LONDON, UK - 30 August, 2015: Heart attack patients without heart failure derive no benefit from the addition of mineralocortoid receptor antagonists (MRA), to standard therapy, results of the ALBATROSS study show. The Hot Line findings, reported at ESC Congress 2015, "do not warrant the extension of MRA use" to such patients, said the study's principal investigator Gilles Montalescot, MD, PhD. MRAs, also known as aldosterone antagonists, inhibit sodium retention and excretion of potassium and magnesium, and therefore "there is an indication for MRA therapy in MI ...

LONDON, UK - In patients with a large myocardical infarction (MI), pacing, with the left ventricular (LV) lead placed in the area of the lesion (peri-infarct) did not prevent further enlargement of the heart (remodeling), nor did it improve functional or clinical outcomes after 18 months, according to results of the Pacing Remodeling Prevention Therapy trial (PRomPT) trial. In MI patients with large infarcts, medical therapy and rapid restoration of blood flow to the area is not always enough to prevent cardiac remodeling. One reason for remodeling may be the response ...

LONDON, UK - 30 August, 2015: The immunosuppressant drug cyclosporine did not improve clinical outcomes compared to placebo in patients receiving percutaneous coronary intervention (PCI) for the more severe form of heart attack known as ST-segment elevation myocardial infarction (STEMI). Results of the CIRCUS trial, presented today in a Hot Line session at ESC Congress 2015, and published simultaneously in the New England Journal of Medicine. showed that the drug, administered prior to PCI, had no impact on a composite of all-cause death, hospitalisation for - or worsening ...

LONDON, UK - In patients with chronic ischemic heart disease, a small left ventricle with thick walls, is the strongest predictor of morphologic remodelling, which is generally considered a first step towards heart failure, according to unexpected findings presented today at ESC Congress 2015. Results of the DOPPLER-CIP (which stands for "Determining Optimal non-invasive Parameters for the Prediction of Left vEntricular morphologic and functional Remodeling in Chronic Ischemic Patients") study were not expected and, if confirmed by other studies, "could completely change ...

A major multi-national study of suicides has identified the behaviour patterns which precede many suicide attempts. This may lead to changes in clinical practice in the care of patients affected with depression, as it shows the clinical factors which confer major risk of suicide attempts. The statistics for suicide are frightening. According to the WHO, more than 800,000 people commit suicide every year, with perhaps 20 times that number attempting suicide. Suicide is one of the leading causes of death in the young (in the UK for example, it is the leading cause of death ...

A group of UK scientists have found a way of understanding how transcranial magnetic stimulation (TMS) can give relief to severely depressed patients. TMS is used as an alternative to Electro-Convulsive Therapy (ECT)*, but it is not known how it achieves its therapeutic effect. Understanding how it works may open the door to better, more targeted treatment for depression and other conditions. Transcranial magnetic stimulation works by applying a magnetic pulse to the frontal part of the brain of depressed patients. Like ECT, it seems to 'reset' the brain, but is easier ...

A single dose of cocaine can interfere with the ability to recognise negative emotions, according to new research presented at the ECNP conference in Amsterdam. In a placebo-controlled within subject study, researchers from the Netherlands and Germany took 24 students (aged 19 to 27) with light to moderate cocaine use, and gave them either 300mg of oral cocaine, or a placebo. After 1 to 2 hours, each participant was then subject to a series of biochemical tests, as well as the facial emotion recognition test to measure response to a series of basic emotions, such ...

London, UK - 29 Aug 2015: Depressive symptoms and extremes of blood pressure predict the highest rates of harmful vascular events in patients with existing heart disease, diabetes or stroke, according to research presented at ESC Congress today by Dr Bhautesh Jani, clinical academic fellow in the Institute of Health and Wellbeing, University of Glasgow, UK.1 The study in more than 35 000 patients found that the risk of further stroke or heart attack, heart failure or dying due to heart disease at four years was 83% higher in depressed patients with high blood pressure ...

