Increased iron levels may be causally associated with a decreased risk of developing Parkinson's disease, says a new paper published this week in PLOS Medicine. Irene Pichler from EURAC in Italy and a group of international colleagues investigated whether there was any evidence of an association between serum iron levels and the risk of Parkinson's disease. While the causes of Parkinson's disease are currently unknown, a combination of genetic and environmental factors are said to be attributed to the disease. Because previous studies have shown a possible association ...

Addressing the burden of household air pollution from solid fuel combustion— the leading environmental cause of death and disability in the world—has led to the implementation of many important interventions to promote access to improved stoves and clean fuels, but there is little demonstrated evidence of health benefits from most of these programs or technologies. Such are the conclusions of a new Policy Forum article published in this week's PLOS Medicine by authors who also outline a set of research priorities for addressing household air pollution. A group of international ...

Among mild to moderately obese patients with type 2 diabetes, adding gastric bypass surgery to lifestyle and medical management was associated with a greater likelihood of improved levels of metabolic risk factors such as blood glucose, LDL-cholesterol and systolic blood pressure, according to a study in the June 5 issue of JAMA. "The foundation of treatment for type 2 diabetes mellitus is weight loss, achieved through reduction of energy intake and increased physical activity via lifestyle modification. Results from the Look AHEAD (Action for Health in Diabetes) trial ...

A review of more than 50 studies found limited evidence supporting the use of bariatric surgical procedures for non-morbidly obese adults (body mass index [BMI] 30-35) with diabetes or impaired glucose intolerance, according to a study in the June 5 issue of JAMA. For the limited data that was available for this patient group, bariatric surgery was associated with greater improvements in short-term weight loss, intermediate blood glucose levels, blood pressure, and high cholesterol than nonsurgical interventions such as medications, diet, and behavioral changes. "Bariatric ...

"Exposure to high altitude can cause acute mountain sickness (AMS) and, in severe cases, cerebral or pulmonary edema. Capillary leakage has been hypothesized to play a role in the pathogenesis of AMS, although the mechanism of altitude-related illnesses remains largely unknown," writes Gabriel Willmann, M.D., of the University of Tubingen, Germany, and colleagues. "Vessel leakage in the retinal periphery has not been investigated. Our objective was to assess retinal vessel integrity at high altitude using fluorescein angiography." As reported in a Researcher Letter, the ...

Some 40 million years before rock and roll singer Jim Morrison's lyrics earned him the moniker "the Lizard King," an actual king lizard roamed the hot tropical forests of Southeast Asia, competing with mammals for food and other resources. A team of U.S. paleontologists, led by Jason Head of the University of Nebraska-Lincoln, describes fossils of the giant lizard from Myanmar this week in the scientific journal Proceedings of the Royal Society B. Their analysis shows that it is one of the biggest known lizards ever to have lived on land. Fittingly, it's been named ...

A joint project between the Griffith University and the UQ Centre for clinical Research (UQCCR) has characterised an in vitro model that allows further studies on the breast cancer biology. These studies include the confirmation that primary tissue obtained from patients with breast cancer behaves similarly to those derived from long-term cultured cell lines. Griffith University's Associate Professor Alejandro Lopez said the team was working towards making breast cancer stem cells the target of specific cancer therapies, to improve current treatment outcomes. "We ...

Drugs that are used for treating Alzheimer's disease in its early stages are linked to a reduced risk of heart attacks and death, according to a large study of over 7,000 people with Alzheimer's disease in Sweden. The research, which is published online today (Wednesday) in the European Heart Journal [1], looked at cholinesterase inhibitors (ChEIs), such as donepezil, rivastigmine and galantamine, which are used for treating mild to moderate Alzheimer's disease [2]. Side-effects of ChEIs include a beneficial effect on the vagus nerve, which controls the rate at which ...

