A breakthrough in drug testing developed by a University of Huddersfield lecturer could lead to cheaper, more effective medicines. Dr Hamid Merchant is a member of the team that has created a device which accurately simulates the gastro-intestinal tract and how it absorbs medication. This means that the cost of clinical trials could be greatly reduced, with savings passed on to customers. Dr Merchant has joined the University as a Senior Lecturer in Pharmaceutics. Previously a postdoctoral fellow at University College London (UCL), he has extensive research experience, ...

While patients diagnosed with bladder cancer usually face a favorable prognosis, many experience recurrence after treatment. Because frequent, painful screenings are needed to identify recurrences, the ablility to identify patients at high risk of recurrent cancer could help to improve quality of life for all bladder cancer patients. A new study published in BJU International, "Genetic polymorphisms modify bladder cancer recurrence and survival in a U.S. population-based prognostic study," suggests that certain inherited DNA sequences may affect a bladder cancer patient's ...

WASHINGTON (March 31, 2014) — In a comparison of two blood-thinning medications, heparin was associated with significantly fewer major cardiovascular events at 28 days than bivalirudin in patients receiving primary percutaneous coronary intervention after a heart attack, according to research presented at the American College of Cardiology's 63rd Annual Scientific Session. The single-center, open label trial enrolled 1,829 patients with suspected heart attack who received a coronary angiography, an imaging test to see how blood flows through the heart. Patients were randomized ...

Anti-anxiety drugs and sleeping pills have been linked to an increased risk of death, according to new research from the University of Warwick. The large study, published in BMJ, shows that several anxiolytic (anti-anxiety) drugs or hypnotic drugs (sleeping pills) are associated with a doubling in the risk of mortality. Although these findings are based on routine data and need to be interpreted cautiously, the researchers recommended that a greater understanding of their impact is essential. Professor Scott Weich, Professor of Psychiatry at the University of ...

WASHINGTON (March 31, 2014) — Use of drug-eluting stents is associated with a lower risk of major cardiovascular events at one year compared to bare metal stents when followed by an individualized course of blood-thinning medication among patients previously thought to be uncertain candidates for drug-eluting stents due to their heightened risk of bleeding or blood clots, according to research presented at the American College of Cardiology's 63rd Annual Scientific Session. Positive study findings for patients receiving a shorter than currently recommended course of ...

This news release is available in German. Objects with sizes in the nanometer range, such as the molecular building blocks of living cells or nanotechnological devices, are continuously exposed to random collisions with surrounding molecules. In such fluctuating environments the fundamental laws of thermodynamics that govern our macroscopic world need to be rewritten. An international team of researchers from Barcelona, Zurich and Vienna found that a nanoparticle trapped with laser light temporarily violates the famous second law of thermodynamics, something that ...

WASHINGTON (March 31, 2014) — Patients with severe ischemic heart disease and heart failure can benefit from a new treatment in which stem cells found in bone marrow are injected directly into the heart muscle, according to research presented at the American College of Cardiology's 63rd Annual Scientific Session. "Our results show that this stem cell treatment is safe and it improves heart function when compared to placebo," said Anders Bruun Mathiasen, M.D., research fellow in the Cardiac Catherization Lab at Rigshospitalet University Hospital Copenhagen, and lead investigator ...

WASHINGTON (March 31, 2014) — The first one-year outcomes data of transcatheter heart valve replacement (TAVR) in nearly all U.S. patients undergoing this procedure shows that real-world outcomes are comparable to or slightly better than those found in clinical trials, according to registry data presented at the American College of Cardiology's 63rd Annual Scientific Session. However, specific baseline characteristics of patients undergoing TAVR are associated with differing degrees of death and survival and may be important considerations for patient counseling and shared ...

A new research discovery published in the April 2014 issue of the Journal of Leukocyte Biology may open the door to new therapies that help treat immune disorders or curb runaway inflammation. Specifically, scientists have discovered a molecule that can induce cell death (apoptosis) in a key type of immune cell (dendritic cells). With this understanding, it may be possible to develop new therapies that essentially shut down dendritic cell activity, and thereby reducing an immune reaction. "We hope that our findings provide better understanding of immune regulation, which ...

The sun emitted a significant solar flare, peaking at 1:48 p.m. EDT March 29, 2014, and NASA's Solar Dynamics Observatory captured images of the event. Solar flares are powerful bursts of radiation. Harmful radiation from a flare cannot pass through Earth's atmosphere to physically affect humans on the ground, however -- when intense enough -- they can disturb the atmosphere in the layer where GPS and communications signals travel. To see how this event impacted Earth, please visit NOAA's Space Weather Prediction Center at http://spaceweather.gov, the U.S. government's ...

VIDEO: New statistics from the American Society of Plastic Surgeons show that since 2000, breast lift procedures have grown by 70 percent, twice the rate of breast implants. According to the... Click here for more information. ARLINGTON HEIGHTS, Ill., March 31, 2014 – New statistics released today by the American Society of Plastic Surgeons (ASPS) show that breast lift procedures are growing at twice the rate of breast implant surgeries. Since 2000, breast lifts have grown by ...

A comparison of the safety of biodegradable polymer biolimus-eluting stents vs durable polymer everolimus-eluting stents finds similar outcomes for measures including death and heart attack after two years, according to a JAMA study released online to coincide with presentation at the 2014 American College of Cardiology Scientific Sessions. Recent studies have raised concerns about the safety of biodegradable polymer drug-eluting stents (BP-DES) compared with durable polymer everolimus-eluting stents (DP-EES). The NOBORI Biolimus-Eluting vs XIENCE/PROMUS Everolimus-Eluting ...

