One of the deadliest forms of paediatric brain tumour, Group 3 medulloblastoma, is linked to a variety of large-scale DNA rearrangements which all have the same overall effect on specific genes located on different chromosomes. The finding, by scientists at the European Molecular Biology Laboratory (EMBL), the German Cancer Research Centre (DKFZ), both in Heidelberg, Germany, and Sanford-Burnham Medical Research Institute in San Diego, USA, is published online today in Nature. To date, the only gene known to play an important role in Group 3 medulloblastoma was a gene ...

(SACRAMENTO, Calif.) -- Pregnant women who lived in close proximity to fields and farms where chemical pesticides were applied experienced a two-thirds increased risk of having a child with autism spectrum disorder or other developmental delay, a study by researchers with the UC Davis MIND Institute has found. The associations were stronger when the exposures occurred during the second and third trimesters of the women's pregnancies. The large, multisite California-based study examined associations between specific classes of pesticides, including organophosphates, pyrethroids ...

DURHAM, N.C. -- National and state air pollution controls that went into effect in the early 1990s coincide with decreasing death rates from emphysema, asthma and pneumonia among people in North Carolina, according to a study led by Duke University researchers. Using mortality trends from state public health data, along with monthly measurements from air-monitoring stations across North Carolina from 1993-2010, the researchers were able to draw a close association between improved air quality and declining death rates from respiratory illnesses. "This research tends ...

Ann Arbor, MI, June 23, 2014 – Bisexual men have many unmet public health needs, which leave them vulnerable to sexually transmitted infections (STIs) and other health problems. This new study from the Centers for Disease Control and Prevention (CDC) illuminates the behavioral, interpersonal, and social realities of men who have sex with men and women (MSMW), and it explores possible interventions to better serve their needs. The findings are published today in the American Journal of Preventive Medicine. MSMW represent a small portion of the population, with about 2% ...

As millions of Americans struggle to help loved ones with dementia, policymakers should consider more ways to improve long-term services and supports for the soaring numbers of people with the debilitating condition and their caregivers, a new RAND Corporation study says -- and it offers possible ways to do so. Unlike other, existing national plans or reports that focus on either long-term care or dementia, the RAND study examines where these concerns intersect, providing a national blueprint that could bolster dementia caregiving. Earlier RAND research estimated that ...

ITHACA, N.Y. – Robots are getting smarter, but they still need step-by-step instructions for tasks they haven't performed before. Before you can tell your household robot "Make me a bowl of ramen noodles," you'll have to teach it how to do that. Since we're not all computer programmers, we'd prefer to give those instructions in English, just as we'd lay out a task for a child. But human language can be ambiguous, and some instructors forget to mention important details. Suppose you told your household robot how to prepare ramen noodles, but forgot to mention heating the ...

Biologists at UC San Diego have found the "missing link" in the chemical system that enables animal cells to produce ribosomes—the thousands of protein "factories" contained within each cell that manufacture all of the proteins needed to build tissue and sustain life. Their discovery, detailed in the June 23 issue of the journal Genes & Development, will not only force a revision of basic textbooks on molecular biology, but also provide scientists with a better understanding of how to limit uncontrolled cell growth, such as cancer, that might be regulated by controlling ...

Researchers at the University of California, San Diego School of Medicine have discovered a fundamental mechanism by which the brain maintains its internal balance. The mechanism, described in the June 22 advanced online publication of the journal Nature, involves the brain's most basic inner wiring and the processes that control whether a neuron relays information to other neurons or suppresses the transmission of information. Specifically, the scientists have shown that there is a constant ratio between the total amount of pro-firing stimulation that a neuron receives ...

ITHACA, N.Y. – Now you don't see it. Now, you do. And now you don't see it again. Astronomers have discovered a bright, mysterious geologic object – where one never existed – on Cassini mission radar images of Ligeia Mare, the second-largest sea on Saturn's moon Titan. Scientifically speaking, this spot is considered a "transient feature," but the astronomers have playfully dubbed it "Magic Island." Reporting in the journal Nature Geoscience June 22, the scientists say this may be the first observation of dynamic, geological processes in Titan's northern hemisphere. ...

Variations in high-altitude wind patterns expose particular parts of Europe, Asia and the US to different extreme weather conditions, a new study has shown. Changes to air flow patterns around the Northern Hemisphere are a major influence on prolonged bouts of unseasonal weather – whether it be hot, cold, wet or dry. The high altitude winds normally blow from west to east around the planet, but do not follow a straight path. The flow meanders to the north and south, in a wave-like path. These wave patterns are responsible for sucking either warm air from the tropics, ...

DURHAM, N.C. -- A team of scientists from Duke Medicine, the University of Michigan and Stanford University has determined the underlying architecture of a cellular signaling complex involved in the body's response to stimuli such as light and pain. This complex, consisting of a human cell surface receptor and its regulatory protein, reveals a two-step mechanism that has been hypothesized previously but not directly documented. The findings, reported on June 22, 2014, in the journal Nature, provide structural images of a G-protein coupled receptor (GPCR) in action. "It ...

Concentrating solar power (CSP) could supply a large fraction of the power supply in a decarbonized energy system, shows a new study of the technology and its potential practical application. Concentrating solar power (CSP) could supply a substantial amount of current energy demand, according to the study published in the journal Nature Climate Change. In the Mediterranean region, for example, the study shows that a connected CSP system could provide 70-80% of current electricity demand, at no extra cost compared to gas-fired power plants. That percentage is similar to ...

The discovery of a new therapeutic target for certain kinds of myeloproliferative disease is, without doubt, good news. This is precisely the discovery made by the Stem Cell Physiopathology group at the CNIC (the Spanish National Cardiovascular Research Center), led by Dr. Simón Méndez–Ferrer. The team has shown that the microenvironment that controls hematopoietic stem cells can be targeted for the treatment of a set of disorders called myeloproliferative neoplasias, the most prominent of which are chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia ...

