Infectious disease specialists at the Johns Hopkins Children's Center have identified a protein that regulates the body's immune response to cytomegalovirus (CMV), a common pathogen that causes lifelong infections and can lead to devastating illness in newborns and those with weakened immune systems. The protein — a cell receptor called NOD2 found in several types of immune cells — has long been known for its role in fighting off bacterial invaders by sensing their presence and alerting immune cells to release chemicals that weaken or destroy the harmful bacteria. That ...

RICHARDSON, Texas (March 26, 2014) — The legalization of medical marijuana has sparked debate across the nation for decades. Some opponents have argued that medical marijuana's legalization will lead to higher crime rates, but according to a new study at UT Dallas, legalization of medical cannabis is not an indicator of increased crime. It actually may be related to reductions in certain types of crime, said Dr. Robert Morris, associate professor of criminology and lead author of the study, published in the journal PLOS ONE. "We're cautious about saying, 'Medical ...

The architecture of the autistic brain is speckled with patches of abnormal neurons, according to research partially funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health. Published in the New England Journal of Medicine on March 27, 2014, this study suggests that brain irregularities in children with autism can be traced back to prenatal development. "While autism is generally considered a developmental brain disorder, research has not identified a consistent or causative lesion," said Thomas R. Insel, M.D., director of NIMH. ...

Bacteria are invisible to the naked eye, but they reside on nearly every surface humans encounter—including the skin. Uncovering the role these microorganisms play in human health is a major focus of research in skin microbiology, but little is known about the identity or function of skin bacteria in other mammals. In a paper published in the open access journal PLOS ONE, researchers at Woods Hole Oceanographic Institution (WHOI) and colleagues identified a core skin bacterial community that humpback whales share across populations, which could point to a way to assess ...

A smartphone application appears to help patients with alcohol use disorder (AUD) reduce risky drinking days compared to patients who received usual care after leaving treatment in a residential program. Alcohol dependence is a lifetime psychiatric diagnosis with relapse rates similar to other chronic illnesses. Continuing care for AUDs has been associated with better outcomes, but patients leaving treatment for AUDs typically are not offered aftercare. The authors randomized 349 patients with alcohol dependence leaving three residential programs to treatment as ...

NEW YORK (March 26, 2014) – Migraine sufferers who experienced reduced stress from one day to the next are at significantly increased risk of migraine onset on the subsequent day, according to a new study conducted by researchers at the Montefiore Headache Center and Albert Einstein College of Medicine at Yeshiva University. Stress has long been believed to be a common headache trigger. In this study, researchers found that relaxation following heightened stress was an even more significant trigger for migraine attacks. Findings may aid in recommending preventive treatments ...

Athens, Ga. – Developmental biologists at the University of Georgia are discovering new roles for a specific gene known as Max's Giant Associated protein, or MGA. A little studied protein, MGA appears to control a number of developmental processes, and also may be connected to cancer development. The researchers detail their findings in a paper published recently in the journal Developmental Cell. "The same genes that are involved in building a person during embryonic development can mutate and cause cancer later in life," said Scott Dougan the study's principal investigator ...

DALLAS – March 26, 2014 – "Today, we're going to make history," said 18-year-old Eric Ramos on the day UT Southwestern Medical Center doctors operated on his ailing heart. Eric, who has Duchenne muscular dystrophy, is one of only three patients in the United States with the condition to receive a battery-operated left ventricular assist device (LVAD) to keep his weakening heart pumping blood through his body. He is the first patient in the country to be given a specific, smaller LVAD, which means doctors would not need to manipulate his diaphragm, which could compromise ...

Scientists seeking a more efficient way of protecting the heart of Africa's wildlife—the Greater Virunga Landscape—have developed a method to make the most of limited enforcement resources, according to a new study by the Wildlife Conservation Society, the University of Queensland, Imperial College London, and the Uganda Wildlife Authority. By channeling data on wildlife sightings and park guard patrolling routes into spatial planning software, conservationists have devised a cost-effective method for maximizing the deterrence effect of patrolling to protect Africa's ...

