A higher resting heart rate and lower heart rate variability in older adults at high risk of heart disease are associated with poorer ability to function in daily life as well as future decline, according to a new research in CMAJ (Canadian Medical Association Journal). "It has been hypothesized that heart rate and heart rate variability are markers of frailty, an increased vulnerability to stressors and functional decline," writes Dr. Behnam Sabayan, Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands, with coauthors. "However, ...

Lyme disease is becoming increasingly common in Canada, and Canadians with Lyme disease symptoms may seek diagnoses from laboratories in the United States, although many of the results will be false-positives, according to a commentary in CMAJ (Canadian Medical Association Journal). "Patients with chronic subjective symptoms without a diagnosis can be vulnerable and desperate for an answer as to the cause of their illness," writes Dr. Dan Gregson, divisions of Medical Microbiology and Infectious Diseases, departments of Pathology and Laboratory Medicine, and Medicine, ...

(Philadelphia, PA) - Early intervention facilitated by a digital health application for reporting symptoms of Chronic Obstructive Pulmonary Disease (COPD) provides key benefits for patients, according to the results of a Temple-led, two-year clinical study. COPD is a serious chronic respiratory disease that is often characterized by flare-ups, called acute exacerbations, in which the patient may experience increased coughing, mucus, shortness of breath, wheezing, and a feeling of tightness in their chest. If exacerbation symptoms are not detected and treated in a timely ...

(SACRAMENTO, Calif.) -- In addition to restricting when and where tobacco is used at work, UC Davis Health System research shows that employers can do something else to reduce smoking: raise wages. Published in the August issue of the Annals of Epidemiology, the study found that a 10 percent increase in wages leads to about a 5 percent drop in smoking rates among workers who are male or who have high school educations or less and improves their overall chances of quitting smoking from 17 to 20 percent. "Our findings are especially important as inflation-adjusted wages ...

Amsterdam, NL, August 31, 2015 - About 50% of patients with Parkinson's disease (PD) experience freezing of gait (FOG), an inability to move forward while walking. This can affect not only mobility but also balance. In a new study published in Restorative Neurology and Neuroscience, researchers report that repetitive transcranial magnetic stimulation (rTMS) can reduce FOG and improve other motor skills in PD patients. In a study conducted by researchers at the Sungkyunkwan University School of Medicine, Seoul, Korea, 17 PD patients experiencing FOG were treated with either ...

BOSTON - Clinicians at Boston Medical Center (BMC) showed that expanding the number of sites offering office-based opioid treatment with buprenorphine (OBOT B) utilizing addiction nurse care managers, trainings and technical support resulted in more physicians becoming waivered to prescribe buprenorphine and more patients accessing treatment at sites across Massachusetts. This model, highlighted online in the Journal of Substance Abuse Treatment, demonstrates the efficacy of this medication-assisted treatment modality as a sustainable way to treat greater numbers of patients ...

NASA's Aqua satellite and NOAA's GOES-East satellites provided views of Hurricane Jimena that showed it maintained a large eye and powerful thunderstorms around it. On August 31, Jimena continued moving through the Eastern Pacific as a major hurricane. An infrared image from NOAA's GOES-West satellite on August 31 at 8:00 a.m. EDT revealed that Hurricane Jimena's wide-eye continued to be cloud free. The GOES image also showed thick bands of powerful thunderstorms circling the eye. The Atmospheric Infrared Sounder or AIRS instrument aboard Aqua gathers infrared data ...

A bill to improve the nutritional value of fast food restaurant meals marketed to children--like McDonald's Happy Meals--could have a wide enough impact to reduce calories, fat, and sodium, according to a new study led by researchers at NYU Langone Medical Center. The study, which will publish in the American Journal of Preventive Medicine online on August 31, includes collaboration from NYU College of Global Public Health, NYU Wagner Graduate School of Public Service, and NYU Steinhardt School of Culture, Education, and Human Development. The "Healthy Happy Meals" ...

