The final results from an international clinical trial involving nearly 2,000 patients with Crohn's disease support the use of a new management strategy referred to as accelerated step-care as a best practice for the care of active Crohn's disease. The REACT (Randomized Evaluation of an Algorithm for Crohn's Treatment) study, led by Robarts Clinical Trials at Western University (London, Canada) provides valuable new insights for community gastroenterologists which should benefit patients. The results of the study will be presented at the European Crohn's and Colitis Organisation ...

OAK RIDGE, Tenn., Feb. 19, 2014 -- Using a new microscopy method, researchers at the Department of Energy's Oak Ridge National Laboratory can image and measure electrochemical processes in batteries in real time and at nanoscale resolution. Scientists at ORNL used a miniature electrochemical liquid cell that is placed in a transmission electron microscope to study an enigmatic phenomenon in lithium-ion batteries called the solid electrolyte interphase, or SEI, as described in a study published in Chemical Communications. The SEI is a nanometer-scale film that forms ...

HOUSTON – (Feb. 19, 2014) – Many Texans were struggling to pay for basic health services on the eve of the launch of the Affordable Care Act's Health Insurance Marketplace, according to a report released today by Rice University's Baker Institute for Public Policy and the Episcopal Health Foundation. The report also found that even those with health insurance reported dissatisfaction with the cost and availability of services. Most Texans expect more of the same in 2014. The Health Reform Monitoring Survey (HRMS)-Texas report is based on the HRMS, a national project that ...

Several scientists, including one at Simon Fraser University, have made a discovery that strongly links a little understood molecule, which is similar to DNA, to cancer and cancer survival. EMBO Reports, a life sciences journal published by the European Molecular Biology Organization, has just published online the scientists' findings about small non-coding RNAs. While RNA is known to be key to our cells' successful creation of proteins, the role of small non-coding RNAs, a newly discovered cousin of the former, has eluded scientific understanding for the most part. ...

NEW YORK, February 19, 2014 — Investigators from Memorial Sloan Kettering Cancer Center have reported more encouraging news about one of the most exciting methods of cancer treatment today. The largest clinical study ever conducted to date of patients with advanced leukemia found that 88 percent achieved complete remissions after being treated with genetically modified versions of their own immune cells. The results were published today in Science Translational Medicine. "These extraordinary results demonstrate that cell therapy is a powerful treatment for patients who ...

A new study led by City College of New York psychologist Margaret Rosario found that youths of same-sex orientation are more likely to engage in behaviors associated with cancer risk than heterosexuals. The peer-reviewed findings appear in the February 2014 issue of the American Journal of Public Health. Titled "Sexual Orientation Disparities in Cancer-Related Risk Behaviors of Tobacco, Alcohol, Sexual Behaviors, and Diet and Physical Activity: Pooled Youth Risk Behavior Surveys," the study pooled YRBS (Youth Risk Behavior Survey) data from 2005 and 2007. The YRBS is ...

RIVERSIDE, Calif. (http://www.ucr.edu) — A team of researchers from the University of California, Riverside Bourns College of Engineering and Russian Academy of Science have demonstrated a new type of holographic memory device that could provide unprecedented data storage capacity and data processing capabilities in electronic devices. The new type of memory device uses spin waves – a collective oscillation of spins in magnetic materials – instead of the optical beams. Spin waves are advantageous because spin wave devices are compatible with the conventional electronic ...

Philadelphia, PA—Vast amounts of data related to climate change are being compiled by research groups all over the world. Data from these many and various sources results in different climate projections; hence, the need arises to combine information across data sets to arrive at a consensus regarding future climate estimates. In a paper published last December in the SIAM Journal on Uncertainty Quantification, authors Matthew Heaton, Tamara Greasby, and Stephan Sain propose a statistical hierarchical Bayesian model that consolidates climate change information ...