ORONO, ME--Researchers have released a new Capsicum annuum pepper germplasm that contains high concentrations of capsinoids. The release was announced in the January 2014 issue of HortScience by researchers Robert L. Jarret from the USDA/Agricultural Research Service in Griffin, Georgia, in collaboration with Jason Bolton and L. Brian Perkins from the Department of Food Science and Human Nutrition at the University of Maine. According to the report, the germplasm called "509-45-1" is a small-fruited Capsicum annuum L. pepper. Fruit of 509-45-1 contain high concentrations ...

WASHINGTON, D.C. -- Six massive glaciers in West Antarctica are moving faster than they did 40 years ago, causing more ice to discharge into the ocean and global sea level to rise, according to new research. The amount of ice draining collectively from those half-dozen glaciers increased by 77 percent from 1973 to 2013, scientists report this month in Geophysical Research Letters, a journal of the American Geophysical Union. Pine Island Glacier, the most active of the studied glaciers, has accelerated by 75 percent in 40 years, according to the paper. Thwaites Glacier, ...

LAKE ALFRED, FL--Citrus Huanglongbing (citrus greening disease) is highly destructive and fast-spreading, contributing to a reduction in crop yields in Florida and threatening the future of the citrus industry worldwide. Once infected, trees never fully recover and there currently is no cure, although proper nutrient and water management appear to slow tree decline in some situations. A bacterium called Candidatus Liberibacter asiaticus (CLas), vectored by the Asian citrus psyllid, is the presumed causal agent of the disease. Citrus trees affected by HLB exhibit a progressive ...

Amyotrophic lateral sclerosis, also known as Lou Gehrig's disease, is marked by a cascade of cellular and inflammatory events that weakens and kills vital motor neurons in the brain and spinal cord. The process is complex, involving cells that ordinarily protect the neurons from harm. Now, a new study by scientists in The Research Institute at Nationwide Children's Hospital points to a potential culprit in this good-cell-gone-bad scenario, a key step toward the ultimate goal of developing a treatment. Motor neurons, or nerve cells, in the brain and spinal cord control ...

Beverly, MA, March 26, 2014 – Surgical aortic valve replacement generally improves patients' symptoms and prolongs survival. However, the perceived risk of surgical aortic valve replacement in patients over 80 may result in surgery being denied or a recommendation for alternative therapy. Investigators at the Mayo Clinic challenge the way these patients have been managed. They report that repeat sternotomy in patients over 80 who have previously had coronary bypass graft surgery can be done with low risk. Their findings are published in the Journal of Thoracic and Cardiovascular ...

EAST LANSING, MI--Since the introduction of 'Honeycrisp' apples in 1991, the variety has become a consumer favorite for its unusual texture and delicious flavor. Honeycrisp has increased in popularity with growers as well; Michigan, New York, and Washington boast significant numbers of 'Honeycrisp' orchards. As the growing area dedicated to the variety has grown, the need to find better methods for improving storage performance has become more important to growers. Because 'Honeycrisp' is very sensitive to low temperatures and can be damaged by controlled-atmosphere conditions, ...

TAIPEI, TAIWAN--The Phalaenopsis orchid, also known as the moth orchid, is the most important pot flower in terms of market value in the world's major floriculture markets. Because nitrogen significantly affects the growth and flowering of Phalaenopsis, nitrogen needs during flowering are of particular interest to growers. Researchers Hadi Susilo, Ying-Chun Peng, and Yao-Chien Alex Chang from the Department of Horticulture and Landscape Architecture at National Taiwan University published a study in the Journal of the American Society for Horticultural Science that determined ...

