factors for disease in European populations, this is an understudied area in Africa," says ...

ROSEMONT, Ill.--Compression fractures in the spine due to osteoporosis, a common condition causing progressive bone loss and increased fracture risk, are especially common in older women. A new study appearing in the December 3rd issue of the Journal of Bone & Joint Surgery (JBJS) found that patients who wore a brace as treatment for a spinal compression fracture had comparable outcomes in terms of pain, function and healing when compared to patients who did not wear a brace. Nearly 700,000 men and women suffer from a spinal compression fracture each year. These fractures, ...