Seeing is believing, but smellizing – a new term for prompting consumers to imagine the smell of a product – could be the next step toward more effective advertising. Researchers came to this conclusion through four studies of products most of us would like to smellize: cookies and cake. Professor of Marketing Maureen Morrin of Temple University's Fox School of Business co-authored Smellizing Cookies and Salivating: A Focus on Olfactory Imagery to examine the impact imagining what a food smells like would have on consumer behavior. "Before we started this project, ...

WACO, Texas (Feb. 18, 2014)-- Baylor University researchers, in collaboration with an international team of scientists, have discovered definitive evidence of the environment inhabited by the early ape Proconsul on Rusinga Island, Kenya. The groundbreaking discovery provides additional information that will help scientists understand and interpret the connection between habitat preferences and the early diversification of the ape-human lineage. Their research findings--published this month in Nature Communications--demonstrate that Proconsul and its primate relative Dendropithecus ...

Ottawa, February, 19, 2014—In the world of science, one of the most exciting things a researcher can do is pin down an answer to a widely asked question. This experience came early for Carleton University graduate Thomas Cullen, who made a discovery about pinnipeds—the suborder that makes up seals, sea lions and walruses—while doing research for his Master's degree under the supervision of Canadian Museum of Nature palaeontologist Dr. Natalia Rybczynski. His discovery, published the journal Evolution, relates to sexual dimorphism (a large variance in size between males ...

WASHINGTON D.C. Feb. 19, 2014 -- Proteins are the workhorses of the cell, and their correctly folded three-dimensional structures are critical to cellular functions. Misfolded structures often fail to properly perform these vital jobs, leading to cellular stress and devastating neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's disease. In comparison with the mysteries of Alzheimer's or Parkinson's disease, Huntington's disease has a seemingly simple culprit: an expansion in the polyglutamine (polyQ) tract of a protein called "Huntingtin" (Htt). ...

Rutgers University scientists have determined the structure of a hepatitis C surface protein, a finding that could assist in the development of a vaccine to halt the spread of the the deadly disease that has infected 3.2 million Americans. Joseph Marcotrigiano, associate professor of chemistry and chemical biology, says this new research – published online today in Nature – describes an outer region of hepatitis C that enables the virus to evade the body's natural immune system response, causing persistent, chronic infection. Hepatitis C is constantly mutating, allowing ...

RIVERSIDE, Calif. — A team of biogeochemists at the University of California, Riverside, give us a nontraditional way of thinking about the earliest accumulation of oxygen in the atmosphere, arguably the most important biological event in Earth history. A general consensus asserts that appreciable oxygen first accumulated in Earth's atmosphere around 2.3 billion years ago during the so-called Great Oxidation Event (GOE). However, a new picture is emerging: Oxygen production by photosynthetic cyanobacteria may have initiated as early as 3 billion years ago, with oxygen ...

Astronomers for the first time have peered into the heart of an exploding star in the final minutes of its existence. The feat is one of the primary goals of NASA's NuSTAR mission, launched in June 2012 to measure high-energy X-ray emissions from exploding stars, or supernovae, and black holes, including the massive black hole at the center of our Milky Way Galaxy. The NuSTAR team reported in this week's issue of the journal Nature the first map of titanium thrown out from the core of a star that exploded in 1671. That explosion produced the beautiful supernova remnant ...

Diseases that are common in managed honeybee colonies are now widespread in the UK's wild bumblebees, according to research published in Nature. The study suggests that some diseases are being driven into wild bumblebee populations from managed honeybees. Dr Matthias Fürst and Professor Mark Brown from Royal Holloway University of London (who worked in collaboration with Dr Dino McMahon and Professor Robert Paxton at Queen's University Belfast, and Professor Juliet Osborne working at Rothamsted Research and the University of Exeter) say the research provides vital information ...