A team of scientists has successfully measured particles of light being "squeezed", in an experiment that had been written off in physics textbooks as impossible to observe. Squeezing is a strange phenomenon of quantum physics. It creates a very specific form of light which is "low-noise" and is potentially useful in technology designed to pick up faint signals, such as the detection of gravitational waves. The standard approach to squeezing light involves firing an intense laser beam at a material, usually a non-linear crystal, which produces the desired effect. For ...

In animals, numerous behaviors are governed by the olfactory perception of their surrounding world. Whether originating in the nose of a mammal or the antennas of an insect, perception results from the combined activation of multiple receptors located in these organs. Identifying the full repertoire of receptors stimulated by a given odorant would represent a key step in deciphering the code that mediates these behaviors. To this end, a tool that provides a complete olfactory receptor signature corresponding to any specific smell was developed in the Faculties of Science ...

Researchers at the Babraham Institute have discovered a strong physical gene interaction network that is responsible for holding genes in a silencing grip during early development. In the same way that people can interact with others in close proximity, say within the same room, or others millions of miles apart, there are also short- and long-range interactions within the genome forming a three-dimensional configuration where different parts of the genome come into contact with each other. The research, reported online in Nature Genetics, presents how key decision-making ...

Outpatient human immunodeficiency virus (HIV) health care facilities funded by the federal Ryan White HIV/AIDS Program (RWHAP) were more likely to provide case management, mental health, substance abuse and other support services than those facilities not funded by the program, according to an article published online by JAMA Internal Medicine. RWHAP was established in 1990 to provide funds to states, metropolitan areas and clinics to increase access to high-quality HIV care and treatment for low-income, uninsured and underinsured individuals and families affected by ...

Religious or spiritual considerations were discussed in 16 percent of family meetings in intensive care units and health care professionals only rarely explored the patient's or family's religious or spiritual ideas, according to an article published online by JAMA Internal Medicine. Understanding how frequently discussions of spiritual concerns take place - and what characterizes them - is a first step toward clarity regarding best practices of responding to spiritual concerns in advanced illness. Douglas B. White, M.D., M.A.S., of the University of Pittsburgh School ...

Women with multiple sclerosis (MS) who intended to breastfeed their infants exclusively for two months had a lower risk of relapse during the first six months after giving birth compared with women who did not breastfeed exclusively , according to an article published online by JAMA Neurology. About 20 percent to 30 percent of women with MS experience a relapse within the first three to four months after giving birth and there are no interventions for effective prevention of postpartum relapse. The effect of exclusive breastfeeding on postpartum risk of MS relapse is ...

It was long believed that acquired immunity--a type of immunity mediated by T- and B-cells--had memory, meaning that it could learn from new pathogens, making subsequent reactions more effective, whereas innate immunity--which is mediated by macrophages and other types of cells that react to certain molecules typically associated with pathogens--did not. However, it gradually became clear that things were not so simple. Plants and insects, which only have innate immunity, also seem to have immunological memory. Further, it has been reported that herpes virus infection increases ...

By changing the mouse model they use to study how the immune system responds to cancer, a team of researchers hopes to shift the focus for one emerging form of cancer immunotherapy back to the standard approach--relying on antigen-presenting dendritic cells--and away from the current upstart, macrophages. Although macrophages, like dendritic cells, also take up antigens, they are more likely to degrade them than present them to T cells. The recent emphasis on macrophages stems, in part, from promising, but problematic, efforts to develop an effective macrophage-driven ...

Cancer cells become addicted to glucose, which they use as their regular source of energy to grow and develop. Although this was observed over nine decades ago by the German physiologist, Otto Warburg; there is still not therapeutic strategy today that can effectively take advantage of this special energy requirement. The initial approach appears to be simple: the lack of glucose could specifically induce the death of cancer cells. A new study by the Spanish National Cancer Research Centre Cell and Cancer Unit, headed by the Cell Division and Cancer group of the Spanish ...

