ROCHESTER, Minn. -- Low-dose intravenous infusions of ketamine, a general anesthetic used in minor surgeries, given over a long period are an effective treatment for depression, Mayo Clinic researchers found. The study is published in the Journal of Psychopharmacology. About a decade ago researchers discovered that ketamine had the potential to alleviate severe depression. However, ketamine also can have serious psychiatric side effects, so studies have been exploring the safest way to use it. "It's surprising both that it works and how rapidly it has effects," says ...

Cartilage injuries are difficult to repair. Current surgical options generally involve taking a piece from another part of the injured joint and patching over the damaged area, but this approach involves damaging healthy cartilage, and a person's cartilage may still deteriorate with age. Bioengineers are interested in finding innovative ways to grow new cartilage from a patient's own stem cells, and, thanks to a new study from the University of Pennsylvania, such a treatment is a step closer to reality. The research was conducted by associate professor Jason Burdick ...

Obese teenagers who reduced their body mass index (BMI) by 8 percent or more had improvements in insulin sensitivity, an important metabolic factor related to the later development of type 2 diabetes. The teens followed a family-based, lifestyle-modification weight loss program that offers the potential to become a broader model. BMI is a measure of body weight adjusted for height. "This threshold effect that occurs at 8 percent suggests that obese adolescents don't need to lose enormous amounts of weight to achieve improvements," said pediatric endocrinologist Lorraine ...

ANN ARBOR—Zebrafish with very weak muscles helped scientists decode the elusive genetic mutation responsible for Native American myopathy, a rare, hereditary muscle disease that afflicts Native Americans in North Carolina. Scientists led by John Kuwada, professor of molecular, cellular and developmental biology at the University of Michigan, and Hiromi Hirata of the National Institute of Genetics in Japan originally identified the gene in mutant zebrafish that exhibited severe muscle weakness. Native American myopathy causes muscle weakness from birth and other severe ...

COLUMBIA, Mo. –Stories often appear in health communication in order to encourage individuals to change behaviors, such as smoking or not wearing sunscreen. A University of Missouri researcher studied how stories influence patients' decision-making when behavior change is not the desired outcome of the health communication. "Patient stories can be very persuasive, and people tend to seek stories from others when they make health decisions," said Victoria Shaffer, an assistant professor of health sciences and psychological sciences at MU. "We were concerned about whether ...

More than a third of marriages between 2005 and 2012 began online, according to new research at the University of Chicago, which also found that online couples have happier, longer marriages. Although the study did not determine why relationships that started online were more successful, the reasons may include the strong motivations of online daters, the availability of advance screening, and the sheer volume of opportunities online. "These data suggest that the Internet may be altering the dynamics and outcomes of marriage itself," said the study's lead author, ...

Researchers at the University of California, San Diego School of Medicine, with colleagues at the University of Rochester Medical Center, have identified a new mechanism that appears to suppress tumor growth, opening the possibility of developing a new class of anti-cancer drugs. Writing in this week's online Early Edition of the Proceedings of the National Academy of Sciences (PNAS), Willis X. Li, PhD, a professor in the Department of Medicine at UC San Diego, reports that a particular form of a signaling protein called STAT5A stabilizes the formation of heterochromatin ...

Researchers at Karolinska Institutet in Sweden have found a promising strategy for defeating neuroblastoma – a malignant form of cancer in children – that focuses on the so-called MYCN protein. A specific chemical molecule helps to break down MYCN, which either kills the cancer cell or makes it mature into a harmless neuron. The discovery, which is published in the scientific journal PNAS, raises hopes for new and more effective treatments in the future. Neuroblastoma is the third most common form of cancer in children. It usually develops before the age of two and affects ...

States that choose not to expand Medicaid under federal health care reform will leave millions of their residents without health insurance and increase spending, at least in the short term, on the cost of treating uninsured residents, according to a new RAND Corporation study. If 14 states decide not to expand Medicaid under the Affordable Care Act as intended by their governors, those state governments collectively will spend $1 billion more on uncompensated care in 2016 than they would if Medicaid is expanded. In addition, those 14 state governments would forego ...

Early-life risk factors -- most of which could be changed -- appear to explain the recognized racial and ethnic disparities in the incidence of childhood overweight and obesity. In a report being published online in JAMA Pediatrics, a team of researchers report a prospective study finding that increased prevalence of obesity and overweight among black and Hispanic 7-year-olds could largely be explained by risk factors such as rapid infant weight gain, early introduction of solid foods and a lack of exclusive breast feeding. "We know that, already by the age of 2, black ...

PHILADELPHIA, PA June 2013—France is renowned the world over as a leader in the crafts of viticulture and winemaking—but the beginnings of French viniculture have been largely unknown, until now. Imported ancient Etruscan amphoras and a limestone press platform, discovered at the ancient port site of Lattara in southern France, have provided the earliest known biomolecular archaeological evidence of grape wine and winemaking—and point to the beginnings of a Celtic or Gallic vinicultural industry in France circa 500-400 BCE. Details of the discovery are published as "The ...

To comply with a statewide "fair pricing" law, hospitals throughout California have significantly lowered prices to uninsured patients, with nearly all even going beyond the state mandate and offering free care to those below the poverty line. The surprising success of the legislation represents the beginnings of a safety net not in place for other states. Some 6.8 million people in California lack health insurance, often relying on hospital emergency departments for healthcare. Based on hospital billing plans, those visits can rack up huge bills that the uninsured ...

SAN FRANCISCO (June 3, 2013) — The old saying "You are what you eat" takes on new significance in the most comprehensive analysis to date of early human teeth from Africa. Prior to about 3.5 million years ago, early humans dined almost exclusively on leaves and fruits from trees, shrubs, and herbs—similar to modern-day gorillas and chimpanzees. However, about 3.5 million years ago, early human species like Australopithecus afarensis and Kenyanthropus platyops began to also nosh on grasses, sedges, and succulents—or on animals that ate those plants. Evidence of this ...