Six new species of Dracula ants from the Malagasy region have been discovered by scientists at the California Academy of Sciences. The discoveries, by postdoctoral fellow Masashi Yoshimura from Japan and curator of entomology Brian L. Fisher, represent a completely new twist in the typically rigid caste system of ants, where anatomy is typically destiny. The study was published in the open access journal ZooKeys. "The genus Mystrium is the most mysterious group within the bizarre Dracula ants," said Yoshimura. Mystrium species have unique features such as long, spatulate ...

(WASHINGTON, March 31, 2014) – New research further illuminates the heart-healthy benefits of the Mediterranean diet, tying the eating plan to lower levels of platelets and white blood cells, two markers of inflammation. Inflammation has an association with greater risk of heart attack and stroke. Study, results are published online today in Blood, the Journal of the American Society of Hematology (ASH). The Mediterranean diet, characterized by generous servings of foods such as greens, whole grains, fish, and olive oil, has long been hailed as a heart-healthy eating ...

A team of scientists from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore and National University Cancer Institute Singapore (NCIS), and their collaborators from the Cedars-Sinai Medical Centre, UCLA School of Medicine, demonstrated that a number of novel genetic defects are able to induce oesophageal cancer. The research group, led by Professor H. Phillip Koeffler, Senior Principal Investigator at CSI Singapore and Deputy Director of NCIS, has conducted a successful comprehensive genomic study of oesophageal squamous ...

Limiting climate change to 2°C means shutting down coal power plants - an unpopular proposition for coal power companies. But a new study shows that delaying climate policies could prove even worse for power plant owners. Coal power plants are a major source of greenhouse gas emissions, and new plants are planned around the world, particularly in India and China. These new power plants are built to run for 30-50 years, paying off only after years of operation. But stringent climate policies could make the cost of emission so high that coal power generation is no longer ...

People seeking help or information online about cutting and other forms of self-injury are likely finding falsehoods and myths, according to new research from the University of Guelph. Only about 10 per cent of websites providing information about non-suicidal self-injury (NSSI) are endorsed by health or academic institutions, according to a study published recently in JAMA Pediatrics, a journal of the American Medical Association. It's a troubling finding, says lead author Stephen Lewis, a Guelph psychology professor. "This is a salient public health issue," he said. People ...

Tamiflu is one of the few available treatments for those who come down with the flu. But the virus quickly develops resistance; multiplying at a rate of several generations a day, these tiny pathogens rapidly accumulate genetic mutations. Because of this, they have a good chance of developing counterattacks to the antiviral. How can these infinitesimal variations be identified within the immensity of the virus' genetic code? EPFL researchers have created a computer tool that can shed light on the flu virus' formidable adaptability. They were able to find mutations that ...

Flowering plants attract pollinating insects with scent from their flowers and bright colours. If they have become infested with herbivores like caterpillars, they attract beneficial insects like parasitic wasps with the help of scent signals from their leaves. The wasps then lay their eggs in the caterpillars and kill the parasites. Floral and foliar scents can, however, mutually reduce their attractiveness. That's why flowering plants face a dilemma: should they use their resources to attract pollinating insects and, by extension, for reproduction or should they invest ...

Exploding stars, random impacts involving comets and meteorites, and even near misses between two bodies can create regions of great heat and high pressure. Researchers from Imperial College London have now developed a method for analysing the pressure experienced by tiny samples of organic material that may have been ejected from dying stars before making a long journey through the cosmos. The researchers have investigated a type of aromatic hydrocarbon called dimethylnaphthalene, which should enable them to identify violent events in the history of the universe. Samples ...

The researchers studied 400 individuals 80-98 years old over a six-year period. Every two years, the subjects were assessed in terms of physical and mental measures as well as personality aspects such as extraversion, which reflects the inclination to be outgoing, and emotional stability. The results show that even if the emotional stability remained constant over the period, the participants became less outgoing. Interestingly, the researchers were not able to connect the observed changes to physical and cognitive impairments or to age-related difficulties finding social ...

Mild hypothermia has been shown to exert apparent neuroprotective effects in animal models of diffuse axonal injury. However, the clinical efficacy of mild hypothermia is controversial. Thus, a noninvasive, accurate, and objective technique is urgently required to verify the effect of mild hypothermia in diffuse axonal injury and its prognosis. Fractional anisotropy values in diffusion tensor imaging (DTI) can quantitatively reflect the consistency of nerve fibers after brain damage, where higher values generally indicate less damage to nerve fibers. Therefore, Guojie Jing ...

In an experimental legal psychology study, two young actors (one girl and one boy) portrayed victims in a mock-police investigation. They were questioned by the police about how they had been harassed by older schoolmates. The police interviews were videotaped in two versions: In one version the children appeared in a neutral manner but in the other version, the children showed clear signs of distress, as they sobbed and hesitated before answering the police officers' questions. The films were later shown and assessed by law students that were familiar with the Supreme ...

Nanotechnology and Functional Materials, Uppsala University have developed a paper filter, which can remove virus particles with the efficiency matching that of the best industrial virus filters. The paper filter consists of 100 percent high purity cellulose nanofibers, directly derived from nature. The research was carried out in collaboration with virologists from the Swedish University of Agricultural Sciences/Swedish National Veterinary Institute and is published in the Advanced Healthcare Materials journal. Virus particles are very peculiar objects- tiny (about ...

(Toronto) March 31, 2014 – Researchers at the Centre for Addiction and Mental Health have discovered two new genes linked to intellectual disability, according to two research studies published concurrently this month in the journals Human Genetics and Human Molecular Genetics. "Both studies give clues to the different pathways involved in normal neurodevelopment," says CAMH Senior Scientist Dr. John Vincent, who heads the MiND (Molecular Neuropsychiatry and Development) Laboratory in the Campbell Family Mental Health Research Institute at CAMH. "We are building up a ...