CINCINNATI—University of Cincinnati (UC) researchers have discovered a biomarker, known as phosphatidylserine (PS), for pancreatic cancer that could be effectively targeted, creating a potential therapy for a condition that has a small survival rate. These findings, being published in the Oct. 4, 2013, online edition of PLOS ONE, also show that the use of a biotherapy consisting of a lysosomal protein, known as saposin C (SapC), and a phospholipid, known as dioleoylphosphatidylserine (DOPS), can be combined into tiny cavities, or nanovesicles, to target and kill pancreatic ...

SAN FRANCISCO – Oct. 4, 2013 – Healthcare workers' use of disposable gowns and gloves upon entering all patient rooms on an intensive care unit (ICU), versus only in rooms on standard isolation protocol, helped reduce patient acquisition of methicillin-resistant Staphylococcus aureus (MRSA) by approximately 40 percent, according to new research co-led by the University of Maryland School of Medicine and the Yale New Haven Health System Center for Healthcare Solutions. While the study did not show statistically significant results for preventing patient acquisition of another ...

The wearing of gloves and gowns by health care workers for all intensive care unit (ICU) patient contact did not reduce the rate of acquisition of a combination of the bacteria methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE), although there was a lower risk of MRSA acquisition alone, according to a study published online by JAMA. The study is being released early to coincide with its presentation at IDWeek 2013. Antibiotic-resistance is associated with considerable illness, death, and costs. MRSA and VRE are primary causes ...

INDIANAPOLIS -- An Indiana University cancer researcher and his colleagues have discovered new therapeutic targets and drugs that may someday benefit people with certain types of leukemia or blood cancer. Reuben Kapur, Ph.D., the Frieda and Albrecht Kipp Professor of Pediatrics at the IU School of Medicine and a researcher at the Indiana University Melvin and Bren Simon Cancer Center, and colleagues discovered in pre-clinical and pharmacological models that cancer cells with a mutation in the KIT receptor -- an oncogenic/cancerous form of the receptor -- in mast cell ...

HOUSTON – Children of melanoma survivors were more likely to wear hats and re-apply sunscreen after receiving a multi-media informational program designed specifically for them. These new findings were included in research published in the journal of Cancer Epidemiology, Biomarkers and Prevention – a publication of the American Association for Cancer Research. A team of researchers led by Ellen R. Gritz, Ph.D., and Mary Tripp, Ph.D., M.P.H., both researchers of Behavioral Science at The University of Texas MD Anderson Cancer Center, conducted a randomized trial to determine ...

WASHINGTON, D.C. Oct. 4, 2013 -- Researchers in Japan have developed a new photodiode that can detect in just milliseconds a certain type of high-energy ultraviolet light, called UVC, which is powerful enough to break the bonds of DNA and harm living creatures. The researchers describe their new device in the journal Applied Physics Letters. Although this radiation doesn't normally reach the Earth's surface, it can leak through to just below the hole in the ozone layer. Monitoring this radiation is a way of tracking the hole in the ozone layer, and photodiodes that measure ...

University of Notre Dame researchers Shahriar Mobashery and Mayland Chang and their collaborators in Spain have published research results this week that show how methicillin-resistant Staphylococcus aureus (MRSA) regulates the critical crosslinking of its cell wall in the face of beta-lactam antibiotics. The work, published in the Proceedings of the National Academy of Sciences, reveals the mechanistic basis for how the MRSA bacterium became such a difficult pathogen over the previous 50 years, in which time it spread rapidly across the world. Modern strains of MRSA ...

Understanding how genes act in specific tissues is critical to our ability to combat many human diseases, from heart disease to kidney failure to cancer. Yet isolating individual cell types for study is impossible for most human tissues. A new method developed by researchers at Princeton University and the University of Michigan called "in silico nano-dissection" uses computers rather than scalpels to separate and identify genes from specific cell types, enabling the systematic study of genes involved in diseases. The team used the new method to successfully identify ...

