Putnam Valley, NY. (Sept. 17, 2013) –A research team in Spain has developed high-yield preparations of viable hepatocytes (liver cells) isolated for transplantation from cryopreserved (frozen), banked neonatal livers that ranged in age from one day to 23 days. The researchers also assessed cell quality and function and found that neonatal hepatocytes show better thawing recovery than hepatocytes isolated from adult livers. The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-cog_09636897_ct1036tolosa "There ...

Traditional peer review is not enough to ensure data quality amid the recent boom in scientific research findings, according to results of a 10-year collaboration between the National Institute of Standards and Technology (NIST) and five technical journals. While production of research data is growing about 7 percent annually, about one-third of papers submitted to participating journals contained erroneous or incomplete chemical property data, according to a report by 32 authors from NIST and the collaborating journals.* Poor data can lead to mistakes in equipment selection, ...

The proclivity of Spaniards to bask in regions like the Costa del Sol while their northern European counterparts must stay under cover to protect their paler skin or risk skin cancer is due in large part to the pigment producing qualities of the MC1R gene locus. The MC1R gene, expressed in skin and hair follicle cells, is more diverse in Eurasian populations compared to African populations. Now, a team of researchers led by Santos Alonso, et. al., have examined the evolutionary selective pressure for MC1R among a large population of Spaniards in comparison to their Northern ...

Diversity of microbial growth strategies in a limited nutrient world The budding yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the cell cycle and signaling networks found in human biology having first been discovered in yeast. Now, scientists from New York University have now developed a sophisticated assay to track cell growth at very low nutrient concentrations. The assay uses time-lapse microscopy to monitor individual yeast cells undergoing a small number of divisions ...

(SACRAMENTO, Calif.) — Children with a genetic disorder called 22q11.2 deletion syndrome, who frequently are believed to also have autism, often may be misidentified because the social impairments associated with their developmental delay may mimic the features of autism, a study by researchers with the UC Davis MIND Institute suggests. The study is the first to examine autism in children with chromosome 22q11.2 deletion syndrome, in whom the prevalence of autism has been reported at between 20 and 50 percent, using rigorous gold-standard diagnostic criteria. The research ...

Pregnant women with a body mass index (BMI) that is too high or too low are more likely to have maternal complications, require additional hospital care and incur higher medical costs, according to a new study published today (18 September) in BJOG: An International Journal of Obstetrics and Gynaecology. The study was carried out in collaboration between researchers at the Universities of Edinburgh and Aberdeen, and the Information Services Division of NHS Scotland. It used routine obstetric records in Scotland, between 2003-2010, to investigate the impact of pregnant ...

DURHAM, N.C. -- Explorers need good maps, which they often end up drawing themselves. Pursuing their interests in using the brains of birds as a model for the human brain, an international team of researchers led by Duke neuroscientist Erich Jarvis and his collaborators Chun-Chun Chen and Kazuhiro Wada have just completed a mapping of the bird brain based on a 10-year exploration of the tiny cerebrums of eight species of birds. In a special issue appearing online in the Journal of Comparative Neurology, two papers from the Jarvis group propose a dramatic redrawing ...

Your smartphone now can see what the naked eye cannot: A single virus and bits of material less than one-thousandth of the width of a human hair. Aydogan Ozcan, a professor of electrical engineering and bioengineering at the UCLA Henry Samueli School of Engineering and Applied Science, and his team have created a portable smartphone attachment that can be used to perform sophisticated field testing to detect viruses and bacteria without the need for bulky and expensive microscopes and lab equipment. The device weighs less than half a pound. "This cellphone-based ...

Despite higher rates of diabetes in black and Hispanic women, the rate at which women die of diabetes-related diseases such as cardiovascular disease and cancer is the same for all postmenopausal women, regardless of race or ethnicity, according to a new UMass Medical School study. Lead author Yunsheng Ma, MD, PhD, MPH, associate professor of medicine, concludes that the way to reduce high diabetes-related death rates among all postmenopausal women—including black and Hispanic women—is through prevention of diabetes. This is particularly important, since much remains unknown ...

