Inflammatory skin diseases such as psoriasis may result from abnormal activation of cell death pathways previously believed to suppress inflammation, a surprise finding that could help to develop new ways of treating these diseases. Mr James Rickard, Associate Professor John Silke and colleagues from the Walter and Eliza Hall Institute made the discovery while investigating how cell death pathways are linked to inflammatory disease development. The study was published today in the journal eLife. Infected cells, cancerous cells, or those that are simply unnecessary to ...

Vitamin D deficiency is not just harmful to physical health--it also might impact mental health, according to a team of researchers that has found a link between seasonal affective disorder, or SAD, and a lack of sunlight. "Rather than being one of many factors, vitamin D could have a regulative role in the development of SAD," said Alan Stewart of the University of Georgia College of Education. An international research partnership between UGA, the University of Pittsburgh and the Queensland University of Technology in Australia reported the finding in the November ...

URBANA, Ill. - A 12-year University of Illinois study shows that, although the use of cover crops does not improve crop yields, the practice does increase the amount of sequestered soil organic carbon using three different soil management systems. U of I soil scientist Ken Olson evaluated plots that were subjected to no-till, chisel plow and moldboard plow treatments with and without hairy vetch and cereal rye cover crops. "By 2012, we found that the soil tillage plots that had cover-crop treatments had more soil organic carbon stock than those without cover crops ...

ROCHESTER, Minn. -- Most patients with triple-negative breast cancer should undergo genetic testing for mutations in known breast cancer predisposition genes, including BRCA1 and BRCA2, a Mayo Clinic-led study has found. The findings come from the largest analysis to date of genetic mutations in this aggressive form of breast cancer. The results of the research appear in the Journal of Clinical Oncology. "Clinicians need to think hard about screening all their triple-negative patients for mutations because there is a lot of value in learning that information, both in ...

Researchers from Brigham and Women's Hospital (BWH) have identified what they believe to be the cells responsible for fibrosis, the buildup of scar tissue. Fibrotic diseases, such as chronic kidney disease and failure, lung disease, heart failure and cirrhosis of the liver, are estimated to be responsible for up to 45 percent of deaths in the developed world. The findings are published online in the journal Cell Stem Cell. "Previous research indicated that myofibroblasts are the cells responsible for fibrosis," said Benjamin Humphreys, MD, PhD, senior author of ...

New research from North Carolina State University and the University of Minnesota shows that the majority of consumers will accept the presence of nanotechnology or genetic modification (GM) technology in foods - but only if the technology enhances the nutrition or improves the safety of the food. "In general, people are willing to pay more to avoid GM or nanotech in foods, and people were more averse to GM tech than to nanotech," says Dr. Jennifer Kuzma, senior author of a paper on the research and co-director of the Genetic Engineering in Society Center at NC State. ...

Bethesda, MD (Dec. 2, 2014) -- Women with celiac disease present with fertility problems no more often than women in the general population, according to a new study in Gastroenterology1, the official journal of the American Gastroenterological Association. "Despite inconsistent findings from small studies, concern has been raised that celiac disease may cause infertility," said lead study author Nafeesa N. Dhalwani, PhD, from the University of Nottingham, United Kingdom. "Celiac patients should rest assured; our findings indicate that women with celiac disease do not ...

A research team from Kiel University (CAU) and Goethe University Frankfurt has jointly created a synthetic surface on which the adhesion of E. coli bacteria can be controlled. The layer, which is only approximately four nanometres thick, imitates the saccharide coating (glycocalyx) of cells onto which the bacteria adhere such as during an infection. This docking process can be switched on and off using light. This means that the scientists have now made an important step towards understanding the relationship between sugar (carbohydrates) and bacterial infections. Their ...

This news release is available in German. The FK506-binding protein 51 (FKBP51) is an established risk factor for stress-related psychiatric disorders such as major depression. Drug discovery for FKBP51 has been hampered by the inability to pharmacologically differentiate against the very similar functional counterplayer FKBP52. Scientists at the Max Planck Institute of Psychiatry in Munich have now developed the first potent and highly selective inhibitor of FKBP51. The so-called SAFit-ligand inhibits FKBP51 enhancing growth of neuronal cell cultures and improving ...

Molecular clocks -- based on changes in genetic material -- indicate much younger ages for a wide variety of plants found as fossils in southern Argentina than do the solid, geologic dates of those fossils, according to geoscientists who surveyed recent paleobotanical discoveries in Patagonia. The finding suggests serious biases in molecular clocks, which are heavily used to date many kinds of living things. It also directly refutes a widely-held idea about how most Southern Hemisphere plant and animal groups attained their current distributions. Geologists date fossils ...

A team of scientists has revealed how certain harmful bacteria drill into our cells to kill them. Their study shows how bacterial 'nanodrills' assemble themselves on the outer surfaces of our cells, and includes the first movie of how they then punch holes in the cells' outer membranes. The research, published today in the journal eLife, supports the development of new drugs that target this mechanism, which is implicated in serious diseases. The team brings together researchers from UCL, Birkbeck, University of London, the University of Leicester, and Monash University ...

In the city that never sleeps, it's easy to overlook the insects underfoot. But that doesn't mean they're not working hard. A new study from North Carolina State University shows that insects and other arthropods play a significant role in disposing of garbage on the streets of Manhattan. "We calculate that the arthropods on medians down the Broadway/West St. corridor alone could consume more than 2,100 pounds of discarded junk food, the equivalent of 60,000 hot dogs, every year - assuming they take a break in the winter," says Dr. Elsa Youngsteadt, a research associate ...