London, UK - 29 Aug 2015: Prolonged television watchers have a higher risk of fatal pulmonary embolism, a condition associated with long haul flights, reveals research presented at ESC Congress today by Mr Toru Shirakawa, public health research fellow in the Department of Social Medicine at Osaka University in Japan.1 The 18 year study in more than 86 000 people found that watching an average of five or more hours of television per day was associated with twice the risk of fatal pulmonary embolism as watching less than two and a half hours daily. "The association between ...

London, UK - 29 Aug 2015: Midday naps are associated with reduced blood pressure levels and prescription of fewer antihypertensive medications, according to research presented at ESC Congress today by Dr Manolis Kallistratos, a cardiologist at Asklepieion Voula General Hospital in Athens, Greece.1 "Although William Blake affirms that it is better to think in the morning, act at noon, eat in the evening and sleep at night, noon sleep seems to have beneficial effects," said Dr Kallistratos. "Two influential UK Prime Ministers were supporters of the midday nap. Winston Churchill ...

London, UK - 29 Aug 2015: Coffee drinking is associated with increased risk of cardiovascular events (mainly heart attacks) in young adults (18-45) with mild hypertension, according to research presented at ESC Congress today by Dr Lucio Mos, a cardiologist at Hospital of San Daniele del Friuli in Udine, Italy.1 The 12 year study in more than 1 200 patients found that heavy coffee drinkers had a four-fold increased risk while moderate drinkers tripled their risk. Future prediabetes attenuated the associations suggesting that the effect of coffee on cardiovascular events ...

London, UK - 29 Aug 2015: Pollution and weather influence outcomes after a heart attack, according to research presented at ESC Congress today by Ms Aneta Cislak, research fellow in the Silesian Centre for Heart Diseases, Medical University of Silesia in Zabrze, Poland.1 "Weather changes like rain or heat affect our daily activity and even our productivity at work," said Ms Cislak. "Since this influence is so noticeable we were interested to see if weather has any connection with cardiovascular diseases including acute coronary syndromes. Moreover, air pollution affects ...

London, UK - 29 Aug 2015: Refractory cardiac arrest patients brought to hospital with ongoing cardiopulmonary resuscitation (CPR) can survive with good brain function, according to research in nearly 4 000 patients presented at ESC Congress today by Dr Helle Søholm, a cardiologist at Copenhagen University Hospital Righospitalet in Denmark.1 "The faster a patient with cardiac arrest is resuscitated and brought back to life the better," said Dr Søholm. "The prognosis for patients with refractory cardiac arrest with long resuscitation attempts has previously been ...

London, UK - 29 Aug 2015: For the first time, ESC Guidelines published today give the highest degree of recommendation for the radial approach over the femoral one for coronary angiography and percutaneous coronary intervention (PCI) in patients with acute coronary syndromes (ACS). The ACS without persistent ST-segment elevation (NSTE-ACS) guidelines, drafted by an international multidisciplinary Task Force, are published online in European Heart Journal1 and on the ESC Website.2 "New data shows that the radial approach is superior to the femoral not only in terms of ...

London, UK - 29 Aug 2015: ESC Guidelines published today on infective endocarditis boost the role of imaging in diagnosis of this deadly disease. "We emphasise the need for a multimodality imaging approach to diagnosing endocarditis," said Professor Gilbert Habib, Chairperson of the guidelines Task Force. "While the 2009 guidelines1 focused on echocardiography, the 2015 guidelines show the important role of other imaging techniques such as PET-CT. These new imaging techniques are increasingly useful for the diagnosis and management of infective endocarditis and we recommend ...

London, UK - 29 Aug 2015: New ESC Guidelines on pericardial diseases are published today. Until now there was insufficient evidence for strong recommendations in this group of conditions which can severely restrict quality of life. "Pericardial diseases include different clinical presentations and various aetiologies that require appropriate management," said Professor Yehuda Adler, Co-Chairperson of the guidelines Task Force. "We hope these new recommendations will help clinicians to manage these diseases with resulting improvements in outcomes and quality of life." The ...