Philadelphia, Pa. (October 4, 2013) – Doctors who abuse prescription drugs often do so for "self-medication"—whether for physical or emotional pain or stress relief, reports a study in the October Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. Based on focus groups with physicians in treatment for substance abuse, the findings lend "unique insights" into the reasons why doctors abuse prescription medications—as well as important ...

NASA's footage of the first moon landing promised a future of sci-fi heroism that never came to pass, according to a new study. The paper, by Professor Steve Brown and Professor Martin Parker, of the University of Leicester's School of Management, and Dr Lewis Goodings, of the University of Roehampton, is published in the International Journal of Management Concepts and Philosophy. The first moon landing is overwhelmingly remembered as an exciting and important turning point in world history, which continues to inspire space exploration projects to Mars and beyond today. However, ...

SAN FRANCISCO – Swallowing pills containing a concentrate of fecal bacteria successfully stops recurrent bouts of debilitating Clostridium difficile (C. diff) infection by rebalancing the bacteria in the gut, suggests a study being presented at the IDWeek 2013™ meeting today. Infection from C. diff bacteria is such a concern that the Centers for Disease Control and Prevention (CDC) named it one of the three most urgent threats in its recent landmark report on antibiotic resistance. C. diff sickens half a million Americans and kills 14,000 every year. C. diff infection ...

SAN FRANCISCO – A vast majority of people who see their doctors for sore throats or acute bronchitis receive antibiotics, yet only a small percentage should, according to analyses of two major national surveys being presented at IDWeek 2013™. Those illnesses usually are caused by viruses, and antibiotics – which only treat bacterial infections – do not help. Harvard University researchers analyzed the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey and determined that doctors prescribed antibiotics in 60 percent of visits ...

SAN FRANCISCO – When patients with HIV are hospitalized for other conditions, such as a heart problem, surgery or complications of diabetes, mistakes are often made involving their complicated anti-retroviral therapy (ART) regimens. But those errors are more than twice as likely to be corrected when patients are seen by an infectious diseases (ID) physician, suggests a Cleveland Clinic study being presented at IDWeek 2013™ today. Most patients with HIV are cared for by physicians with HIV expertise in the community, and when they are hospitalized for non-HIV conditions, ...

VIDEO: In this video, scientists demonstrate how to deliver drugs to the mammary gland via nipple-injection. Click here for more information. On October 4, JoVE, the Journal of Visualized Experiments, will publish a new technique for breast cancer treatment and prevention—injection of therapeutics via the nipple. The procedure, demonstrated on mice, offers direct access to the most common origin of breast cancer, the milk ducts, and could be used to offer cancer therapy ...

Portland, Ore., USA (October 4, 2013) --- Being overweight shortens a dog's life expectancy according to new research by the WALTHAM® Centre for Pet Nutrition. Data on a range of popular dog breeds from across the USA showed that dogs that are overweight in middle age have a shorter life expectancy than ideal weight dogs. Specifically, overweight dogs were found to suffer a reduction in life expectancy of up to ten months compared to ideal weight dogs. Being overweight in middle age can have potentially far-reaching consequences for a dog's life span, highlighting the importance ...

SAN FRANCISCO – An investigational vaccine appears generally well tolerated and effective against the most common strain of norovirus, reducing the main symptoms of the gastrointestinal (GI) infection, vomiting and/or diarrhea, by 52 percent, suggests research being presented at IDWeek 2013™. Currently, there is no treatment or cure for norovirus, the most common cause of severe GI infection in the United States. Norovirus is highly contagious. Significant outbreaks occur in health care facilities, childcare centers and other places where people are in close quarters, ...

SAN FRANCISCO – Although they are at higher risk for cervical cancer, girls from low-income families are less likely to receive the human papillomavirus (HPV) vaccine that prevents it, and the reasons they are not fully vaccinated differ depending on whether their parents are English-speaking or Spanish-speaking, suggests research being presented at IDWeek 2013™. In the study, Spanish-speaking parents whose daughters were not fully vaccinated said their providers either did not encourage the vaccine or didn't explain that three shots were necessary for full protection. ...