A remote controlled helicopter has been flown through a series of hoops around a college gymnasium in Minnesota. It sounds like your everyday student project; however, there is one caveat…the helicopter was controlled using just the power of thought. The experiments have been performed by researchers hoping to develop future robots that can help restore the autonomy of paralysed victims or those suffering from neurodegenerative disorders. Their study has been published today, 4 June 2013, in IOP Publishing's Journal of Neural Engineering and is accompanied by a video ...

Researchers at the University of Exeter and the University of Hamburg investigated how personality is transferred between generations. They found that foster parents have a greater influence on the personalities of fostered offspring than the genes inherited from birth parents. Dr Nick Royle from the University of Exeter said: "This is one of the first experiments to show that behaviour can be non-genetically transmitted from parents to offspring. Our study shows that in zebra finches, personality traits can be transmitted from one generation to another through behaviour ...

In the first genome-wide association study to focus on warfarin dose requirement in African-Americans, a multi-institutional team of researchers has identified a common genetic variation that can help physicians estimate the correct dose of the widely used blood-thinning drug warfarin. The discovery, reported online first in The Lancet, suggests that people of African ancestry who carry this variant—more than 40 percent of the patients enrolled in this study—need significantly less warfarin to obtain optimal benefits compared to those who lack this variant. "Adding ...

Biologists have uncovered new insights into how the male sexual behaviour of the peculiar southern bottletail squid is primed to produce the greatest number of offspring. Recent studies published in the journals Biology Letters and Behavioral Ecology, have revealed the female squid ingest the ejaculates of their mates, a trait never before associated with any species of cephalopod – a group including squid, octopus, cuttlefish and nautilus. The studies, led by PhD student Benjamin Wegener and Dr Bob Wong from Monash University's School of Biological Sciences, in collaboration ...

Bariatric surgery such as gastric bypass is associated with better short-term control of abnormal blood sugar and more weight loss than conventional nonsurgical therapy in diabetic patients who are moderately obese, but there is not enough evidence to more widely recommend the procedure, according to a new RAND Corporation study. A review of more than 30 studies found that diabetic people with moderate obesity lost more weight and had better glucose control over two years if they were treated with bariatric surgery rather than non-surgical alternatives like dieting and ...

A scientific team led by University of Louisville doctoral student Karen Collins has discovered a hot Saturn-like planet in another solar system 700 light-years away. Collins announced the discovery of exoplanet KELT-6b Tuesday, June 4, during the American Astronomical Society's national meeting in Indianapolis. Astronomers caught sight of the planet when it passed in front of, or "transited," its host star—and they've since discovered that the planet resembles one of the most famous and well-studied transiting planets, HD 209458b. The discovery was made using inexpensive ...

ANN ARBOR—Researchers at the University of Michigan have evidence that a single gene controls both halves of nerve cells, and their research demonstrates the need to consider that design in the development of new treatments for regeneration of nerve cells. A paper published online in PLOS Biology by U-M Life Sciences Institute faculty member Bing Ye and colleagues shows that manipulating genes of the fruit fly Drosophila to promote the growth of one part of the neuron simultaneously stunts the growth of the other part. Understanding this bimodal nature of neurons ...

TAMPA, Fla. (June 4, 2013) – Scientists may not know for certain whether life exists in outer space, but new research from a team of scientists led by a University of South Florida astrobiologist now shows that one key element that produced life on Earth was carried here on meteorites. In an article published in the new edition of the Proceedings of the National Academies of Sciences, USF Assistant Professor of Geology Matthew Pasek and researchers from the University of Washington and the Edinburg Centre for Carbon Innovation, revealed new findings that explain how the ...

In a new publication that appears in Human Molecular Genetics, the laboratory of Christine DiDonato, PhD reports on their pharmacological characterization of the drug RG3039, demonstrating that it can extend survival and improve function in two spinal muscular atrophy (SMA) mouse models. They have determined the minimum effective dose and drug action, thus contributing to dose selection and exposure estimates for the first studies with RG3039 in humans. As in cellular assays, the animal studies have shown that drug treatment leads to improvement in nuclear gem/Cajal body ...

