The combination of a cholesterol-lowering drug, Bezafibrate, and a contraceptive steroid, Medroxyprogesterone Acetate, could be an effective, non-toxic treatment for a range of cancers, researchers at the University of Birmingham have found. The findings published in the journal Cancer Research show that the drugs kill cancer cells in a completely new way. Early stage clinical trials of the drugs in elderly patients with acute myeloid leukaemia (AML) have shown promising results, with survival three months longer on average than standard palliative care. The combination, ...

Alexandria, VA - The evolutionary age of grass has been hotly contested. Scientists have previously dated the earliest grasses to 55 million years ago; after the dinosaurs went extinct. Now, a new 100-million-year-old specimen of amber from Myanmar potentially pushes back grass evolution to the Late Cretaceous. Scientists from the Oregon State University who studied the amber believe they identified "spikelet" - grass in its flowering state - and a cluster of fossilized ergot, a major ingredient in LSD. While their conclusions are intriguing, and have implications for ...

The knock-on effects of the economic downturn have been explored in economy and psychology. Now researchers are examining the effects of unemployment on an even darker subject - cancer mortality. One would think that dealing with unemployment was challenge enough. But according to the latest research published in ecancermedicalscience, rises in unemployment are associated with significant increases in prostate cancer mortality. This is the first study that has systematically explored the consequences that changes in unemployment - in particular the Great Recession ...

ALEXANDRIA, Va. - The American Society of Clinical Oncology (ASCO) today announced results from four major studies to be presented at ASCO's 51st Annual Meeting, May 29-June 2, in Chicago. Findings showed that use of a widely available vitamin pill reduces the risk of non-melanoma skin cancers; that early chemotherapy extends the lives of men with advanced prostate cancers; and that new therapies can improve outcomes for children with a rare form of kidney cancer and adults with relapsed multiple myeloma. The studies are among the around 5,000 abstracts publicly released ...

WASHINGTON - A special issue of American Psychologist provides a comprehensive review of over 40 years of research on bullying among school age youth, documenting the current understanding of the complexity of the issue and suggesting directions for future research. "The lore of bullies has long permeated literature and popular culture. Yet bullying as a distinct form of interpersonal aggression was not systematically studied until the 1970s. Attention to the topic has since grown exponentially," said Shelley Hymel, PhD, professor of human development, learning and culture ...

LOS ANGELES (May 14, 2015) - Millions of people afflicted by irritable bowel syndrome can now be diagnosed quickly and accurately with two simple blood tests developed by a Cedars-Sinai gastroenterologist. The tests, created by Mark Pimentel, MD, director of the GI Motility Program and Laboratory, confirm when a patient has developed IBS because of food poisoning, a major cause of the disorder. Toxins produced by bacteria, such as salmonella, can severely harm the digestive system by damaging nerves critical to healthy gut function. The new blood tests identify the ...

Researchers have published results in Environmental Research Letters confirming strong warming in the upper troposphere, known colloquially as the tropospheric hotspot. The hot has been long expected as part of global warming theory and appears in many global climate models. The inability to detect this hotspot previously has been used by those who doubt man-made global warming to suggest climate change is not occurring as a result of increasing carbon dioxide emissions. "Using more recent data and better analysis methods we have been able to re-examine the global weather ...

A new report by the Nuffield Council on Bioethics calls for a change in culture across all areas of children's health research, so that children's and young people's views and opinions can help to shape how research is prioritised, designed and reviewed. Unless ethical concerns about asking children to take part in research are addressed, our understanding of childhood disorders and ability to provide evidence based care will remain limited. "It will always be easier to say 'no' to research with children on the grounds that it's too difficult, but we should challenge ...

A new Australian study shows that cells which form the bulk of our fast-acting 'innate' immune system behave differently, depending on whether an injury is infected or not. It is well known that paparazzi-like 'neutrophils' swarm to sites of injury within minutes to undertake damage control and kill invaders. Most have very short lives and self-destruct once their job is done. Sydney researchers now demonstrate that in certain cases neutrophils can also enlist reinforcements in their fight against pathogens. If the injury is infected, neutrophils seek out accomplices ...

A ground-breaking discovery by Monash University researchers could revolutionise treatments given to lupus sufferers, saving thousands of people each year from serious illness or death caused by secondary infections. Lupus is a vicious and widespread autoimmune disease that can attack any part of the body. It affects one in 1,000 Australians and 5 million people worldwide, and its victims are typically young women. Indigenous and Asian people suffer higher rates than other groups. Current treatments for lupus essentially 'switch off' the patient's immune system to stop ...

This news release is available in Spanish. Compelling clinical activity of PM1183 in second line, achieving 67% response rate and a progression-free survival of 4.7 months in patients with small cell lung cancer (SCLC), a type of tumor with very limited treatment alternatives Data from an interim analysis from the pivotal Phase 3 trial of YONDELIS® in soft tissue sarcoma, SAR-3007, will be presented in an oral presentation Phase 2 data showcase activity of YONDELIS® in malignant pleural mesothelioma, a rare form of lung cancer that is largely related ...

Even a busy job may not provide enough exercise to meet current activity recommendations for the prevention of cardiovascular disease, according to a study reported today at the EuroPRevent congress in Lisbon.1 Dr Eleanor McIntyre from the Galway University Hospital in Ireland said that the workplace - where most adults spend around 60% of their waking hours - "represents a significant domain where short bouts of physical activity can be accrued and counted towards the recommended guidelines" for CVD prevention. However, results from this small study, which assessed the ...