CORVALLIS, Ore. – In an analysis of 446 compounds for their the ability to boost the innate immune system in humans, researchers in the Linus Pauling Institute at Oregon State University discovered just two that stood out from the crowd – the resveratrol found in red grapes and a compound called pterostilbene from blueberries. Both of these compounds, which are called stilbenoids, worked in synergy with vitamin D and had a significant impact in raising the expression of the human cathelicidin antimicrobial peptide, or CAMP gene, that is involved in immune function. The ...

HEIDELBERG, 17 September 2013 – Scientists have succeeded in growing stem cells that have the ability to develop into two different types of cells that make up a healthy pancreas. The research team led by Dr. Hans Clevers of the Hubrecht Institute, The Netherlands, have isolated and grown stem cells from the pancreases of mice using a 3-D culture system previously developed by the scientists. The results, which are reported in The EMBO Journal, could eventually lead to ways to repair damaged insulin-producing beta cells or pancreatic duct cells. Cell signalling molecules ...

On Tuesday, September 17, JoVE, the Journal of Visualized Experiments, will publish a novel technique for imaging muscle function while in motion. Research in this area could uncover the root of musculoskeletal disorders, such as the development of osteoarthritis following ACL surgery. "The technique uses ultrasound waves to detect the motion of muscles using the Doppler principle," said the lab's principal investigator Dr. Siddhartha Sikdar, "We use a stereo method, where ultrasound waves from multiple directions are combined ... with a number of other biomechanical ...

The structure of the brain may predict whether a person will suffer chronic low back pain, according to researchers who used brain scans. The results, published in the journal Pain, support the growing idea that the brain plays a critical role in chronic pain, a concept that may lead to changes in the way doctors treat patients. The research was supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health. "We may have found an anatomical marker for chronic pain in the brain," said Vania Apkarian, Ph.D., ...

Raleigh-Durham, NC. -- A new meta-analysis of 29 randomized studies involving more than 4,500 patients with knee osteoarthritis (OA) found that intra-articular hyaluronic acid (HA) injections provided significant improvement in pain and function compared to saline injections. The study, "US-Approved Intra-Articular Hyaluronic Acid Injections are Safe and Effective in Patients with Knee Osteoarthritis: Systematic Review and Meta-Analysis of Randomized, Saline-Controlled Trials," was published online this month in Clinical Medicine Insights: Arthritis and Musculoskeletal ...

Bethesda, MD -- Carbonation, an essential component of popular soft drinks, alters the brain's perception of sweetness and makes it difficult for the brain to determine the difference between sugar and artificial sweeteners, according to a new article in Gastroenterology, the official journal of the American Gastroenterological Association. "This study proves that the right combination of carbonation and artificial sweeteners can leave the sweet taste of diet drinks indistinguishable from normal drinks," said study author, Rosario Cuomo, associate professor, gastroenterology, ...

The first of its kind, the review showed 461 cases of links between racism and child and youth health outcomes. Lead researcher Dr Naomi Priest at the McCaughey VicHealth Centre for Community Wellbeing at the University of Melbourne said the review demonstrated racism as an important factor influencing the health and wellbeing of children and youth. "The review showed there are strong and consistent relationships between racial discrimination and a range of detrimental health outcomes such as low self-esteem, reduced resilience, increased behaviour problems and lower ...

In excavating sites in a long-inhabited urban area like Jerusalem, archaeologists are accustomed to noting complexity in their finds -- how various occupying civilizations layer over one another during the site's continuous use over millennia. But when an area has also been abandoned for intermittent periods, paradoxically there may be even richer finds uncovered, as some layers have been buried and remainundisturbed by development. Such appears be the case at an archaeological dig on Jerusalem's Mount Zion, conducted by the University of North Carolina at Charlotte, ...