NASA's Aqua satellite captured multiple plumes of smoke from agricultural fires and industrial pollution in China. The smoke and haze stretches from Inner Mongolia, located north of Beijing, south and west including the provinces of Hebei, Shedong, Henan, Shanxi, Hubai, Hunan, and Chongqing. The Moderate Resolution Imaging Spectroradiometer (MODIS) instrument aboard NASA's Aqua satellite has infrared capabilities that can detect heat from the various wildfires. This image was captured on June 2, 2013 5:55 UTC (1:55 a.m. EDT/2:05 p.m. MT). In the MODIS images, fires, or ...

TORONTO, ON, June 4, 2013 — While only a small percentage of adult males who are victims of sex assault report the crime, a new study by Women's College Research Institute (WCRI) and the Ontario Network of Sexual Assault/Domestic Violence Treatment Centres (ONSA/DVTCs) shows of those who do, an overwhelming majority — almost 90 per cent — use five or more services ranging from counselling to medical care and treatment. The study, published in the Journal of Interpersonal Violence, sheds light on the characteristics of male victims of sex assault and the services they ...

About one of every two people diagnosed with posttraumatic stress disorder (PTSD) also suffer symptoms of depression, according to new research by Case Western Reserve University's Department of Psychological Sciences. The analysis also concludes that both genders diagnosed with PTSD equally suffer from depression. Since women tend to report more symptoms of depression than men, this contradicts a general belief that women are more inclined to struggle with both. The findings were based on an analysis of 57 peer-reviewed studies, representing data on 6,670 people (civilians ...

Berkeley — In a quest to make concrete more durable and sustainable, an international team of geologists and engineers has found inspiration in the ancient Romans, whose massive concrete structures have withstood the elements for more than 2,000 years. Using the Advanced Light Source at Lawrence Berkeley National Laboratory (Berkeley Lab), a research team from the University of California, Berkeley, examined the fine-scale structure of Roman concrete. It described for the first time how the extraordinarily stable compound -- calcium-aluminum-silicate-hydrate (C-A-S-H) ...

What do swimmers like trout, eels and sandfish lizards have in common? According to a new study, the similar timing patterns that these animals use to contract their muscles and produce undulatory swimming motions can be explained using a simple model. Scientists have now applied the new model to understand the connection between the electrical signals and body movement in the sandfish. Most swimming creatures rely on an undulating pattern of body movement to propel themselves through fluids. Though differences in body flexibility may lead to different swimming styles, ...

When it comes to taking diet advice from a physician—size matters. This is according to a new study led by a team of researchers at the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins University School of Medicine who examined the impact of primary care physician BMI (body mass index) on their patients' trust and perceptions of weight-related stigma. They found that overweight and obese patients trust weight-related counseling from overweight physicians more than normal weight physicians and patients seeing an obese primary care physician were more ...

SAN FRANCISCO, June 4, 2013 -- An innovative financial lending program is helping low-income individuals build credit, reduce debt and find their financial footing, according to a pair of studies released today from San Francisco State University's César E. Chávez Institute (CCI). Lending Circles, a program managed by the nonprofit Mission Asset Fund, dramatically improved credit scores for low-income residents of San Francisco, the studies found. In addition, the reports suggest the program can be successfully replicated in other communities and could serve as a nationwide ...

WINSTON-SALEM, N.C. – June 4, 2013 – People suffering from type 2 diabetes and cardiovascular disease (CVD) are at an increased risk of cognitive decline, according to a new study from Wake Forest Baptist Medical Center. Lead author Christina E. Hugenschmidt, Ph.D., an instructor of gerontology and geriatric medicine at Wake Forest Baptist, said the results from the Diabetes Heart Study-Mind (DHS-Mind) suggest that CVD is playing a role in cognition problems before it is clinically apparent in patients. The research appears online ahead of print in the Journal of Diabetes ...