Proteins are vital participants in virtually all life processes, including growth, repair and signaling in cells; catalysis of chemical reactions and defense against infection. For these reasons, proteins can provide critical signposts of health and disease, provided they can be identified and assessed in a clinical setting. Accurately characterizing proteins for diagnostic and therapeutic purposes has been an enormous challenge for the medical community. At the Biodesign Institute's Molecular Biomarkers Laboratory at Arizona State University, research focuses on the ...

Mathematicians at the University of York have joined forces with experimentalists at the University of Leeds to take an important step in discovering how viruses make new copies of themselves during an infection. The researchers have constructed a mathematical model that provides important new insights about the molecular mechanisms behind virus assembly which helps to explain the efficiency of their operation. The discovery opens up new possibilities for the development of anti-viral therapies and could help in the treatment of a range of diseases from HIV and Hepatitis ...

Wrinkling is a common phenomenon for thin stiff film adhered on soft substrate. Various wrinkling phenomenon has been reported previously. Wu Dan, Yin Yajun, Xie Huimin,et al from Tsinghua University proposed a new method to control wrinkling and buckling of thin stiff film on soft substrate. It is found that the curve pattern on the soft substrate has obvious influence on the wrinkling distribution of the thin film/soft substrate. Their work, entitled "Controlling the surface buckling wrinkles by patterning the material system of hard-nano-film/soft-matter-substrate", ...

(NEW YORK, NY, March 24, 2014) – Polycystic ovary syndrome (PCOS), a hormone imbalance that causes infertility, obesity, and excessive facial hair in women, can also lead to severe mental health issues including anxiety, depression, and eating disorders. A study supervised by Columbia University School of Nursing professor Nancy Reame, MSN, PhD, FAAN, and published in the Journal of Behavioral Health Services & Research, identifies the PCOS complications that may be most responsible for psychiatric problems. While weight gain and unwanted body hair can be distressing, irregular ...

Young children who sleep less eat more, which can lead to obesity and related health problems later in life, reports a new study by UCL researchers. The study found that 16 month-old children who slept for less than 10 hours each day consumed on average 105kcal more per day than children who slept for more than 13 hours. This is an increase of around 10% from 982kcal to 1087kcal. Associations between eating, weight and sleep have been reported previously in older children and adults, but the study, published in the International Journal of Obesity, is the first to directly ...

AUDIO: This is a podcast interview with Professor Schwaeble. Click here for more information. "I am really excited about this landmark discovery. We demonstrate that boosting the innate immune system can have a significant impact on the body's ability to defend itself against life-threatening infections" - Professor Wilhelm Schwaeble from the University of Leicester's Department of Infection, Immunity and Inflammation IMAGES AND A PODCAST INTERVIEW WITH PROFESSOR SCHWAEBLE ...

CAMBRIDGE, Mass., March 24 — Scientists at Forsyth, along with a colleague from Northwestern University, have discovered that the protein, Transgultaminase 2 (TG2), is a key component in the process of gum disease. TG2 is widely distributed inside and outside of human cells. The scientists found that blocking some associations of TG2 prevents the bacteria Porphyromonas gingivalis (PG) from adhering to cells. This insight may one day help lead to novel therapies to prevent gum disease caused by PG. Periodontal, or gum, disease is one of the most common infectious diseases. ...

Washington, D.C.— Plants convert energy from sunlight into chemical energy during a process called photosynthesis. This energy is passed on to humans and animals that eat the plants, and thus photosynthesis is the primary source of energy for all life on Earth. But the photosynthetic activity of various regions is changing due to human interaction with the environment, including climate change, which makes large-scale studies of photosynthetic activity of interest. New research from a team including Carnegie's Joe Berry reveals a fundamentally new approach for measuring ...