University of Calgary scientists have discovered metabolic enzymes in the opium poppy that play "widespread roles" in enabling the plant to make painkilling morphine and codeine, and other important compounds. The discovery, by university researcher Peter Facchini and PhD student Scott Farrow, includes the first biochemical reaction of its kind ever reported in plants, which may also occur in garden-variety poppies and other plants. Their research, published this week as a cover story in the Journal of Biological Chemistry, sheds light on how the opium poppy – the world's ...

The mystery of why life on Earth evolved when it did has deepened with the publication of a new study in the latest edition of the journal Science. Scientists at the CRPG-CNRS University of Lorraine, The University of Manchester and the Institut de Physique du Globe de Paris have ruled out a theory as to why the planet was warm enough to sustain the planet's earliest life forms when the Sun's energy was roughly three-quarters the strength it is today. Life evolved on Earth during the Archean, between 3.8 and 2.4 billion years ago, but the weak Sun should have meant ...

Two French physicists, Bernard Sapoval and Marcel Filoche from École Polytechnique in Palaiseau, France, suggest in a study published in EPJ E how evolution has shaped our lungs through successive optimisations of physical parameters such as conservation of energy and speed of delivery. Our respiratory system consists of a bronchial tree designed to transport air through the lungs combined with an alveolar system designed to capture the oxygen. Both are subjected to different type of optimisations. Only tree-like structures, the paper shows, are able to efficiently feed ...

It's not visible to the naked eye and you can't feel it, but up to 40 per cent of your body's energy goes into supplying the microscopic sodium-potassium pump with the energy it needs. The pump is constantly doing its job in every cell of all animals and humans. It works much like a small battery which, among other things, maintains the sodium balance which is crucial to keep muscles and nerves working. The sodium-potassium pump transports sodium out and potassium into the cell in a fixed cycle. During this process the structure of the pump changes. It is well-established ...

CAMBRIDGE, MA -- In 2011, when an MIT senior named John Romanishin proposed a new design for modular robots to his robotics professor, Daniela Rus, she said, "That can't be done." Two years later, Rus showed her colleague Hod Lipson, a robotics researcher at Cornell University, a video of prototype robots, based on Romanishin's design, in action. "That can't be done," Lipson said. In November, Romanishin — now a research scientist in MIT's Computer Science and Artificial Intelligence Laboratory (CSAIL) — Rus, and postdoc Kyle Gilpin will establish once and for all that ...

Hanover, N.H.—In a study published in published in EMBO Molecular Medicine, a Dartmouth researcher found that dying heart cells are kept alive with spikes of oxygen. During a heart attack when the flow of oxygen-rich blood to a section of the heart is interrupted, and not quickly restored, heart muscle begins dying. Deprived of oxygen and other essential nutrients, cell death continues occurring over a period of time leading to progressive loss of heart function and congestive heart failure. Current therapies are not effective at limiting cell loss—they only slow down ...

TALLAHASSEE, Fla. - The left and right hemispheres of Albert Einstein's brain were unusually well connected to each other and may have contributed to his brilliance, according to a new study conducted in part by Florida State University evolutionary anthropologist Dean Falk. "This study, more than any other to date, really gets at the 'inside' of Einstein's brain," Falk said. "It provides new information that helps make sense of what is known about the surface of Einstein's brain." The study, "The Corpus Callosum of Albert Einstein's Brain: Another Clue to His High ...

A group of Brigham and Women's Hospital, and Harvard Stem Cell Institute researchers and collaborators at MIT and MGH have found a way to use stem cells as drug delivery vehicles. The researchers inserted modified strands of messenger RNA into connective tissue stem cells—called mesenchymal stem cells—which stimulated the cells to produce adhesive surface proteins and secrete interleukin-10, an anti-inflammatory molecule. When injected into the bloodstream of a mouse, these modified human stem cells were able to target and stick to sites of inflammation and release biological ...