At a time when cancer drug prices are rising rapidly, an innovative new study provides the framework for establishing value-based pricing for all new oncology drugs entering the marketplace. Using a highly sophisticated economic model, researchers from Winship Cancer Institute of Emory University and Georgia Institute of Technology used an example of a new lung cancer drug. The study findings will be published August 27, 2015 in JAMA Oncology. Researchers focused their investigation on a drug called necitumumab, which is awaiting approval from the U.S. Food and Drug ...

Use of the 21-gene recurrence test score was associated with lower chemotherapy use in high-risk patients and greater use of chemotherapy in low-risk patients compared with not using the test among a large group of Medicare beneficiaries, according to an article published online by JAMA Oncology. National Comprehensive Cancer Network (NCCN) guidelines recommend considering chemotherapy in estrogen receptor (ER)-positive, node-negative breast cancer for all but the smallest tumors. Several studies have suggested the 21-gene recurrence score assay (testing) is cost-effective ...

Microfocused ultrasound (MFU) treatment to tighten and lift skin on the face and neck appeared to be safe for patients with darker skin types in a small study that resulted in only a few temporary adverse effects, according to a report published online by JAMA Facial Plastic Surgery. Normal aging results in changes in the skin and underlying connective tissue. A system that uses MFU together with ultrasound visualization was developed to treat lax, aging skin. Previous clinical trials have shown the system to be a safe and effective noninvasive aesthetic treatment, according ...

PITTSBURGH, Aug. 27, 2015 - Researchers have identified in an animal model the molecular mechanisms behind resilience to noise-induced tinnitus and a possible drug therapy that could reduce susceptibility to this chronic and sometimes debilitating condition. The findings by a team from the University of Pittsburgh School of Medicine were published online in the journal eLife. Tinnitus is typically induced by exposure to loud noise and causes whistling, clicking, roaring and other phantom sounds. It is estimated that 5 to 15 percent of Americans suffer from tinnitus, said ...

Each spring, powerful dust storms in the deserts of Mongolia and northern China send thick clouds of particles into the atmosphere. Eastward winds sweep these particles as far as the Pacific, where dust ultimately settles in the open ocean. This desert dust contains, among other minerals, iron -- an essential nutrient for hundreds of species of phytoplankton that make up the ocean's food base. Now scientists at MIT, Columbia University, and Florida State University have determined that once iron is deposited in the ocean, it has a very short residence time, spending ...

Women lag behind men in the lucrative computer science and technology industries, and one of the possible contributors to this disparity is that they're less likely to enroll in introductory computer science courses. A new study of 270 high school students shows that three times as many girls were interested in enrolling in a computer science class if the classroom was redesigned to be less "geeky" and more inviting. The results, by University of Washington researchers, reveal a practical way for teachers to help narrow the gender gap in computer science by helping ...

About 10 percent of mothers experienced chronic, persistent depressive symptoms two years after Hurricane Katrina slammed into the Gulf Coast, killing more than 1,800 people, displacing hundreds of thousands and causing widespread damage estimated at more than $100 billion, according to a Georgia State University study. While most people don't develop persistent depression after a major disaster like that, a small but significant number will, according to a study led by Dr. Betty S. Lai, assistant professor of epidemiology and biostatistics at the School of Public Health ...

A team of European researchers have developed a model to simulate the impact of tsunamis generated by earthquakes and applied it to the Eastern Mediterranean. The results show how tsunami waves could hit and inundate coastal areas in southern Italy and Greece. The study is published today (27 August) in Ocean Science, an open access journal of the European Geosciences Union (EGU). Though not as frequent as in the Pacific and Indian oceans, tsunamis also occur in the Mediterranean, mainly due to earthquakes generated when the African plate slides underneath the Eurasian ...

For over a century, nitroglycerin has been used medically - particularly in the treatment of angina, or chest pain. It is a safe, cheap and effective treatment. Now, according to the latest study in ecancermedicalscience, researchers find that nitroglycerin is the latest in a series of medicines that could be repurposed to treat cancer. The Repurposing Drugs in Oncology (ReDO) project, an international collaboration between the Anticancer Fund, Belgium, and US based GlobalCures, finds that existing and widely-used non-cancer drugs may represent a relatively untapped source ...

Physicists at the University of Basel succeed in synthesizing boron-doped graphene nanoribbons and characterizing their structural, electronic and chemical properties. The modified material could potentially be used as a sensor for the ecologically damaging nitrogen oxides, scientists report in the latest issue of Nature Communications. Graphene is one of the most promising materials for improving electronic devices. The two-dimensional carbon sheet exhibits high electron mobility and accordingly has excellent conductivity. Other than usual semiconductors, the material ...

When they're not being the stars of various animated movies, penguins are playing an important role in evolutionary studies. Penguins are unique among modern birds in that they 'fly' through the water. Although flightless in air, penguins have a number of adaptations which allow them glide effortlessly through the water. And some of these adaptations are in an unlikely part of their anatomy - their brains. Recent finds of fossil penguins from 35 million year old sediments in Antarctica have begun to shed light on the changes in penguin brains that accompanied their ...

More than a cause of a simple infection, viruses are often involved in the development of serious diseases. Such is the case with liver cancer, which often develops in an organ that has been weakened by hepatitis B or C virus. Researchers at Inserm, the Paris Public Hospitals (AP-HP), Paris Descartes University, Paris 13 University (USPC), and Paris Diderot University have just identified the role of a new virus, hitherto unsuspected, in the occurrence of a rare type of liver cancer. This study, based on follow-up and observation of 193 patients, is published in the 24 ...

