Chronically homeless, alcohol-dependent individuals might benefit from a new intervention that does not require them to stop or even reduce drinking, according to the results of a preliminary study in Seattle. Participants in the 12-week pilot program received monthly injections of an anti-craving medication, extended-release naltrexone. They also met regularly with study physicians to set their own goals for treatment and to learn to be safer in their use of alcohol. "Abstinence-based alcohol treatment has not been effective for or desirable to many homeless people ...

HOUSTON – (May 15, 2014) – Children of fathers who are in technical occupations are more likely to have an autism spectrum disorder, according to researchers at The University of Texas Health Science Center at Houston (UTHealth). The findings will be presented Friday at the International Meeting for Autism Research in Atlanta. During participation in the LoneStar LEND program, first author Aisha S. Dickerson, Ph.D., a researcher at UTHealth's Center for Clinical and Translational Sciences, used the United States government's Standard Occupational Classification system. ...

The immune system's B cells protect us from disease by producing antibodies, or "smart bullets," that specifically target invaders such as pathogens and viruses while leaving harmless molecules alone. But how do B cells determine whether a threat is real and whether to start producing these weapons? An international team of life scientists shows in the May 16 issue of the journal Science how and why these cells respond only to true threats. "It is critical for B cells to respond either fully or not at all. Anything in between causes disease," said the study's senior ...

PITTSBURGH—Clouds play a critical role in Earth's climate. Clouds also are the largest source of uncertainty in present climate models, according to the latest report of the Intergovernmental Panel on Climate Change. Much of the uncertainty surrounding clouds' effect on climate stems from the complexity of cloud formation. New research from scientists at the CLOUD (Cosmics Leaving OUtdoor Droplets) experiment at CERN, including Carnegie Mellon University's Neil Donahue, sheds light on new-particle formation — the very first step of cloud formation and a critical component ...

The newly updated, online, interactive state data tool allows policymakers, educators and other users to discern trends in education, science and research in each of the 50 states. This free resource supplements the state data in the 2014 Science and Engineering Indicators report, the premier source of information and analysis of the nation's position in science and engineering education and research. The biennial report is published by the National Science Board, the policy making body of the National Science Foundation (NSF). The tool features 59 state indicators of ...

CLEVELAND -- At the 2014 American Association of Neurological Surgeons Annual Meeting, neurosurgical researchers from University Hospitals (UH) Case Medical Center presented results from a small study looking at deep brain electrode implantation as a possible alternative to the traditional WADA test used prior to epilepsy surgery. The WADA test is considered the gold standard for identifying the side of the brain for speech dominance. In the WADA test, doctors put one half of a patient's brain to sleep for a few minutes using medication and then have the patient read ...

CORVALLIS, Ore. – The quality of early child care and education programs is influenced both by funding and by the characteristics of the communities in which the programs operate, new research from Oregon State University shows. The findings indicate that law- and policy-makers may need to consider the demographics of communities when making funding decisions about early childhood programs, said Bridget Hatfield, an assistant professor in OSU's College of Public Health and Human Sciences. That's especially important now because many states, including Oregon, are adopting ...

The single fire that ignited and split into nine separate fires still blazes in Southern California today. Firefighters are hoping for a break today (Thursday, May 15, 2014) but it doesn't look like luck may be on their side. Conditions continue to be bone dry with unseasonal heat (98-106 degrees) and the Santa Ana winds are kicking up and allowing these fires to easy jump fire lines. This particular fire started on Wednesday as a single fire and within a day is now nine separate fires which have burned close to 10,000 acres. These fires are threatening more than just ...

Using one of the world's largest telescopes, a Lawrence Livermore team and international collaborators have tracked the orbit of a planet at least four times the size of Jupiter. The scientists were able to identify the orbit of the exoplanet, Beta Pictoris b, which sits 63 light years from our solar system, by using the Gemini Planet Imager's (GPI) next-generation, high-contrast adaptive optics (AO) system. This approach is sometimes referred to as extreme AO. The Gemini Planet Imager snapped an amazingly clear and bright image of the gas giant Beta Pictoris b after ...

St. Jude Children's Research Hospital scientists have mapped the structural details of how p53 attaches to its regulatory protein, called BCL-xL, in the cell. The protein p53 is a key activator of the cell's protective machinery against genetic damage, such as the mutations that drive cancer cells' explosive growth. The detailed understanding of how these two molecular puzzle pieces fit together will help scientists design drugs that release p53 in cancer cells, triggering their suicide, called apoptosis. The findings appear in the current online journal Nature Structural ...

A new collection of articles appearing in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences examine how the basic biology of aging drives chronic disease. Together, they highlight the value of the emerging field of geroscience, which uses an integrated approach to the study of diseases and disability associated with growing older. Geroscience seeks to bridge the divide between studies of aging and studies of chronic disease, with the hope of understanding their complex relationship and pointing the way to novel interventions for disease, ...

RIVERSIDE, Calif. (http://www.ucr.edu) — Using a material found in Silly Putty and surgical tubing, a group of researchers at the University of California, Riverside Bourns College of Engineering have developed a new way to make lithium-ion batteries that will last three times longer between charges compared to the current industry standard. The team created silicon dioxide (SiO2) nanotube anodes for lithium-ion batteries and found they had over three times as much energy storage capacity as the carbon-based anodes currently being used. This has significant implications ...

BUFFALO, N.Y. – Photodynamic therapy (PDT) is an effective treatment for easily accessible tumors such as oral and skin cancer. But the procedure, which uses lasers to activate special drugs called photosensitizing agents, isn't adept at fighting cancer deep inside the body. Thankfully, that's changing due to new technology that could bring PDT into areas of the body which were previously inaccessible. Described May 11 in the journal Nature Photonics, the approach involves using near-infrared beams of light that, upon penetrating deep into the body, are converted into ...