Case Western Reserve University scientists have discovered how a family of proteins — cation diffusion facilitators (CDFs) — regulates an important cellular cycle where a cell's energy generated is converted to necessary cellular functions. The finding has the potential to inform future research aimed at identifying ways to ensure the process works as designed and, if successful, could lead to significant breakthroughs in the treatment of Parkinson's, chronic liver disease and heart disease. The results of this research were posted online June 22 by the journal Nature ...

For the first time, scientists from the CMS experiment on the Large Hadron Collider (LHC) at CERN have succeeded in finding evidence for the direct decay of the Higgs boson into fermions. Previously, the Higgs particle could only be detected through its decay into bosons. "This is a major step forwards," explains Professor Vincenzo Chiochia from the University of Zurich's Physics Institute, whose group was involved in analyzing the data. "We now know that the Higgs particle can decay into both bosons and fermions, which means we can exclude certain theories predicting that ...

Researchers at The Johns Hopkins University report they have deciphered the inner workings of a protein called YiiP that prevents the lethal buildup of zinc inside bacteria. They say understanding YiiP's movements will help in the design of drugs aimed at modifying the behavior of ZnT proteins, eight human proteins that are similar to YiiP, which play important roles in hormone secretion and in signaling between neurons. Certain mutations in one of them, ZnT8, have been associated with an increased susceptibility to type 2 diabetes, but mutations that destroy its function ...

This work focuses on the interactions between molecules and in particular on "amphiphilic" molecules, which contain two distinct parts to them. Household detergent is a good example of a product that relies on interacting amphiphilic molecules. Detergent molecules comprise two distinct parts: one that prefers to form bonds with water (hydrophilic) and the other that likes oily substances (hydrophobic). Detergents are used for cleaning because when they are added to dirty water, they orient and assemble around oily dirt, forming small clusters that allow grease and dirt ...

Hamilton, ON (June 21, 2014) - Women who take antidepressants during pregnancy may be unknowingly predisposing their infants to type 2 diabetes and obesity later in life, according to new research from McMaster University. The study finds a correlation between the use of the medication fluoxetine during pregnancy and an increased risk of obesity and diabetes in children. Currently, up to 20 per cent of woman in the United States and approximately seven per cent of Canadian women are prescribed an antidepressant during pregnancy. "Obesity and Type 2 diabetes in ...

A congregation's beliefs about work attitudes and practices affect a churchgoer on the job — but how much depends in part on how involved that person is in the congregation, according to a Baylor University study funded by the National Science Foundation. "We already knew that about 60 percent of American adults are affiliated with congregations, but we wanted to delve into whether that carries over from weekend worship services to the work day," said Jerry Z. Park, Ph.D., associate professor of sociology in Baylor's College of Arts & Sciences. "It turns out it does make ...

Computed tomography scans are an accepted standard of care for diagnosing heart and lung conditions. But clinicians worry that the growing use of CT scans could be placing patients at a higher lifetime risk of cancer from radiation exposure. Beaumont Health System research, published in the June 20 online issue of the Journal of Cardiovascular Computed Tomography, found that the use of advanced CT scanning equipment is helping to address this important concern. The study, of 2,085 patients at nine centers in the U.S. and Middle East, found that using newer generation, ...

New Rochelle, NY, June 20, 2014—Spiral ganglion cells are essential for hearing and their irreversible degeneration in the inner ear is common in most types of hearing loss. Adult spiral ganglion cells are not able to regenerate. However, new evidence in a mouse model shows that spiral ganglion stem cells present in the inner ear are capable of self-renewal and can be grown and induced to differentiate into mature spiral ganglion cells as well as neurons and glial cells, as described in an article in BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, ...

PROVIDENCE, R.I. – In a study of South African men who drink alcohol in informal drinking environments or "shebeens," researchers from The Miriam Hospital have found a high prevalence of Alcohol Use Disorder (AUD) that directly correlates to unprotected sex. Findings support the need for interventions targeting both alcohol and HIV-risk behaviors among South African men who drink alcohol in alcohol-serving venues. The study and its findings are published in the July issue of Drug and Alcohol Dependence. Lori A. Scott-Sheldon, Ph.D., lead author and researcher at The ...

Ottawa – June 20, 2014 – In a report published today in Nature Communications, an Ottawa-led team of researchers describe the role of a specific gene, called Snf2h, in the development of the cerebellum. Snf2h is required for the proper development of a healthy cerebellum, a master control centre in the brain for balance, fine motor control and complex physical movements. Athletes and artists perform their extraordinary feats relying on the cerebellum. As well, the cerebellum is critical for the everyday tasks and activities that we perform, such as walking, eating and ...

This news release is available in Portuguese. This news release is available in Portuguese. A research group led by Christen Mirth at Instituto Gulbenkian de Ciência (Portugal) uncovered that the development of wings in fruit flies does not progress synchronously with the organism's development. Instead, it is coordinated with the whole body only at distinct 'milestones'. This study, published in the latest issue of the scientific journal PLOS Genetics*, helps explain how an organism facing environmental and physiological perturbations retains the ability to build ...

Yes, Virginia, there is greed. Greedy managers. Corporate greed. Greedy behavior. In fact, a web database search shows you can find such phrases in the business press over 18,000 times, confirming the subject's popularity in everyday media. But you need not fear greed, Virginia, because believe it or not, you can moderate it. In a forthcoming article in the top-ranked Journal of Management, new research by University of Delaware assistant professor Katalin Takacs Haynes examines the effects of greed on shareholder wealth and looks at whether various contextual factors, ...