Bottom Line: Habitually playing violent video games appears to increase aggression in children, regardless of parental involvement and other factors. Author: Douglas A. Gentile, Ph.D., of Iowa State University, Ames, and colleagues. Background: More than 90 percent of American youths play video games, and many of these games depict violence, which is often portrayed as fun, justified and without negative consequences. How the Study Was Conducted: The authors tracked children and adolescents in Singapore over three years on self-reported measures of gaming habits, ...

Bottom Line: The use of electronic cigarettes (e-cigarettes) by smokers is not associated with greater rates of quitting cigarettes or reduced cigarette consumption after one year. Author: Rachel A. Grana, Ph.D., M.P.H., and colleagues from the University California, San Francisco. Background: E-cigarettes are promoted as smoking cessation tools, but studies of their effectiveness have been unconvincing. How the Study Was Conducted: The authors analyzed self-reported data from 949 smokers (88 of the smokers used e-cigarettes at baseline) to determine if e-cigarettes ...

Treatment with natalizumab in patients with multiple sclerosis (MS) appears linked with JC virus (JCV) infection, which can lead to a rare and often fatal demyelinating disease of the central nervous system called progressive multifocal leukoencephalopathy (PML) that destroys the myelin that protects nerve cells. The movement of cells with JC virus into the blood stream may provide researchers with a possible reason why patients with MS develop PML Since natalizumab was reintroduced as a biologic therapy for MS in 2006, more than 440 cases of PML have been reported. ...

(Lebanon, NH, 03/24/2014)- Dartmouth researchers at its Norris Cotton Cancer Center have compiled a review of the role that information gathered through genetic testing plays in the diagnosis and treatment of breast cancer. The paper entitled "Personalized Therapy for Breast Cancer" was accepted on March 17, 2014, for publication in Clinical Genetics. The paper discusses targeted therapies, new biomarkers, and the quality of commercially available testing methods. Genomic testing is changing the way breast cancer is diagnosed and treated. By examining a woman's genes ...

TORONTO – 'Watch out for weight gain within a year of giving birth to prevent new risk of diabetes and cardiovascular disease.' That advice for women comes from a study published today in the journal Diabetes Care. While it has long been believed that not losing 'baby weight' for several years after pregnancy carries long-term risks of diabetes and heart disease the research team at Mount Sinai Hospital, Toronto, aimed to test this theory by tracking risk factors and weight in the first 12 months after giving birth. The team led by clinician-researcher Dr. Ravi ...

A revolution in cancer treatment could soon be underway following a breakthrough that may lead to a dramatic improvement in cancer survival rates. A new study at the University of Warwick, published today in the journal Angewandte Chemie International Edition, has developed a new drug that can manipulate the body's natural signalling and energy systems, allowing the body to attack and shut down cancerous cells. Called ZL105, the drug is a compound based on the precious metal iridium. The study has found ZL105 could potentially replace currently used anticancer drugs, ...

New Rochelle, NY, March 25, 2014—Posttraumatic stress disorder (PTSD) is common among military veterans and together with the often-related anxiety, depression, and psychological and emotional impairment can dramatically affect quality of life. A type of virtual reality (VR) treatment called Graded Exposure Therapy (GET) can improve PTSD symptoms and may also have a positive impact on these associated disorders, as described in an article in Cyberpsychology, Behavior, and Social Networking, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is ...

INDIANAPOLIS -- Changing how medication alerts are presented in electronic medical records resulted in safer prescribing, increased efficiency and reduced workload for health care providers who placed drug orders in a study published online in the Journal of the American Medical Informatics Association. "The VA electronic medical record system is one of the most widely used and respected EMR systems in the country," said Alissa L. Russ, Ph.D., a human factors engineer who led the study. "This EMR is used by providers at over 150 VA hospitals. We are looking at ways to ...

Pesticides have a direct impact on the physiology and behaviour of earthworms, a Danish/French research team reports after having studied earthworms that were exposed to pesticides over generations. "We see that the worms have developed methods to detoxify themselves, so that they can live in soil sprayed with fungicide. They spend a lot of energy on detoxifying, and that comes with a cost: The worms do not reach the same size as other worms, and we see that there are fewer of them in sprayed soil. An explanation could be that they are less successful at reproducing, ...