A UCSF-led team has developed a technique to build tiny models of human tissues, called organoids, more precisely than ever before using a process that turns human cells into a biological equivalent of LEGO bricks. These mini-tissues in a dish can be used to study how particular structural features of tissue affect normal growth or go awry in cancer. They could be used for therapeutic drug screening and to help teach researchers how to grow whole human organs. The new technique -- called DNA Programmed Assembly of Cells (DPAC) and reported in the journal Nature Methods ...

Scientists from the D'Or Institute of Research and Education (IDOR), the Federal University of Rio de Janeiro (UFRJ) and the Yale University School of Medicine have elucidated the chemical process behind a mysterious gastrointestinal disease that is becoming more frequent every day: the eosinophilic esophagitis (EoE), also known as the "asthma of the esophagus". The researchers identified a molecule which plays a key role in this condition and that can be a target in a new therapeutic strategy. The eosinophilic esophagitis is a chronic inflammatory disorder of the esophagus. ...

While the French High Council for Public Health (HCSP) made public on Monday, 24 August 2015, a positive opinion regarding the relevance of the 5-colour code for the public, a team of researchers (Inserm/INRA/Paris 13 University) directed by Serge Hercberg, on publication of their article in the journal Nutrients, demonstrated that the 5-colour nutrition label (5-CNL) is the most effective nutritional information system for allowing consumers to recognise and compare the nutritional quality of foods, including "at-risk" populations (older subjects, those with a lower educational ...

Amsterdam, NL, August 31, 2015 -- Every week in the U.S. an average of 645 people lose their lives to firearm violence and 1,565 more are treated in an emergency department for a firearm-related injury. Most of these events do not make headlines, but they account for about 7% of the premature deaths before age 65 in the U.S. In a special issue of Preventive Medicine, preventive medicine and health policy experts address a wide range of critical topics related to firearm violence, from the interaction of alcohol abuse with gun violence, effects of changes to gun laws in ...

Alzheimer's disease is associated with the appearance of characteristic neurotoxic protein aggregates in various regions in the brain. Chemical analysis of these insoluble deposits reveals that they are made up of a family of short protein fragments, referred to as beta-amyloid peptides, which are derived from a precursor protein called APP by the sequential action of two enzymes. An international team of researchers led by Christian Haass (Professor of Metabolic Biochemistry at LMU and Speaker for the German Center for Neurodegenerative Diseases in Munich) and Dr. Michael ...

ROCHESTER, Minn. -- About 20 percent of colorectal cancer patients have cancers that have spread (metastasized) beyond the colon at the time of their diagnosis. The liver is the most common site for these metastases. The approach to treating primary tumors within the colon and metastatic tumors in the liver continues to evolve; however, it typically involves chemotherapy plus surgical removal (resection) of both types of tumors. However, experts continue to debate whether surgical resection of primary tumors and metastatic tumors should be performed at the same time (synchronously) ...

LAWRENCE -- Renewable wind energy is experiencing a boom, with more wind turbines popping up across landscapes in the U.S. and abroad. Indeed, wind energy accounted for 3.3 percent of electricity generation in the United States in 2011, according to the U.S. Energy Information Administration. Globally, that number was 2.9 percent for the same year. But as wind turbines proliferate, researchers at the University of Kansas are looking at how these forests of turbines affect the wind itself. What happens to the wind when a larger number of wind turbines removes more and ...

NASA's Aqua satellite passed over Hurricane Ignacio and viewed the storm in infrared light, providing valuable temperature data. Aqua saw a weaker Ignacio moving parallel to the Hawaiian Islands. The Atmospheric Infrared Sounder or AIRS instrument aboard Aqua gathers infrared data that shows temperatures. That AIRS data was made into a false-colored infrared image from August 30 at 22:47 UTC (6:47 p.m. EDT) and showed high, cold, strong thunderstorms surrounded the center of Hurricane Ignacio. AIRS imagery also showed a thick band of thunderstorms spiraling into the ...