Consumers aren't embracing electric cars and trucks, partly due to the dearth of charging stations required to keep them moving. Even the conservation-minded are hesitant to go electric in some states because, studies show, if fossil fuels generate the electricity, the car is no greener than one powered with an efficient gasoline. Charging cars by solar cell would appear to be the answer. But most cells fail to meet the power requirements needed to directly charge lithium-ion batteries used in today's all-electric and plug-in hybrid electric vehicles. Researchers at ...

New research published in Acta Obstetricia et Gynecologica Scandinavica, a journal of the Nordic Federation of Societies of Obstetrics and Gynecology, found that pregnant women in Sweden had inadequate levels of iodine in their diets. Proper iodine nutrition is necessary for neurological development of the fetus. Iodine is an element that is involved in the production of thyroid hormones. Pregnant and breastfeeding women need about 50% more iodine in the diets, and WHO recommends a total daily iodine intake of 250 μg/d for pregnant and lactating women. Medical evidence ...

Probiotics show no benefit for preventing or eliminating gastrointestinal colonization with drug-resistant organisms in patients in the intensive care unit compared to standard care, according to new research published online today in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America. "Our research suggests that probiotics do not help prevent gastrointestinal colonization with multidrug-resistant organisms in critically ill patients," said Jennie H. Kwon, DO, lead author of the study. This prospective, randomized ...

August 27, 2015 - Do you have problems with dry eyes? If so, you're not alone--it's one of the most common reasons for patient visits to eye care professionals. Recent years have seen significant progress in management of patients with dry eyes, according to the September special issue of Optometry and Vision Science, official journal of the American Academy of Optometry. The journal is published by Wolters Kluwer. "There has been a growing interest among clinicians and patients on treatment and management and origins of the signs and symptoms of dry eye," comments Anthony ...

This news release is available in French. Not even close to every person who faces challenges or lives with severe depression commits suicide. Some people are more vulnerable than others. A series of studies has shown that the way in which a person makes decisions is among the main factors that determines whether that person is protected from or vulnerable to suicide. High-risk decision-making was prevalent among many parents of individuals who committed suicide, which may serve to explain its apparent "inheritability". Dr. Fabrice Jollant, Assistant Professor ...

While most primary care physicians responding to a survey taken in late 2014 and early 2015 expressed confidence in their ability to identify potential cases of Ebola and communicate Ebola risks to their patients, only 50 to 70 percent of them gave answers that fit with CDC guidelines when asked how they would care for hypothetical patients who might have been exposed to Ebola. In addition, those who were least likely to encounter an Ebola patient - based on their location and characteristics of their patients - were most likely to choose overly intense management of patients ...

Knut, the famous polar bear of the Berlin Zoological Garden (Germany) died of encephalitis, as diagnosed soon after his death. However, the cause of his disease has remained elusive until now. A team of scientists from the German Center for Neurodegenerative Diseases (DZNE), the Leibniz Institute for Zoo and Wildlife Research (IZW) and the Charite - Universitaetsmedizin Berlin has now solved the case: The polar bear suffered from an autoimmune disease of the brain. This non-infectious illness is called "anti-NMDA receptor encephalitis", with symptoms in human patients similar ...

A team of international scientists, led by astronomers from Cardiff University's School of Physics and Astronomy, has shown for the first time that galaxies can change their structure over the course of their lifetime. By observing the sky as it is today, and peering back in time using the Hubble and Herschel telescopes, the team have shown that a large proportion of galaxies have undergone a major 'metamorphosis' since they were initially formed after the Big Bang. By providing the first direct evidence of the extent of this transformation, the team hope to shed light ...

Subject, verb, object: a triad that in spoken discourse (as well as written) can be arranged in different positions (six, in principle) although in the overwhelming majority of world languages, 86%, they occur in two forms: SVO ("Johnny eats the banana") and SOV ("Johnny the banana eats"). In particular, the latter is the most common and scientific literature supports the hypothesis that it is a basic form, perhaps the first to emerge when a new language or communication system is born. To back this up is the fact that over the course of history many languages have passed ...

Eating foods rich in amino acids could be as good for your heart as stopping smoking or getting more exercise - according to new research from the University of East Anglia (UEA). A new study published today reveals that people who eat high levels of certain amino acids found in meat and plant-based protein have lower blood pressure and arterial stiffness. And the magnitude of the association is similar to those previously reported for lifestyle risk factors including salt intake, physical activity, alcohol consumption and smoking. Researchers investigated the effect ...

Cells continually form membrane vesicles that are released into the cell. If this vital process is disturbed, nerve cells, for example, cannot communicate with each other. The protein molecule dynamin is essential for the regulated formation and release of many vesicles. Scientists of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and the Institute for Biophysical Chemistry of Hannover Medical School (MHH), together with researchers from the Freie Universität Berlin and the Leibniz-Institut für Molekulare Pharmakologie (FMP), ...

Products labeled with a Fair Trade logo cause prospective buyers to dig deeper into their pockets. In an experiment conducted at the University of Bonn, participants were willing to pay on average 30 percent more for ethically produced goods, compared to their conventionally produced counterparts. The neuroscientists analyzed the neural pathways involved in processing products with a Fair Trade emblem. They identified a potential mechanism that explains why Fair Trade products are evaluated more positively. For instance, activity in the brain's reward center increases and ...

This news release is available in German. The yields of many important crops in Europe have been stagnating since the 1990s. As a result, the input of organic matter into the soil - the crucial source for humus formation - is decreasing. Scientists from the Technical University Munich (TUM) suspect that the humus stocks of arable soils are declining due to the influence of climate change. Humus, however, is a key factor for soil functionality, which is why this development poses a threat to agricultural production - and, moreover, in a worldwide context. In their ...