VIDEO: An octopus is treating its own freshly amputated arm in a strange and exploratory manner that is not commonly seen with respect to food items. Note the 'startle' response of... Click here for more information. An octopus's arms are covered in hundreds of suckers that will stick to just about anything, with one important exception. Those suckers generally won't grab onto the octopus itself; otherwise, the impressively flexible animals would quickly find themselves all tangled ...

Researchers have shown for the first time in an animal that is more closely related to humans that it is possible to make new bone from stem-cell-like induced pluripotent stem cells (iPSCs) made from an individual animal's own skin cells. The study in monkeys reported in the Cell Press journal Cell Reports on May 15th also shows that there is some risk that those iPSCs could seed tumors, but that unfortunate outcome appears to be less likely than studies in immune-compromised mice would suggest. "We have been able to design an animal model for testing of pluripotent ...

(SALT LAKE CITY) - Mice severely disabled by a condition similar to multiple sclerosis (MS) were able to walk less than two weeks following treatment with human neural stem cells. The finding, which uncovers potential new avenues for treating MS, will be published online on May 15, 2014, in the journal Stem Cell Reports. In striking contrast to active, healthy mice, those with an MS-like condition must be fed by hand because they cannot stand long enough to eat and drink on their own. When scientists transplanted human neural stem cells into the MS mice, they expected ...

Female politicians' success can be predicted by their facial features, especially in conservative states where women with more feminine faces tend to do better at the ballot box, a Dartmouth College-led study finds. The results don't mean a supermodel will win the White House, but they do suggest women's electoral success requires a delicate balance between voters' perception of traditional femininity and political competence. The study appears in the journal Social Psychological and Personality Science. A PDF of the study is available on request. Here is a video animation ...

LA JOLLA, CA—May 15, 2014—Mice crippled by an autoimmune disease similar to multiple sclerosis (MS) regained the ability to walk and run after a team of researchers led by scientists at The Scripps Research Institute (TSRI), University of Utah and University of California (UC), Irvine implanted human stem cells into their injured spinal cords. Remarkably, the mice recovered even after their bodies rejected the human stem cells. "When we implanted the human cells into mice that were paralyzed, they got up and started walking a couple of weeks later, and they completely ...

The gene mutations driving cancer have been tracked for the first time in patients back to a distinct set of cells at the root of cancer – cancer stem cells. The international research team, led by scientists at the University of Oxford and the Karolinska Institutet in Sweden, studied a group of patients with myelodysplastic syndromes – a malignant blood condition which frequently develops into acute myeloid leukaemia. The researchers say their findings, reported in the journal Cancer Cell, offer conclusive evidence for the existence of cancer stem cells. The concept ...

CAMBRIDGE, Mass. (May 15, 2014) – By studying nerve and liver cells grown from patient-derived induced pluripotent stem cells (iPSCs), Whitehead Institute researchers have identified a potential dual-pronged approach to treating Niemann-Pick type C (NPC) disease, a rare but devastating genetic disorder. According to the National Institutes of Health (NIH), approximately 1 in 150,000 children born are afflicted with NPC, the most common variant of Niemann-Pick. Children with NPC experience abnormal accumulation of cholesterol in their liver and nerve cells, leading to ...

PHILADELPHIA – Studies of vaccine programs in the developing world have revealed that individuals with chronic infections such as malaria and hepatitis tend to be less likely to develop the fullest possible immunity benefits from vaccines for unrelated illnesses. The underlying mechanisms for that impairment, however, are unclear, and distinguishing these so-called "bystander" effects on priming the immune system to fight future assaults versus development of immunological memory has been challenging. A team from the Perelman School of Medicine at the University of Pennsylvania ...

PHILADELPHIA (May 15, 2014) – Americans are unquestionably more aware of e-cigarettes, those vapor-emitting alternatives to tobacco cigarettes, according to a national survey. Yet, at the same time, the belief that e-cigarettes are safer than traditional smokes may be starting to diminish. A national survey of 3,630 adults found that 77 percent of the respondents have heard of e-cigarettes; that's way up from 16 percent just five years ago. But the perception that e-cigarettes are actually less harmful than tobacco cigarettes among current smokers decreased slightly, ...

A tiny nanoscale syringe is Salmonella's weapon. Using this, the pathogen injects its molecular agents into the host cells and manipulates them to its own advantage. A team of scientists at the Biozentrum of the University of Basel demonstrate in their current publication in Cell Reports that a much investigated protein, which plays a role in Salmonella metabolism, is required to activate these needles and makes the replication and spread of Salmonella throughout the whole body possible. The summer months are the prime time for Salmonella infections. Such an infection ...

MADISON, Wis. – The small but charismatic Hawaiian bobtail squid is known for its predator-fooling light organ. To survive, the nocturnal cephalopod depends on a symbiotic association with a luminescent bacterium that gives it the ability to mimic moonlight on the surface of the ocean and, in the fashion of a Klingon cloaking device, deceive barracuda and other fish that would happily make a meal of the small creature. The relationship between the squid and the bacterium Vibrio fischeri is well chronicled, but writing in the current issue of the journal Proceedings ...

The Synthetic Biology Project at the Woodrow Wilson International Center for Scholars is releasing the results of a new set of focus groups, which find continued low awareness of synthetic biology among the general public. The focus groups also sought opinions on the emerging field of neural engineering. The focus group results support the findings of a quantitative national poll conducted by Hart Research Associates in January 2013, which found just 23 percent of respondents reported they had heard a lot (6 percent) or some (17 percent) about synthetic biology. The ...