Researchers at the Georgia Institute of Technology and the Joint BioEnergy Institute have engineered a bacterium to synthesize pinene, a hydrocarbon produced by trees that could potentially replace high-energy fuels, such as JP-10, in missiles and other aerospace applications. With improvements in process efficiency, the biofuel could supplement limited supplies of petroleum-based JP-10, and might also facilitate development of a new generation of more powerful engines. By inserting enzymes from trees into the bacterium, first author and Georgia Tech graduate student ...

The animals lived 520 million years ago during the Early Cambrian, a period known as the 'Cambrian Explosion' in which all the major animal groups and complex ecosystems suddenly appeared. Tamisiocaris belongs to a group of animals called anomalocarids, a type of early arthropod that included the largest and some of the most iconic animals of the Cambrian period. They swam using flaps down either side of the body and had large appendages in front of their mouths that they most likely used to capture larger prey, such as trilobites. However, the newly discovered fossils ...

The rings of Saturn are one of the most spectacular sights in the sky, and less prominent rings have also been found around the other giant planets. Despite many careful searches, no rings had been found around smaller objects orbiting the Sun in the Solar System. Now observations of the distant minor planet [1] (10199) Chariklo [2] as it passed in front of a star have shown that this object too is surrounded by two fine rings. "We weren't looking for a ring and didn't think small bodies like Chariklo had them at all, so the discovery — and the amazing amountof detail ...

CINCINNATI—It's not the size of the stomach that causes weight loss after a specific type of bariatric surgery, but rather a change in the gut metabolism, say researchers from the University of Cincinnati (UC), the University of Gothenburg in Sweden and Cincinnati Children's Hospital Medical Center. The scientists, publishing their results in the March 26, 2014, advanced online edition of Nature, have found that following vertical sleeve gastrectomy, there is a change in bile acids that bind to a nuclear receptor called FXR. In the absence of FXR, the researchers showed, ...

PITTSBURGH, March 26, 2014 – A breast cancer therapy that blocks estrogen synthesis to activate cancer-killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, including permanent DNA modifications in the patient's tumor, once again allowing tumor growth, according to an international team headed by the University of Pittsburgh Cancer Institute (UPCI). The finding warrants research into adding drugs that could prevent the cancer from hijacking patients' repressive gene regulatory machinery, which might allow the original therapy ...

Boston, MA — A large international consortium of researchers has produced the first comprehensive, detailed map of the way genes work across the major cells and tissues of the human body. The findings describe the complex networks that govern gene activity, and the new information could play a crucial role in identifying the genes involved with disease. "Now, for the first time, we are able to pinpoint the regions of the genome that can be active in a disease and in normal activity, whether it's in a brain cell, the skin, in blood stem cells or in hair follicles," said ...

Working with genetically engineered mice, Johns Hopkins neuroscientists report they have identified what they believe is the cause of the vast disintegration of a part of the brain called the corpus striatum in rodents and people with Huntington's disease: loss of the ability to make the amino acid cysteine. They also found that disease progression slowed in mice that were fed a diet rich in cysteine, which is found in foods such as wheat germ and whey protein. Their results suggest further investigation into cysteine supplementation as a candidate therapeutic in people ...

Until now, rings of material in a disc have only been observed around giant planets like Jupiter, Uranus, Neptune and especially Saturn, which is known for its spectacular rings. Now astronomers from the Niels Bohr Institute, among others, have observed the first miniature planet with two rings of ice and pebbles. It is a smaller celestial body, called Chariklo, located two billion kilometers out in the solar system between Saturn and Uranus. The results are published in the prestigious scientific journal, Nature. Chariklo was located in the Kuiper Belt, a collection ...

Scientists have built the clearest picture yet of how our genetic material is regulated in order to make the human body work. They have mapped how a network of switches, built into our DNA, controls where and when our genes are turned on and off. University of Edinburgh scientists played a leading role in the international project – called FANTOM5 – which has been examining how our genome holds the code for creating the fantastic diversity of cell types that make up a human. The three year project, steered by the RIKEN Center for Life Science Technologies in Japan, ...