About The Study: In patients with cardiometabolic heart failure with preserved ejection fraction, semaglutide and tirzepatide showed more than 40% risk reduction for the composite of hospitalization for heart failure or all-cause mortality compared with a placebo proxy. Tirzepatide showed no meaningful benefit over semaglutide. Corresponding Author: To contact the corresponding author, Nils Krüger, MD, email nkruger1@bwh.harvard.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ Editor’s Note: Please ...

Heart failure with preserved ejection fraction (HFpEF) appears to develop as a result of changes in the biology of a person’s internal fat tissue, according to the Adipokine Hypothesis, a new way of understanding how fat may impact the heart. The hypothesis paper was published today in JACC, the flagship journal of the American College of Cardiology, and is being presented at ESC Congress 2025. The author of the paper is Milton Packer, MD, FACC, Distinguished Scholar in Cardiovascular Science at Baylor University Medical Center at Dallas and Visiting Professor at Imperial College in London. “Up ...

About The Study: In this individual participant data meta-analysis of 4 randomized clinical trials (RCTs), and an overall meta-analysis of 8 RCTs of patients with severe symptomatic aortic stenosis at low to intermediate risk, transcatheter aortic valve implantation (TAVI) was associated with a reduction in the 1-year incidence of all-cause death or any stroke. These findings emphasize TAVI as alternative option in patients at low to intermediate risk. Long-term follow-up is warranted to evaluate sustainability of these findings. Corresponding Authors: To contact the corresponding authors, email Moritz Seiffert, MD, (moritz.seiffert@bergmannsheil.de) and ...

A new treatment has been shown to significantly lower blood pressure in people whose levels stay dangerously high, despite taking several existing medicines, according to the results of a Phase III clinical trial led by a UCL Professor. Globally around 1.3 billion people have high blood pressure (hypertension), and in around half of cases the condition is uncontrolled or treatment resistant. These individuals face a much greater risk of heart attack, stroke, kidney disease, and early death. In the UK the number of people with hypertension is around 14 ...

One shot of an RSV vaccine protects adults ages 60 or older from RSV-associated hospitalization and critical illness during two consecutive RSV seasons, according to a study published in JAMA today by the IVY Network research group. RSV causes substantial seasonal illness during fall and winter in the U.S., with an estimated 100,000-150,000 hospitalizations and 4,000-8,000 deaths occurring annually among adults 60 or older. The results reinforce the recommendations for RSV vaccines in older adults and lay the groundwork for understanding how long a single dose of the vaccine may be effective, ...

About The Study: In adults age 60 or older, all-cause cardiorespiratory hospitalization was significantly lower with respiratory syncytial virus (RSV) prefusion F protein than with no vaccine. The findings suggest potential downstream cardiorespiratory benefits of RSV immunization, although the effect on all-cause cardiovascular hospitalization was not statistically significant.  Corresponding Author: To contact the corresponding author, Tor Biering-Sørensen, MD, MSc, MPH, PhD, email tor.biering@gmail.com.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ Editor’s ...

About The Study: In this study, clonal hematopoiesis of indeterminate potential (CHIP) was a strong risk factor for myocarditis and pericarditis among middle-aged adults. Targeting CHIP and its downstream pathways may represent a strategy for preventing or treating pericarditis and myocarditis. Corresponding Author: To contact the corresponding author, Michael C. Honigberg, MD, MPP, email mhonigberg@mgh.harvard.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ Editor’s Note: Please see the article for additional information, including other authors, author contributions ...

About The Study: In this prespecified analysis of the DANFLU-2 trial, the risk of incident myocarditis or pericarditis was lower among individuals randomized to high-dose inactivated influenza vaccine vs standard-dose- inactivated influenza vaccine. Despite sporadic reports of myocarditis and pericarditis associated with influenza vaccination, the consistency of our results with vs without inclusion of events occurring immediately after vaccination negates a dose-response association and a causal link. Corresponding Author: To ...

About The Study: This study found reduced incidence of cardiorespiratory hospitalization among those who received high-dose inactivated influenza vaccine vs standard-dose inactivated influenza vaccine, driven by a lower incidence of cardiovascular hospitalizations, and particularly heart failure hospitalizations. These differences should be interpreted as exploratory findings in the setting of a large randomized clinical trial with a neutral primary outcome. Corresponding Author: To contact the corresponding author, Tor Biering-Sørensen, ...

About The Study: This situational analysis of cross-sectional WHO STEPS surveys of cardiovascular health (CVH) status region identified actionable factors of the CVH status across 22 countries in the WHO African Region. This information is crucial for guiding policy efforts in cardiovascular disease prevention in countries of the WHO African Region. Corresponding Author: To contact the corresponding author, Jean-Philippe Empana, MD, PhD, email jean-philippe.empana@inserm.fr. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ Editor’s Note: Please see the article for additional information, including ...

A major new analysis from REBOOT (Treatment with Beta-blockers after Myocardial Infarction without Reduced Ejection Fraction) clinical trial, an international study coordinated by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), published at the European Heart Journal has revealed important sex-specific differences in the effects of beta-blockers following heart attacks, raising questions about long-standing treatment practices. REBOOT, presented in a Hotline session of the ESC congress in Madrid, ...

Madrid, August 30, 2025. An international clinical trial coordinated by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), in collaboration with the Mario Negri Institute for Pharmacological Research in Milan, has found that beta-blockers—drugs commonly prescribed for a range of cardiac conditions—offer no clinical benefit for patients who have had an uncomplicated myocardial infarction (i.e., without deterioration of the heart function after the event). The findings—published in two articles in The New England Journal of Medicine and The Lancet and presented today during a “Hot Line” ...