(MEMPHIS, Tenn. – February 19, 2014) The St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project has identified the most common genetic alteration ever reported in the brain tumor ependymoma and evidence that the alteration drives tumor development. The research appears February 19 as an advanced online publication in the scientific journal Nature. The results provide a foundation for new research to improve diagnosis and treatment of ependymoma, the third most common brain tumor in children. St. Jude has begun work to translate the ...

ROSEMONT, Ill.—Musculoskeletal pain of the bone, joint and muscles is one of the most common reasons for primary care visits in the United States. According to a literature review appearing in a recent issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS), chronic pain, or pain that persists beyond an expected period of healing, is estimated to affect 100 million Americans. The majority of chronic pain complaints concern the musculoskeletal system, but they also include headaches and abdominal pain. "As orthopaedic surgeons, we are experts in the ...

MAYWOOD, IL – A major study has found that giving stroke patients medications to lower their blood pressure during the first 48 hours after a stroke does not reduce the likelihood of death or major disability. The study is published in the Journal of the American Medical Association. At least 25 percent of the population has high blood pressure, which greatly increases the risk of stroke. Lowering blood pressure has been shown to reduce the risk of stroke. The study investigated whether there also would be a benefit to lowering blood pressure immediately after a stroke. The ...

COLUMBIA, Mo. – Self-employment can allow older workers to stay in the labor market longer and earn additional income, yet little research has addressed if reasons for self-employment vary across gender and culture. Now, University of Missouri researchers have studied factors that contribute to self-employment and found these factors differ for men and women in the United States and New Zealand. "Gender is one of the most enduring social factors in the U.S. and New Zealand, a fact that is particularly evident in differing economic opportunities for men and women and their ...

Progressive degeneration of photoreceptors—the rods and cones of the eyes—causes blinding diseases such as retinitis pigmentosa and age-related macular degeneration. While there are currently no available treatments to reverse this degeneration, a newly developed compound allows other cells in the eye to act like photoreceptors. As described in a study appearing in the February 19 issue of the Cell Press journal Neuron, the compound may be a potential drug candidate for treating patients suffering from degenerative retinal disorders. The retina has three layers of nerve ...

PROVIDENCE, R.I. [Brown University] — Keep this in mind: Scientists say they've learned how your brain plucks information out of working memory when you decide to act. Say you're a busy mom trying to wrap up a work call now that you've arrived home. While you converse on your Bluetooth headset, one kid begs for an unspecified snack, another asks where his homework project has gone, and just then an urgent e-mail from your boss buzzes the phone in your purse. During the call's last few minutes these urgent requests — snack, homework, boss — wait in your working memory. ...

CHICAGO --- If you're 60 and older, every additional hour a day you spend sitting is linked to doubling the risk of being disabled -- regardless of how much moderate exercise you get, reports a new Northwestern Medicine® study. The study is the first to show sedentary behavior is its own risk factor for disability, separate from lack of moderate vigorous physical activity. In fact, sedentary behavior is almost as strong a risk factor for disability as lack of moderate exercise. If there are two 65-year-old women, one sedentary for 12 hours a day and another sedentary ...

The switch in the brain that sends us off to sleep has been identified by researchers at Oxford University's Centre for Neural Circuits and Behaviour in a study in fruit flies. The switch works by regulating the activity of a handful of sleep-promoting nerve cells, or neurons, in the brain. The neurons fire when we're tired and need sleep, and dampen down when we're fully rested. 'When you're tired, these neurons in the brain shout loud and they send you to sleep,' says Professor Gero Miesenböck of Oxford University, in whose laboratory the new research was performed. Although ...

WASHINGTON (Feb. 19, 2014) — Collaborative research out of the George Washington University (GW) reveals new information on the pathogenesis of feeding and swallowing difficulties often found in children with neurodevelopmental disorders, including autism and intellectual disability. Using an animal model of DiGeorge/22q11 Deletion Syndrome, a genetic disorder that causes autism and intellectual disability, the GW group found clear signs of early feeding and swallowing disruption, and underlying changes in brain development. The research, featured on the cover of Disease ...