Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient.  Now, researchers at the Broad Institute of MIT and Harvard have developed a machine-learning approach that promises to speed up AAV engineering for gene therapy. The tool helps researchers engineer the protein shells of AAVs, called capsids, to have multiple desirable ...

NEW YORK, NY (Aug. 8, 2024) -- Since the genetic code was first deciphered in the 1960s, our genes seemed like an open book. By reading and decoding our chromosomes as linear strings of letters, like sentences in a novel, we can identify the genes in our genome and learn why changes in a gene’s code affect health. This linear rule of life was thought to govern all forms of life—from humans down to bacteria. But a new study by Columbia researchers shows that bacteria break that rule and can create free-floating and ephemeral genes, raising the possibility that similar genes exist outside ...

STARKVILLE, Miss.—NASA is awarding a Mississippi State University assistant professor a $1.13 million grant to develop a new simulation tool to aid the design of hypersonic vehicles used in space exploration. Vilas Shinde of MSU’s Department of Aerospace Engineering won the grant to develop a new flow stability and transition analysis tool, which will aid researchers and aircraft designers in understanding and predicting changes associated with the boundary layer—air flow in the vicinity of an aircraft’s ...

Houston Methodist researchers have discovered a more accurate and timely way to deliver life-saving drug therapies to the brain, laying the groundwork for more effective treatment of brain tumors and other neurological diseases. In a study published this month in Communications Biology, an open access journal from Nature Portfolio, investigators used an electric field to infuse medicine from a reservoir outside the brain to specific targets inside the brain. This adds a new dimension to the 30-year-old process of injecting therapeutics into the brain through ...

URBANA, Ill. – You’ve probably heard that cultivating gratitude can boost your happiness. But in marriage and families, it’s not just about being more grateful for your loved ones — it’s also important to feel appreciated by them. Researchers at the University of Illinois Urbana-Champaign have previously explored the positive impact of perceived gratitude from romantic partners for couples’ relationship quality. In a new study, they show the benefits of perceived gratitude ...

The Food and Drug Administration (FDA) is tasked with overseeing the safety of the U.S. food supply, setting requirements for nutrition labeling, working with companies on food recalls, and responding to outbreaks of foodborne illness. But when it comes to additives already in our food and the safety of certain ingredients, FDA has taken a hand-off approach, according to a new article in the American Journal of Public Health. The current FDA process allows the food industry to regulate itself when it comes to thousands of added ...

A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a technological advance that promises to reduce the time required to develop new drugs and other medical treatments. The tool, called Deep Predictor of Binding Specificity (DeepPBS), is a geometric deep learning model designed to predict protein–DNA binding specificity from protein–DNA complex structures. DeepPBS ...

Solid-state electrolytes have been explored for decades for use in energy storage systems and in the pursuit of solid-state batteries. These materials are safer alternatives to the traditional liquid electrolyte—a solution that allows ions to move within the cell—used in batteries today. However, new concepts are needed to push the performance of current solid polymer electrolytes to be viable for next generation materials. Materials science and engineering researchers at the University of Illinois Urbana-Champaign have explored the role of helical secondary structure on the conductivity of solid-state peptide polymer ...

PHILADELPHIA – It has been two years since the World Health Organization declared a global health emergency over an outbreak of mpox, a disease endemic to Africa that had spread to scores of countries. Now, in the summer of 2024, a deadlier version of the infectious disease has spread from the Democratic Republic of Congo to other African nations, the strain that originally hit the United States has shown signs of a resurgence, and this week the Centers for Disease Control and Prevention (CDC) issued a new alert on mpox to health care providers. But while the American public quickly learned about the disease during the summer of 2022, as ...

RIVERSIDE, Calif. -- A traumatic brain injury, or TBI, is caused by a contusion to the head that may result in injury to the brain. This type of injury combined with the inherited genetic risk factors can result in the accelerated development of Alzheimer’s disease and related dementia, or ADRD. TBIs range from mild to severe, with the majority being mild. They are especially common in adolescents engaging in contact sports and in the elderly who tend to fall with greater frequency as they age. Regardless of the source, TBI and how it progresses to ADRD is an understudied area of research. A $3.5 million grant to the University of California, ...

When Katey Walter Anthony heard rumors of methane, a potent greenhouse gas, ballooning under the lawns of fellow Fairbanks residents, she nearly didn’t believe it. “I ignored it for years because I thought ‘I am a limnologist, methane is in lakes,’” she said. But when a local reporter contacted Walter Anthony, who is a research professor at the Institute of Northern Engineering at University of Alaska Fairbanks, to inspect the waterbed-like ground at a nearby golf course, she started to pay attention. Like others in Fairbanks, they lit “turf bubbles” on fire and confirmed the presence of methane ...

Royal Commission for AlUla Collaborates with SETI Institute to Support Development of AlUla Manara Observatory   Experts from SETI Institute will support the advancement of telescope technology and data analysis at AlUla Manara Observatory.  The collaboration will enhance the future observatory's capabilities as it welcomes global scientists, researchers, and tourists interested in astronomy and space science. Ambitions to foster curiosity, knowledge sharing, and upskilling local capabilities in astronomical and space sciences field Mountain View, CA , 8 August 2024 -- The Royal Commission for AlUla (RCU) and SETI Institute ...