The National Heart Centre Singapore (NHCS) research team has successfully and completely reversed the effects of the hERG (human ether-a-go-go-related gene) mutation in long QT syndrome 2 (LQTS 2) in patient-specific heart cells, scoring a world's first. Long QT syndrome 2 is a dangerous heart rhythm disorder that can lead to sudden cardiac death, even in young patients. It is caused by a mutation in a specific gene known as hERG, which helps to control the electrical activity in the heart cells and coordinate its beating rhythm. Using the patient's own skin stem cells ...

More children than ever before are living with a debilitating digestive disease, research has shown. Scientists have found that coeliac disease affects six times more children living in Scotland now than it did in 1990. A team from the University of Edinburgh and Queen Margaret University analysed the health records of children from South East Scotland aged under 16 years who were newly diagnosed with the condition between 1990 and 2009. The team – based at Royal Hospital for Sick Children in Edinburgh – found that the rate of children being newly diagnosed with Coeliac ...

Using a simple survey tool, a team of researchers has done what complex studies have failed to do -- provide data that identifies starting points for preventing diarrheal disease outbreaks in at least one region of Africa. Diarrheal illness is a leading cause of disease and death in children under 5, and in HIV-plagued Botswana, it is a significant issue for those over 5 as well. "Yet we still know little about the dynamics of this illness and other infectious diseases," said disease ecologist Kathleen Alexander, an associate professor of wildlife in the College of ...

Should surgery be performed immediately, or is it better to first administer antibiotics and then perform surgery? A study led by Heidelberg University Hospital Department of Surgery has demonstrated that patients suffering from acute cholecystitis should be operated on immediately. There are no advantages to delaying surgery until antibiotic therapy has been administered for several weeks. After undergoing surgery performed within 24 hours of diagnosis, the patients have fewer complications, are back on their feet earlier, and can leave the hospital more quickly. "With ...

A first-ever study of air trapped in the deep snowpack of Greenland shows that atmospheric levels of carbon monoxide (CO) in the 1950s were actually slightly higher than what we have today. This is a surprise because current computer models predict much higher CO concentrations over Greenland today than in 1950. Now it appears the opposite is in fact true. In a paper recently published in the journal Atmospheric Chemistry and Physics, Vasilii Petrenko, an assistant professor of earth and environmental sciences, concluded that CO levels rose slightly from 1950 until the ...

The study, led by McGill University evolutionary biologist Ben Haller in collaboration with IIASA Evolution and Ecology Program Leader Ulf Dieckmann and IIASA researcher Rupert Mazzucco, suggests that a varied environment spurs the evolution of new species and promotes biodiversity by creating places of refuge—"refugia"—for new organisms to evolve. The model represents asexual organisms that reproduce like plants. To investigate how environmental variation affects evolution, Haller modeled an environment with complex spatial structure. "We wanted to look at more realistic ...

Putnam Valley, NY. (Sept. 17 2013) – Vaginal delivery presents the possibility of injury for mothers that can lead to "stress urinary incontinence" (SUI), a condition affecting from four to 35 percent of women who have had babies via vaginal delivery. Many current treatments, such as physiotherapy and surgery, are not very effective. Seeking better methods to alleviate SUI, researchers carried out a study in which female laboratory rats modeled with simulated childbirth injuries received injections of mesenchymal stem cells (MSCs; multipotent cells found in connective ...

(Edmonton) Researchers at the University of Alberta have developed a synthetic peptide that could be the first in a new class of drugs to treat heart disease, high blood pressure and diabetes. Researchers at the U of A found that a deficiency in the peptide apelin is associated with heart failure, pulmonary hypertension and diabetes. They also developed a synthetic version that targets pathways in the heart and promotes blood vessel growth. Lead author Gavin Oudit, an associate professor in the Faculty of Medicine & Dentistry, said the synthetic form of apelin is far ...