New research published in the journal Nature Chemical Biology shows that a group of scientists, led by faculty at the University of Notre Dame, has made concrete progress toward the development of the first-ever inhibitory therapeutic for Type I hypersensitive allergic reactions. "Our allergy inhibition project is innovative and significant because we brought a novel molecular design approach to selectively inhibit mast cell degranulation — the key event in triggering a food allergic response — which has the potential to improve the quality of life for affected patients," ...

Case Western Reserve University researchers today published findings that point to a promising discovery for the treatment and prevention of prion diseases, rare neurodegenerative disorders that are always fatal. The researchers discovered that recombinant human prion protein stops the propagation of prions, the infectious pathogens that cause the diseases. "This is the very first time recombinant protein has been shown to inhibit diseased human prions," said Wen-Quan Zou, MD, PhD, senior author of the study and associate professor of pathology and neurology at Case Western ...

BUFFALO, N.Y. — Rocky pillars dotting Iceland's Skaelingar valley were projectiles tossed into the fields by warring trolls. That, at least, is the tale that University at Buffalo geologist Tracy Gregg heard from a tour guide and local hiker when she visited the site on two occasions. But Gregg and a colleague have a new explanation for the presence of the lava formations — this one also unexpected. In the Journal of Volcanology and Geothermal Research, she and former UB master's student Kenneth Christle report that the pillars, hollow and made from basalt, likely formed ...

CAMBRIDGE, MA -- The structure of the auditing business appears problematic: Typically, major companies pay auditors to examine their books under the so-called "third-party" audit system. But when an auditing firm's revenues come directly from its clients, the auditors have an incentive not to deliver bad news to them. So: Does this arrangement affect the actual performance of auditors? In an eye-opening experiment involving roughly 500 industrial plants in the state of Gujarat, in western India, changing the auditing system has indeed produced dramatically different ...

New brain imaging technology is helping researchers to bridge the gap between art and science by mapping the different ways in which the brain responds to poetry and prose. Scientists at the University of Exeter used state-of-the-art functional magnetic resonance imaging (fMRI) technology, which allows them to visualise which parts of the brain are activated to process various activities. No one had previously looked specifically at the differing responses in the brain to poetry and prose. In research published in the Journal of Consciousness Studies, the team found ...

Two purportedly royal relics recently surfaced on the collectors' market in France: a mummified head and a handkerchief with blood residues. The head was said to be that of French king Henry IV and the blood on the handkerchief that of King Louis XVI. This was confirmed by Spanish and French researchers, who reported positive DNA matches. Several historians voiced doubts about these claims and enrolled the help of forensic identification specialist Professor Jean-Jacques Cassiman and his team to investigate the relics. Professor Cassiman's team compared the published ...

(Boston)-- A study by physicians at Boston Medical Center (BMC), has found that patients with a high degree of activation (possessing the knowledge, skills, confidence and inclination to assume responsibility for managing one's health and health-care needs) were less likely to be readmitted to the hospital within 30 days of discharge than those with a low level of activation. This study, which appears online in Journal of General Internal Medicine, is the first to evaluate patient activation and its effects on utilization of hospital services after discharge. Hospital ...

For the first time, researchers have created a model that could help unlock what causes adenomyosis, a common gynecological disease that is a major contributor to women having to undergo hysterectomies. In a two-step process, a team led by Michigan State University's Jae-Wook Jeong first identified a protein known as beta-catenin that may play a key role in the development of the disease. When activated, beta-catenin causes changes in certain cells in a woman's uterus, leading to adenomyosis. Then Jeong, an associate professor in the College of Human Medicine's Department ...

Philadelphia, PA, October 9, 2013 – Investigators who studied a group of recreational marathon runners have established that strenuous exercise such as running a marathon can damage the heart muscle. Although they found the effect is temporary and reversible, they warn that these effects are more widespread in less fit distance runners and that recreational distance runners should prepare properly before marathons. Their findings are published in the October issue of the Canadian Journal of Cardiology. Previous reports have established that a significant percentage of ...

(PHILADELPHIA) High levels of high density lipoprotein (HDL), also known as the "good cholesterol," are thought to protect against heart disease. However, what's good for one disease may not be good for another. High levels of HDL have also been linked to increased breast cancer risks and to enhanced cancer aggressiveness in animal experiments. Now, a team of researchers led by Philippe Frank, Ph.D., a cancer biologist in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University, has shown that an HDL receptor found on breast cancer cells may be ...

ROCHESTER, Minn. -- As baby boomers enter their retirement years, health care costs for complex and debilitating conditions such as Alzheimer's disease are expected to soar. Not drawing as much attention is the likelihood of similarly rising expenses for common age-related medical procedures. A Mayo Clinic study looked at one of those -- cataract surgery-- and found that more people are getting the vision-improving procedure, seeking it at younger ages and having both eyes repaired within a few months, rather than only treating one eye. The demand shows no sign of leveling ...

(Boston) - Investigators at Boston University School of Medicine (BUSM) have identified that lack of time and a paucity of trained faculty are perceived as the most significant barriers to incorporating complementary and alternative medicine (CAM) and integrative medicine (IM) training into family medicine residency curricula and training programs. The study results, which are published online in Explore: The Journal of Science and Healing, were collected using data from an online survey completed by 212 national residency program directors. The study was led by Paula ...

As human life expectancy increases, so does the percentage of invasive and endangered birds and mammals, according to a new study by the University of California, Davis. The study, published in the September issue of Ecology and Society, examined a combination of 15 social and ecological variables -- from tourism and per capita gross domestic product to water stress and political stability. Then researchers analyzed their correlations with invasive and endangered birds and mammals, which are two indicators of what conservationist Aldo Leopold termed "land sickness," ...