Diseases such as tuberculosis, anthrax, and shigellosis -- a severe food-borne illness -- eventually could be treated with an entirely new and more-effective kind of antibiotic, thanks to a team of scientists led by Kenneth Keiler, an associate professor of biochemistry and molecular biology at Penn State University. In a research paper that will be published in the journal Proceedings of the National Academy of Sciences during the week beginning 3 June 2013, the team describes 46 previously untested molecules that target and disrupt an important step in the process of ...

A new look at the diets of ancient African hominids shows a "game changer" occurred about 3.5 million years ago when some members added grasses or sedges to their menus, according to a new study led by the University of Colorado Boulder. High-tech tests on tooth enamel by researchers indicate that prior to about 4 million years ago, Africa's hominids were eating essentially chimpanzee style, likely dining on fruits and some leaves, said CU-Boulder anthropology Professor Matt Sponheimer, lead study author. Despite the fact that grasses and sedges were readily available ...

GALVESTON, Texas — Prescriptions for testosterone therapy have increased significantly during the last 10 years, according to a study in the current issue of JAMA Internal Medicine conducted by researchers at the University of Texas Medical Branch. About 50 percent of the men in the study who had received testosterone therapy had been diagnosed as having hypogonadism, a condition where a man is unable to produce the normal levels of testosterone. But the study also found that, among new users of a prescription androgen product, about 25 percent did not have their testosterone ...

Using cholesterol-lowering statins may be associated with musculoskeletal conditions, arthropathies (joint diseases) and injuries, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication. While statins effectively lower cardiovascular illnesses and death, the full spectrum of statin musculoskeletal adverse events (AEs) is unknown. Statin-associated musculoskeletal AEs include a wide variety of clinical presentations, including muscle weakness, muscle cramps and tendinous (tendon) diseases, the authors write in the study background. Ishak ...

Vegetarian diets are associated with reduced death rates in a study of more than 70,000 Seventh-day Adventists with more favorable results for men than women, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication. The possible relationship between diet and mortality is an important area of study. Vegetarian diets have been associated with reductions in risk for several chronic diseases, including hypertension, metabolic syndrome, diabetes mellitus and ischemic heart disease (IHD), according to the study background. Michael ...

Racial and ethnic disparities in children who are overweight and obese may be determined by risk factors in infancy and early childhood, according to a study published Online First by JAMA Pediatrics, a JAMA Network publication. Over three decades, the rates of overweight and obesity among children have substantially increased worldwide. In the United States, the prevalence is estimated to be 32 percent among children and adolescents, according to the study background. Elsie M. Taveras, M.D., M.P.H., now of the MassGeneral Hospital for Children, Boston, and colleagues ...

A study by Helen Wong, R.D., of The Hospital for Sick Children, Ontario, Canada, and colleagues examined the safety and efficacy of dietary flaxseed supplementation in the management of hypercholesterolemia (high levels of cholesterol) in children. (Online First) The randomized clinical trial included 32 participants ages 8 to 18 years with low-density lipoprotein cholesterol levels ranging from 135 mg/dL to less than 193 mg/dL. Participants were randomly assigned to either the intervention group or control group. The intervention group ate 2 muffins and 1 slice of bread ...

A study by Hans-Peter Hartung, M.D., of Heinrich-Heine-Universität, Düsseldoft, Germany, and colleagues examines the association between IL-17F and treatment response to interferon beta-1b among patients with relapsing-remitting multiple sclerosis. (Online First) Serum samples were analyzed with an immunoassay from 239 randomly selected patients treated with interferon beta-1b, 250 micrograms, for at least 2 years in the Betaferon Efficacy Yielding Outcomes of a New Dose Study. Researchers measured the levels of IL-17F at baseline and month 6, as well as the difference ...

Employers have to pay around £4,000 more a year to employ a member of staff who smokes compared to a non-smoking employee, finds research published online in the Tobacco Control journal. US researchers found that several factors including absenteeism, smoking breaks and healthcare costs result in a greater cost to the employer for having a smoker on staff and this cost could help inform their workplace tobacco policies. The risks to a person's health from smoking include a higher risk of developing cancer, heart or lung disease and currently around 10 million adults ...

Around half of people with an extreme form of obsessive compulsive disorder responded well to a type of psychosurgery that proved to be safe and effective, according to research published online in the Journal of Neurology, Neurosurgery, & Psychiatry. Researchers from Canada have now recommended physicians should consider this approach in helping people with OCD who have not responded to any other type of treatment. Obsessive compulsive disorder (OCD) is a psychiatric disease which leads to anxiety-provoking thoughts (obsessions) causing repeated, time-consuming behaviors ...

Less than half of terminally ill patients are placed on the Liverpool Care Pathway for the Dying Patient (LCP) despite it being recommended nationally, concludes UK research published online in the BMJ Supportive & Palliative Care journal. Durham University researchers found that in many parts of England, staff may have limited training or support to use the care pathway, which is a model of care that enables healthcare professionals to focus on care in the last hours or days of life when a death is expected. The pathway was jointly developed by the Marie Curie Hospice ...

Scientists have discovered a new enzyme that could prove an important step in the quest to turn waste (such as paper, scrap wood and straw) into liquid fuel. To do this they turned to the destructive power of tiny marine wood-borers called 'gribble', which have been known to destroy seaside piers. Using advanced biochemical analysis and X-ray imaging techniques, researchers from the University of York, University of Portsmouth and the National Renewable Energy Laboratory in the USA have determined the structure and function of a key enzyme used by gribble to break down ...