WASHINGTON (May 13, 2015) -- An early phase study testing an anti-PDL1 agent in combination with standard chemotherapy in the treatment of advanced non-small cell lung cancer has provided promising early results, prompting multiple phase III studies in lung cancer. The findings are being presented at the annual meeting of the American Society of Clinical Oncology (ASCO). In this phase 1b study, patients with untreated non-small cell lung cancer received one of three standard platinum-based chemotherapy regimens (paclitaxel/carboplatin, pemetrexed/carboplatin or nab-paclitaxel/carboplatin) ...

MANHATTAN, Kansas -- Our belief in pure evil influences our feelings about capital punishment, finds a Kansas State University psychology study. Donald Saucier, associate professor of psychological sciences and 2015-2016 Coffman chair for distinguished teaching scholars, looked at how beliefs in pure evil influenced how people treated those who committed crimes. He recently completed the study with Russell Webster at St. Mary's College of Maryland. Approximately 200 participants were given a summary of a case in which a murderer confessed to his crime. Researchers then ...

AURORA, Colo. (May 14, 2015) - More than half of all Medicaid enrollees prefer the "one-stop shop" of a hospital emergency department to receive care for conditions that could be treated effectively at a primary care clinic, according to an article by a researcher at the University of Colorado School of Medicine on the Anschutz Medical Campus. The finding exposes a gap in the services provided to Medicaid enrollees. From a patient's perspective, going to the hospital emergency department may be less expensive because patients can avoid costs of travel and time away from ...

PHILADELPHIA - In the first-of-its-kind study since the passage of the HIV Organ Policy Equity Act (the HOPE Act), which lifted the ban on organ donations from one HIV-positive person to another, Penn Medicine researchers report on the quality of these organs and how their use might impact the country's organ shortage. The study, published online ahead of print May 14 in the American Journal of Transplantation, revealed that there are nearly 400 HIV-positive potential organ donors who could be sources of donated organs annually for HIV-positive patients waiting for organ ...

All land is not created equal. Some ecosystems do triple duty in the benefits they provide to society. Massachusetts forests, for example, filter public drinking water while also providing habitat for threatened species and storing carbon to combat climate change. Ecologists and conservation groups single out the hardest-working ecosystems -- called "hotspots" -- for their exceptional conservation value. A new study published today in the Journal of Applied Ecology reports that the number of ecosystem hotspots has increased in Massachusetts over the past decade, with ...

In 2013, the United States government passed the HIV Organ Policy Equity (HOPE) Act, which allows research to be conducted on the safety of organ donation from deceased donors with HIV to recipients with HIV. A new study published in the American Journal of Transplantation explores the quality of these organs and how their use might impact the country's organ shortage. In the United States, there are not enough organ donors to meet the needs of all patients who might benefit from lifesaving organ transplants. Some patients waiting for organs are infected with HIV, and ...

CHICAGO -- With the increasing demand for food with health benefits, high nutritional value food materials are attracting more attention from both consumers and food manufacturers. A new study by researchers at Wilmar (Shanghai) Biotechnology Research and Development Center Co., Ltd. in the Journal of Food Science, published by the Institute of Food Technologists (IFT), found that germinated buckwheat, an important raw material for food and functional food production, had better nutritional value than ungerminated buckwheat. Germination is a complex process in which ...

An article publishing online today in Brain: A Journal of Neurology has found that individual differences in brain structure could help to determine the risk for future drug addiction. The study found that occasional users who subsequently increased their drug use compared with those who did not, showed brain structural differences when they started using drugs. In the two studies, researchers, led by Dr. Benjamin Becker, scanned the brain structure of 66 participants to provide the first likely evidence showing volumes of fronto-striato-limbic regions of the brain have ...

A robotic arm that can bend, stretch and squeeze through cluttered environments has been created by a group of researchers from Italy. Inspired by the eight arms of the octopus, the device has been specifically designed for surgical operations to enable surgeons to easily access remote, confined regions of the body and, once there, manipulate soft organs without damaging them. It is believed the device could reduce the number of instruments, and thus entry incisions, necessary in surgical operations, with part of the arm being used to manipulate organs whilst another ...

The use of glycated haemoglobin (sugar-bound haemoglobin, or HbA1c) is now in almost universal use to assist doctors in the diagnosis of type 2 diabetes. However new research published in Diabetologia (the journal of the European Association for the Study of Diabetes) highlights how anaemia--a common condition in the general population, especially in women--can lead to a false diagnosis of diabetes based on HbA1c, when a person's blood sugar control is actually normal. The research is by Dr Emma English, University of Nottingham, UK, and colleagues. In recent years, ...

Weak grip strength is linked with shorter survival and a greater risk of having a heart attack or stroke, according to an international study involving almost 140000 adults from 17 culturally and economically diverse countries [1]. The study, published in The Lancet, also found that grip strength is a stronger predictor of death than systolic blood pressure, and the authors suggest that it could be used as a quick, low-cost screening tool by doctors or other healthcare professionals to identify high-risk patients among people who develop major illnesses such as heart ...

Hamilton, ON (May 13, 2015) - The firmness of your hand grip is better than your blood pressure at assessing your health, Hamilton researchers have found, and reduced muscular strength, measured by your grip, is consistently linked with early death, disability and illness. The research by the Population Health Research Institute of McMaster University and Hamilton Health Sciences was published in the journal The Lancet today. "Grip strength could be an easy and inexpensive test to assess an individual's risk of death and cardiovascular disease," said principal investigator ...

PHILADELPHIA - Four different financial incentive programs, each worth roughly $800 over six months, all help more smokers kick the habit than providing free access to behavioral counseling and nicotine replacement therapy. Further, the way in which equally-sized payouts are structured influences their effectiveness. The findings are the result of a year-long randomized trial among CVS Caremark (now CVS Health) employees that was conducted by researchers at the Perelman School of Medicine at the University of Pennsylvania and is published online first in the New England ...