CAMBRIDGE, MA -- It was a result so unexpected that MIT researchers initially thought it must be a mistake: Under certain conditions, putting a cracked piece of metal under tension -- that is, exerting a force that would be expected to pull it apart -- has the reverse effect, causing the crack to close and its edges to fuse together. The surprising finding could lead to self-healing materials that repair incipient damage before it has a chance to spread. The results were published in the journal Physical Review Letters in a paper by graduate student Guoqiang Xu and professor ...

For many, music is a universal language that unites people when words cannot. But for those who use cochlear implants -- technology that allows deaf and hard of hearing people to comprehend speech -- hearing music remains extremely challenging. University of Washington scientists hope to change this. They have developed a new way of processing the signals in cochlear implants to help users hear music better. The technique lets users perceive differences between musical instruments, a significant improvement from what standard cochlear implants can offer, said lead researcher ...

(Boston) - Researchers from Boston University School of Medicine (BUSM) and several other institutions including the National Center for PSTD, VA Boston Healthcare System, Suffolk University, Massachusetts General Hospital and Harvard University, have determined that psychophysiologic reactivity to trauma-related, script-driven imagery procedures is a promising biological predictor of a post-traumatic stress disorder (PTSD) diagnosis. These findings appear online in the Journal of Abnormal Psychology. Approximately seven to 12 percent of the general adult population ...

Clinical trial outcomes are more complete in unpublished reports than in publicly available information Publicly available sources of information reporting findings from clinical trials provide much less information on patient-relevant outcomes than unpublished reports, according to a study by German researchers published in this week's PLOS Medicine. The results of the study by Beate Wieseler and colleagues from the Institute for Quality and Efficiency in Health Care in Cologne, Germany, found that the publicly available information contained less information about both ...

The current influenza (flu) vaccination policy in England and Wales should be expanded to target 5 to 16-year-olds in order to further reduce the number of deaths from flu, according to a study by UK researchers published in this week's PLOS Medicine. The results of the study by Marc Baguelin and colleagues from the London School of Hygiene & Tropical Medicine in the UK, Public Health England, and Athens University of Economics and Business, show that the current flu vaccination policy that targets people aged 65 years and over and also those in high risk groups has ...

In this week's PLOS Medicine two independently written articles call for a shift away from the leader-centric approach that polio eradication campaigns are currently pursuing in the three countries (Nigeria, Pakistan and Afghanistan) where the disease remains endemic. In a Policy Forum article, authors from Nigeria, Pakistan and Afghanistan led by Seye Abimbola from the National Primary Health Care Development Agency, Nigeria, argue that the global health community and governments involved in polio eradication efforts need to build trust and prioritise polio eradication ...

Using a common test of brain functioning, UC Davis researchers have found differences in the brains of adolescents with the inattentive and combined subtypes of attention-deficit/hyperactivity disorder (ADHD) and teens who do not have the condition, suggesting that the test may offer a potential biomarker for differentiating the types of the disorder. The differences were observed in brain waves exhibited during electroencephalograms (EEGs) of teens with the inattentive and combined subtypes of the condition and typical adolescents, illustrating that these groups display ...

KNOXVILLE—Although a turtle's home may be on its back, some North American turtles face an uncertain future as a warming climate threatens to reduce their suitable habitat. A new study that reconstructs the effects of past climatic changes on 59 species of North American turtles finds that the centers of the turtles' ranges shifted an average of 45 miles for each degree of warming or cooling. While some species were able to find widespread suitable climate, other species, many of which today are endangered, were left with only minimal habitat. Species in temperate ...

WASHINGTON, DC— Researchers at the National Institutes of Health (NIH), Bethesda, MD, have taken the first steps to determine if a protein, called Programmed Death Ligand 1 (PD-L1), can help to predict which thyroid cancer patients will most likely have a recurrence of the disease. Study findings were presented today at the 2013 Clinical Congress of the American College of Surgeons. More than 80 percent of patients diagnosed with thyroid cancer have a type called papillary thyroid cancer, which usually grows on only one side of the thyroid gland, according to the American ...

With the abundance of sequencing data, scientists can use ever more powerful evolutionary biology tools to pinpoint the transmission and death rates for epidemics such as HIV, which has remained elusive to a cure. Reconstructed evolutionary trees, called phylogenies, can trace a family of viral mutations over time. When combined with epidemiology, tree construction can allow for great insight into the dynamics of disease transmission and how a pathogen eludes its host to spread infection. Professor Gabriel Leventhal, et. al., from the ETH Zurich in Switzerland report ...

WASHINGTON — A team of researchers at Georgetown University Medical Center (GUMC) has found that loss of an anti-aging gene induces retinal degeneration in mice and might contribute to age-related macular degeneration, the major cause of blindness in the elderly. In the Oct. 9 issue of the Journal of Neuroscience, the scientists demonstrated a key role for the aging-suppressor gene Klotho in maintaining the health of the mouse and human retina. They say that in their animal studies, loss of Klotho expression leads to characteristics observed in both kinds of macular degeneration ...

The greater the empathy skills of children, the easier it is for them to recognize sarcasm, according to a new study in the open-access journal Frontiers in Psychology. For children, sarcastic language can be difficult to understand. They generally begin to recognize sarcasm between ages 6 and 8, especially familiar sarcastic praise such as "Thanks a lot!" and "Nice going!" But some children take much longer to begin to understand sarcasm, with detection improving even through adolescence. In a new study, Penny Pexman, Juanita Whalen, and Andrew Nicholson investigated ...