London, UK - 29 Aug 2015: A novel treatment algorithm for pulmonary arterial hypertension is launched today in new pulmonary hypertension guidelines from the European Society of Cardiology (ESC) and European Respiratory Society (ERS). The protocol aims to give patients the best chance of a good clinical outcome in a condition with dismal prognosis which puts severe limitations on patient choices including avoiding pregnancy, excessive physical activity and certain types of travel. The 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension are ...

London, UK - 29 Aug 2015: ESC Guidelines published today recommend DNA analysis as a fundamental component of post mortem assessment in young sudden death victims. Identification of a genetic cause helps to quickly diagnose and protect relatives. The Guidelines are published online in European Heart Journal1 and on the ESC Website2 and are the European update to the 2006 European/American guidelines.3 They focus on preventing sudden cardiac death in patients with ventricular arrhythmias. "For the first time these guidelines have incorporated the concept proposed by ...

Are some people immune to hangovers, and can eating or drinking water after heavy drinking prevent a hangover? The answers appear to be 'no' and 'no' according to new research presented the ECNP conference in Amsterdam. Excessive alcohol consumption has familiar consequences, many of them quite damaging. If a person does not experience a hangover - and 25% to 30% of drinkers regularly claim this - they may be more likely to continue drinking, so good research into the outcomes of drinking to excess is needed. A group of international researchers from the Netherlands ...

Tropical Storm Erika was centered in the Eastern Caribbean Sea and affecting Puerto Rico and Hispaniola when NASA's Terra satellite passed overhead mid-day on Friday, August 28, 2015. Two hours after Terra passed, NOAA's GOES-East satellite saw Erika's western side over the Dominican Republic. At 15:05 UTC (11:05 a.m. EDT) the Moderate Resolution Imaging Spectroradiometer instrument aboard NASA's Terra satellite captured a visible light image Tropical Storm Erika approaching Hispaniola. Erika's center was in the eastern Caribbean Sea, and the northern quadrant of the ...

To understand how confidence in parenting may predict parenting behaviors in women who were abused as children, psychologists at the University of Rochester have found that mothers who experienced more types of maltreatment as children are more critical of their ability to parent successfully. Intervention programs for moms at-risk, therefore, should focus on bolstering mothers' self-confidence--not just teach parenting skills, the researchers said. "We know that maltreated children can have really low self-esteem," said Louisa Michl, a doctoral student in the department ...

A simple change in the wording of a traffic sign - from "Share the Road" to "Bicycles May Use Full Lane" - could help clarify the rules of the road for bicyclists and motorists, according to a North Carolina State University study. "'Share the Road' signs are common but what that means in terms of how drivers and bicycle riders should interact can be ambiguous," says George Hess, natural resources professor and co-author of the study in PLOS One. Some bicyclists complain that motorists consider them to be in the way, while some motorists accuse bicyclists of hogging ...

Consider the pendulum of a grandfather clock. If you forget to wind it, you will eventually find the pendulum at rest, unmoving. However, this simple observation is only valid at the level of classical physics--the laws and principles that appear to explain the physics of relatively large objects at human scale. However, quantum mechanics, the underlying physical rules that govern the fundamental behavior of matter and light at the atomic scale, state that nothing can quite be completely at rest. For the first time, a team of Caltech researchers and collaborators has ...

Washington DC - August 28, 2015 - Oysters not only transmit human norovirus; they also serve as a major reservoir for these pathogens, according to research published August 28 in Applied and Environmental Microbiology, a journal of the American Society for Microbiology. "More than 80 percent of human norovirus genotypes were detected in oyster samples or oyster-related outbreaks," said corresponding author Yongjie Wang, PhD. "The results highlight oysters' important role in the persistence of norovirus in the environment, and its transmission to humans, and they demonstrate ...

NASA-NOAA's Suomi NPP satellite flew over Hurricane Jimena in the Eastern Pacific and saw the strongest thunderstorms building up quickly, especially in the northern quadrant of the storm. Jimena intensified rapidly overnight on August 27 and early August 28 and the National Hurricane Center expects it to become a major hurricane. The Visible Infrared Imaging Radiometer Suite or VIIRS instrument aboard the satellite provided infrared data of the storm that showed the coldest cloud top temperatures, which indicate the strongest thunderstorms were in Jimena's northern ...