A new UC Riverside study demonstrates that calorie restriction doesn’t deter mice from exercising, challenging the belief that dieting drains workout energy. The study, published in the journal Physiology & Behavior, shows that cutting calories by 20% did not significantly reduce the distance that mice voluntarily chose to run each day.  The researchers set out to understand what happens to mice when the amount of food available to them is reduced.  The findings, they hoped, would be relevant ...

Early-stage trials in Alzheimer’s disease patients and studies in mouse models of the disease have suggested positive impacts on pathology and symptoms from exposure to light and sound presented at the “gamma” band frequency of 40 Hz. A new study zeroes in on how 40Hz sensory stimulation helps to sustain an essential process in which the signal-sending branches of neurons, called axons, are wrapped in a fatty insulation called myelin. Often called the brain’s “white matter,” myelin protects axons and insures better ...

Scientists have recovered the first long section of rocks that originated in the Earth’s mantle, the layer below the crust and the planet’s largest component. The rocks will help unravel the mantle’s role in the origins of life on Earth, the volcanic activity generated when it melts, and how it drives the global cycles of important elements such as carbon and hydrogen, according to the team. The nearly continuous 1,268 metres of mantle rock was recovered from a “tectonic window,” a section ...

Researchers have uncovered a surprising way bacteria defend themselves: when a bacterium is infected, bacterial enzymes that copy genetic information from RNA into DNA synthesize genes whose protein products help shut down cell growth. This prevents further viral spread in the neighboring bacterial population. The results highlight the potential for other “hidden” genes, like the one found here, to be unearthed in different biological contexts. Bacteria defend themselves from viral ...

Prenatal exposure to famine significantly increases the risk of developing Type 2 diabetes mellitus (T2DM) in adulthood, according to a new study of people impacted by the 1932-1933 Holodomor famine in Ukraine. While the immediate and short-term effects of famines on mortality and morbidity are well-documented, deciphering famines’ long-term health consequences – as this study did – has been more difficult. Previous research has suggested a link between prenatal nutrition and adult health ...

Marine algae Prymnesium parvum use massive enzymes dubbed PKZILLAs – some of the largest proteins ever to be identified in nature – to make large and complex prymnesin neurotoxins responsible for mass fish kills during harmful algal blooms worldwide, researchers report. “The discovery and initial characterization of the prymnesin PKZILLA gigasynthases now elucidates the long-standing question about how microalgae biosynthesize their giant polyketide polyether molecules,” write the authors. It also expands ...

A record-breaking 1268-meter drill core into Earth’s mantle, collected from the Mid-Atlantic Ridge in the North Atlantic, has provided a deep and detailed mineralogical glimpse of the oceanic mantle. The findings reveal new insights into mantle composition, Earth’s deep geology, and the potential biogeochemical conditions involved in the origins of life. Understanding the Earth’s mantle is crucial for comprehending important details of the Earth system, including terrestrial magmatism, crust formation, and the cycling ...

The American College of Cardiology has issued updated guidance on managing patients hospitalized for heart failure (HF) to provide a decision-making pathway that tailors therapy to clinical trajectory to better manage disease. The updated Expert Consensus Decision Pathway incorporates the latest evidence to provide guidance for clinicians to use at the point of care in conjunction with the 2022 ACC/AHA Heart Failure Guideline. Heart failure refers to several conditions that can affect the way the heart works, its structure or both. Over time, heart failure makes ...

Researchers at Columbia University Mailman School of Public Health, the University of North Carolina at Chapel Hill and at the National Academy of Sciences of Ukraine used the setting of the man-made Ukrainian Holodomor famine of 1932-1933 to examine the relation between prenatal famine and adult Type 2 diabetes mellitus (T2DM). They studied 128,225 Type 2 diabetes cases diagnosed between 2000-2008 among 10,186,016 male and female Ukrainians born between 1930 and 1938. Individuals who were exposed in early gestation to the famine had a more than two-fold likelihood of developing Type 2 diabetes compared to those ...

In brief: Disruption of the functioning of vegetation due to warming can lead to the failure of climate regulating mechanisms for millions of years. Vegetation changes can alter the planet’s climate equilibrium. Geological and climatic history provide insight into the effects of global warming today. Scientists often seek answers to humanity’s most pressing challenges in nature. When it comes to global warming, geological history offers a unique, long-term perspective. Earth’s geological ...

[Vienna, August 7 2024] — The ongoing war between Russia and Ukraine has led to severe humanitarian crises, including widespread food shortages. According to the United Nations World Food Programme, an estimated 11 million Ukrainians—about one-third of the population—were at risk of hunger in 2023. This crisis, exacerbated by supply chain disruptions and extreme weather events, could increase diabetes prevalence not only in Ukraine but globally, argue Peter Klimek and Stefan Thurner from the Complexity Science Hub in a commentary published in the journal Science. Malnutrition during early pregnancy is known to elevate diabetes ...

August 8, 2024—(BRONX NY)—A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body’s different blood cells. The findings, made in mice, were published today in the journal Science. “Our research has the potential to improve the success of stem-cell transplants and expand their use,” explained Ulrich Steidl, ...

While seeking to unravel how marine algae create their chemically complex toxins, scientists at UC San Diego’s Scripps Institution of Oceanography have discovered the largest protein yet identified in biology. Uncovering the biological machinery the algae evolved to make its intricate toxin also revealed previously unknown strategies for assembling chemicals, which could unlock the development of new medicines and materials.   Researchers found the protein, which they named PKZILLA-1, while studying how a type of algae called Prymnesium parvum makes its toxin, which is responsible for massive fish kills.  “This is the Mount Everest of proteins,” ...