About The Study: Randomization systolic blood pressure (SBP) was associated with the survival benefit of microaxial flow pump treatment, with the most hypotensive patients deriving the largest survival benefit. Early SBP may help identify patients most likely to gain a net benefit from microaxial flow pump treatment. Findings are hypothesis generating. Corresponding Author: To contact the corresponding author, Astrid Duus Mikkelsen, MD, email astrid.duus.mikkelsen@reigonh.dk. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ Editor’s Note: Please see the article for additional information, including ...

Beta blockers—drugs commonly prescribed for a range of cardiac conditions, including heart attacks—provide no clinical benefit for patients who have had an uncomplicated myocardial infarction with preserved heart function. Beta blockers have been the standard treatment for these patients for 40 years. This is a breakthrough discovery from the “REBOOT Trial” with senior investigator Valentin Fuster, MD, PhD, President of Mount Sinai Fuster Heart Hospital and General Director of Spain’s Centro Nacional de Investigaciones Cardiovasculares ...

Glaciers across High Mountain Asia are losing more than 22 gigatons of ice per year—the equivalent to nearly 9 million Olympic swimming pools, according to research from the University of Utah and Virginia Tech. The impact of a warming climate on glacial loss is undisputed—this new study provides the first evidence that seasonal shifts in rainfall and snowfall patterns, particularly of the South Asian monsoons, are also exacerbating glacier melting across the region. “These findings highlight that glaciers dominated by the South Asian monsoons, such as the Central Himalaya, ...

LA JOLLA (August 29, 2025)—A plant’s number one priority is to grow—a feat that demands sunlight, nutrients, and water. If just one of these three inputs is missing, like water in a drought, growth halts. You might then think that at the end of that drought, the plant would jump right back into growing. Instead, its priorities shift. Salk plant biologists used advanced single-cell and spatial transcriptomic techniques to look closely at how a small, flowering plant called Arabidopsis thaliana recovers after drought. They discovered that immunity became the plant’s number one priority during this ...

The stereotypical employee may be at a desk in front of a computer screen working a nine-to-five, but for many employees, the work day is filled with manual labor, hazardous environments and late-night shifts. Your local garbage collector, for example, is someone with a job that society might consider “dirty,” both literally and socially. Scott Dust, PhD, professor in the management department at the University of Cincinnati Carl H. Lindner College of Business, worked with doctoral candidates Sodiq Babatunde and Ben Fagan to analyze the impact of stress and ...

Picture this: You’re stuck in traffic on a summer afternoon, checking the weather app on your phone as dark storm clouds roll in. You might think about power outages or possible flooding, but you probably don’t think about how every lightning bolt that flashes across the sky also emits a gas, nitrogen oxide (NO), that is also emitted in the exhaust from your car’s engine. Yet, that’s exactly what occurs during a thunderstorm. For the first time, scientists from the University of Maryland were able to detect lightning and its impact on air quality using high-frequency ...

Hormonal birth control is a fact of life for millions of women. In the U.S. alone, more than 60 million women of reproductive age have used contraceptives according to the Centers for Disease Control and Prevention, most often to prevent pregnancy but also to manage conditions such as endometriosis, polycystic ovary syndrome and irregular cycles. And as many women will attest, these drugs can affect more than the body. Mood changes, weight fluctuations and emotional ups and downs are common stories women ...

The Philippines, like other tropical countries, is known more for its balmy climate than for hailstorms. But a new Philippine study—the first of its kind—has found that the country’s hottest days are, in fact, more likely to produce hail. Hailstorms are so few and far between in the Philippines that, even in an age of pervasive social media updates, they are still met with amazement and astonishment. “Most people are surprised when hail happens because it is relatively rare in the Philippines,” ...

The European Society of Cardiology (ESC) has selected Roxana Mehran, MD, Director of Interventional Cardiovascular Research and Clinical Trials at the Zena and Michael A. Wiener Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai, as a winner of the organization’s top honor. Dr. Mehran was presented with the “ESC Gold Medal” during a special ceremony at the ESC Congress in Madrid on Friday, August 29. The ESC Gold Medal recognizes exceptional scientists for their contributions to cardiovascular ...

Chronic kidney disease (CKD) is a major health issue worldwide. Many patients end up requiring regular dialysis to avoid kidney failure and stay alive. Despite the severity of the condition, there are currently no drugs available that improve kidney function. A research group led by Tohoku University Graduate School of Medicine’s Professor Takaaki Abe has found a remarkable solution to treat patients with CKD by co-opting a drug typically used for constipation. This is the first time that this drug (lubiprostone) was shown to prevent the decline of renal function in patients with ...

Throughout human history, there have been many instances where two populations came into contact – especially in the past few thousand years because of large-scale migrations as a consequence of conquests, colonialization, and, more recently, globalization. During these encounters, not only did populations exchange genetic material, but also cultural elements. When populations interact, they may borrow technologies, beliefs, practices, and also, crucially, aspects of language. With this, sounds, words or grammatical patterns can be exchanged ...

With control of Congress and a check on the Trump administration at issue in the 2026 midterm elections, the upcoming election cycle may again see claims of voter fraud. But warning voters beforehand that there may be false claims about the election, and providing them with information on election security measures through "prebunking," can increase confidence in the results and decrease beliefs in voter fraud, according to a new study published in Science Advances. "Prebunking is effective because it provides people with novel facts about how elections are ...

Carbon dioxide levels in the atmosphere vary naturally between ice ages and interglacial periods. A new study by researchers at the University of Gothenburg shows that an unexpectedly large proportion of carbon dioxide emissions after the ice age may have come from thawing permafrost. For a long time, it was the shifts between ice ages and interglacial periods that determined how much carbon dioxide was in the atmosphere. During ice ages, CO2 levels fell, only to rise by around 100 ppm (parts per million) during interglacial ...