ARLINGTON HEIGHTS, Ill. (December 2, 2014) - If you are one of the millions of Americans who experiences a severe allergic reaction to food, latex or an insect sting, you should know the first line of defense in combating the reaction is epinephrine. Unfortunately, not all medical personnel know how important epinephrine is in bringing an allergic reaction under control. According to new guidelines published in the Annals of Allergy, Asthma and Immunology, the scientific publication of the American College of Allergy, Asthma and Immunology (ACAAI), the fast administration ...

AUSTIN, Texas -- Researchers at The University of Texas at Austin have identified a network of genes that appear to work together in determining alcohol dependence. The findings, which could lead to future treatments and therapies for alcoholics and possibly help doctors screen for alcoholism, are being published this week in the journal Molecular Psychiatry. By comparing patterns of genetic code from the brain tissue of alcoholics and nonalcoholics, the researchers discovered a particular set of genes co-expressed together in the individuals who had consumed the most ...

CHICAGO - According to a new long-term study, diabetic patients with even mild coronary artery disease face the same relative risk for a heart attack or other major adverse heart events as diabetics with serious single-vessel obstructive disease. Results of the study were presented today at the annual meeting of the Radiological Society of North America (RSNA). Researchers at the University of British Columbia and St. Paul's Hospital in Vancouver analyzed data from the Coronary CT Angiography Evaluation For Clinical Outcomes: An International Multicenter (CONFIRM) Registry, ...

CHICAGO - A major new study being presented at the annual meeting of the Radiological Society of North America (RSNA) has found that digital breast tomosynthesis, also known as 3-D mammography, has the potential to significantly increase the cancer detection rate in mammography screening of women with dense breasts. Breasts are considered dense if they have a lot of fibrous or glandular tissue but not much fatty tissue. Research has shown that dense breasts are more likely to develop cancer, a problem compounded by the fact that cancer in dense breasts can be difficult ...

CHICAGO - A study of breast cancers detected with screening mammography found that strong family history and dense breast tissue were commonly absent in women between the ages of 40 and 49 diagnosed with breast cancer. Results of the study were presented today at the annual meeting of the Radiological Society of North America (RSNA). "Screening recommendations for this age group continue to be debated," said Bonnie N. Joe, M.D., Ph.D., associate professor in residence and chief of women's imaging at University of California, San Francisco (UCSF). "Recent publications ...

CHICAGO - Patients value direct, independent access to their medical exams, according to a new study presented at the annual meeting of the Radiological Society of North America (RSNA). Fragmentation of health information among physicians, healthcare institutions or practices, and inefficient exchange of test results can decrease quality of care and contribute to high medical costs. Improving communications and giving patients more control over their care are critical goals of health IT initiatives. "Easy and timely electronic access to an online unified source of ...

Disparities in mental-health treatment are known to be associated with patients' racial and ethnic backgrounds. Now, a large study by researchers with UC Davis has found one possible reason for those disparities: Some racial and ethnic minorities are less likely to be assessed and referred for treatment by their medical providers. The study of more than 9,000 diverse individuals, including Latinos, African-Americans, Asian-Americans and non-Hispanic whites, found that patients of different racial and ethnic backgrounds reported experiencing differing treatment approaches ...

ANN ARBOR, Mich. -- Patients with head and neck cancer who used antacid medicines to control acid reflux had better overall survival, according to a new study from the University of Michigan Comprehensive Cancer Center. Reflux can be a common side effect of chemotherapy or radiation treatment for head and neck cancer. Doctors at the University of Michigan frequently prescribe two types of antacids - proton pump inhibitors or histamine 2 blockers - to help treat this side effect. The researchers looked at 596 patients who were treated for head and neck cancer. More than ...

Sons whose fathers have criminal records tend to have lower cognitive abilities than sons whose fathers have no criminal history, data from over 1 million Swedish men show. The research, conducted by scientists in Sweden and Finland, indicates that the link is not directly caused by fathers' behavior but is instead explained by genetic factors that are shared by father and son. The study is published in Psychological Science, a journal of the Association for Psychological Science. "The findings are important because cognitive ability is among the most important psychological ...

EVANSTON, Ill. --- Birth weight makes a difference to a child's future academic performance, according to new Northwestern University research that found heavier newborns do better in elementary and middle school than infants with lower birth weights. Led by a multidisciplinary team of Northwestern researchers, the study raises an intriguing question: Does a fetus benefit from a longer stay in the mother's womb? "A child who is born healthy doesn't necessarily have a fully formed brain," said David Figlio, one of the study's authors and director of Northwestern's Institute ...

Gorlin syndrome causes an increased risk of developing cancers of the skin and, rarely, in the brain. Around 1 in 30,000 people has the condition. Most people with Gorlin syndrome have a change in a gene called PTCH1, but the new research has revealed that changes in a gene called SUFU also cause Gorlin syndrome and it is children with a change in SUFU that are 20 times more likely to develop a brain tumour. Dr Miriam Smith, a lecturer in cancer genomics from the University's Institute of Human Development led the research, which was also carried out with The Christie ...

Whereas most adults are members of the Clean Plate Club, they eat an average of about 90% of the food they serve themselves, this is not true for children. New Cornell research aggregated six different studies of 326 elementary school-aged children. It showed that, if their parents are not around, the average child only eats about 60% of what they serve themselves. More than a third goes right in the trash. Unlike adults, kids are still learning about what foods they like and how much it will take to fill them up. "It's natural, for them to make some ...

Vitamin D supplements can reduce COPD lung disease flare-ups by over 40% in patients with a vitamin D deficiency - according to new research from Queen Mary University of London. COPD (chronic obstructive pulmonary disease) includes conditions such as chronic bronchitis and emphysema, and is thought to affect more than 3 million people in the UK. The NIHR-funded randomised trial, published in the journal Lancet Respiratory Medicine, included 240 patients with COPD in and around London. Half of the patients (122) received vitamin D supplements (6 x 2-monthly oral doses ...