PROVIDENCE, R.I. – The emergence of community-acquired infections, such as urinary tract infections (UTI), due to strains resistant to common antibiotics are on the rise, according to Rhode Island Hospital researchers. The study is published online in the journal Antimicrobial Resistance and Infection Control. "Over the last several years, we've seen an increase in the number of bacteria -- many of which are forms of E. coli -- that are resistant to commonly administered antibiotics," said Leonard Mermel, D.O., medical director of the department of epidemiology and infection ...

ANN ARBOR, Mich. — Four years after being treated for breast cancer, a quarter of survivors say they are worse off financially, at least partly because of their treatment, according to a new study led by University of Michigan Comprehensive Cancer Center researchers. In addition, 12 percent reported that they still have medical debt from their treatment. Financial decline varied significantly by race, with Spanish-speaking Latinas most likely to be impacted. Debt was reported more frequently in English-speaking Latinas and Blacks, the study found. Results appear in ...

Scientists have found that a simple blood test, which can read DNA, could be used to predict obesity levels in children. Researchers at the Universities of Southampton, Exeter and Plymouth used the test to assess the levels of epigenetic switches in the PGC1a gene – a gene that regulates fat storage in the body. Epigenetic switches take place through a chemical change called DNA methylation which controls how genes work and is set during early life. The Southampton team found that the test, when carried out on children at five years old, differentiates between children ...

TORONTO, ON – A new study by University of Toronto researchers has found that kids' books featuring animals with human characteristics not only lead to less factual learning but also influence children's reasoning about animals. Researchers also found that young readers are more likely to attribute human behaviors and emotions to animals when exposed to books with anthropomorphized animals than books depicting animals realistically. "Books that portray animals realistically lead to more learning and more accurate biological understanding," says lead author Patricia ...

CAMBRIDGE, MA -- Doctors commonly use magnetic resonance imaging (MRI) to diagnose tumors, damage from stroke, and many other medical conditions. Neuroscientists also rely on it as a research tool for identifying parts of the brain that carry out different cognitive functions. Now, a team of biological engineers at MIT is trying to adapt MRI to a much smaller scale, allowing researchers to visualize gene activity inside the brains of living animals. Tracking these genes with MRI would enable scientists to learn more about how the genes control processes such as forming ...

WASHINGTON - A large proportion of teenage boys and college men report having been coerced into sex or sexual behavior, according to research published by the American Psychological Association. A total of 43 percent of high school boys and young college men reported they had an unwanted sexual experience and of those, 95 percent said a female acquaintance was the aggressor, according to a study published online in the APA journal Psychology of Men and Masculinity. "Sexual victimization continues to be a pervasive problem in the United States, but the victimization ...

The study, published in the journal Technovation and written by Pere Ortín Ángel and Ferran Vendrell Herrero, covers financial data from two comparison samples of companies founded between 1994 and 2005. One sample is made up of 104 university spin-offs and the other is made up of 73 technology-based, non-university companies. The study compares what is known as the total factor productivity of these two samples. According to the study, in the university spin-offs this productivity is, on average, lower in the year in which the company is founded. Nevertheless, data shows ...

Alteration of the autophagic process is involved in neurodegeneration. The beclin 1 complex is shown to play a key role in the initial stage of autophagy. Dr. Yanming Wei and co-coworkers from College of Life Science, Northwest Agriculture & Forestry University in China pointed out the amyotrophic lateral sclerosis-linked Cu/Zn superoxide dismutase 1 G93A mutant can upregulate autophagic activity in NSC34 cells, but that this does not markedly affect beclin 1 complex components. The relevant paper has been published in the Neural Regeneration Research (Vol. 9, No. 1, 2014). INFORMATION: Article: ...